Identification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains

Biochemical Journal

Volumn 408, Issue 2, 2007, Pages 231-240

  Villar, Diego ^a   Vara Vega, Alicia ^a   Landázuri, Manuel O ^a   Del Peso, Luis ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

EGL nine homologue (EGLN); Hypoxia; Hypoxia inducible factor (HIF); Oxygen degradation domain (ODD); Proline hydroxylase domain (PHD); Von Hippel Lindau protein (VHL protein)

Indexed keywords

DOMAIN SWAPPING; HYPOXIA; PROLINE HYDROXYLASE DOMAINS; PROTEASOMAL DEGRADATION;

BINDING SITES; DEGRADATION; HYDROXYLATION; OXYGEN;

TRANSCRIPTION FACTORS;

EGLN1 ENZYME; EGLN2 ENZYME; EGLN3 ENZYME; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE;

HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; OXYGEN; PROCOLLAGEN-PROLINE DIOXYGENASE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 36749095315     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20071052     Document Type: Article

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