Cleavage of aggrecan at the ASN341-PHE342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: A pivotal role for stromelysin 1 in matrix metalloproteinase activity

Arthritis and Rheumatism

Volumn 42, Issue 10, 1999, Pages 2074-2084

  Van Meurs, Joyce ^a   Van Lent, Peter ^a   Stoop, Reinout ^a   Holthuysen, Astrid ^a   Singer, Irwin ^b   Bayne, Ellen ^b   Mudgett, John ^b   Poole, Robin ^c   Billinghurst, Clark ^c   Van Der Kraan, Peter ^a   Buma, Pieter ^a   Van Den Berg, Wim ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MERCK RESEARCH LABORATORIES   (United States)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; ASPARAGINE; COLLAGEN TYPE 2; EPITOPE; INTERLEUKIN 1; MATRIX METALLOPROTEINASE; PHENYLALANINE; PROCOLLAGENASE; PROTEOGLYCAN; STROMELYSIN; AGC1 PROTEIN, MOUSE; ANTIGEN; COLLAGEN; LECTIN; OLIGOPEPTIDE; PEPTIDE FRAGMENT; PEPTIDE VDIPEN; SCLEROPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTHRITIS; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE DEGENERATION; COLLAGEN DEGRADATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; KNOCKOUT MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; ANIMAL; C57BL MOUSE; CARTILAGE; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE; MOUSE MUTANT; PATHOLOGY;

AGGRECANS; ANIMALS; ANTIGENS; ARTHRITIS; CARTILAGE; COLLAGEN; EPITOPES; EXTRACELLULAR MATRIX; EXTRACELLULAR MATRIX PROTEINS; LECTINS, C-TYPE; MATRIX METALLOPROTEINASE 3; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PROTEOGLYCANS;

EID: 17044461667     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(199910)42:10<2074::AID-ANR7>3.0.CO;2-5     Document Type: Article

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