-
1
-
-
0002115901
-
Aggrecan, the chondroitin sulfate/keratan sulfate proteoglycan from cartilage
-
Kuettner K.E., Schleyerbach R., Peyton J.G., and Hascall V.C. (Eds), Raven Press, New York
-
Hardingham T.E., Fosang A.J., and Dudhia J. Aggrecan, the chondroitin sulfate/keratan sulfate proteoglycan from cartilage. In: Kuettner K.E., Schleyerbach R., Peyton J.G., and Hascall V.C. (Eds). Articular Cartilage and Osteoarthritis (1992), Raven Press, New York 5-20
-
(1992)
Articular Cartilage and Osteoarthritis
, pp. 5-20
-
-
Hardingham, T.E.1
Fosang, A.J.2
Dudhia, J.3
-
2
-
-
10444239424
-
Proteolytic degradation of normal and osteoarthritic cartilage matrix
-
Brandt K.D., Doherty M., and Lohmander L.S. (Eds), Oxford University Press, Oxford
-
Sandy J.D. Proteolytic degradation of normal and osteoarthritic cartilage matrix. In: Brandt K.D., Doherty M., and Lohmander L.S. (Eds). Osteoarthritis (2003), Oxford University Press, Oxford 82-92
-
(2003)
Osteoarthritis
, pp. 82-92
-
-
Sandy, J.D.1
-
3
-
-
0035884605
-
Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivo
-
Sandy J.D., and Verscharen C. Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivo. Biochem J 358 Pt 3 (2001) 615-626
-
(2001)
Biochem J
, vol.358
, Issue.PART 3
, pp. 615-626
-
-
Sandy, J.D.1
Verscharen, C.2
-
4
-
-
0037151084
-
Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage
-
Malfait A.M., Liu R.Q., Ijiri K., Komiya S., and Tortorella M.D. Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage. J Biol Chem 277 (2002) 22201-22208
-
(2002)
J Biol Chem
, vol.277
, pp. 22201-22208
-
-
Malfait, A.M.1
Liu, R.Q.2
Ijiri, K.3
Komiya, S.4
Tortorella, M.D.5
-
5
-
-
0036295493
-
ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors
-
Rodriguez-Manzaneque J.C., Westling J., Thai S.N., Luque A., Knauper V., Murphy G., et al. ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors. Biochem Biophys Res Commun 293 1 (2002) 501-508
-
(2002)
Biochem Biophys Res Commun
, vol.293
, Issue.1
, pp. 501-508
-
-
Rodriguez-Manzaneque, J.C.1
Westling, J.2
Thai, S.N.3
Luque, A.4
Knauper, V.5
Murphy, G.6
-
6
-
-
18544389543
-
ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain
-
Westling J., Fosang A.J., Last K., Thompson V.P., Tomkinson K.N., Hebert T., et al. ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain. J Biol Chem 277 18 (2002) 16059-16066
-
(2002)
J Biol Chem
, vol.277
, Issue.18
, pp. 16059-16066
-
-
Westling, J.1
Fosang, A.J.2
Last, K.3
Thompson, V.P.4
Tomkinson, K.N.5
Hebert, T.6
-
7
-
-
0141884802
-
Variations in aggrecan structure modulate its susceptibility to aggrecanases
-
Roughley P.J., Barnett J., Zuo F., and Mort J.S. Variations in aggrecan structure modulate its susceptibility to aggrecanases. Biochem J 375 Pt 1 (2003) 183-189
-
(2003)
Biochem J
, vol.375
, Issue.PART 1
, pp. 183-189
-
-
Roughley, P.J.1
Barnett, J.2
Zuo, F.3
Mort, J.S.4
-
8
-
-
30544448357
-
Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments
-
Struglics A., Larsson S., Pratta M.A., Kumar S., Lark M.W., and Lohmander L.S. Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments. Osteoarthritis Cartilage 14 2 (2006) 101-113
-
(2006)
Osteoarthritis Cartilage
, vol.14
, Issue.2
, pp. 101-113
-
-
Struglics, A.1
Larsson, S.2
Pratta, M.A.3
