Structure-function relationships in the IL-17 receptor: Implications for signal transduction and therapy

Cytokine

Volumn 41, Issue 2, 2008, Pages 92-104

  Shen, Fang ^a   Gaffen, Sarah L ^a,b  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Act1; Interleukin 17; Receptor; Signal transduction; Synergy

Indexed keywords

INTERLEUKIN 17 RECEPTOR;

FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE CONTROL; LIGAND BINDING; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN MOTIF; RECEPTOR INTRINSIC ACTIVITY; REVIEW; SIGNAL TRANSDUCTION; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION;

ANIMALS; ANTIBODIES; ARTHRITIS, RHEUMATOID; BONE REMODELING; CCAAT-ENHANCER-BINDING PROTEINS; CYTOKINES; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; NF-KAPPA B; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, INTERLEUKIN-17; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES, HELPER-INDUCER; TRANSCRIPTION FACTORS;

EID: 38949194566     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2007.11.013     Document Type: Review

References (160)

1. Ozaki K., and Leonard W.J. Cytokine and cytokine receptor pleiotropy and redundancy. J Biol Chem 277 (2002) 29355-29358
2. Aggarwal S., and Gurney A.L. IL-17: a prototype member of an emerging family. J Leukoc Biol 71 (2002) 1-8
3. Moseley T.A., Haudenschild D.R., Rose L., and Reddi A.H. Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev 14 (2003) 155-174
4. Fossiez F., Djossou O., Chomarat P., Flores-Romo L., Ait-Yahia S., Maat C., et al. T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med 183 (1996) 2593-2603
5. He D., Wu L., Kim H.K., Li H., Elmets C.A., and Xu H. CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses. J Immunol 177 (2006) 6852-6858
6. Shibata K., Yamada H., Hara H., Kishihara K., and Yoshikai Y. Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production. J Immunol 178 (2007) 4466-4472
7. Stark M.A., Huo Y., Burcin T.L., Morris M.A., Olson T.S., and Ley K. Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity 22 (2005) 285-294
8. Aarvak T., Chabaud M., Miossec P., and Natvig J.B. IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells. J Immunol 162 (1999) 1246-1251
9. Albanesi C., Cavani A., and Girolomoni G. IL-17 is produced by nickel-specific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: Synergistic or antagonistic effects with IFN-γ and TNF-α. J Immunol 162 (1999) 494-502
10. Aggarwal S., Ghilardi N., Xie M.H., De Sauvage F.J., and Gurney A.L. Interleukin 23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin 17. J Biol Chem 3 (2002) 1910-1914
11. Happel K.I., Zheng M., Young E., Quinton L.J., Lockhart E., Ramsay A.J., et al. Cutting edge: roles of toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection. J Immunol 170 (2003) 4432-4436
12. Murphy C.A., Langrish C.L., Chen Y., Blumenschein W., McClanahan T., Kastelein R.A., et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med 198 (2003) 1951-1957
13. Cua D.J., Sherlock J., Chen Y., Murphy C.A., Joyce B., Seymour B., et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421 (2003) 744-748
14. Trinchieri G., Pflanz S., and Kastelein R.A. The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity 19 (2003) 641-644
15. Langrish C.L., Chen Y., Blumenschein W.M., Mattson J., Basham B., Sedgwick J.D., et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 201 (2005) 233-240
16. Langrish C.L., McKenzie B.S., Wilson N.J., de Waal Malefyt R., Kastelein R.A., and Cua D.J. IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol Rev 202 (2004) 96-105
