-
1
-
-
0033551844
-
Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family
-
Abbaszade I, Liu RQ, Yang F, Rosenfeld SA, Ross OH, Link JR, Ellis DM, Tortorella MD, Pratta MA, Hollis JM, Wynn R, Duke JL, George HJ, Hillman MC, Jr, Murphy K, Wiswall BH, Copeland RA, Decicco CP, Bruckner R, Nagase H, Itoh Y, Newton RC, Magolda RL, Trzaskos JM, Burn TC (1999) Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. J Biol Chem 274: 23443-23450.
-
(1999)
J Biol Chem
, vol.274
, pp. 23443-23450
-
-
Abbaszade, I.1
Liu, R.Q.2
Yang, F.3
Rosenfeld, S.A.4
Ross, O.H.5
Link, J.R.6
Ellis, D.M.7
Tortorella, M.D.8
Pratta, M.A.9
Hollis, J.M.10
Wynn, R.11
Duke, J.L.12
George, H.J.13
Hillman Jr, M.C.14
Murphy, K.15
Wiswall, B.H.16
Copeland, R.A.17
Decicco, C.P.18
Bruckner, R.19
Nagase, H.20
Itoh, Y.21
Newton, R.C.22
Magolda, R.L.23
Trzaskos, J.M.24
Burn, T.C.25
more..
-
2
-
-
34447509660
-
Global analyses of gene expression in early experimental osteoarthritis
-
Appleton CT, Pitelka V, Henry J, Beier F (2007) Global analyses of gene expression in early experimental osteoarthritis. Arthritis Rheum 56: 1854-1868.
-
(2007)
Arthritis Rheum
, vol.56
, pp. 1854-1868
-
-
Appleton, C.T.1
Pitelka, V.2
Henry, J.3
Beier, F.4
-
3
-
-
3543123557
-
Effect of adenovirus-mediated overexpression of bovine ADAMTS-4 and human ADAMTS-5 in primary bovine articular chondrocyte pellet culture system
-
Arai M, Anderson D, Kurdi Y, Annis-Freeman B, Shields K, Collins-Racie LA, Corcoran C, DiBlasio-Smith E, Pittman DD, Dorner AJ, Morris E, LaVallie ER (2004) Effect of adenovirus-mediated overexpression of bovine ADAMTS-4 and human ADAMTS-5 in primary bovine articular chondrocyte pellet culture system. Osteoarthritis Cartilage 12: 599-613.
-
(2004)
Osteoarthritis Cartilage
, vol.12
, pp. 599-613
-
-
Arai, M.1
Anderson, D.2
Kurdi, Y.3
Annis-Freeman, B.4
Shields, K.5
Collins-Racie, L.A.6
Corcoran, C.7
DiBlasio-Smith, E.8
Pittman, D.D.9
Dorner, A.J.10
Morris, E.11
LaVallie, E.R.12
-
4
-
-
0030910398
-
Cleavage of native cartilage aggrecan by neutrophil collagenase (MMP-8) is distinct from endogenous cleavage by aggrecanase
-
Arner EC, Decicco CP, Cherney R, Tortorella MD (1997) Cleavage of native cartilage aggrecan by neutrophil collagenase (MMP-8) is distinct from endogenous cleavage by aggrecanase. J Biol Chem 272: 9294-9299.
-
(1997)
J Biol Chem
, vol.272
, pp. 9294-9299
-
-
Arner, E.C.1
Decicco, C.P.2
Cherney, R.3
Tortorella, M.D.4
-
5
-
-
0033525533
-
Generation and Characterization of Aggrecanase. A soluble, cartilage- derived aggrecan-degrading activity
-
Arner EC, Pratta MA, Trzaskos JM, Decicco CP, Tortorella MD (1999) Generation and Characterization of Aggrecanase. A soluble, cartilage- derived aggrecan-degrading activity. J Biol Chem 274: 6594-6601.
-
(1999)
J Biol Chem
, vol.274
, pp. 6594-6601
-
-
Arner, E.C.1
Pratta, M.A.2
Trzaskos, J.M.3
Decicco, C.P.4
Tortorella, M.D.5
-
6
-
-
0026760277
-
Hyaluronan-binding region of aggrecan from pig laryngeal cartilage
-
Barry FP, Gaw JU, Young CN, Neame PJ (1992) Hyaluronan-binding region of aggrecan from pig laryngeal cartilage. Biochem J 286: 761-769.
-
(1992)
Biochem J
, vol.286
, pp. 761-769
-
-
Barry, F.P.1
Gaw, J.U.2
Young, C.N.3
Neame, P.J.4
-
7
-
-
0028982223
-
N- and O-linked keratan sulfate on the hyaluronan binding region of aggrecan from mature and immature bovine cartilage
-
Barry FP, Rosenberg LC, Gaw JU, Koob TJ, Neame PJ (1995) N- and O-linked keratan sulfate on the hyaluronan binding region of aggrecan from mature and immature bovine cartilage. J Biol Chem 270: 20516-20524.
-
(1995)
J Biol Chem
, vol.270
, pp. 20516-20524
-
-
Barry, F.P.1
Rosenberg, L.C.2
Gaw, J.U.3
Koob, T.J.4
Neame, P.J.5
-
8
-
-
0036822797
-
Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro
-
Bau B, Gebhard PM, Haag J, Knorr T, Bartnik E, Aigner T (2002) Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro. Arthritis Rheum 46: 2648-2657.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 2648-2657
-
-
Bau, B.1
Gebhard, P.M.2
Haag, J.3
Knorr, T.4
Bartnik, E.5
Aigner, T.6
-
10
-
-
0032533543
-
An aggrecan-degrading activity associated with chondrocyte membranes
-
Billington CJ, Clark IM, Cawston TE (1998) An aggrecan-degrading activity associated with chondrocyte membranes. Biochem J 336: 207-212.
-
(1998)
Biochem J
, vol.336
, pp. 207-212
-
-
Billington, C.J.1
Clark, I.M.2
Cawston, T.E.3
-
11
-
-
33646481194
-
Connective tissue growth factor/CCN2 overexpression in mouse synovial lining results in transient fibrosis and cartilage damage
-
Blaney Davidson EN, Vitters EL, Mooren FM, Oliver N, Berg WB, van der Kraan PM (2006) Connective tissue growth factor/CCN2 overexpression in mouse synovial lining results in transient fibrosis and cartilage damage. Arthritis Rheum 54: 1653-1661.
-
(2006)
Arthritis Rheum
, vol.54
, pp. 1653-1661
-
-
Blaney Davidson, E.N.1
Vitters, E.L.2
Mooren, F.M.3
Oliver, N.4
Berg, W.B.5
van der Kraan, P.M.6
-
12
-
-
21744443437
-
The metzincins: A superfamily of structurally related metalloproteinases
-
Bode W, Grams F, Reinemer P, Gomis-Ruth FX, Baumann U, McKay DB, Stocker W (1995) The metzincins: A superfamily of structurally related metalloproteinases. Zoology 99: 237-246.
-
(1995)
Zoology
, vol.99
, pp. 237-246
-
-
Bode, W.1
Grams, F.2
Reinemer, P.3
Gomis-Ruth, F.X.4
Baumann, U.5
McKay, D.B.6
Stocker, W.7
-
13
-
-
33846815065
-
The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis
-
Bondeson J, Wainwright SD, Lauder S, Amos N, Hughes CE (2006) The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis. Arthritis Res Ther 8: R187.
-
(2006)
Arthritis Res Ther
, vol.8
-
-
Bondeson, J.1
Wainwright, S.D.2
Lauder, S.3
Amos, N.4
Hughes, C.E.5
-
14
-
-
33847686338
-
Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent
-
Bondeson J, Lauder S, Wainwright S, Amos N, Evans A, Hughes C, Feldmann M, Caterson B (2007) Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent. J Rheumatol 34: 523-533.
-
(2007)
J Rheumatol
, vol.34
, pp. 523-533
-
-
Bondeson, J.1
Lauder, S.2
Wainwright, S.3
Amos, N.4
Evans, A.5
Hughes, C.6
Feldmann, M.7
Caterson, B.8
-
15
-
-
33846919398
-
Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2)
-
Bursavich MG, Gilbert AM, Lombardi S, Georgiadis KE, Reifenberg E, Flannery CR, Morris EA (2007a) Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2). Bioorg Med Chem Lett 17: 1185-1188.
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 1185-1188
-
-
Bursavich, M.G.1
Gilbert, A.M.2
Lombardi, S.3
Georgiadis, K.E.4
Reifenberg, E.5
Flannery, C.R.6
Morris, E.A.7
-
16
-
-
34548584976
-
5′-Phenyl-3′H-spiro[indoline-3,2'-[1, 3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2)
-
Bursavich MG, Gilbert AM, Lombardi S, Georgiadis KE, Reifenberg E, Flannery CR, Morris EA (2007b) 5′-Phenyl-3′H-spiro[indoline-3,2'-[1, 3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2). Bioorg Med Chem Lett 17: 5630-5633.
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 5630-5633
-
-
Bursavich, M.G.1
Gilbert, A.M.2
Lombardi, S.3
Georgiadis, K.E.4
Reifenberg, E.5
Flannery, C.R.6
Morris, E.A.7
-
17
-
-
0032127129
-
Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of mt1-mmp catabolic activities on the interglobular domain of aggrecan
-
Büttner FH, Hughes CE, Margerie D, Lichte A, Tschesche H, Caterson B, Bartnik E (1998) Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of mt1-mmp catabolic activities on the interglobular domain of aggrecan. Biochem J 333: 159-165.
-
(1998)
Biochem J
, vol.333
, pp. 159-165
-
-
Büttner, F.H.1
Hughes, C.E.2
Margerie, D.3
Lichte, A.4
Tschesche, H.5
Caterson, B.6
Bartnik, E.7
-
18
-
-
0022616440
-
Human articular cartilage secretes characteristic metal dependent proteinases upon stimulation by mononuclear cell factor
-
Campbell IK, Golds EE, Mort JS, Roughley PJ (1986) Human articular cartilage secretes characteristic metal dependent proteinases upon stimulation by mononuclear cell factor. J Rheumatol 13: 20-27.
-
(1986)
J Rheumatol
, vol.13
, pp. 20-27
-
-
Campbell, I.K.1
Golds, E.E.2
Mort, J.S.3
Roughley, P.J.4
-
19
-
-
0034971357
-
Matrix metalloproteinases and aggrecanases cleave aggrecan in different zones of normal cartilage but colocalize in the development of osteoarthritic lesions in STR/ort mice
-
Chambers MG, Cox L, Chong L, Suri N, Cover P, Bayliss MT, Mason RM (2001) Matrix metalloproteinases and aggrecanases cleave aggrecan in different zones of normal cartilage but colocalize in the development of osteoarthritic lesions in STR/ort mice. Arthritis Rheum 44: 1455-1465.
-
(2001)
Arthritis Rheum
, vol.44
, pp. 1455-1465
-
-
Chambers, M.G.1
Cox, L.2
Chong, L.3
Suri, N.4
Cover, P.5
Bayliss, M.T.6
Mason, R.M.7
-
20
-
-
33745798175
-
Short-term gene expression changes in cartilage explants stimulated with interleukin beta plus glucosamine and chondroitin sulfate
-
Chan PS, Caron JP, Orth MW (2006) Short-term gene expression changes in cartilage explants stimulated with interleukin beta plus glucosamine and chondroitin sulfate. J Rheumatol 33: 1329-1340.
