ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

Nature

Volumn 434, Issue 7033, 2005, Pages 648-652

  Stanton, Heather ^a   Rogerson, Fraser M ^a   East, Charlotte J ^a   Golub, Suzanne B ^a   Lawlor, Kate E ^a   Meeker, Clare T ^a   Little, Christopher B ^b   Last, Karena ^a   Farmer, Pamela J ^c   Campbell, Ian K ^d   Fourie, Anne M ^e   Fosang, Amanda J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c ROYAL CHILDREN'S HOSPITAL   (Australia)

^d WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^e J/J Pharmaceut Res/Development   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; PATHOLOGY; TISSUE;

CARTILAGE DESTRUCTION; MOUSE CARTILAGE; PROTEOGLYCAN; THROMBOSPONDIN MOTIFS;

CARTILAGE;

AGGRECANASE; AGGRECANASE 2; FREUND ADJUVANT; MESSENGER RNA; METALLOPROTEINASE; PROTEIN ADAMTS5; PROTEOGLYCAN; UNCLASSIFIED DRUG; ADAM PROTEIN; ADAMTS5 PROTEIN, MOUSE; AGC1 PROTEIN, MOUSE; AGGRECAN; AGGRECANASE 1; AGGRECANASE-1; ANTIGEN; INTERLEUKIN 1; LECTIN; PROCOLLAGEN N PROTEINASE; PROTEINASE; SCLEROPROTEIN;

MEDICINE;

ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; CARTILAGE DEGENERATION; CONTROLLED STUDY; GENOTYPE; KNEE OSTEOARTHRITIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN MOTIF; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; ANIMAL; CARTILAGE; DISEASE MODEL; DRUG EFFECT; ENZYMOLOGY; GENETICS; IMMUNOLOGY; IN VITRO STUDY; METABOLISM; MOUSE MUTANT; SECRETION; TISSUE CULTURE TECHNIQUE;

ADAM PROTEINS; AGGRECANS; ANIMALS; ANTIGENS; ARTHRITIS; CARTILAGE; DISEASE MODELS, ANIMAL; ENDOPEPTIDASES; EXTRACELLULAR MATRIX PROTEINS; GENOTYPE; INTERLEUKIN-1; LECTINS, C-TYPE; METALLOENDOPEPTIDASES; MICE; MICE, KNOCKOUT; PROCOLLAGEN N-ENDOPEPTIDASE; PROTEOGLYCANS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TISSUE CULTURE TECHNIQUES;

EID: 15844384854     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03417     Document Type: Article

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