17. Dong C. Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells. Nat Rev Immunol 6 (2006) 329-333
18. Cua D.J., and Kastelein R.A. TGF-beta, a 'double agent' in the immune pathology war. Nat Immunol 7 (2006) 557-559
19. Weaver C.T., Hatton R.D., Mangan P.R., and Harrington L.E. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 25 (2007) 821-852
20. Weaver C.T., and Murphy K.M. T-cell subsets: the more the merrier. Curr Biol 17 (2007) R61-R63
21. Sutton C., Brereton C., Keogh B., Mills K.H., and Lavelle E.C. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med 203 (2006) 1685-1691
22. Nurieva R., Yang X.O., Martinez G., Zhang Y., Panopoulos A.D., Ma L., et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448 (2007) 480-483
23. Korn T., Bettelli E., Gao W., Awasthi A., Jager A., Strom T.B., et al. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 448 (2007) 484-487
24. Zhou L., Ivanov I.I., Spolski R., Min R., Shenderov K., Egawa T., et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol (2007)
25. Liang S.C., Tan X.Y., Luxenberg D.P., Karim R., Dunussi-Joannopoulos K., Collins M., et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 203 (2006) 2271-2279
26. Chung Y., Yang X., Chang S.H., Ma L., Tian Q., and Dong C. Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes. Cell Res 16 (2006) 902-907
27. Stockinger B., and Veldhoen M. Differentiation and function of Th17 T cells. Curr Opin Immunol 19 (2007) 281-286
28. Gaffen S.L. Interleukin-17: a unique inflammatory cytokine with roles in bone biology and arthritis. Arthritis Res Ther 6 (2004) 240-247
29. Weaver C.T., Harrington L.E., Mangan P.R., Gavrieli M., and Murphy K.M. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 24 (2006) 677-688
30. Kolls J.K., and Linden A. Interleukin-17 family members and inflammation. Immunity 21 (2004) 467-476
31. Rouvier E., Luciani M.-F., Mattei M.-G., Denizot F., and Golstein P. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a Herpesvirus Saimiri gene. J Immunol 150 (1993) 5445-5456
32. Starnes T., Robertson M.J., Sledge G., Kelich S., Nakshatri H., Broxmeyer H.E., et al. Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. J Immunol 167 (2001) 4137-4140
33. Hymowitz S.G., Filvaroff E.H., Yin J.P., Lee J., Cai L., Risser P., et al. IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMBO J 20 (2001) 5332-5341
34. Wright J.F., Guo Y., Quazi A., Luxenberg D.P., Bennett F., Ross J.F., et al. Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells. J Biol Chem 282 (2007) 13447-13455
35. Chang S.H., and Dong C. A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses. Cell Res 17 (2007) 435-440
36. Harrington L.E., Hatton R.D., Mangan P.R., Turner H., Murphy T.L., Murphy K.M., et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6 (2005) 1123-1132
37. Wang Y.H., Angkasekwinai P., Lu N., Voo K.S., Arima K., Hanabuchi S., et al. IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. J Exp Med 204 (2007) 1837-1847
38. Kleinschek M.A., Owyang A.M., Joyce-Shaikh B., Langrish C.L., Chen Y., Gorman D.M., et al. IL-25 regulates Th17 function in autoimmune inflammation. J Exp Med 204 (2007) 161-170
39. Sharkhuu T., Matthaei K.I., Forbes E., Mahalingam S., Hogan S.P., Hansbro P.M., et al. Mechanism of interleukin-25 (IL-17E)-induced pulmonary inflammation and airways hyper-reactivity. Clin Exp Allergy 36 (2006) 1575-1583
40. Angkasekwinai P., Park H., Wang Y.H., Wang Y.H., Chang S.H., Corry D.B., et al. Interleukin 25 promotes the initiation of proallergic type 2 responses. J Exp Med 204 (2007) 1509-1517