-
(2006)
J Rheumatol
, vol.33
, pp. 1329-1340
-
-
Chan, P.S.1
Caron, J.P.2
Orth, M.W.3
-
21
-
-
0037424680
-
Potent and selective aggrecanase inhibitors containing cyclic P1 substituents
-
Cherney RJ, Mo R, Meyer DT, Wang L, Yao W, Wasserman ZR, Liu RQ, Covington MB, Tortorella MD, Arner EC, Qian M, Christ DD, Trzaskos JM, Newton RC, Magolda RL, Decicco CP (2003) Potent and selective aggrecanase inhibitors containing cyclic P1 substituents. Bioorg Med Chem Lett 13: 1297-1300.
-
(2003)
Bioorg Med Chem Lett
, vol.13
, pp. 1297-1300
-
-
Cherney, R.J.1
Mo, R.2
Meyer, D.T.3
Wang, L.4
Yao, W.5
Wasserman, Z.R.6
Liu, R.Q.7
Covington, M.B.8
Tortorella, M.D.9
Arner, E.C.10
Qian, M.11
Christ, D.D.12
Trzaskos, J.M.13
Newton, R.C.14
Magolda, R.L.15
Decicco, C.P.16
-
22
-
-
0030033710
-
Chondrocyte matrix metalloproteinase-8: Upregulation of neutrophil collagenase by interleukin-1b in human cartilage from knee and ankle joints
-
Chubinskaya S, Huch K, Mikecz K, Cs.-Szabó G, Hasty KA, Kuettner KE, Cole AA (1996) Chondrocyte matrix metalloproteinase-8: Upregulation of neutrophil collagenase by interleukin-1b in human cartilage from knee and ankle joints. Lab Invest 74: 232-240.
-
(1996)
Lab Invest
, vol.74
, pp. 232-240
-
-
Chubinskaya, S.1
Huch, K.2
Mikecz, K.3
Cs4
Szabó, G.5
Hasty, K.A.6
Kuettner, K.E.7
Cole, A.A.8
-
23
-
-
3543043776
-
ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage
-
Collins-Racie LA, Flannery CR, Zeng W, Corcoran C, Annis-Freeman B, Agostino MJ, Arai M, DiBlasio-Smith E, Dorner AJ, Georgiadis KE, Jin M, Tan X-Y, Morris EA, LaVallie ER (2004) ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage. Matrix Biol 23: 219-230.
-
(2004)
Matrix Biol
, vol.23
, pp. 219-230
-
-
Collins-Racie, L.A.1
Flannery, C.R.2
Zeng, W.3
Corcoran, C.4
Annis-Freeman, B.5
Agostino, M.J.6
Arai, M.7
DiBlasio-Smith, E.8
Dorner, A.J.9
Georgiadis, K.E.10
Jin, M.11
Tan, X.-Y.12
Morris, E.A.13
LaVallie, E.R.14
-
24
-
-
33744905343
-
Activation by IL-1 of bovine articular chondrocytes in culture within a 3D collagen-based scaffold. An in vitro model to address the effect of compounds with therapeutic potential in osteoarthritis
-
Cortial D, Gouttenoire J, Rousseau CF, Ronziere MC, Piccardi N, Msika P, Herbage D, Mallein-Gerin F, Freyria AM (2006) Activation by IL-1 of bovine articular chondrocytes in culture within a 3D collagen-based scaffold. An in vitro model to address the effect of compounds with therapeutic potential in osteoarthritis. Osteoarthritis Cartilage 14: 631-640.
-
(2006)
Osteoarthritis Cartilage
, vol.14
, pp. 631-640
-
-
Cortial, D.1
Gouttenoire, J.2
Rousseau, C.F.3
Ronziere, M.C.4
Piccardi, N.5
Msika, P.6
Herbage, D.7
Mallein-Gerin, F.8
Freyria, A.M.9
-
25
-
-
0033977182
-
n-3 fatty acids specifically modulate catabolic factors involved in articular cartilage degradation
-
Curtis CL, Hughes CE, Flannery CR, Little CB, Harwood JL, Caterson B (2000) n-3 fatty acids specifically modulate catabolic factors involved in articular cartilage degradation. J Biol Chem 275: 721-724.
-
(2000)
J Biol Chem
, vol.275
, pp. 721-724
-
-
Curtis, C.L.1
Hughes, C.E.2
Flannery, C.R.3
Little, C.B.4
Harwood, J.L.5
Caterson, B.6
-
26
-
-
18644370594
-
ADAMTS-9 is synergistically induced by interleukin-1beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes
-
Demircan K, Hirohata S, Nishida K, Hatipoglu OF, Oohashi T, Yonezawa T, Apte SS, Ninomiya Y (2005) ADAMTS-9 is synergistically induced by interleukin-1beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes. Arthritis Rheum 52: 1451-1460.
-
(2005)
Arthritis Rheum
, vol.52
, pp. 1451-1460
-
-
Demircan, K.1
Hirohata, S.2
Nishida, K.3
Hatipoglu, O.F.4
Oohashi, T.5
Yonezawa, T.6
Apte, S.S.7
Ninomiya, Y.8
-
27
-
-
34247855812
-
Microenvironmental changes during differentiation of mesenchymal stem cells towards chondrocytes
-
Djouad F, Delorme B, Maurice M, Bony C, Apparailly F, Louis-Plence P, Canovas F, Charbord P, Noel D, Jorgensen C (2007) Microenvironmental changes during differentiation of mesenchymal stem cells towards chondrocytes. Arthritis Res Ther 9: R33.
-
(2007)
Arthritis Res Ther
, vol.9
-
-
Djouad, F.1
Delorme, B.2
Maurice, M.3
Bony, C.4
Apparailly, F.5
Louis-Plence, P.6
Canovas, F.7
Charbord, P.8
Noel, D.9
Jorgensen, C.10
-
28
-
-
38949136134
-
Mechanism of proteoglycan aggregate degradation in cartilage stimulated with oncostatin M
-
in press
-
Durigova M, Roughley PJ, Mort JS (2007) Mechanism of proteoglycan aggregate degradation in cartilage stimulated with oncostatin M. Osteoarthritis Cartilage, in press.
-
(2007)
Osteoarthritis Cartilage
-
-
Durigova, M.1
Roughley, P.J.2
Mort, J.S.3
-
29
-
-
46849122149
-
ADAMTS-5 activity in synovial fibroblasts is different to chondrocytes
-
San Diego, abstr
-
East CJ, Rogerson FM, Lawlor KE, Stanton H, Fosang AJ (2007a) ADAMTS-5 activity in synovial fibroblasts is different to chondrocytes. Trans Orthop Res Soc, San Diego, 576 (abstr).
-
(2007)
Trans Orthop Res Soc
, pp. 576
-
-
East, C.J.1
Rogerson, F.M.2
Lawlor, K.E.3
Stanton, H.4
Fosang, A.J.5
-
30
-
-
34247891816
-
ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulphate-rich region of aggrecan
-
East CJ, Stanton H, Golub SB, Rogerson FM, Fosang AJ (2007b) ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulphate-rich region of aggrecan. J Biol Chem 282 :8632-8640.
-
(2007)
J Biol Chem
, vol.282
, pp. 8632-8640
-
-
East, C.J.1
Stanton, H.2
Golub, S.B.3
Rogerson, F.M.4
Fosang, A.J.5
-
31
-
-
32944469305
-
MMPs and ADAMTSs: Functional studies
-
Flannery CR (2006) MMPs and ADAMTSs: functional studies. Front Biosci 11: 544-569.
-
(2006)
Front Biosci
, vol.11
, pp. 544-569
-
-
Flannery, C.R.1
-
32
-
-
18644373574
-
Autocatalytic Cleavage of ADAMTS-4 (Aggrecanase-1) Reveals Multiple Glycosaminoglycan-binding Sites
-
Flannery CR, Zeng W, Corcoran C, Collins-Racie LA, Chockalingam PS, Hebert T, Mackie SA, McDonagh T, Crawford TK, Tomkinson KN, LaVallie ER, Morris EA (2002) Autocatalytic Cleavage of ADAMTS-4 (Aggrecanase-1) Reveals Multiple Glycosaminoglycan-binding Sites. J Biol Chem 277: 42775-42780.
-
(2002)
J Biol Chem
, vol.277
, pp. 42775-42780
-
-
Flannery, C.R.1
Zeng, W.2
Corcoran, C.3
Collins-Racie, L.A.4
Chockalingam, P.S.5
Hebert, T.6
Mackie, S.A.7
McDonagh, T.8
Crawford, T.K.9
Tomkinson, K.N.10
LaVallie, E.R.11
Morris, E.A.12
-
33
-
-
0028127495
-
Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan
-
Fosang AJ, Last K, Neame PJ, Murphy G, Knäuper V, Tschesche H, Hughes CE, Caterson B, Hardingham TE (1994) Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan. Biochem J 304: 347-351.
-
(1994)
Biochem J
, vol.304
, pp. 347-351
-
-
Fosang, A.J.1
Last, K.2
Neame, P.J.3
Murphy, G.4
Knäuper, V.5
Tschesche, H.6
Hughes, C.E.7
Caterson, B.8
Hardingham, T.E.9
-
34
-
-
0029085839
-
Development of a cleavage site-specific monoclonal antibody for detecting metalloproteinase- derived aggrecan fragments: Detection of fragments in human synovial fluids
-
Fosang AJ, Last K, Gardiner P, Jackson DC, Brown L (1995) Development of a cleavage site-specific monoclonal antibody for detecting metalloproteinase- derived aggrecan fragments: detection of fragments in human synovial fluids. Biochem J 310: 337-343.
-
(1995)
Biochem J
, vol.310
, pp. 337-343
-
-
Fosang, A.J.1
Last, K.2
Gardiner, P.3
Jackson, D.C.4
Brown, L.5
-
35
-
-
0029852094
-
Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent
-
Fosang AJ, Last K, Maciewicz RA (1996) Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent. J Clin Invest 98: 2292-2299.
-
(1996)
J Clin Invest
, vol.98
, pp. 2292-2299
-
-
Fosang, A.J.1
Last, K.2
Maciewicz, R.A.3
-
36
-
-
4444291440
-
Keratan sulphate in the aggrecan interglobular domain has a microstructure that is distinct from keratan sulphate elsewhere on aggrecan
-
San Francisco
-
Fosang AJ, Last K, Plaas AH, Poon CJ (2004) Keratan sulphate in the aggrecan interglobular domain has a microstructure that is distinct from keratan sulphate elsewhere on aggrecan. Trans Orthop Res Soc, San Francisco, 232.
-
(2004)
Trans Orthop Res Soc
, pp. 232
-
-
Fosang, A.J.1
Last, K.2
Plaas, A.H.3
Poon, C.J.4
-
37
-
-
0037192814
-
Activation of the Proteolytic Activity of ADAMTS4 (Aggrecanase-1) by C-terminal Truncation
-
Gao G, Westling J, Thompson VP, Howell TD, Gottschall PE, Sandy JD (2002) Activation of the Proteolytic Activity of ADAMTS4 (Aggrecanase-1) by C-terminal Truncation. J Biol Chem 277: 11034-11041.
-
(2002)
J Biol Chem
, vol.277
, pp. 11034-11041
-
-
Gao, G.1
Westling, J.2
Thompson, V.P.3
Howell, T.D.4
Gottschall, P.E.5
Sandy, J.D.6
-
38
-
-
1642354112
-
ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1
-
Gao G, Plaas A, Thompson VP, Jin S, Zuo F, Sandy JD (2004) ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1. J Biol Chem 279: 10042-10051.
