TIMP-3 inhibition of ADAMTS-4 (Aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4

Journal of Biological Chemistry

Volumn 282, Issue 29, 2007, Pages 20991-20998

  Wayne, Gareth J ^a   Deng, Su Jun ^b   Amour, Augustin ^a   Borman, Satty ^a   Matico, Rosalie ^b   Carter, H Luke ^b   Murphy, Gillian ^c  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; CARTILAGE; DISEASES; ENERGY TRANSFER; FLUORESCENCE; METABOLISM; PEPTIDES; RESONANCE;

AGGRECAN; FLUORESCENCE RESONANCE; GLYCOSAMINOGLYCANS;

ENZYMES;

AGGRECAN; AGGRECANASE; CHONDROITIN 6 SULFATE; GLYCOSAMINOGLYCAN; THROMBOSPONDIN 1; TISSUE INHIBITOR OF METALLOPROTEINASE 3;

ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME INHIBITION; FLUORESCENCE RESONANCE ENERGY TRANSFER; MODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION;

ADAM PROTEINS; AGGRECANS; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING SITES; CHONDROITIN SULFATES; ENDOPEPTIDASES; ENZYME INHIBITORS; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; PROCOLLAGEN N-ENDOPEPTIDASE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TISSUE INHIBITOR OF METALLOPROTEINASE-3;

EID: 34547125794     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M610721200     Document Type: Article

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