41. Ballantyne S.J., Barlow J.L., Jolin H.E., Nath P., Williams A.S., Chung K.F., et al. Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma. J Allergy Clin Immunol (2007)
42. Hurst S.D., Muchamuel T., Gorman D.M., Gilbert J.M., Clifford T., Kwan S., et al. New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25. J Immunol 169 (2002) 443-453
43. Fort M.M., Cheung J., Yen D., Li J., Zurawski S.M., Lo S., et al. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity 15 (2001) 985-995
44. Gaffen S.L., Kramer J.M., Yu J.J., and Shen F. The IL-17 cytokine family. In: Litwack G. (Ed). Vitamins and hormones (2006), Academic Press, London 255-282
45. Feldmann M., and Steinman L. Design of effective immunotherapy for human autoimmunity. Nature 435 (2005) 612-619
46. Filler S.G., Yeaman M.R., and Sheppard D.C. Tumor necrosis factor inhibition and invasive fungal infections. Clin Infect Dis 41 Suppl 3 (2005) S208-S212
47. Kikly K., Liu L., Na S., and Sedgwick J.D. The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation. Curr Opin Immunol 18 (2006) 670-675
48. Yao Z., Fanslow W.C., Seldin M.F., Rousseau A.-M., Painter S.L., Comeau M.R., et al. Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 3 (1995) 811-821
49. Yao Z., Spriggs M.K., Derry J.M.J., Strockbine L., Park L.S., VandenBos T., et al. Molecular characterization of the human interleukin-17 receptor. Cytokine 9 (1997) 794-800
50. Toy D., Kugler D., Wolfson M., Vanden Bos T., Gurgel J., Derry J., et al. Cutting edge: interleukin-17 signals through a heteromeric receptor complex. J Immunol 177 (2006) 36-39
51. Haudenschild D., Moseley T., Rose L., and Reddi A.H. Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer. J Biol Chem 277 (2002) 4309-4316
52. Haudenschild D.R., Curtiss S.B., Moseley T.A., and Reddi A.H. Generation of interleukin-17 receptor-like protein (IL-17RL) in prostate by alternative splicing of RNA. Prostate 66 (2006) 1268-1274
53. Kuestner R., Taft D., Haran A., Brandt C., Brender T., Lum K., et al. Identification of the IL-17 receptor related molecule, IL-17RC, as the receptor for IL-17F. J Immunol 179 (2007) 5462-5473
54. Latz E., Verma A., Visintin A., Gong M., Sirois C.M., Klein D.C., et al. Ligand-induced conformational changes allosterically activate Toll-like receptor 9. Nat Immunol 8 (2007) 772-779
55. Livnah O., Stura E.A., Middleton S.A., Johnson D.L., Jolliffe L.K., and Wilson I.A. Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. Science 283 (1999) 987-990
56. Krause C., Mei E., Xie J., Bopp M., Hochstrasser R., and Pestka S. Seeing the light: preassembly and ligand-induced changes of the interferon gamma receptor complex in cells. Mol Cell Proteomics 1 (2002) 805-815
57. Chan F.K. Three is better than one: pre-ligand receptor assembly in the regulation of TNF receptor signaling. Cytokine 37 (2007) 101-107
58. Chan F.K., Chun H.J., Zheng L., Siegel R.M., Bui K.L., and Lenardo M.J. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science 288 (2000) 2351-2354
59. Chan F.K.-M. The pre-ligand binding assembly domain: a potential target of inhibition of tumour necrosis factor receptor function. Ann Rheum Dis 59 Suppl I (2000) i50-i53
60. Siegel R.M., Frederiksen J.K., Zacharias D.A., Chan F.K., Johnson M., Lynch D., et al. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science 288 (2000) 2354-2357
61. Sedger L.M., Osvath S.R., Xu X.M., Li G., Chan F.K., Barrett J.W., et al. Poxvirus tumor necrosis factor receptor (TNFR)-like T2 proteins contain a conserved preligand assembly domain that inhibits cellular TNFR1-induced cell death. J Virol 80 (2006) 9300-9309
62. Deng G.M., Zheng L., Chan F.K., and Lenardo M. Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors. Nat Med 11 (2005) 1066-1072