-
(2004)
J Biol Chem
, vol.279
, pp. 10042-10051
-
-
Gao, G.1
Plaas, A.2
Thompson, V.P.3
Jin, S.4
Zuo, F.5
Sandy, J.D.6
-
39
-
-
0345735683
-
TIMP-3 inhibits aggrecanase-mediated glycosaminoglycan release from cartilage explants stimulated by catabolic factors
-
Gendron C, Kashiwagi M, Hughes C, Caterson B, Nagase H (2003) TIMP-3 inhibits aggrecanase-mediated glycosaminoglycan release from cartilage explants stimulated by catabolic factors. FEBS Lett 555: 431-436.
-
(2003)
FEBS Lett
, vol.555
, pp. 431-436
-
-
Gendron, C.1
Kashiwagi, M.2
Hughes, C.3
Caterson, B.4
Nagase, H.5
-
40
-
-
34547110152
-
Proteolytic activities of human ADAMTS-5: Comparative studies with ADAMTS-4
-
Gendron C, Kashiwagi M, Lim NH, Enghild JJ, Thogersen IB, Hughes C, Caterson B, Nagase H (2007) Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4. J Biol Chem 282: 18294-18306.
-
(2007)
J Biol Chem
, vol.282
, pp. 18294-18306
-
-
Gendron, C.1
Kashiwagi, M.2
Lim, N.H.3
Enghild, J.J.4
Thogersen, I.B.5
Hughes, C.6
Caterson, B.7
Nagase, H.8
-
41
-
-
33846896972
-
5-((1H-pyrazol-4-yl)methylene)-2- thioxothiazolidin-4-one inhibitors of ADAMTS-5
-
Gilbert AM, Bursavich MG, Lombardi S, Georgiadis KE, Reifenberg E, Flannery CR, Morris EA (2007) 5-((1H-pyrazol-4-yl)methylene)-2- thioxothiazolidin-4-one inhibitors of ADAMTS-5. Bioorg Med Chem Lett 17: 1189-1192.
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 1189-1192
-
-
Gilbert, A.M.1
Bursavich, M.G.2
Lombardi, S.3
Georgiadis, K.E.4
Reifenberg, E.5
Flannery, C.R.6
Morris, E.A.7
-
42
-
-
4043154293
-
Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice
-
Glasson SS, Askew R, Sheppard B, Carito BA, Blanchet T, Ma HL, Flannery CR, Kanki K, Wang E, Peluso D, Yang Z, Majumdar MK, Morris EA (2004) Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. Arthritis Rheum 50: 2547-2558.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 2547-2558
-
-
Glasson, S.S.1
Askew, R.2
Sheppard, B.3
Carito, B.A.4
Blanchet, T.5
Ma, H.L.6
Flannery, C.R.7
Kanki, K.8
Wang, E.9
Peluso, D.10
Yang, Z.11
Majumdar, M.K.12
Morris, E.A.13
-
43
-
-
15844413814
-
Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
-
Glasson SS, Askew R, Sheppard B, Carito B, Blanchet T, Ma HL, Flannery CR, Peluso D, Kanki K, Yang Z, Majumdar MK, Morris EA (2005) Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature 434: 644-648.
-
(2005)
Nature
, vol.434
, pp. 644-648
-
-
Glasson, S.S.1
Askew, R.2
Sheppard, B.3
Carito, B.4
Blanchet, T.5
Ma, H.L.6
Flannery, C.R.7
Peluso, D.8
Kanki, K.9
Yang, Z.10
Majumdar, M.K.11
Morris, E.A.12
-
44
-
-
0038019916
-
Structural aspects of the metzincin clan of metalloendopeptidases
-
Gomis-Ruth F (2003) Structural aspects of the metzincin clan of metalloendopeptidases. Mol Biotechnol 24: 157-202.
-
(2003)
Mol Biotechnol
, vol.24
, pp. 157-202
-
-
Gomis-Ruth, F.1
-
45
-
-
2442655498
-
Galectin-3 surface expression on human adult chondrocytes: A potential substrate for collagenase-3
-
Guevremont M, Martel-Pelletier J, Boileau C, Liu FT, Richard M, Fernandes JC, Pelletier JP, Reboul P (2004) Galectin-3 surface expression on human adult chondrocytes: a potential substrate for collagenase-3. Ann Rheum Dis 63: 636-643.
-
(2004)
Ann Rheum Dis
, vol.63
, pp. 636-643
-
-
Guevremont, M.1
Martel-Pelletier, J.2
Boileau, C.3
Liu, F.T.4
Richard, M.5
Fernandes, J.C.6
Pelletier, J.P.7
Reboul, P.8
-
46
-
-
0035853456
-
Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4)
-
Hashimoto G, Aoki T, Nakamura H, Tanzawa K, Okada Y (2001) Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4). FEBS Lett 494: 192-195.
-
(2001)
FEBS Lett
, vol.494
, pp. 192-195
-
-
Hashimoto, G.1
Aoki, T.2
Nakamura, H.3
Tanzawa, K.4
Okada, Y.5
-
47
-
-
3543004686
-
ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan
-
Hashimoto G, Shimoda M, Okada Y (2004) ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan. J Biol Chem 279: 32483-32491.
-
(2004)
J Biol Chem
, vol.279
, pp. 32483-32491
-
-
Hashimoto, G.1
Shimoda, M.2
Okada, Y.3
-
48
-
-
0031572290
-
Complete coding sequence of bovine aggrecan: Comparative structural analysis
-
Hering TM, Kollar J, Huynh TD (1997) Complete coding sequence of bovine aggrecan: comparative structural analysis. Arch Biochem Biophys 345: 259-270.
-
(1997)
Arch Biochem Biophys
, vol.345
, pp. 259-270
-
-
Hering, T.M.1
Kollar, J.2
Huynh, T.D.3
-
49
-
-
0027941838
-
Families of zinc metalloproteases
-
Hooper NM (1994) Families of zinc metalloproteases. FEBS Lett 354: 1-6.
-
(1994)
FEBS Lett
, vol.354
, pp. 1-6
-
-
Hooper, N.M.1
-
50
-
-
0028919163
-
Monoclonal antibodies that specifically recognise neo-epitope sequences generated by "aggrecanase" and matrix metalloproteinase cleavage of aggrecan: Application to catabolism in situ and in vitro
-
Hughes CE, Caterson B, Fosang AJ, Roughley PJ, Mort JS (1995) Monoclonal antibodies that specifically recognise neo-epitope sequences generated by "aggrecanase" and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro. Biochem J 305: 799-804.
-
(1995)
Biochem J
, vol.305
, pp. 799-804
-
-
Hughes, C.E.1
Caterson, B.2
Fosang, A.J.3
Roughley, P.J.4
Mort, J.S.5
-
51
-
-
27444448206
-
Oncostatin M in combination with tumour necrosis factor {alpha} induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2
-
Hui W, Barksby HE, Young DA, Cawston TE, McKie N, Rowan AD (2005) Oncostatin M in combination with tumour necrosis factor {alpha} induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2. Ann Rheum Dis 64: 1624-1632.
-
(2005)
Ann Rheum Dis
, vol.64
, pp. 1624-1632
-
-
Hui, W.1
Barksby, H.E.2
Young, D.A.3
Cawston, T.E.4
McKie, N.5
Rowan, A.D.6
-
52
-
-
0033520318
-
ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family
-
Hurskainen TL, Hirohata S, Seldin MF, Apte SS (1999) ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. J Biol Chem 274: 25555-25563.
-
(1999)
J Biol Chem
, vol.274
, pp. 25555-25563
-
-
Hurskainen, T.L.1
Hirohata, S.2
Seldin, M.F.3
Apte, S.S.4
-
54
-
-
38049115682
-
Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice
-
Ilic MZ, East CJ, Rogerson FM, Fosang AJ, Handley CJ (2007) Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice. J Biol Chem 282: 37420-37428.
-
(2007)
J Biol Chem
, vol.282
, pp. 37420-37428
-
-
Ilic, M.Z.1
East, C.J.2
Rogerson, F.M.3
Fosang, A.J.4
Handley, C.J.5
-
55
-
-
33947258510
-
Extracellular localization of galectin-3 has a deleterious role in joint tissues
-
Janelle-Montcalm A, Boileau C, Poirier F, Pelletier JP, Guevremont M, Duval N, Martel-Pelletier J, Reboul P (2007) Extracellular localization of galectin-3 has a deleterious role in joint tissues. Arthritis Res Ther 9: R20.
-
(2007)
Arthritis Res Ther
, vol.9
-
-
Janelle-Montcalm, A.1
Boileau, C.2
Poirier, F.3
Pelletier, J.P.4
Guevremont, M.5
Duval, N.6
Martel-Pelletier, J.7
Reboul, P.8
-
56
-
-
0242655673
-
Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation
-
Jimenez MJ, Balbin M, Lopez JM, Alvarez J, Komori T, Lopez-Otin C (1999) Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation. Mol Cell Biol 19: 4431-4442.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 4431-4442
-
-
Jimenez, M.J.1
Balbin, M.2
Lopez, J.M.3
Alvarez, J.4
Komori, T.5
Lopez-Otin, C.6
-
57
-
-
21644449866
-
ADAMTS proteinases: A multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis
-
Jones GC, Riley GP (2005) ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis. Arthritis Res Ther 7:160-169.
-
(2005)
Arthritis Res Ther
, vol.7
, pp. 160-169
-
-
Jones, G.C.1
Riley, G.P.2
-
58
-
-
0032170247
-
Cultured human ankle and knee cartilage differ in susceptibility to damage mediated by fibronectin fragments
-
Kang Y, Koepp H, Cole AA, Kuettner KE, Homandberg GA (1998) Cultured human ankle and knee cartilage differ in susceptibility to damage mediated by fibronectin fragments. J Orthop Res 16: 551-556.
-
(1998)
J Orthop Res
, vol.16
, pp. 551-556
-
-
Kang, Y.1
Koepp, H.2
Cole, A.A.3
Kuettner, K.E.4
Homandberg, G.A.5
-
59
-
-
0035918309
-
TIMP-3 Is a Potent Inhibitor of Aggrecanase 1 (ADAMTS4) and Aggrecanase 2 (ADAM-TS5)
-
Kashiwagi M, Tortorella M, Nagase H, Brew K (2001) TIMP-3 Is a Potent Inhibitor of Aggrecanase 1 (ADAMTS4) and Aggrecanase 2 (ADAM-TS5). J Biol Chem 276: 12501-12504.
-
(2001)
J Biol Chem
, vol.276
, pp. 12501-12504
-
-
Kashiwagi, M.1
Tortorella, M.2
Nagase, H.3
Brew, K.4
-
60
-
-
1642280932
-
Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing
-
Kashiwagi M, Enghild JJ, Gendron C, Hughes C, Caterson B, Itoh Y, Nagase H (2004) Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing. J Biol Chem 279: 10109-10119.
-
(2004)
J Biol Chem
, vol.279
, pp. 10109-10119
-
-
Kashiwagi, M.1
Enghild, J.J.2
Gendron, C.3
Hughes, C.4
Caterson, B.5
Itoh, Y.6
Nagase, H.7
-
61
-
-
0034029067
-
The new kids on the block: ADAMTSs, potentially multifunctional metalloproteinases of the ADAM family
-
Kaushal GP, Shah SV (2000) The new kids on the block: ADAMTSs, potentially multifunctional metalloproteinases of the ADAM family. J Clin Invest 105: 1335-1337.
