Cleavage of native cartilage aggrecan by neutrophil collagenase (MMP-8) is distinct from endogenous cleavage by aggrecanase

Journal of Biological Chemistry

Volumn 272, Issue 14, 1997, Pages 9294-9299

  Arner, Elizabeth C ^a   Decicco, Carl P ^a   Cherney, Robert ^a   Tortorella, Micky D ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; AGGRECANASE; COLLAGENASE; ENZYME; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CARTILAGE DEGENERATION; ENZYME ACTIVITY; ENZYME DEGRADATION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

AGGRECANS; ALANINE; ANIMALS; BINDING SITES; CARTILAGE; CATTLE; COLLAGENASES; ENDOPEPTIDASES; EXTRACELLULAR MATRIX PROTEINS; GLUTAMINE; HUMANS; INTERLEUKIN-1; LECTINS, C-TYPE; MATRIX METALLOPROTEINASE 8; POLYETHYLENE GLYCOLS; PROTEOCHONDROITIN SULFATES; PROTEOGLYCANS;

EID: 0030910398     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.14.9294     Document Type: Article

References (27)

1. Hardingham, T. E., Fosang, A. J., and Dudhia, J. (1992) in Articular Cartilage and Osteoarthritis (Kuettner, K. E., Schleyerbach, R., Peyton, J. G., and Hascall, V. C., eds) pp. 5-20, Raven Press, New York
2. Paulson, M., Morgolin, M., Wiedemann, H., Beardmore-Gray, M. Dunham, D., Hardingham, T. E., and Heinegard, D. (1987) Biochem. J. 245, 763-772
3. Hardingham, T. E., and Muir, H. (1972) Biochim. Biophys. Acta 279, 401-405
4. Heinegard, D., and Hascall, V. C. (1974) J. Biol. Chem. 249, 4250-4256
5. Hardingham, T. E. (1979) Biochem. J. 177, 237-247
6. Flannery, C. R., Lark, M. W., and Sandy, J. D. (1992) J. Biol. Chem. 267, 1008-1014
7. Sandy, J. D., Flannery, C. R., Neame, P. J., and Lohmander, L. S. (1992) J. Clin. Invest. 69, 1512-1516
8. Lohmander, L. S., Neame, P. J., and Sandy, J. D. (1993) Arthritis Rheum. 36, 1214-1222
9. Sandy, J. D., Boynton, R. E., and Flannery, C. R. (1991) J. Biol. Chem. 266, 8198-8205
10. Sandy, J. D., Neame, P. J., Boynton, R. E., and Flannery, C. R. (1991) J. Biol. Chem. 266, 8683-8685
11. Leulakis, P., Shirkhanda, A. V., Davis, G., and Maniglia, C. A. (1992) Biochem. J. 264, 589-593
12. Ilic, M. Z., Handley, C. J., Robinson, H. C., and Mok, M. T. (1992) Arch. Biochem. Biophys. 294, 115-122
13. Lark, M. W., Gordy, J. T., Weidner, J. R., Ayala, J., Kimura, J. H., Williams, H. R., Mumford, R. A., Flannery, C. R., Carlson, S. S., Iwata, M., and Sandy, J. D. (1995) J. Biol. Chem. 270, 2550-2556
14. Fosang, A. J., Neame, P. J., Last, K., Hardhingham, T. E., Murphy, G., and Hamilton, J. A. (1992) J. Biol. Chem. 267, 19470-19474
15. Fosang, A. J., Last, K., Knauper, V., Neame, P. J., Murphy, G., Hardingham, T. E., Tschesche, H., and Hamilton, J. A. (1993) Biochem. J. 295, 273-276
16. Fosang, A. J., Last, K., Knauper, V., Murphy, G., Neame, P. J. (1996) FEBS Lett. 380, 17-20
17. Flannery, C. R., and Sandy, J. D. (1993) Orthop. Trans. 17, 677
18. Fosang, A. J., Last, K., Neame, P. J., Murphy, G., Knauper, V., Tschesche, H., Hughers, C. E., Caterson, B., and Hardingham, T. E. (1994) Biochem. J. 305, 347-351
19. Chubinskaya, S., Huch, K., Mikecz, K., Cs-Szabo, G., Hastey, K. A., Kuettner, K. E., and Cole, A. A. (1996) Lab. Invest. 74, 232-240
20. Cole A. A., and Kuettner K. E. (1995) Acta Orthop. Scand. 66, Suppl. 266, 1-5
21. Hughes C. E., Caterson, B., Fosang, A. J., Roughley, P. J., and Mort, J. S. (1995) Biochem. J. 305, 799-804
22. Huang, J. J., Newton, R. C., Pezzella, K., Covington, M., Tamblyn, T., Rutledge, S. J., Kelley, M., Gray, J, and Lin, Y. (1987) Mol. Biol. Med. 4, 169-181
23. Arner, E. C., Pratta, M. A., Freimark, B., Lischwe, M., Trzaskos, J. M., Magolda, R. L., Wright, S. W. (1996) Biochem. J. 318, 417-424
24. Arner, E. C., and Pratta, M. A. (1991) Arthritis Rheum. 34, 1006-1013
25. Farndale, R. W., Sayers, C. A., Barrett, A. J. (1982) Connect. Tissue Res. 9, 247-248
26. Walakovits, L. A., Moore, V. L., Bhardwaj, N., Gallick, G. S., Lark, M. W. (1992) Arthritis Rheum. 35, 35-42
27. Loehmander, S. L., Hoerrner, L. A., Lark, M. W. (1993) Arthritis Rheum. 36, 181-189