63. Kramer J., Yi L., Shen F., Maitra A., Jiao X., Jin T., et al. Cutting edge: evidence for ligand-independent multimerization of the IL-17 receptor. J Immunol 176 (2006) 711-715
64. Remy I., Wilson I.A., and Michnick S.W. Erythropietin receptor activation by a ligand-induced conformation change. Science 283 (1999) 990-993
65. Neiditch M.B., Federle M.J., Pompeani A.J., Kelly R.C., Swem D.L., Jeffrey P.D., et al. Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing. Cell 126 (2006) 1095-1108
66. Novatchkova M., Leibbrandt A., Werzowa J., Neubuser A., and Eisenhaber F. The STIR-domain superfamily in signal transduction, development and immunity. Trends Biochem Sci 28 (2003) 226-229
67. Murphy J.M., and Young I.G. IL-3, IL-5, and GM-CSF signaling: crystal structure of the human beta-common receptor. Vitam Horm 74 (2006) 1-30
68. Kramer J., Hanel W., Shen F., Isik N., Malone J., Maitra A., Sigurdson W., Swart D., Tocker J., Jin T., and Gaffen S.L. Cutting edge: identification of the pre-ligand assembly domain (PLAD) and ligand binding site in the IL-17 receptor. J Immunol 179 (2007) 6379-6383
69. Yao Z., Painter S.L., Fanslow W.C., Ulrich D., Macduff B.M., Spriggs M.K., et al. Cutting edge: human IL-17: A novel cytokine derived from T cells. J Immunol 155 (1995) 5483-5486
70. Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., and Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 (2006) 179-189
71. Shimada M., Andoh A., Hata K., Tasaki K., Araki Y., Fujiyama Y., et al. IL-6 secretion by human pancreatic periacinar myofibroblasts in response to inflammatory mediators. J Immunol 168 (2002) 861-868
72. Ruddy M.J., Wong G.C., Liu X.K., Yamamoto H., Kasayama S., Kirkwood K.L., et al. Functional cooperation between interleukin-17 and tumor necrosis factor-α is mediated by CCAAT/enhancer binding protein family members. J Biol Chem 279 (2004) 2559-2567
73. Chabaud M., Fossiez F., Taupin J.L., and Miossec P. Enhancing effect of IL-17 on IL-1-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines. J Immunol 161 (1998) 409-414
74. Teunissen M.B., Koomen C.W., de Waal Malefyt R., Wierenga E.A., and Bos J.D. Interleukin-17 and interferon-γ synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. J Invest Dermatol 111 (1998) 645-649
75. Lindsten T., June C.H., Ledbetter J.A., Stella G., and Thompson C.B. Regulation of lymphokine messenger RNA stability by a surface-mediated T-cell activation pathway. Science 244 (1989) 339-343
76. Hata K., Andoh A., Shimada M., Fujino S., Bamba S., Araki Y., et al. IL-17 stimulates inflammatory responses via NF-kappaB and MAP kinase pathways in human colonic myofibroblasts. Am J Physiol Gastrointest Liver Physiol 282 (2002) G1035-G1044
77. Henness S., Johnson C.K., Ge Q., Armour C.L., Hughes J.M., and Ammit A.J. IL-17A augments TNF-alpha-induced IL-6 expression in airway smooth muscle by enhancing mRNA stability. J Allergy Clin Immunol 114 (2004) 958-964
78. Tokuda H., Kanno Y., Ishisaki A., Takenaka M., Harada A., and Kozawa O. Interleukin (IL)-17 enhances tumor necrosis factor-alpha-stimulated IL-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts. J Cell Biochem 91 (2004) 1053-1061
79. Cai X.Y., Gommoll Jr. C.P., Justice L., Narula S.K., and Fine J.S. Regulation of granulocyte colony-stimulating factor gene expression by interleukin-17. Immunol Lett 62 (1998) 51-58
80. Andoh A., Yasui H., Inatomi O., Zhang Z., Deguchi Y., Hata K., et al. Interleukin-17 augments tumor necrosis factor-alpha-induced granulocyte and granulocyte/macrophage colony-stimulating factor release from human colonic myofibroblasts. J Gastroenterol 40 (2005) 802-810