-
(2000)
J Clin Invest
, vol.105
, pp. 1335-1337
-
-
Kaushal, G.P.1
Shah, S.V.2
-
62
-
-
9144230209
-
Expression profiling of metalloproteinases and their inhibitors in cartilage
-
Kevorkian L, Young DA, Darrah C, Donell ST, Shepstone L, Porter S, Brockbank SM, Edwards DR, Parker AE, Clark IM (2004) Expression profiling of metalloproteinases and their inhibitors in cartilage. Arthritis Rheum 50: 131-141.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 131-141
-
-
Kevorkian, L.1
Young, D.A.2
Darrah, C.3
Donell, S.T.4
Shepstone, L.5
Porter, S.6
Brockbank, S.M.7
Edwards, D.R.8
Parker, A.E.9
Clark, I.M.10
-
63
-
-
34447512614
-
Regulation of ADAMTS9 secretion and enzymatic activity by its propeptide
-
Koo BH, Longpré JM, Somerville RP, Alexander JP, Leduc R, Apte SS (2007) Regulation of ADAMTS9 secretion and enzymatic activity by its propeptide. J Biol Chem 282: 16146-16154.
-
(2007)
J Biol Chem
, vol.282
, pp. 16146-16154
-
-
Koo, B.H.1
Longpré, J.M.2
Somerville, R.P.3
Alexander, J.P.4
Leduc, R.5
Apte, S.S.6
-
64
-
-
0036222734
-
The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: A time-course study using real-time quantitative reverse transcription-polymerase chain reaction
-
Koshy PJ, Lundy CJ, Rowan AD, Porter S, Edwards DR, Hogan A, Clark IM, Cawston TE (2002) The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: A time-course study using real-time quantitative reverse transcription-polymerase chain reaction. Arthritis Rheum 46: 961-967.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 961-967
-
-
Koshy, P.J.1
Lundy, C.J.2
Rowan, A.D.3
Porter, S.4
Edwards, D.R.5
Hogan, A.6
Clark, I.M.7
Cawston, T.E.8
-
65
-
-
0032577568
-
ADAMTS-1 protein anchors at the extracellular matrix through the thrombospondin type I motifs and its spacing region
-
Kuno K, Matsushima K (1998) ADAMTS-1 protein anchors at the extracellular matrix through the thrombospondin type I motifs and its spacing region. J Biol Chem 273:13912-13917.
-
(1998)
J Biol Chem
, vol.273
, pp. 13912-13917
-
-
Kuno, K.1
Matsushima, K.2
-
66
-
-
0034604613
-
ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan
-
Kuno K, Okada Y, Kawashima H, Nakamura H, Miyasaka M, Ohno H, Matsushima K (2000) ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan. FEBS Lett 478: 241-245.
-
(2000)
FEBS Lett
, vol.478
, pp. 241-245
-
-
Kuno, K.1
Okada, Y.2
Kawashima, H.3
Nakamura, H.4
Miyasaka, M.5
Ohno, H.6
Matsushima, K.7
-
67
-
-
0028815147
-
374) is a primary event in proteolysis of the interglobular domain
-
374) is a primary event in proteolysis of the interglobular domain. J Biol Chem 270: 2550-2556.
-
(1995)
J Biol Chem
, vol.270
, pp. 2550-2556
-
-
Lark, M.W.1
Gordy, J.T.2
Weidner, J.R.3
Ayala, J.4
Kimura, J.H.5
Williams, H.R.6
Mumford, R.A.7
Flannery, C.R.8
Carlson, S.S.9
Iwata, M.10
Sandy, J.D.11
-
68
-
-
0028968899
-
Quantification of a matrix metalloproteinase-generated aggrecan G1 fragment using monospecific anti-peptide serum
-
Lark MW, Williams H, Hoerrner LA, Weidner J, Ayala JM, Harper CF, Christen A, Olszewski J, Konteatis Z, Webber R, Mumford RA (1995b) Quantification of a matrix metalloproteinase-generated aggrecan G1 fragment using monospecific anti-peptide serum. Biochem J 307: 245-252.
-
(1995)
Biochem J
, vol.307
, pp. 245-252
-
-
Lark, M.W.1
Williams, H.2
Hoerrner, L.A.3
Weidner, J.4
Ayala, J.M.5
Harper, C.F.6
Christen, A.7
Olszewski, J.8
Konteatis, Z.9
Webber, R.10
Mumford, R.A.11
-
69
-
-
18744437369
-
Aggrecan degradation in human cartilage. Evidence for both metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints
-
Lark MW, Bayne EK, Flanagan J, Harper CF, Hoerrner LA, Hutchinson NI, Singer II, Donatelli SA, Weidner JR, Williams HR, Mumford RA, Lohmander LS (1997) Aggrecan degradation in human cartilage. Evidence for both metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints. J Clin Invest 100: 93-106.
-
(1997)
J Clin Invest
, vol.100
, pp. 93-106
-
-
Lark, M.W.1
Bayne, E.K.2
Flanagan, J.3
Harper, C.F.4
Hoerrner, L.A.5
Hutchinson, N.I.6
Singer, I.I.7
Donatelli, S.A.8
Weidner, J.R.9
Williams, H.R.10
Mumford, R.A.11
Lohmander, L.S.12
-
70
-
-
33747640560
-
Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes
-
LaVallie ER, Chockalingam PS, Collins-Racie LA, Freeman BA, Keohan CC, Leitges M, Dorner AJ, Morris EA, Majumdar MK, Arai M (2006) Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes. J Biol Chem 281: 24124-24137.
-
(2006)
J Biol Chem
, vol.281
, pp. 24124-24137
-
-
LaVallie, E.R.1
Chockalingam, P.S.2
Collins-Racie, L.A.3
Freeman, B.A.4
Keohan, C.C.5
Leitges, M.6
Dorner, A.J.7
Morris, E.A.8
Majumdar, M.K.9
Arai, M.10
-
71
-
-
0031688163
-
Immunolocalization of the cleavage of the aggrecan core protein at the Asn341-Phe342 bond, as an indicator of the location of the metalloproteinases active in the lysis of the rat growth plate
-
Lee ER, Lamplugh L, Leblond CP, Mordier S, Magny MC, Mort JS (1998) Immunolocalization of the cleavage of the aggrecan core protein at the Asn341-Phe342 bond, as an indicator of the location of the metalloproteinases active in the lysis of the rat growth plate. Anat Rec 252: 117-132.
-
(1998)
Anat Rec
, vol.252
, pp. 117-132
-
-
Lee, E.R.1
Lamplugh, L.2
Leblond, C.P.3
Mordier, S.4
Magny, M.C.5
Mort, J.S.6
-
72
-
-
0027373233
-
cDNA cloning of chick cartilage chondroitin sulfate (aggrecan) core protein and identification of a stop codon in the aggrecan gene associated with the chondrodystrophy, nanomelia
-
Li H, Schwartz NB, Vertel BM (1993) cDNA cloning of chick cartilage chondroitin sulfate (aggrecan) core protein and identification of a stop codon in the aggrecan gene associated with the chondrodystrophy, nanomelia. J Biol Chem 268: 23504-23511.
-
(1993)
J Biol Chem
, vol.268
, pp. 23504-23511
-
-
Li, H.1
Schwartz, N.B.2
Vertel, B.M.3
-
73
-
-
0036164196
-
Cyclosporin A inhibition of aggrecanase-mediated proteoglycan catabolism in articular cartilage
-
Little CB, Hughes CE, Curtis CL, Jones SA, Caterson B, Flannery CR (2002) Cyclosporin A inhibition of aggrecanase-mediated proteoglycan catabolism in articular cartilage. Arthritis Rheum 46: 124-129.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 124-129
-
-
Little, C.B.1
Hughes, C.E.2
Curtis, C.L.3
Jones, S.A.4
Caterson, B.5
Flannery, C.R.6
-
74
-
-
16244418694
-
Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development
-
Little CB, Meeker CT, Hembry RM, Sims NA, Lawlor KE, Golub SB, Last K, Fosang AJ (2005) Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development. Mol Cell Biol 25: 3388-3399.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 3388-3399
-
-
Little, C.B.1
Meeker, C.T.2
Hembry, R.M.3
Sims, N.A.4
Lawlor, K.E.5
Golub, S.B.6
Last, K.7
Fosang, A.J.8
-
75
-
-
34249897267
-
Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair
-
Little CB, Meeker CT, Golub SB, Lawlor KE, Farmer PJ, Smith SM, Fosang AJ (2007) Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair. J Clin Invest 117: 1627-1636.
-
(2007)
J Clin Invest
, vol.117
, pp. 1627-1636
-
-
Little, C.B.1
Meeker, C.T.2
Golub, S.B.3
Lawlor, K.E.4
Farmer, P.J.5
Smith, S.M.6
Fosang, A.J.7
-
76
-
-
0027445981
-
The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis
-
Lohmander LS, Neame PJ, Sandy JD (1993) The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis. Arthritis Rheum 36: 1214-1222.
-
(1993)
Arthritis Rheum
, vol.36
, pp. 1214-1222
-
-
Lohmander, L.S.1
Neame, P.J.2
Sandy, J.D.3
-
77
-
-
0026771893
-
N-terminal sequence of proteoglycan fragments isolated from medium of interleukin-1-treated articular-cartilage cultures. Putative site(s) of enzymic cleavage
-
Loulakis P, Shrikhande A, Davis G, Maniglia CA (1992) N-terminal sequence of proteoglycan fragments isolated from medium of interleukin-1-treated articular-cartilage cultures. Putative site(s) of enzymic cleavage. Biochem J 284: 589-593.
-
(1992)
Biochem J
, vol.284
, pp. 589-593
-
-
Loulakis, P.1
Shrikhande, A.2
Davis, G.3
Maniglia, C.A.4
-
78
-
-
38449102464
-
G1-G2 aggrecan product that can be generated by M-calpain on truncation at Ala709-Ala710 is present abundantly in human articular cartilage
-
Maehara H, Suzuki K, Sasaki T, Oshita H, Wada E, Inoue T, Shimizu K (2007) G1-G2 aggrecan product that can be generated by M-calpain on truncation at Ala709-Ala710 is present abundantly in human articular cartilage. J Biochem (Tokyo) 141: 469-477.
-
(2007)
J Biochem (Tokyo)
, vol.141
, pp. 469-477
-
-
Maehara, H.1
Suzuki, K.2
Sasaki, T.3
Oshita, H.4
Wada, E.5
Inoue, T.6
Shimizu, K.7
-
79
-
-
0344875565
-
Cleavage of the ADAMTS13 propeptide is not required for protease activity
-
Majerus EM, Zheng X, Tuley EA, Sadler JE (2003) Cleavage of the ADAMTS13 propeptide is not required for protease activity. J Biol Chem 278: 46643-46648.
-
(2003)
J Biol Chem
, vol.278
, pp. 46643-46648
-
-
Majerus, E.M.1
Zheng, X.2
Tuley, E.A.3
Sadler, J.E.4
-
80
-
-
36048985974
-
Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis
-
Majumdar MK, Askew R, Schelling S, Stedman N, Blanchet T, Hopkins B, Morris EA, Glasson SS (2007) Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis. Arthritis Rheum 56: 3670-3674.
