Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1α-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: Substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for the proline leads to a high rate of uncoupled 2-oxoglutarate decarboxylation

Journal of Biological Chemistry

Volumn 279, Issue 53, 2004, Pages 55051-55059

  Li, Dongxia ^b   Hirsilä, Maija ^a   Koivunen, Peppi ^a   Brenner, Mitchell C ^b   Xu, Leon ^b   Yang, Charles ^b   Kivirikko, Kari I ^a   Myllyharju, Johanna ^a  

^a UNIVERSITY OF OULU   (Finland)

^b FIBROGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CARBOXYLIC ACIDS; ENZYMES; HYDROXYLATION;

AMINO ACID SUBSTITUTIONS; DECARBOXYLATION; HYPOXIA-INDUCIBLE TRANSCRIPTION FACTOR (HIF); PROPYL 4-HYDROXYLASES (P4H);

AMINO ACIDS;

2 OXOGLUTARIC ACID; 3,4 DEHYDROPROLINE; ALANINE; AZETIDINE 2 CARBOXYLIC ACID; GLUTAMIC ACID; HYPOXIA INDUCIBLE FACTOR 1ALPHA; ISOLEUCINE; LEUCINE; METHIONINE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLINE; SERINE; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DECARBOXYLATION; HYDROXYLATION; INSECT CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN STRUCTURE;

ALANINE; AMINO ACID MOTIFS; ANIMALS; AZETIDINECARBOXYLIC ACID; BACULOVIRIDAE; CELL LINE; CHROMATOGRAPHY, LIQUID; CULTURE MEDIA, SERUM-FREE; GLUTAMIC ACID; HUMANS; HYDROXYLATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INSECTS; KETOGLUTARIC ACIDS; KINETICS; LEUCINE; MASS SPECTROMETRY; METHIONINE; MODELS, CHEMICAL; PEPTIDES; PROCOLLAGEN-PROLINE DIOXYGENASE; PROLINE; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY; TIME FACTORS; TRANSCRIPTION FACTORS;

ANIMALIA; INSECTA;

EID: 11244279649     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M410287200     Document Type: Article

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