81. Witowski J., Pawlaczyk K., Breborowicz A., Scheuren A., Kuzlan-Pawlaczyk M., Wisniewska J., et al. IL-17 stimulates intraperitoneal neutrophil infiltration through the release of GRO alpha chemokine from mesothelial cells. J Immunol 165 (2000) 5814-5821
82. Ruddy M.J., Shen F., Smith J., Sharma A., and Gaffen S.L. Interleukin-17 regulates expression of the CXC chemokine LIX/CXCL5 in osteoblasts: implications for inflammation and neutrophil recruitment. J Leukoc Biol 76 (2004) 135-144
83. Shen F., Hu Z., Goswami J., and Gaffen S.L. Identification of common transcriptional regulatory elements in interleukin-17 target genes. J Biol Chem 281 (2006) 24138-24148
84. Yamazaki S., Muta T., Matsuo S., and Takeshige K. Stimulus-specific induction of a novel nuclear factor-kappaB regulator, IkappaB-zeta, via Toll/Interleukin-1 receptor is mediated by mRNA stabilization. J Biol Chem 280 (2005) 1678-1687
85. Faour W.H., Mancini A., He Q.W., and Di Battista J.A. T-cell-derived interleukin-17 regulates the level and stability of cyclooxygenase-2 (COX-2) mRNA through restricted activation of the p38 mitogen-activated protein kinase cascade: role of distal sequences in the 3′-untranslated region of COX-2 mRNA. J Biol Chem 278 (2003) 26897-26907
86. LeGrand A., Fermor B., Fink C., Pisetsky D.S., Weinberg J.B., Vail T.P., et al. Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci. Arthritis Rheum 44 (2001) 2078-2083
87. Andoh A., Hata K., Araki Y., Fujiyama Y., and Bamba T. Interleukin (IL)-4 and IL-17 synergistically stimulate IL-6 secretion in human colonic myofibroblasts. Int J Mol Med 10 (2002) 631-634
88. Jones C.E., and Chan K. Interleukin-17 stimulates the expression of interleukin-8, growth-related oncogene-alpha, and granulocyte-colony-stimulating factor by human airway epithelial cells. Am J Respir Cell Mol Biol 26 (2002) 748-753
89. Dragon S., Rahman M.S., Yang J., Unruh H., Halayko A.J., and Gounni A.S. IL-17 enhances IL-1beta-mediated CXCL-8 release from human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 292 (2007) L1023-L1029
90. Khader S.A., Bell G.K., Pearl J.E., Fountain J.J., Rangel-Moreno J., Cilley G.E., et al. IL-23 and IL-17 in the establishment of protective pulmonary CD4(+) T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol 8 (2007) 369-377
91. Linden A., Laan M., and Anderson G. Neutrophils, interleukin-17A and lung disease. Eur Respir J 25 (2005) 159-172
92. Laan M., Cui A.-H., Hoshino H., Lötvall J., Sjöstrand M., Gruenert D.C., et al. Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J Immunol 162 (1999) 2347-2352
93. Van Kooten C., Boonstra J.G., Paape M.E., Fossiez F., Banchereau J., Lebecque S., et al. Interleukin-17 activates human renal epithelial cells in vitro and is expressed during renal allograft rejection. J Am Soc Nephrol 9 (1998) 1526-1534
94. Takaya H., Andoh A., Makino J., Shimada M., Tasaki K., Araki Y., et al. Interleukin-17 stimulates chemokine (interleukin-8 and monocyte chemoattractant protein-1) secretion in human pancreatic periacinar myofibroblasts. Scand J Gastroenterol 37 (2002) 239-245
95. Rahman M.S., Yamasaki A., Yang J., Shan L., Halayko A.J., and Gounni A.S. IL-17A induces eotaxin-1/CC chemokine ligand 11 expression in human airway smooth muscle cells: role of MAPK (Erk1/2, JNK, and p38) pathways. J Immunol 177 (2006) 4064-4071
96. Kao C.-Y., Huang F., Chen Y., Thai P., Wachi S., Kim C., et al. Up-regulation of CC chemokine ligand 20 expression in human airway epithelium by IL-17 through a JAK-independent but MEK-NF-kappaB-dependent signaling pathway. J Immunol 175 (2005) 6676-6685
