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Volumn 277, Issue 18, 2002, Pages 16059-16066

ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain

(11) Westling, Jennifer a Fosang, Amanda J b Last, Karena c Thompson, Vivian P a Tomkinson, Kathy N a Hebert, Tracy b McDonagh, Thomas a Collins Racie, Lisa A a Lavallie, Edward R a Morris, Elisabeth A a Sandy, John D a,d

a UNIVERSITY OF SOUTH FLORIDA (United States)

b UNIVERSITY OF MELBOURNE (Australia)

c PFIZER INC (United States)

d SHRINERS HOSPITALS FOR CHILDREN (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEGRADATION; ENZYMES; PH;

PROTEOLYSIS;

BIOCHEMISTRY;

AGGRECAN; AGGRECANASE; CATHEPSIN B; MATRIX METALLOPROTEINASE; PROTEIN ADAMTS4; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN COS1; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MOLECULAR CLONING; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING;

ADAM PROTEINS; ALANINE; AMINO ACID SEQUENCE; ASPARAGINE; BINDING SITES; CATHEPSIN B; GLUTAMIC ACID; HUMANS; HYDROGEN-ION CONCENTRATION; MATRIX METALLOPROTEINASES; METALLOENDOPEPTIDASES; OLIGOPEPTIDES; PHENYLALANINE; PROCOLLAGEN N-ENDOPEPTIDASE; SUBSTRATE SPECIFICITY; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 18544389543 PISSN: 00219258 EISSN: None Source Type: Journal
DOI: 10.1074/jbc.M108607200 Document Type: Article

Times cited : (79)

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