Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters

European Journal of Biochemistry

Volumn 270, Issue 11, 2003, Pages 2394-2403

  Vankemmelbeke, Mireille N ^a   Jones, Gavin C ^a   Fowles, Cyprianne ^a   Ilic, Mirna Z ^b   Handley, Christopher J ^b   Day, Anthony J ^c   Knight, C Graham ^d   Mort, John S ^e   Buttle, David J ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b LA TROBE UNIVERSITY   (Australia)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e SHRINERS HOSPITAL FOR CHILDREN   (Canada)

Author keywords

ADAMTS; Aggrecanase; Catechin; Enzyme inhibition; Gallate

Indexed keywords

AGGRECANASE; CAMELLIA SINENSIS EXTRACT; CATECHIN; COLLAGENASE; GALLIC ACID DERIVATIVE; MEMBRANE PROTEIN; METALLOPROTEINASE; PLANT EXTRACT; POLYPHENOL DERIVATIVE; PROTEIN ADAM10; PROTEIN ADAMTS1; PROTEIN ADAMTS4; PROTEIN ADAMTS5; UNCLASSIFIED DRUG;

ARTHRITIS; ARTHROPATHY; ARTICLE; CARTILAGE DEGENERATION; CONCENTRATION RESPONSE; DISEASE MODEL; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TEA;

ADAM PROTEINS; AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BLOTTING, WESTERN; CATECHIN; CATTLE; CELL LINE; CULTURE MEDIA, CONDITIONED; DISINTEGRINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOPEPTIDASES; ENZYME INHIBITORS; ESTERS; GENETIC VECTORS; HUMANS; INHIBITORY CONCENTRATION 50; INSECTS; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; PROCOLLAGEN N-ENDOPEPTIDASE; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; TEA;

CAMELLIA; CAMELLIA SINENSIS; MAMMALIA;

EID: 0037716455     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2003.03607.x     Document Type: Article

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