97. Schwandner R., Yamaguchi K., and Cao Z. Requirement of tumor necrosis factor-associated factor (TRAF)6 in interleukin 17 signal transduction. J Exp Med 191 (2000) 1233-1239
98. Shalom-Barak T., Quach J., and Lotz M. Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB. J Biol Chem 273 (1998) 27467-27473
99. Li X., Afif H., Cheng S., Martel-Pelletier J., Pelletier J.P., Ranger P., et al. Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes. J Rheumatol 32 (2005) 887-895
100. Trajkovic V., Stosic-Grujicic S., Samardzic T., Markovic M., Miljkovic D., Ramic Z., et al. Interleukin-17 stimulates inducible nitric oxide synthase activation in rodent astrocytes. J Neuroimmunol 119 (2001) 183-191
101. Miljkovic D., and Trajkovic V. Inducible nitric oxide synthase activation by interleukin-17. Cytokine Growth Factor Rev 15 (2004) 21-32
102. Flo T.H., Smith K.D., Sato S., Rodriguez D.J., Holmes M.A., Strong R.K., et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 432 (2004) 917-921
103. Shen F., Ruddy M.J., Plamondon P., and Gaffen S.L. Cytokines link osteoblasts and inflammation: microarray analysis of interleukin-17- and TNF-alpha-induced genes in bone cells. J Leukoc Biol 77 (2005) 388-399
104. Kao C.Y., Chen Y., Thai P., Wachi S., Huang F., Kim C., et al. IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J Immunol 173 (2004) 3482-3491
105. Chen Y., Thai P., Zua Y.-H., Ho Y.-S., DeSouza M., and Wu R. Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. J Biol Chem 278 (2003) 17036-17043
106. Lubberts E., Koenders M.I., and van den Berg W.B. The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models. Arthritis Res Ther 7 (2005) 29-37
107. Theill L., Boyle W., and Penninger J. RANK-L and RANK: T cells, bone loss and mammalian evolution. Annu Rev Immunol 20 (2002) 795-823
108. Taubman M.A., Valverde P., Han X., and Kawai T. Immune response: the key to bone resorption in periodontal disease. J Periodontol 76 (2005) 2033-2041
109. Kotake S., Udagawa N., Takahashi N., Matsuzaki K., Itoh K., Ishiyama S., et al. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 103 (1999) 1345-1352
110. Nakashima T., Kobayashi Y., Yamasaki S., Kawakami A., Eguchi K., Sasaki H., et al. Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotropic factors and cytokines. Biochem Biophys Res Commun 275 (2000) 768-775
111. Lubberts E., Koenders M.I., Oppers-Walgreen B., van den Bersselaar L., Coenen-de Roo C.J., Joosten L.A., et al. Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis Rheum 50 (2004) 650-659
112. Lubberts E., van den Bersselaar L., Oppers-Walgreen B., Schwarzenberger P., Coenen-de Roo C.J., Kolls J.K., et al. IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance. J Immunol 170 (2003) 2655-2662
113. Sato K., Suematsu A., Okamoto K., Yamaguchi A., Morishita Y., Kadono Y., et al. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med (2006)
114. Rannou F., Francois M., Corvol M.T., and Berenbaum F. Cartilage breakdown in rheumatoid arthritis. Joint Bone Spine 73 (2006) 29-36
115. Chabaud M., Garnero P., Dayer J.M., Guerne P.A., Fossiez F., and Miossec P. Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis. Cytokine 12 (2000) 1092-1099
116. Koenders M.I., Kolls J.K., Oppers-Walgreen B., van den Bersselaar L., Joosten L.A., Schurr J.R., et al. Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis. Arthritis Rheum 52 (2005) 3239-3247
117. Koshy P.J., Henderson N., Logan C., Life P.F., Cawston T.E., and Rowan A.D. Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines. Ann Rheum Dis 61 (2002) 704-713
