Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2)

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 5, 2007, Pages 1185-1188

  Bursavich, Matthew G ^a   Gilbert, Adam M ^a   Lombardi, Sabrina ^a   Georgiadis, Katy E ^b   Reifenberg, Erica ^b   Flannery, Carl R ^b   Morris, Elisabeth A ^b  

^a WYETH RESEARCH   (United States)

^b PFIZER INC   (United States)

Author keywords

ADAMTS 5; Aggrecanase; Metalloprotease inhibitor; Thioxothiazolidinone; Zinc chelator

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; AGGRECANASE; AGGRECANASE 2; CHELATING AGENT; HYDANTOIN DERIVATIVE; HYDROXAMIC ACID DERIVATIVE; IMIDAZOLIDINE DERIVATIVE; METALLOPROTEINASE INHIBITOR; PROTEIN ADAMTS5; UNCLASSIFIED DRUG; ZINC;

ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; IC 50; OSTEOARTHRITIS; STRUCTURE ACTIVITY RELATION;

ADAM PROTEINS; CHELATING AGENTS; ENZYME INHIBITORS; HUMANS; METALLOPROTEASES; OSTEOARTHRITIS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINEDIONES; ZINC;

EID: 33846919398     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.12.027     Document Type: Article

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