-
(2007)
Arthritis Rheum
, vol.56
, pp. 3670-3674
-
-
Majumdar, M.K.1
Askew, R.2
Schelling, S.3
Stedman, N.4
Blanchet, T.5
Hopkins, B.6
Morris, E.A.7
Glasson, S.S.8
-
81
-
-
0037846360
-
Thyroid hormone enhances aggrecanase-2/ADAMTS5 expression and proteoglycan degradation in growth plate cartilage
-
Makihira S, Yan W, Murakami H, Furukawa M, Kawai T, Nikawa H, Yoshida E, Hamada T, Okada Y, Kato Y (2003) Thyroid hormone enhances aggrecanase-2/ADAMTS5 expression and proteoglycan degradation in growth plate cartilage. Endocrinology 144: 2480-2488.
-
(2003)
Endocrinology
, vol.144
, pp. 2480-2488
-
-
Makihira, S.1
Yan, W.2
Murakami, H.3
Furukawa, M.4
Kawai, T.5
Nikawa, H.6
Yoshida, E.7
Hamada, T.8
Okada, Y.9
Kato, Y.10
-
82
-
-
0037151084
-
Inhibition of ADAM-TS4 and ADAM-TS5 Prevents Aggrecan Degradation in Osteoarthritic Cartilage
-
Malfait A-M, Liu R-Q, Ijiri K, Komiya S, Tortorella MD (2002) Inhibition of ADAM-TS4 and ADAM-TS5 Prevents Aggrecan Degradation in Osteoarthritic Cartilage. J Biol Chem 277: 22201-22208.
-
(2002)
J Biol Chem
, vol.277
, pp. 22201-22208
-
-
Malfait, A.-M.1
Liu, R.-Q.2
Ijiri, K.3
Komiya, S.4
Tortorella, M.D.5
-
83
-
-
0033527662
-
Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase
-
Mercuri FA, Doege KJ, Arner EC, Pratta MA, Last K, Fosang AJ (1999) Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase. J Biol Chem 274: 32387-32395.
-
(1999)
J Biol Chem
, vol.274
, pp. 32387-32395
-
-
Mercuri, F.A.1
Doege, K.J.2
Arner, E.C.3
Pratta, M.A.4
Last, K.5
Fosang, A.J.6
-
84
-
-
0032211766
-
Cathepsin B: An alternative protease for the generation of an aggrecan 'metalloproteinase' cleavage neoepitope
-
Mort JS, Magny MC, Lee ER (1998) Cathepsin B: an alternative protease for the generation of an aggrecan 'metalloproteinase' cleavage neoepitope. Biochem J 335: 491-494.
-
(1998)
Biochem J
, vol.335
, pp. 491-494
-
-
Mort, J.S.1
Magny, M.C.2
Lee, E.R.3
-
85
-
-
1542390443
-
Use of anti-neoepitope antibodies for the analysis of degradative events in cartilage and the molecular basis for neoepitope specificity
-
Mort JS, Flannery CR, Makkerh J, Krupa JC, Lee ER (2003) Use of anti-neoepitope antibodies for the analysis of degradative events in cartilage and the molecular basis for neoepitope specificity. Biochem Soc Symp 70: 107-114.
-
(2003)
Biochem Soc Symp
, vol.70
, pp. 107-114
-
-
Mort, J.S.1
Flannery, C.R.2
Makkerh, J.3
Krupa, J.C.4
Lee, E.R.5
-
86
-
-
1842738084
-
Effects of transforming growth factor-beta on aggrecanase production and proteoglycan degradation by human chondrocytes in vitro
-
Moulharat N, Lesur C, Thomas M, Rolland-Valognes G, Pastoureau P, Anract P, De Ceuninck F, Sabatini M (2004) Effects of transforming growth factor-beta on aggrecanase production and proteoglycan degradation by human chondrocytes in vitro. Osteoarthritis Cartilage 12: 296-305.
-
(2004)
Osteoarthritis Cartilage
, vol.12
, pp. 296-305
-
-
Moulharat, N.1
Lesur, C.2
Thomas, M.3
Rolland-Valognes, G.4
Pastoureau, P.5
Anract, P.6
De Ceuninck, F.7
Sabatini, M.8
-
87
-
-
0033784028
-
Calcium pentosan polysulfate inhibits the catabolism of aggrecan in articular cartilage explant cultures
-
Munteanu SE, Ilic MZ, Handley CJ (2000) Calcium pentosan polysulfate inhibits the catabolism of aggrecan in articular cartilage explant cultures. Arthritis Rheum 43: 2211-2218.
-
(2000)
Arthritis Rheum
, vol.43
, pp. 2211-2218
-
-
Munteanu, S.E.1
Ilic, M.Z.2
Handley, C.J.3
-
88
-
-
0036701822
-
Highly sulfated glycosaminoglycans inhibit aggrecanase degradation of aggrecan by bovine articular cartilage explant cultures
-
Munteanu SE, Ilic MZ, Handley CJ (2002) Highly sulfated glycosaminoglycans inhibit aggrecanase degradation of aggrecan by bovine articular cartilage explant cultures. Matrix Biol 21: 429-440.
-
(2002)
Matrix Biol
, vol.21
, pp. 429-440
-
-
Munteanu, S.E.1
Ilic, M.Z.2
Handley, C.J.3
-
89
-
-
0038639763
-
Aggrecanases and cartilage matrix degradation
-
Nagase H, Kashiwagi M (2003) Aggrecanases and cartilage matrix degradation. Arthritis Res Ther 5: 94-103.
-
(2003)
Arthritis Res Ther
, vol.5
, pp. 94-103
-
-
Nagase, H.1
Kashiwagi, M.2
-
90
-
-
0035837658
-
Paradoxical effects of trichostatin A: Inhibition of NF-Y-associated histone acetyltransferase activity, phosphorylation of hGCN5 and downregulation of cyclin A and B1 mRNA
-
Nair AR, Boersma LJ, Schiltz L, Chaudhry MA, Muschel RJ (2001) Paradoxical effects of trichostatin A: inhibition of NF-Y-associated histone acetyltransferase activity, phosphorylation of hGCN5 and downregulation of cyclin A and B1 mRNA. Cancer Lett 166: 55-64.
-
(2001)
Cancer Lett
, vol.166
, pp. 55-64
-
-
Nair, A.R.1
Boersma, L.J.2
Schiltz, L.3
Chaudhry, M.A.4
Muschel, R.J.5
-
91
-
-
4344601054
-
Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by mcalpain
-
Oshita H, Sandy JD, Suzuki K, Akaike A, Bai Y, Sasaki T, Shimizu K (2004) Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by mcalpain. Biochem J 382: 253-259.
-
(2004)
Biochem J
, vol.382
, pp. 253-259
-
-
Oshita, H.1
Sandy, J.D.2
Suzuki, K.3
Akaike, A.4
Bai, Y.5
Sasaki, T.6
Shimizu, K.7
-
92
-
-
0036741135
-
Molecular determinants of metalloproteinase substrate specificity: Matrix metalloproteinase substrate binding domains, modules, and exosites
-
Overall CM (2002) Molecular determinants of metalloproteinase substrate specificity: matrix metalloproteinase substrate binding domains, modules, and exosites. Mol Biotechnol 22: 51-86.
-
(2002)
Mol Biotechnol
, vol.22
, pp. 51-86
-
-
Overall, C.M.1
-
93
-
-
25644459306
-
Collagen and Aggrecan Degradation Is Blocked in Interleukin-1-Treated Cartilage Explants by an Inhibitor of I{kappa}B Kinase through Suppression of Metalloproteinase Expression
-
Pattoli MA, Macmaster JF, Gregor KR, Burke JR (2005) Collagen and Aggrecan Degradation Is Blocked in Interleukin-1-Treated Cartilage Explants by an Inhibitor of I{kappa}B Kinase through Suppression of Metalloproteinase Expression. J Pharmacol Exp Ther 315: 382-388.
-
(2005)
J Pharmacol Exp Ther
, vol.315
, pp. 382-388
-
-
Pattoli, M.A.1
Macmaster, J.F.2
Gregor, K.R.3
Burke, J.R.4
-
94
-
-
14944371238
-
Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage
-
Patwari P, Gao G, Lee JH, Grodzinsky AJ, Sandy JD (2005) Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage. Osteoarthritis Cartilage 13: 269-277.
-
(2005)
Osteoarthritis Cartilage
, vol.13
, pp. 269-277
-
-
Patwari, P.1
Gao, G.2
Lee, J.H.3
Grodzinsky, A.J.4
Sandy, J.D.5
-
95
-
-
0023393878
-
Extended and globular protein domains in cartilage proteoglycans
-
Paulsson M, Mörgelin M, Wiedemann H, Beardmore-Gray M, Dunham DG, Hardingham TE, Heinegård D, Timpl R, Engel J (1987) Extended and globular protein domains in cartilage proteoglycans. Biochem J 245: 763-772.
-
(1987)
Biochem J
, vol.245
, pp. 763-772
-
-
Paulsson, M.1
Mörgelin, M.2
Wiedemann, H.3
Beardmore-Gray, M.4
Dunham, D.G.5
Hardingham, T.E.6
Heinegård, D.7
Timpl, R.8
Engel, J.9
-
96
-
-
0024409824
-
Immunoglobulin fold and tandem repeat structures in proteoglycan N-terminal domains and link protein
-
Perkins SJ, Nealis AS, Dudhia J, Hardingham TE (1989) Immunoglobulin fold and tandem repeat structures in proteoglycan N-terminal domains and link protein. J Mol Biol 206: 737-754.
-
(1989)
J Mol Biol
, vol.206
, pp. 737-754
-
-
Perkins, S.J.1
Nealis, A.S.2
Dudhia, J.3
Hardingham, T.E.4
-
97
-
-
34249999133
-
Aggrecanolysis in human osteoarthritis: Confocal localization and biochemical characterization of ADAMTS5-hyaluronan complexes in articular cartilages
-
Plaas A, Osborn B, Yoshihara Y, Bai Y, Bloom T, Nelson F, Mikecz K, Sandy JD (2007) Aggrecanolysis in human osteoarthritis: confocal localization and biochemical characterization of ADAMTS5-hyaluronan complexes in articular cartilages. Osteoarthritis Cartilage 15: 719-734.
-
(2007)
Osteoarthritis Cartilage
, vol.15
, pp. 719-734
-
-
Plaas, A.1
Osborn, B.2
Yoshihara, Y.3
Bai, Y.4
Bloom, T.5
Nelson, F.6
Mikecz, K.7
Sandy, J.D.8
-
98
-
-
0015643003
-
Experimentally induced osteoarthritis in the dog
-
Pond MJ, Nuki G (1973) Experimentally induced osteoarthritis in the dog. Ann Rheum Dis 32: 387-388.
-
(1973)
Ann Rheum Dis
, vol.32
, pp. 387-388
-
-
Pond, M.J.1
Nuki, G.2
-
99
-
-
21244433240
-
N-linked keratan sulfate in the aggrecan interglobular domain potentiates aggrecanase activity
-
Poon CJ, Plaas AH, Keene DR, McQuillan DJ, Last K, Fosang AJ (2005) N-linked keratan sulfate in the aggrecan interglobular domain potentiates aggrecanase activity. J Biol Chem 280: 23615-23621.
