TIMP-3 Is a Potent Inhibitor of Aggrecanase 1 (ADAM-TS4) and Aggrecanase 2 (ADAM-TS5)

Journal of Biological Chemistry

Volumn 276, Issue 16, 2001, Pages 12501-12504

  Kashiwagi, Masahide ^a,b   Tortorella, Micky ^b   Nagase, Hideaki ^b   Brew, Keith ^b,c  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^c FLORIDA ATLANTIC UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIOLOGY; CARTILAGE; CATALYSIS; COMPRESSION TESTING; ENZYME INHIBITION; TISSUE CULTURE;

ARTHRITIS;

BIOCHEMISTRY;

AGGRECANASE; AGGRECANASE 1; AGGRECANASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 3; UNCLASSIFIED DRUG; ADAM PROTEIN; ADAMTS5 PROTEIN, HUMAN; AGGRECANASE-1; METALLOPROTEINASE; PROCOLLAGEN N PROTEINASE; RECOMBINANT PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

AMINO TERMINAL SEQUENCE; ARTHRITIS; ARTICLE; ARTICULAR CARTILAGE; CELL INCLUSION; COMPRESSION; CONCENTRATION (PARAMETERS); DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN FUNCTION; ANIMAL; CHEMISTRY; CHO CELL; DRUG ANTAGONISM; GENE DELETION; GENETIC TRANSFECTION; HAMSTER; HUMAN; KINETICS; METABOLISM; MOLECULAR CLONING;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS PHAGE 3A;

ADAM PROTEINS; ANIMALS; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; HUMANS; KINETICS; METALLOENDOPEPTIDASES; PROCOLLAGEN N-ENDOPEPTIDASE; RECOMBINANT PROTEINS; SEQUENCE DELETION; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-3; TRANSFECTION;

EID: 0035918309     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C000848200     Document Type: Article

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