Kumar, S.4
Lark, M.W.5
Lohmander, L.S.6
-
9
-
-
0026682509
-
The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain
-
Sandy J.D., Flannery C.R., Neame P.J., and Lohmander L.S. The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain. J Clin Invest 89 5 (1992) 1512-1516
-
(1992)
J Clin Invest
, vol.89
, Issue.5
, pp. 1512-1516
-
-
Sandy, J.D.1
Flannery, C.R.2
Neame, P.J.3
Lohmander, L.S.4
-
10
-
-
0027445981
-
The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis
-
Lohmander L.S., Neame P.J., and Sandy J.D. The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis. Arthritis Rheum 36 9 (1993) 1214-1222
-
(1993)
Arthritis Rheum
, vol.36
, Issue.9
, pp. 1214-1222
-
-
Lohmander, L.S.1
Neame, P.J.2
Sandy, J.D.3
-
11
-
-
0028843597
-
Changes in cartilage composition and physical properties due to stromelysin degradation
-
Bonassar L.J., Frank E.H., Murray J.C., Paguio C.G., Moore V.L., Lark M.W., et al. Changes in cartilage composition and physical properties due to stromelysin degradation. Arthritis Rheum 38 (1995) 173-183
-
(1995)
Arthritis Rheum
, vol.38
, pp. 173-183
-
-
Bonassar, L.J.1
Frank, E.H.2
Murray, J.C.3
Paguio, C.G.4
Moore, V.L.5
Lark, M.W.6
-
12
-
-
0030024311
-
Degradation of cartilage aggrecan by collagenase-3 (MMP-13)
-
Fosang A.J., Last K., Knauper V., Murphy G., and Neame P.J. Degradation of cartilage aggrecan by collagenase-3 (MMP-13). FEBS Lett 380 1-2 (1996) 17-20
-
(1996)
FEBS Lett
, vol.380
, Issue.1-2
, pp. 17-20
-
-
Fosang, A.J.1
Last, K.2
Knauper, V.3
Murphy, G.4
Neame, P.J.5
-
13
-
-
0028919163
-
Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro
-
Hughes C.E., Caterson B., Fosang A.J., Roughley P.J., and Mort J.S. Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro. Biochem J 305 Pt 3 (1995) 799-804
-
(1995)
Biochem J
, vol.305
, Issue.PART 3
, pp. 799-804
-
-
Hughes, C.E.1
Caterson, B.2
Fosang, A.J.3
Roughley, P.J.4
Mort, J.S.5
-
14
-
-
0000147351
-
Proteoglycans: the chondroitin sulfate/keratan sulfate proteoglycan of cartilage. ISI Atlas of Science
-
Hascall V.C. Proteoglycans: the chondroitin sulfate/keratan sulfate proteoglycan of cartilage. ISI Atlas of Science. Biochemistry 1 (1988) 189-198
-
(1988)
Biochemistry
, vol.1
, pp. 189-198
-
-
Hascall, V.C.1
-
15
-
-
0024421488
-
The keratan sulfate-enriched region of bovine cartilage proteoglycan consists of a consecutively repeated hexapeptide motif
-
Antonsson P., Heinegard D., and Oldberg A. The keratan sulfate-enriched region of bovine cartilage proteoglycan consists of a consecutively repeated hexapeptide motif. J Biol Chem 264 (1989) 16170-16173
-
(1989)
J Biol Chem
, vol.264
, pp. 16170-16173
-
-
Antonsson, P.1
Heinegard, D.2
Oldberg, A.3
-
16
-
-
0028982223
-
N- and O-linked keratan sulfate on the hyaluronan binding region of aggrecan from mature and immature bovine cartilage
-
Barry F.P., Rosenberg L.C., Gaw J.U., Koob T.J., and Neame P.J. N- and O-linked keratan sulfate on the hyaluronan binding region of aggrecan from mature and immature bovine cartilage. J Biol Chem 270 (1995) 20516-20524
-
(1995)
J Biol Chem
, vol.270
, pp. 20516-20524
-
-
Barry, F.P.1
Rosenberg, L.C.2
Gaw, J.U.3
Koob, T.J.4
Neame, P.J.5
-
17
-
-
0025976188
-
Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms
-