-
(2005)
J Biol Chem
, vol.280
, pp. 23615-23621
-
-
Poon, C.J.1
Plaas, A.H.2
Keene, D.R.3
McQuillan, D.J.4
Last, K.5
Fosang, A.J.6
-
101
-
-
34848871992
-
Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system
-
Powell AJ, Little CB, Hughes CE (2007) Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system. Arthritis Rheum 56: 3010-3019.
-
(2007)
Arthritis Rheum
, vol.56
, pp. 3010-3019
-
-
Powell, A.J.1
Little, C.B.2
Hughes, C.E.3
-
102
-
-
0037231877
-
Induction of aggrecanase 1 (ADAM-TS4) by interleukin-1 occurs through activation of constitutively produced protein
-
Pratta MA, Scherle PA, Yang G, Liu RQ, Newton RC (2003a) Induction of aggrecanase 1 (ADAM-TS4) by interleukin-1 occurs through activation of constitutively produced protein. Arthritis Rheum 48: 119-133.
-
(2003)
Arthritis Rheum
, vol.48
, pp. 119-133
-
-
Pratta, M.A.1
Scherle, P.A.2
Yang, G.3
Liu, R.Q.4
Newton, R.C.5
-
103
-
-
0034671485
-
Agerelated changes in aggrecan glycosylation affect cleavage by aggrecanase
-
Pratta MA, Tortorella MD, Arner EC (2000) Agerelated changes in aggrecan glycosylation affect cleavage by aggrecanase. J Biol Chem 275: 39096-39102.
-
(2000)
J Biol Chem
, vol.275
, pp. 39096-39102
-
-
Pratta, M.A.1
Tortorella, M.D.2
Arner, E.C.3
-
104
-
-
0242580819
-
Aggrecan protects cartilage collagen from proteolytic cleavage
-
Pratta MA, Yao W, Decicco C, Tortorella MD, Liu RQ, Copeland RA, Magolda R, Newton RC, Trzaskos JM, Arner EC (2003b) Aggrecan protects cartilage collagen from proteolytic cleavage. J Biol Chem 278: 45539-45545.
-
(2003)
J Biol Chem
, vol.278
, pp. 45539-45545
-
-
Pratta, M.A.1
Yao, W.2
Decicco, C.3
Tortorella, M.D.4
Liu, R.Q.5
Copeland, R.A.6
Magolda, R.7
Newton, R.C.8
Trzaskos, J.M.9
Arner, E.C.10
-
105
-
-
0022515653
-
Articular cartilage cultured with interleukin 1. Increased release of link protein, hyaluronate-binding region and other proteoglycan fragments
-
Ratcliffe A, Tyler JA, Hardingham TE (1986) Articular cartilage cultured with interleukin 1. Increased release of link protein, hyaluronate-binding region and other proteoglycan fragments. Biochem J 238: 571-580.
-
(1986)
Biochem J
, vol.238
, pp. 571-580
-
-
Ratcliffe, A.1
Tyler, J.A.2
Hardingham, T.E.3
-
106
-
-
26844518429
-
Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions
-
Roach HI, Yamada N, Cheung KS, Tilley S, Clarke NM, Oreffo RO, Kokubun S, Bronner F (2005) Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions. Arthritis Rheum 52: 3110-3124.
-
(2005)
Arthritis Rheum
, vol.52
, pp. 3110-3124
-
-
Roach, H.I.1
Yamada, N.2
Cheung, K.S.3
Tilley, S.4
Clarke, N.M.5
Oreffo, R.O.6
Kokubun, S.7
Bronner, F.8
-
107
-
-
0036295493
-
ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors
-
Rodriguez-Manzaneque J, Westling J, Thai SN, Luque A, Knauper V, Murphy G, Sandy JD, Iruela-Arispe ML (2002) ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors. Biochem Biophys Res Commun 293: 501-508.
-
(2002)
Biochem Biophys Res Commun
, vol.293
, pp. 501-508
-
-
Rodriguez-Manzaneque, J.1
Westling, J.2
Thai, S.N.3
Luque, A.4
Knauper, V.5
Murphy, G.6
Sandy, J.D.7
Iruela-Arispe, M.L.8
-
108
-
-
45349087688
-
Evidence for a novel aggrecan-degrading activity in cartilage: Studies of mice deficient in both ADAMTS-4 and ADAMTS-5
-
in press
-
Rogerson FM, Stanton H, East CJ, Golub SB, Tutolo L, Farmer PJ, Fosang AJ (2008) Evidence for a novel aggrecan-degrading activity in cartilage: Studies of mice deficient in both ADAMTS-4 and ADAMTS-5. Arthritis and Rheum in press.
-
(2008)
Arthritis and Rheum
-
-
Rogerson, F.M.1
Stanton, H.2
East, C.J.3
Golub, S.B.4
Tutolo, L.5
Farmer, P.J.6
Fosang, A.J.7
-
109
-
-
27244438584
-
Lack of CpG island methylator phenotype defines a clinical subtype of T-cell acute lymphoblastic leukemia associated with good prognosis
-
Roman-Gomez J, Jimenez-Velasco A, Agirre X, Prosper F, Heiniger A, Torres A (2005) Lack of CpG island methylator phenotype defines a clinical subtype of T-cell acute lymphoblastic leukemia associated with good prognosis. J Clin Oncol 23: 7043-7049.
-
(2005)
J Clin Oncol
, vol.23
, pp. 7043-7049
-
-
Roman-Gomez, J.1
Jimenez-Velasco, A.2
Agirre, X.3
Prosper, F.4
Heiniger, A.5
Torres, A.6
-
110
-
-
0023058313
-
Arg-Gly-Asp: A versatile cell recognition signal
-
Ruoslahti E, Pierschbacher MD (1986) Arg-Gly-Asp: a versatile cell recognition signal. Cell 44: 517-518.
-
(1986)
Cell
, vol.44
, pp. 517-518
-
-
Ruoslahti, E.1
Pierschbacher, M.D.2
-
111
-
-
33947175117
-
Increased collagen and aggrecan degradation with age in the joints of Timp3(-/-) mice
-
Sahebjam S, Khokha R, Mort JS (2007) Increased collagen and aggrecan degradation with age in the joints of Timp3(-/-) mice. Arthritis Rheum 56: 905-909.
-
(2007)
Arthritis Rheum
, vol.56
, pp. 905-909
-
-
Sahebjam, S.1
Khokha, R.2
Mort, J.S.3
-
112
-
-
0025776382
-
Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain
-
Sandy JD, Neame PJ, Boynton RE, Flannery CR (1991) Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain. J Biol Chem 266: 8683-8685.
-
(1991)
J Biol Chem
, vol.266
, pp. 8683-8685
-
-
Sandy, J.D.1
Neame, P.J.2
Boynton, R.E.3
Flannery, C.R.4
-
113
-
-
0026682509
-
The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain
-
Sandy JD, Flannery CR, Neame PJ, Lohmander LS (1992) The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain. J Clin Invest 89: 1512-1516.
-
(1992)
J Clin Invest
, vol.89
, pp. 1512-1516
-
-
Sandy, J.D.1
Flannery, C.R.2
Neame, P.J.3
Lohmander, L.S.4
-
114
-
-
0032189902
-
Chondrocyte-mediated catabolism of aggrecan: Aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine
-
Sandy JD, Gamett D, Thompson V, Verscharen C (1998) Chondrocyte-mediated catabolism of aggrecan: aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine. BiochemJ 335: 59-66.
-
(1998)
BiochemJ
, vol.335
, pp. 59-66
-
-
Sandy, J.D.1
Gamett, D.2
Thompson, V.3
Verscharen, C.4
-
115
-
-
0034306104
-
The intermediates of aggrecanase-dependent cleavage of aggrecan in rat chondrosarcoma cells treated with interleukin-1
-
Sandy JD, Thompson V, Doege K, Verscharen C (2000) The intermediates of aggrecanase-dependent cleavage of aggrecan in rat chondrosarcoma cells treated with interleukin-1. Biochem J 351: 1-166.
-
(2000)
Biochem J
, vol.351
, pp. 1-166
-
-
Sandy, J.D.1
Thompson, V.2
Doege, K.3
Verscharen, C.4
-
116
-
-
0035884605
-
Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivo
-
Sandy JD, Verscharen C (2001) Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivo. Biochem J 358: 615-626.
-
(2001)
Biochem J
, vol.358
, pp. 615-626
-
-
Sandy, J.D.1
Verscharen, C.2
-
117
-
-
38349112018
-
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)
-
in press
-
Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli A (2007) High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2). J Biol Chem, in press.
-
(2007)
J Biol Chem
-
-
Shieh, H.S.1
Mathis, K.J.2
Williams, J.M.3
Hills, R.L.4
Wiese, J.F.5
Benson, T.E.6
Kiefer, J.R.7
Marino, M.H.8
Carroll, J.N.9
Leone, J.W.10
Malfait, A.M.11
Arner, E.C.12
Tortorella, M.D.13
Tomasselli, A.14
-
118
-
-
4143129884
-
ADAMTS7B, the full-length product of the ADAMTS7 gene, is a chondroitin sulfate proteoglycan containing a mucin domain
-
Somerville RP, Longpré JM, Apel ED, Lewis RM, Wang LW, Sanes JR, Leduc R, Apte SS (2004) ADAMTS7B, the full-length product of the ADAMTS7 gene, is a chondroitin sulfate proteoglycan containing a mucin domain. J Biol Chem 279: 35159-35175.
-
(2004)
J Biol Chem
, vol.279
, pp. 35159-35175
-
-
Somerville, R.P.1
Longpré, J.M.2
Apel, E.D.3
Lewis, R.M.4
Wang, L.W.5
Sanes, J.R.6
Leduc, R.7
Apte, S.S.8
-
119
-
-
0038237345
-
Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1
-
Somerville RPT, Longpré J-M, Jungers KA, Engle JM, Ross M, Evanko S, Wight TN, Leduc R, Apte SS (2003) Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. J Biol Chem 278: 9503-9513.
-
(2003)
J Biol Chem
, vol.278
, pp. 9503-9513
-
-
Somerville, R.P.T.1
Longpré, J.-M.2
Jungers, K.A.3
Engle, J.M.4
Ross, M.5
Evanko, S.6
Wight, T.N.7
Leduc, R.8
Apte, S.S.9
-
120
-
-
33847010576
-
Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5
-
Song RH, Tortorella MD, Malfait AM, Alston JT, Yang Z, Arner EC, Griggs DW (2007) Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5. Arthritis Rheum 56: 575-585.
-
(2007)
Arthritis Rheum
, vol.56
, pp. 575-585
-
-
Song, R.H.1
Tortorella, M.D.2
Malfait, A.M.3
Alston, J.T.4
Yang, Z.5
Arner, E.C.6
Griggs, D.W.7
-
121
-
-
15844384854
-
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
-
Stanton H, Rogerson FM, East CJ, Golub SB, Lawlor KE, Meeker CT, Little CB, Last K, Farmer PJ, Campbell IK, Fourie AM, Fosang AJ (2005) ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature 434: 648-652.
-
(2005)
Nature
, vol.434
, pp. 648-652
-
-
Stanton, H.1
Rogerson, F.M.2
East, C.J.3
Golub, S.B.4
Lawlor, K.E.5
Meeker, C.T.6
Little, C.B.7
Last, K.8
Farmer, P.J.9
Campbell, I.K.10
Fourie, A.M.11
Fosang, A.J.12
-
122
-
-
33646377855
-
ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures
-
Stewart MC, Fosang AJ, Bai Y, Osborn B, Plaas A, Sandy JD (2006) ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures. Osteoarthritis and Cartilage 14: 392-402.
