Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

Nature

Volumn 434, Issue 7033, 2005, Pages 644-648

  Glasson, Sonya S ^a   Askew, Roger ^a   Sheppard, Barbara ^a   Carito, Brenda ^a   Blanchet, Tracey ^a   Ma, Hak Ling ^a   Flannery, Carl R ^a   Peluso, Diane ^a   Kanki, Kim ^a   Yang, Zhiyong ^a   Majumdar, Manas K ^a   Morris, Elisabeth A ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; DEGRADATION; DISEASES; GENES; JOINTS (ANATOMY); TISSUE;

ARTICULAR CARTILAGE; CARTILAGE DESTRUCTION; GENE DELETION; PROGRESSIVE DISEASES;

CARTILAGE;

AGGRECANASE; AGGRECANASE 2; MESSENGER RNA; METALLOPROTEINASE; PROTEIN ADAMTS5; PROTEOGLYCAN; UNCLASSIFIED DRUG; ADAM PROTEIN; ADAMTS5 PROTEIN, MOUSE; PROTEINASE;

MEDICINE;

ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE DEGENERATION; DISEASE COURSE; FEMALE; GROWTH PLATE; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN MOTIF; WESTERN BLOTTING; ANIMAL; CHEMISTRY; DISEASE MODEL; ENZYME ACTIVE SITE; EXON; FEMUR HEAD; GENE DELETION; GENETICS; JOINT; METABOLISM; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY;

ADAM PROTEINS; ANIMALS; CARTILAGE, ARTICULAR; CATALYTIC DOMAIN; DISEASE MODELS, ANIMAL; ENDOPEPTIDASES; EXONS; FEMUR HEAD; GENE DELETION; GROWTH PLATE; JOINTS; METALLOENDOPEPTIDASES; MICE; MICE, KNOCKOUT; OSTEOARTHRITIS; PROTEOGLYCANS; RNA, MESSENGER;

EID: 15844413814     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03369     Document Type: Article

References (16)

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