Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4)

Journal of Biological Chemistry

Volumn 275, Issue 24, 2000, Pages 18566-18573

  Tortorella, Micky D ^a,b   Pratta, Michael ^a   Liu, Rui Qin ^a   Austin, Julian ^a   Ross, O Harold ^a   Abbaszade, Ilgar ^a   Burn, Tim ^a   Arner, Elizabeth ^a  

^a DUPONT COMPANY   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; PROTEINASE; RECOMBINANT ENZYME;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARTILAGE; CONTROLLED STUDY; ENZYME SUBSTRATE COMPLEX; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN;

ADAM PROTEINS; AGGRECANS; ALANINE; AMINO ACID SEQUENCE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EXTRACELLULAR MATRIX PROTEINS; GLUTAMINE; HUMANS; LECTINS, C-TYPE; METALLOENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PROCOLLAGEN N-ENDOPEPTIDASE; PROTEOGLYCANS; SUBSTRATE SPECIFICITY;

ANIMALIA;

EID: 0034674771     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M909383199     Document Type: Article

References (24)

1. Tortorella, M. D., Burn, T. C., Pratta, M. A., Abbaszade, I., Hollis, J. M., Liu, R., Rosenfeld, S. A., Copeland, R. A., Decicco, C. P., Wynn, R., Rockwell, A., Yang, F., Duke, J. L., Solomon, K., George, H., Bruckner R., Nagase, H., Itoh, Y., Ellis, D. M., Ross, H., Wiswall, B. H., Murphy, K., Hillman M. C., Jr., Hollis, G. F., Newton, R. C., Magolda, R. L., Trzaskos, J. M., and Arner, E. C. (1999) Science 284, 1664-1666
2. Hardingham, T. E., Fosang, A. J., and Dudhia, J. (1992) in Articular Cartilage and Osteoarthritis (Kuettner, K. E., Schleyerbach, R., Peyton, J. G., and Hascall, V. C., eds) pp. 5-20, Raven Press, New York
3. Paulson, M., Morgolin, M., Wiedemann, H., Beardmore-Gray, M., Dunham, D., Hardingham, T. E., and Heinegard, D. (1987) Biochem. J. 245, 763-772
4. Flannery, C. R., Lark, M. W., and Sandy, J. D. (1992) J. Biol. Chem. 267, 1008-1014
5. Fosang, A. J., Neame, P. J., Last, K., Hardingham, T. E., Murphy, G., and Hamilton, J. A. (1992) J. Biol. Chem. 267, 19470-19474
6. Fosang, A. J., Last, K., Knauper, V., Neame, P. J., Murphy, G., Hardingham, T. E., Tschesche, H., and Hamilton, J. A. (1993) Biochem. J. 295, 273-276
7. Fosang, A. J., Last, K., Knauper, V., Murphy, G., and Neame, P. J. (1996) FEBS Lett. 380, 17-20
8. Flannery, C. R., and Sandy, J. D. (1993) Orthop. Trans. 17, 677
9. Sandy, J. D., Neame, P. J., Boynton, P. L., and Flannery, C. R. (1991) J. Biol. Chem. 288, 8683-8685
10. Leulakis, P., Shirkhanda, A. V., Davis, G., and Maniglia, C. A. (1992) Biochem. J. 284, 589-593
11. Ilic, M. Z., Handley, C. J., Robinson, H. C., and Mok, M. T. (1992) Arch. Biochem. Biophys. 294, 115-122
12. Lark, M. W., Gordy, J. T., Weidner, J. R., Ayaia, J., Kimura, J. H., Williams, H. R., Mumford, R. A., Flannery, C. R., Carisoni, S. S., Iwatai, M., and Sandy, J. D. (1995) J. Biol. Chem. 270, 2550-2556
13. Arner, E. C., Hughes, C. E., Decicco, C. P., Caterson, B., and Tortorella, M. D. (1998) Osteoarthritis Cart. 6, 214-228
14. Sandy, J. D., Plaas, A. H. K., and Koob, T. J. (1995) Acta Orthop. Scand. 66, Suppl. 266, 26-32
15. Ilic, M. Z., Robinson, H. C., and Handley, C. J. (1998) J. Biol. Chem. 273, 17451-17458
16. Abbaszade, I., Liu, R-Q., Yang, F., Rosenfeld, S. A., Ross, O. H., Link, J. R., Ellis, D. M., Tortorella, M. D., Pratta, M. A., Hollis, J. M., Wynn, R., Duke, J. L., George, H. J., Hillman, M. C., Jr., Murphy, K., Wiswall, B. H., Copeland, R. A., Decicco, C. P., Bruckner, R., Nagase, H., Itoh, Y., Newton, R. C., Magolda, R. L., Trzaskos, J. M., Hollis, G. F., Arner, E. C., and Burn, T. C. (1999) J. Biol. Chem. 274, 23443-23450
17. Hughes, C. E., Caterson, B., Fosang, A. J., Roughley, P. J., and Mort, J. S. (1995) Biochem. J. 305, 799-804
18. Fosang, A. J., Last, K., Gardiner, P., Jackson, D. C., and Brown, L. (1995) Biochem. J. 310, 337-343
19. Dudhia, J., Dacidson, C. M., Wells, T. M., Vynios, D. H., Hardingham, T. E., and Bayliss, M. T. (1996) Biochem. J. 313, 933-940
20. Hascall, V. C., and Sajdera, S. W. (1969) J. Biol. Chem. 244, 2384-2396
21. Miller, C. G. (1994) Methods 6, 315-333
22. Fosang, A. J., Last, K., Neame, P. J., Murphy, G., Knauper, V., Tschesche, H., Hughers, C. E., Caterson, B., and Hardingham, T. E. (1994) Biochem. J. 305, 347-351
23. Arner, E. C., Decicco, C. P., Cherney, R., and Tortorella, M. D. (1997) J. Biol. Chem. 272, 9294-9299
24. Tortorella, M. D., Pratta, M. A., Fox, J. W., and Arner, E. C. (1998) J. Biol. Chem. 273, 5846-5850