-
(2006)
Osteoarthritis and Cartilage
, vol.14
, pp. 392-402
-
-
Stewart, M.C.1
Fosang, A.J.2
Bai, Y.3
Osborn, B.4
Plaas, A.5
Sandy, J.D.6
-
123
-
-
33746513929
-
Estimation of the identity of proteolytic aggrecan fragments using PAGE migration and Western immunoblot
-
Struglics A, Larsson S, Lohmander LS (2006a) Estimation of the identity of proteolytic aggrecan fragments using PAGE migration and Western immunoblot. Osteoarthritis Cartilage 14: 898-905.
-
(2006)
Osteoarthritis Cartilage
, vol.14
, pp. 898-905
-
-
Struglics, A.1
Larsson, S.2
Lohmander, L.S.3
-
124
-
-
30544448357
-
Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments
-
Struglics A, Larsson S, Pratta MA, Kumar S, Lark MW, Lohmander LS (2006b) Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments. Osteoarthritis Cartilage 14: 101-113.
-
(2006)
Osteoarthritis Cartilage
, vol.14
, pp. 101-113
-
-
Struglics, A.1
Larsson, S.2
Pratta, M.A.3
Kumar, S.4
Lark, M.W.5
Lohmander, L.S.6
-
125
-
-
0032819417
-
Identification of aggrecanase activity in medium of cartilage culture
-
Sugimoto K, Takahashi M, Yamamoto Y, Shimada K, Tanzawa K (1999) Identification of aggrecanase activity in medium of cartilage culture. J Biochem (Tokyo) 126: 49-455.
-
(1999)
J Biochem (Tokyo)
, vol.126
, pp. 49-455
-
-
Sugimoto, K.1
Takahashi, M.2
Yamamoto, Y.3
Shimada, K.4
Tanzawa, K.5
-
126
-
-
46849083862
-
Analysis of aggrecan degradation in human intervertebral disc utilizing neoepitope-specific antibodies
-
Sztrolovics R, Alini M, Mort JS, Roughley PJ (1997a) Analysis of aggrecan degradation in human intervertebral disc utilizing neoepitope-specific antibodies. Trans Orthop Res Soc 22: 147.
-
(1997)
Trans Orthop Res Soc
, vol.22
, pp. 147
-
-
Sztrolovics, R.1
Alini, M.2
Mort, J.S.3
Roughley, P.J.4
-
127
-
-
0030931594
-
Aggrecan degradation in human intervertebral disc and articular cartilage
-
Sztrolovics R, Alini M, Roughley PJ, Mort JS (1997b) Aggrecan degradation in human intervertebral disc and articular cartilage. Biochem J 326: 235-241.
-
(1997)
Biochem J
, vol.326
, pp. 235-241
-
-
Sztrolovics, R.1
Alini, M.2
Roughley, P.J.3
Mort, J.S.4
-
128
-
-
0036499472
-
Hyaluronate degradation as an alternative mechanism for proteoglycan release from cartilage during interleukin-1[beta]-stimulated catabolism
-
Sztrolovics R, Recklies AD, Roughley PJ, Mort JS (2002) Hyaluronate degradation as an alternative mechanism for proteoglycan release from cartilage during interleukin-1[beta]-stimulated catabolism. Biochem J 362: 473-479.
-
(2002)
Biochem J
, vol.362
, pp. 473-479
-
-
Sztrolovics, R.1
Recklies, A.D.2
Roughley, P.J.3
Mort, J.S.4
-
129
-
-
21444439296
-
Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification
-
Tamamura Y, Otani T, Kanatani N, Koyama E, Kitagaki J, Komori T, Yamada Y, Costantini F, Wakisaka S, Pacifici M, Iwamoto M, Enomoto-Iwamoto M (2005) Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. J Biol Chem 280: 19185-19195.
-
(2005)
J Biol Chem
, vol.280
, pp. 19185-19195
-
-
Tamamura, Y.1
Otani, T.2
Kanatani, N.3
Koyama, E.4
Kitagaki, J.5
Komori, T.6
Yamada, Y.7
Costantini, F.8
Wakisaka, S.9
Pacifici, M.10
Iwamoto, M.11
Enomoto-Iwamoto, M.12
-
130
-
-
0035129903
-
ADAMTS: A novel family of extracellular matrix proteases
-
Tang BL (2001) ADAMTS: a novel family of extracellular matrix proteases. Int J Biochem Cell Biol 33: 33-44.
-
(2001)
Int J Biochem Cell Biol
, vol.33
, pp. 33-44
-
-
Tang, B.L.1
-
131
-
-
33646433471
-
Regulation of the human ADAMTS-4 promoter by transcription factors and cytokines
-
Thirunavukkarasu K, Pei Y, Moore TL, Wang H, Yu XP, Geiser AG, Chandrasekhar S (2006) Regulation of the human ADAMTS-4 promoter by transcription factors and cytokines. Biochem Biophys Res Commun 345: 197-204.
-
(2006)
Biochem Biophys Res Commun
, vol.345
, pp. 197-204
-
-
Thirunavukkarasu, K.1
Pei, Y.2
Moore, T.L.3
Wang, H.4
Yu, X.P.5
Geiser, A.G.6
Chandrasekhar, S.7
-
132
-
-
35148831210
-
Characterization of the human ADAMTS-5 (aggrecanase-2) gene promoter
-
Thirunavukkarasu K, Pei Y, Wei T (2007) Characterization of the human ADAMTS-5 (aggrecanase-2) gene promoter. Mol Biol Rep 34: 225-231.
-
(2007)
Mol Biol Rep
, vol.34
, pp. 225-231
-
-
Thirunavukkarasu, K.1
Pei, Y.2
Wei, T.3
-
133
-
-
84961014924
-
Reversible collapse of rabbit ears after intravenous papain, and prevention of recovery by cortisone
-
Thomas L (1956) Reversible collapse of rabbit ears after intravenous papain, and prevention of recovery by cortisone. J Exp Med 104:245-261.
-
(1956)
J Exp Med
, vol.104
, pp. 245-261
-
-
Thomas, L.1
-
134
-
-
0345211445
-
Purification and cloning of aggrecanase-1: A member of the ADAMTS family of proteins
-
Tortorella MD, Burn TC, Pratta MA, Abbaszade I, Hollis JM, Liu R, Rosenfeld SA, Copeland RA, Decicco CP, Wynn R, Rockwell A, Yang F, Duke JL, Solomon K, George H, Bruckner R, Nagase H, Itoh Y, Ellis DM, Ross H, Wiswall BH, Murphy K, Hillman MC, Jr, Hollis GF, Arner EC (1999) Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins. Science 284:1664-1666.
-
(1999)
Science
, vol.284
, pp. 1664-1666
-
-
Tortorella, M.D.1
Burn, T.C.2
Pratta, M.A.3
Abbaszade, I.4
Hollis, J.M.5
Liu, R.6
Rosenfeld, S.A.7
Copeland, R.A.8
Decicco, C.P.9
Wynn, R.10
Rockwell, A.11
Yang, F.12
Duke, J.L.13
Solomon, K.14
George, H.15
Bruckner, R.16
Nagase, H.17
Itoh, Y.18
Ellis, D.M.19
Ross, H.20
Wiswall, B.H.21
Murphy, K.22
Hillman Jr, M.C.23
Hollis, G.F.24
Arner, E.C.25
more..
-
135
-
-
0034682773
-
The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage
-
Tortorella M, Pratta M, Liu RQ, Abbaszade I, Ross H, Burn T, Arner E (2000a) The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage. J Biol Chem 275: 25791-25797.
-
(2000)
J Biol Chem
, vol.275
, pp. 25791-25797
-
-
Tortorella, M.1
Pratta, M.2
Liu, R.Q.3
Abbaszade, I.4
Ross, H.5
Burn, T.6
Arner, E.7
-
136
-
-
0034674771
-
Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4)
-
Tortorella MD, Pratta M, Liu RQ, Austin J, Ross OH, Abbaszade I, Burn T, Arner E (2000b) Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4). J Biol Chem 275:18566-18573.
-
(2000)
J Biol Chem
, vol.275
, pp. 18566-18573
-
-
Tortorella, M.D.1
Pratta, M.2
Liu, R.Q.3
Austin, J.4
Ross, O.H.5
Abbaszade, I.6
Burn, T.7
Arner, E.8
-
137
-
-
0034840936
-
The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation
-
Tortorella MD, Malfait A, Deccico C, Arner E (2001) The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation. Osteoarthritis Cartilage 9: 539-552.
-
(2001)
Osteoarthritis Cartilage
, vol.9
, pp. 539-552
-
-
Tortorella, M.D.1
Malfait, A.2
Deccico, C.3
Arner, E.4
-
138
-
-
0036775227
-
Characterization of human aggrecanase 2 (ADAMTS5): Substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4)
-
Tortorella MD, Liu RQ, Burn T, Newton RC, Arner E (2002) Characterization of human aggrecanase 2 (ADAMTS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4). Matrix Biol 21: 499-511.
-
(2002)
Matrix Biol
, vol.21
, pp. 499-511
-
-
Tortorella, M.D.1
Liu, R.Q.2
Burn, T.3
Newton, R.C.4
Arner, E.5
-
139
-
-
2342445246
-
Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes
-
Tortorella MD, Arner EC, Hills R, Easton A, Korte-Sarfaty J, Fok K, Wittwer AJ, Liu RQ, Malfait AM (2004) Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes. J Biol Chem 279: 17554-17561.
-
(2004)
J Biol Chem
, vol.279
, pp. 17554-17561
-
-
Tortorella, M.D.1
Arner, E.C.2
Hills, R.3
Easton, A.4
Korte-Sarfaty, J.5
Fok, K.6
Wittwer, A.J.7
Liu, R.Q.8
Malfait, A.M.9
-
140
-
-
0031947366
-
-
van Meurs JB, van Lent PL, Singer II, Bayne EK, van de Loo FA, Van Den Berg WB (1998) Interleukin-1 receptor antagonist prevents expression of the metalloproteinase-generated neoepitope VDIPEN in antigen-induced arthritis. Arthritis Rheum 41: 647-656.
-
van Meurs JB, van Lent PL, Singer II, Bayne EK, van de Loo FA, Van Den Berg WB (1998) Interleukin-1 receptor antagonist prevents expression of the metalloproteinase-generated neoepitope VDIPEN in antigen-induced arthritis. Arthritis Rheum 41: 647-656.
-
-
-
-
141
-
-
17044461667
-
Cleavage of aggrecan at the Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: A pivotal role for stromelysin 1 in matrix metalloproteinase activity
-
van Meurs J, van Lent P, Stoop R, Holthuysen A, Singer I, Bayne E, Mudgett J, Poole R, Billinghurst C, van der Kraan P, Buma P, van den Berg W (1999a) Cleavage of aggrecan at the Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: a pivotal role for stromelysin 1 in matrix metalloproteinase activity. Arthritis Rheum 42: 2074-2084.
-
(1999)
Arthritis Rheum
, vol.42
, pp. 2074-2084
-
-
van Meurs, J.1
van Lent, P.2
Stoop, R.3
Holthuysen, A.4
Singer, I.5
Bayne, E.6
Mudgett, J.7
Poole, R.8
Billinghurst, C.9
van der Kraan, P.10
Buma, P.11
van den Berg, W.12
-
142
-
-
46849086877
-
-
van Meurs JB, van Lent PL, Holthuysen AE, Singer II, Bayne EK, Van Den Berg WB (1999b) Kinetics of aggrecanase- and metalloproteinase-induced neoepitopes in various stages of cartilage destruction in murine arthritis. Arthritis Rheum 42: 1128-1139.
