Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by m-calpain

Biochemical Journal

Volumn 382, Issue 1, 2004, Pages 253-259

  Oshita, Hidefumi ^a   Sandy, John D ^c   Suzuki, Kiichi ^b   Akaike, Atsushi ^a   Bai, Yun ^c   Sasaki, Tomohiro ^a   Shimizu, Katsuji ^a  

^a GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NAGAHAMA CITY HOSPITAL   (Japan)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Aggrecanase; Calcium dependent proteolysis; Calpain; Chondroitin sulphate; Interglobular domain

Indexed keywords

AGGRECANASE; PROTEOLYSIS; SECRETION;

ANTIBODIES; BIODIVERSITY; BIOSYNTHESIS; CHEMICAL BONDS; ENZYMES; MOLECULES;

CARTILAGE;

AGGRECAN; AGGRECANASE; ALANINE; CALPAIN; CHONDROITIN SULFATE; GLOBULAR PROTEIN; GLYCINE; KERATAN SULFATE; MATRIX METALLOPROTEINASE; MONOCLONAL ANTIBODY; SERINE; VALINE;

AMINO TERMINAL SEQUENCE; ARTICLE; ARTICULAR CARTILAGE; CARBOXY TERMINAL SEQUENCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; SWINE;

AGGRECANS; ALANINE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BINDING SITES; BLOTTING, WESTERN; CALPAIN; CARTILAGE, ARTICULAR; CATTLE; EXTRACELLULAR MATRIX PROTEINS; HYDROLYSIS; KIDNEY; LECTINS, C-TYPE; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; PROTEOGLYCANS; SEQUENCE ANALYSIS, PROTEIN; SWINE;

BOVINAE; SUS SCROFA;

EID: 4344601054     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20040113     Document Type: Article

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