5-((1H-Pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 5, 2007, Pages 1189-1192

  Gilbert, Adam M ^a   Bursavich, Matthew G ^a   Lombardi, Sabrina ^a   Georgiadis, Katy E ^b   Reifenberg, Erica ^b   Flannery, Carl R ^b   Morris, Elisabeth A ^b  

^a WYETH RESEARCH   (United States)

^b PFIZER INC   (United States)

Author keywords

ADAMTS 5; Aggrecanase 2; Osteoporosis; Thioxothiazolidin 4 ones

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; AGGRECAN; AGGRECANASE; AGGREGANASE 2; PROTEIN ADAMTS 5; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; IC 50; IN VITRO STUDY; OSTEOPOROSIS; PROTEIN DEGRADATION;

ADAM PROTEINS; AGGRECANS; CARTILAGE; HUMANS; INHIBITORY CONCENTRATION 50; OSTEOPOROSIS; PROCOLLAGEN N-ENDOPEPTIDASE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINEDIONES;

EID: 33846896972     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.12.020     Document Type: Article

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