Doege K.J., Sasaki M., Kimura T., and Yamada Y. Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms. J Biol Chem 266 (1991) 894-902
-
(1991)
J Biol Chem
, vol.266
, pp. 894-902
-
-
Doege, K.J.1
Sasaki, M.2
Kimura, T.3
Yamada, Y.4
-
18
-
-
4344601054
-
Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by m-calpain
-
Oshita H., Sandy J.D., Suzuki K., Akaike A., Bai Y., Sasaki T., et al. Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by m-calpain. Biochem J 382 Pt 1 (2004) 253-259
-
(2004)
Biochem J
, vol.382
, Issue.PART 1
, pp. 253-259
-
-
Oshita, H.1
Sandy, J.D.2
Suzuki, K.3
Akaike, A.4
Bai, Y.5
Sasaki, T.6
-
19
-
-
0034671485
-
Age-related changes in aggrecan glycosylation affect cleavage by aggrecanase
-
Pratta M.A., Tortorella M.D., and Arner E.C. Age-related changes in aggrecan glycosylation affect cleavage by aggrecanase. J Biol Chem 275 50 (2000) 39096-39102
-
(2000)
J Biol Chem
, vol.275
, Issue.50
, pp. 39096-39102
-
-
Pratta, M.A.1
Tortorella, M.D.2
Arner, E.C.3
-
20
-
-
21244433240
-
N-linked keratan sulphate in the aggrecan interglobular domain potentiates aggrecanase activity
-
Poon C.J., Plaas A.H., Keene D.R., McQuillan D.J., Last K., and Fosang A.J. N-linked keratan sulphate in the aggrecan interglobular domain potentiates aggrecanase activity. J Biol Chem (2005)
-
(2005)
J Biol Chem
-
-
Poon, C.J.1
Plaas, A.H.2
Keene, D.R.3
McQuillan, D.J.4
Last, K.5
Fosang, A.J.6
-
21
-
-
0032211766
-
Cathepsin B: an alternative protease for the generation of an aggrecan 'metalloproteinase' cleavage neoepitope
-
Mort J.S., Magny M.C., and Lee E.R. Cathepsin B: an alternative protease for the generation of an aggrecan 'metalloproteinase' cleavage neoepitope. Biochem J 335 Pt 3 (1998) 491-494
-
(1998)
Biochem J
, vol.335
, Issue.PART 3
, pp. 491-494
-
-
Mort, J.S.1
Magny, M.C.2
Lee, E.R.3
-
22
-
-
0036247674
-
Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation
-
Little C.B., Hughes C.E., Curtis C.L., Janusz M.J., Bohne R., Wang-Weigand S., et al. Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation. Matrix Biol 21 (2002) 271-288
-
(2002)
Matrix Biol
, vol.21
, pp. 271-288
-
-
Little, C.B.1
Hughes, C.E.2
Curtis, C.L.3
Janusz, M.J.4
Bohne, R.5
Wang-Weigand, S.6
-
23
-
-
0035197754
-
Cathepsin D cleaves aggrecan at unique sites within the interglobular domain and chondroitin sulfate attachment regions that are also cleaved when cartilage is maintained at acid pH
-
Handley C.J., Mok M.T., Ilic M.Z., Adcocks C., Buttle D.J., and Robinson H.C. Cathepsin D cleaves aggrecan at unique sites within the interglobular domain and chondroitin sulfate attachment regions that are also cleaved when cartilage is maintained at acid pH. Matrix Biol 20 8 (2001) 543-553
-
(2001)
Matrix Biol
, vol.20
, Issue.8
, pp. 543-553
-
-
Handley, C.J.1
Mok, M.T.2
Ilic, M.Z.3
Adcocks, C.4
Buttle, D.J.5
Robinson, H.C.6
-
24
-
-
0036775227
-
Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4)
-
Tortorella M.D., Liu R.Q., Burn T., Newton R.C., and Arner E. Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4). Matrix Biol 21 6 (2002) 499-511
-
(2002)
Matrix Biol
, vol.21
, Issue.6
, pp. 499-511
-
-
Tortorella, M.D.1
Liu, R.Q.2
Burn, T.3
Newton, R.C.4
Arner, E.5
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