-
van Meurs JB, van Lent PL, Holthuysen AE, Singer II, Bayne EK, Van Den Berg WB (1999b) Kinetics of aggrecanase- and metalloproteinase-induced neoepitopes in various stages of cartilage destruction in murine arthritis.
-
-
-
-
143
-
-
0033032249
-
-
van Meurs JB, van Lent PL, van de Loo AA, Holthuysen AE, Bayne EK, Singer II, Van Den Berg WB (1999c) Increased vulnerability of postarthritic cartilage to a second arthritic insult: accelerated MMP activity in a flare up of arthritis. Ann Rheum Dis 58:3 50-356.
-
van Meurs JB, van Lent PL, van de Loo AA, Holthuysen AE, Bayne EK, Singer II, Van Den Berg WB (1999c) Increased vulnerability of postarthritic cartilage to a second arthritic insult: accelerated MMP activity in a flare up of arthritis. Ann Rheum Dis 58:3 50-356.
-
-
-
-
144
-
-
0035081902
-
Expression and activity of ADAMTS-5 in synovium
-
Vankemmelbeke MN, Holen I, Wilson AG, Ilic MZ, Handley CJ, Kelner GS, Clark M, Liu C, Maki RA, Burnett D, Buttle DJ (2001) Expression and activity of ADAMTS-5 in synovium. Eur J Biochem 268: 1259-1268.
-
(2001)
Eur J Biochem
, vol.268
, pp. 1259-1268
-
-
Vankemmelbeke, M.N.1
Holen, I.2
Wilson, A.G.3
Ilic, M.Z.4
Handley, C.J.5
Kelner, G.S.6
Clark, M.7
Liu, C.8
Maki, R.A.9
Burnett, D.10
Buttle, D.J.11
-
145
-
-
0037716455
-
Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters
-
Vankemmelbeke MN, Jones GC, Fowles C, Ilic MZ, Handley CJ, Day AJ, Knight CG, Mort JS, Buttle DJ (2003) Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters. Eur J Biochem 270: 2394-2403.
-
(2003)
Eur J Biochem
, vol.270
, pp. 2394-2403
-
-
Vankemmelbeke, M.N.1
Jones, G.C.2
Fowles, C.3
Ilic, M.Z.4
Handley, C.J.5
Day, A.J.6
Knight, C.G.7
Mort, J.S.8
Buttle, D.J.9
-
146
-
-
33745187332
-
An alternative spliced transcript of ADAMTS4 is present in human synovium from OA patients
-
Wainwright SD, Bondeson J, Hughes CE (2006) An alternative spliced transcript of ADAMTS4 is present in human synovium from OA patients. Matrix Biol 25: 317-320.
-
(2006)
Matrix Biol
, vol.25
, pp. 317-320
-
-
Wainwright, S.D.1
Bondeson, J.2
Hughes, C.E.3
-
147
-
-
2442595171
-
Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network
-
Wang P, Tortorella M, England K, Malfait AM, Thomas G, Arner EC, Pei D (2004a) Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network. J Biol Chem 279: 15434-15440.
-
(2004)
J Biol Chem
, vol.279
, pp. 15434-15440
-
-
Wang, P.1
Tortorella, M.2
England, K.3
Malfait, A.M.4
Thomas, G.5
Arner, E.C.6
Pei, D.7
-
148
-
-
10244219817
-
Regulation of MMP-13 expression by RUNX2 and FGF2 in osteoarthritic cartilage
-
Wang X, Manner PA, Horner A, Shum L, Tuan RS, Nuckolls GH (2004b) Regulation of MMP-13 expression by RUNX2 and FGF2 in osteoarthritic cartilage. Osteoarthritis Cartilage 12: 963-973.
-
(2004)
Osteoarthritis Cartilage
, vol.12
, pp. 963-973
-
-
Wang, X.1
Manner, P.A.2
Horner, A.3
Shum, L.4
Tuan, R.S.5
Nuckolls, G.H.6
-
149
-
-
34547125794
-
TIMP-3 inhibition of ADAMTS-4 (Aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4
-
Wayne GJ, Deng SJ, Amour A, Borman S, Matico R, Carter HL, Murphy G (2007) TIMP-3 inhibition of ADAMTS-4 (Aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4. J Biol Chem 282:20991-20998.
-
(2007)
J Biol Chem
, vol.282
, pp. 20991-20998
-
-
Wayne, G.J.1
Deng, S.J.2
Amour, A.3
Borman, S.4
Matico, R.5
Carter, H.L.6
Murphy, G.7
-
150
-
-
18544389543
-
ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain
-
Westling J, Fosang AJ, Last K, Thompson VP, Tomkinson KN, Hebert T, McDonagh T, Collins-Racie LA, LaVallie ER, Morris EA, Sandy JD (2002) ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain. J Biol Chem 277: 16059-16066.
-
(2002)
J Biol Chem
, vol.277
, pp. 16059-16066
-
-
Westling, J.1
Fosang, A.J.2
Last, K.3
Thompson, V.P.4
Tomkinson, K.N.5
Hebert, T.6
McDonagh, T.7
Collins-Racie, L.A.8
LaVallie, E.R.9
Morris, E.A.10
Sandy, J.D.11
-
151
-
-
0036467471
-
Expression and regulation of aggrecanase in arthritis: The role of TGF-beta
-
Yamanishi Y, Boyle DL, Clark M, Maki RA, Tortorella MD, Arner EC, Firestein GS (2002) Expression and regulation of aggrecanase in arthritis: the role of TGF-beta. J Immunol 168: 1405-1412.
-
(2002)
J Immunol
, vol.168
, pp. 1405-1412
-
-
Yamanishi, Y.1
Boyle, D.L.2
Clark, M.3
Maki, R.A.4
Tortorella, M.D.5
Arner, E.C.6
Firestein, G.S.7
-
152
-
-
0028097742
-
Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein
-
Yang B, Yang BL, Savani RC, Turley EA (1994) Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein. EMBO J 13: 286-296.
-
(1994)
EMBO J
, vol.13
, pp. 286-296
-
-
Yang, B.1
Yang, B.L.2
Savani, R.C.3
Turley, E.A.4
-
153
-
-
0037033136
-
Potent P1' biphenylmethyl substituted aggrecanase inhibitors
-
Yao W, Chao M, Wasserman ZR, Liu RQ, Covington MB, Newton R, Christ D, Wexler RR, Decicco CP (2002) Potent P1' biphenylmethyl substituted aggrecanase inhibitors. Bioorg Med Chem Lett 12: 101-104.
-
(2002)
Bioorg Med Chem Lett
, vol.12
, pp. 101-104
-
-
Yao, W.1
Chao, M.2
Wasserman, Z.R.3
Liu, R.Q.4
Covington, M.B.5
Newton, R.6
Christ, D.7
Wexler, R.R.8
Decicco, C.P.9
-
154
-
-
0035846124
-
Design and synthesis of a series of (2r)-n(4)-hydroxy-2-(3-hydroxybenzyl)-n(1)-[(1s,2r)-2-hydroxy-2, 3-dihydro-1h-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors
-
Yao W, Wasserman ZR, Chao M, Reddy G, Shi E, Liu RQ, Covington MB, Arner EC, Pratta MA, Tortorella M, Magolda RL, Newton R, Qian M, Ribadeneira MD, Christ D, Wexler RR, Decicco CP (2001) Design and synthesis of a series of (2r)-n(4)-hydroxy-2-(3-hydroxybenzyl)-n(1)-[(1s,2r)-2-hydroxy-2, 3-dihydro-1h-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors. J Med Chem 44: 3347-3350.
-
(2001)
J Med Chem
, vol.44
, pp. 3347-3350
-
-
Yao, W.1
Wasserman, Z.R.2
Chao, M.3
Reddy, G.4
Shi, E.5
Liu, R.Q.6
Covington, M.B.7
Arner, E.C.8
Pratta, M.A.9
Tortorella, M.10
Magolda, R.L.11
Newton, R.12
Qian, M.13
Ribadeneira, M.D.14
Christ, D.15
Wexler, R.R.16
Decicco, C.P.17
-
155
-
-
21644471962
-
Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption
-
Young DA, Lakey RL, Pennington CJ, Jones D, Kevorkian L, Edwards DR, Cawston TE, Clark IM. (2005) Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption. Arthritis Res Ther. 27: R503-R512.
-
(2005)
Arthritis Res Ther
, vol.27
-
-
Young, D.A.1
Lakey, R.L.2
Pennington, C.J.3
Jones, D.4
Kevorkian, L.5
Edwards, D.R.6
Cawston, T.E.7
Clark, I.M.8
-
156
-
-
0034613296
-
TIMP-3 binds to sulfated glycosaminoglycans of the extracellular matrix
-
Yu WH, Yu Ss, Meng Q, Brew K, Woessner JF, Jr. (2000) TIMP-3 binds to sulfated glycosaminoglycans of the extracellular matrix. J Biol Chem 275: 31226-31232.
-
(2000)
J Biol Chem
, vol.275
, pp. 31226-31232
-
-
Yu, W.H.1
Yu, S.2
Meng, Q.3
Brew, K.4
Woessner Jr., J.F.5
-
157
-
-
33644883338
-
Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: Comparative analyses with ADAMTS-5, -9, -16 and -18
-
Zeng W, Corcoran C, Collins-Racie LA, LaVallie ER, Morris EA, Flannery CR (2006) Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18. Biochim Biophys Acta 1760: 517-524.
-
(2006)
Biochim Biophys Acta
, vol.1760
, pp. 517-524
-
-
Zeng, W.1
Corcoran, C.2
Collins-Racie, L.A.3
LaVallie, E.R.4
Morris, E.A.5
Flannery, C.R.6
-
158
-
-
43749117128
-
Functional differences of the catalytic and noncatalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity
-
in press
-
Fushimi K, Troeberg L, Nakamura H, Lim NH, Nagase H (2008) Functional differences of the catalytic and noncatalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity. J Biol Chem, in press.
-
(2008)
J Biol Chem
-
-
Fushimi, K.1
Troeberg, L.2
Nakamura, H.3
Lim, N.H.4
Nagase, H.5
-
159
-
-
37549037806
-
Crystal structure of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5
-
Mosyak L, Georgiadis K, Shane T, Svenson K, Hebert T, McDonagh T, Mackie S., Olland S, Lin L, Zhong X, Kriz R, Reifenberg EL, Collins-Racie LA, Corcoran C, Fremman B, Zollner, R, Marvell T, Vera M, Sum PE, Lavallie ER, Stahl M, Somers W (2008) Crystal structure of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5. Protein Sci 17: 16-21.
-
(2008)
Protein Sci
, vol.17
, pp. 16-21
-
-
Mosyak, L.1
Georgiadis, K.2
Shane, T.3
Svenson, K.4
Hebert, T.5
McDonagh, T.6
Mackie, S.7
Olland, S.8
Lin, L.9
Zhong, X.10
Kriz, R.11
Reifenberg, E.L.12
Collins-Racie, L.A.13
Corcoran, C.14
Fremman, B.15
Zollner, R.16
Marvell, T.17
Vera, M.18
Sum, P.E.19
Lavallie, E.R.20
Stahl, M.21
Somers, W.22
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