Autocatalytic cleavage of ADAMTS-4 (aggrecanase-1) reveals multiple glycosaminoglycan-binding sites

Journal of Biological Chemistry

Volumn 277, Issue 45, 2002, Pages 42775-42780

  Flannery, Carl R ^a   Zeng, Weilan ^a   Corcoran, Chris ^a   Collins Racie, Lisa A ^a   Chockalingam, Priya S ^a   Hebert, Tracy ^a   Mackie, Stewart A ^a   McDonagh, Thomas ^a   Crawford, Tara K ^a   Tomkinson, Kathy N ^a   LaVallie, Edward R ^a   Morris, Elisabeth A ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARTILAGE; DISEASES; PROTEINS; SUBSTRATES;

AUTOCATALYSIS;

BIOCHEMISTRY;

ADENINE; AGGRECAN; AGGRECANASE; AGGRECANASE 1; GLYCOSAMINOGLYCAN; GUANINE; ISOPROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; ARTICULAR CARTILAGE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; DEGLYCOSYLATION; ENZYME ACTIVITY; ENZYME ANALYSIS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION;

ADAM PROTEINS; AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; CYSTEINE; GLYCOSAMINOGLYCANS; HUMANS; HYDROLYSIS; ISOENZYMES; KINETICS; METALLOENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PROCOLLAGEN N-ENDOPEPTIDASE; RECOMBINANT PROTEINS;

EID: 18644373574     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M205309200     Document Type: Article

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