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Volumn 277, Issue 25, 2002, Pages 22201-22208
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Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage
a,b,d
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Author keywords
[No Author keywords available]
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Indexed keywords
CARTILAGE;
COMPRESSIBILITY;
DEGRADATION;
JOINTS (ANATOMY);
OSTEOARTHRITIS;
BIOCHEMISTRY;
3 AZA 4 OXO 10 OXA 5 HEXYL 2 (METHYLCARBOXAMIDO) 10 PARACYCLOPHANE 6 N HYDROXYCARBOXAMIDE;
AGGRECAN;
AGGRECANASE;
AGGRECANASE INHIBITOR;
BB 16;
COLLAGEN TYPE 2;
ENZYME INHIBITOR;
HEXAHYDRO 2 [2 [2 (HYDROXYAMINO) 1 METHYL 2 OXYETHYL] 4 METHYL 1 OXYPENTYL] N METHYL] 3 PYRIDAZINECARBOXAMIDE;
MATRIX METALLOPROTEINASE;
MATRIX METALLOPROTEINASE INHIBITOR;
MESSENGER RNA;
PROTEIN;
PROTEIN ADAMTS4;
PROTEIN ADAMTS5;
UNCLASSIFIED DRUG;
XS 309;
ARTICLE;
CARTILAGE;
COLLAGEN METABOLISM;
COMPRESSION;
CONTROLLED STUDY;
ELASTICITY;
ENZYME INHIBITION;
EPITOPE MAPPING;
HUMAN;
HUMAN CELL;
HUMAN TISSUE;
OSTEOARTHRITIS;
PRIORITY JOURNAL;
PROTEIN ANALYSIS;
PROTEIN DEGRADATION;
SYNOVIAL FLUID;
ADAM PROTEINS;
AGGRECANS;
AMINO ACID SEQUENCE;
ANIMALS;
BINDING SITES;
BLOTTING, WESTERN;
CARTILAGE;
CATTLE;
CESIUM;
CHLORIDES;
DOSE-RESPONSE RELATIONSHIP, DRUG;
ENDOPEPTIDASES;
ENZYME INHIBITORS;
EPITOPES;
EXTRACELLULAR MATRIX PROTEINS;
HUMANS;
KINETICS;
LECTINS, C-TYPE;
METALLOENDOPEPTIDASES;
MOLECULAR SEQUENCE DATA;
OSTEOARTHRITIS;
PROCOLLAGEN N-ENDOPEPTIDASE;
PROTEIN STRUCTURE, TERTIARY;
PROTEOGLYCANS;
REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;
RNA, MESSENGER;
SYNOVIAL FLUID;
TIME FACTORS;
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EID: 0037151084
PISSN: 00219258
EISSN: None
Source Type: Journal
DOI: 10.1074/jbc.M200431200 Document Type: Article |
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Times cited : (266)
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References (46)
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