118. Bamba S., Andoh A., Yasui H., Araki Y., Bamba T., and Fujiyama Y. Matrix metalloproteinase-3 secretion from human colonic subepithelial myofibroblasts: role of interleukin-17. J Gastroenterol 38 (2003) 548-554
119. Rifas L., and Arackal S. T cells regulate the expression of matrix metalloproteinase in human osteoblasts via a dual mitogen-activated protein kinase mechanism. Arthritis Rheum 48 (2003) 993-1001
120. Sylvester J., Liacini A., Li W.Q., and Zafarullah M. Interleukin-17 signal transduction pathways implicated in inducing matrix metalloproteinase-3, -13 and aggrecanase-1 genes in articular chondrocytes. Cell Signal 16 (2004) 469-476
121. Jovanovic D.V., Martel-Pelletier J., Di Battista J.A., Mineau F., Jolicoeur F.-C., Benderdour M., et al. Stimulation of 92-kD gelatinase (matrix metalloproteinase 9) production by interleukin-17 in human monocyte/macrophages. Arthritis Rheum 43 (2000) 1134-1144
122. Inatomi O., Andoh A., Yagi Y., Ogawa A., Hata K., Shiomi H., et al. Matrix metalloproteinase-3 secretion from human pancreatic periacinar myofibroblasts in response to inflammatory mediators. Pancreas 34 (2007) 126-132
123. Park H., Li Z., Yang X.O., Chang S.H., Nurieva R., Wang Y.H., et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6 (2005) 1133-1141
124. Jovanovic D.V., Di Battista J.A., Martel-Pelletier J., Reboul P., He Y., Jolicoeur F.C., et al. Modulation of TIMP-1 synthesis by antiinflammatory cytokines and prostaglandin E2 in interleukin 17 stimulated human monocytes/macrophages. J Rheumatol 28 (2001) 712-718
125. Lin X., and Wang D. The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling. Semin Immunol 16 (2004) 429-435
126. Awane M., Andres P.G., Li D.J., and Reinecker H.C. NF-kappa B-inducing kinase is a common mediator of IL-17-, TNF-alpha-, and IL-1 beta-induced chemokine promoter activation in intestinal epithelial cells. J Immunol 162 (1999) 5337-5344
127. Yamamoto M., Yamazaki S., Uematsu S., Sato S., Hemmi H., Hoshino K., et al. Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. Nature 430 (2004) 218-222
128. Hwang S.Y., Kim J.Y., Kim K.W., Park M.K., Moon Y., Kim W.U., et al. IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kappaB- and PI3-kinase/Akt-dependent pathways. Arthritis Res Ther 6 (2004) R120-R128
129. Yang T., and Chow C.-W. Transcription cooperation by NFAT-C/EBP composite enhancer complex. J Biol Chem 278 (2003) 15874-15885
130. Ramji D.P., and Foka P. CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem J 365 (2002) 561-575
131. Chang S.H., Park H., and Dong C. Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor. J Biol Chem 281 (2006) 35603-35607
132. Tang Q.Q., Gronborg M., Huang H., Kim J.W., Otto T.C., Pandey A., et al. Sequential phosphorylation of CCAAT enhancer-binding protein beta by MAPK and glycogen synthase kinase 3beta is required for adipogenesis. Proc Natl Acad Sci USA 102 (2005) 9766-9771
133. Kalvakonalu D., and Roy S. CCAAT/enhancer binding proteins and interferon signaling pathways. J Interferon Cytokine Res 25 (2005) 757-769
134. Yamada T., Tsuchiya T., Osada S., Nishihara T., and Imagawa M. CCAAT/enhancer-binding protein δ gene expression is mediated by autoregulation through downstream binding sites. Biochem Biophys Res Commun 242 (1998) 88-92
135. Maitra A., Shen F., Hanel W., Mossman K., Tocker J., Swart D., et al. Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression. Proc Natl Acad Sci USA 104 (2007) 7506-7511
136. Andoh A., Takaya H., Makino J., Sato H., Bamba S., Araki Y., et al. Cooperation of interleukin-17 and interferon-gamma on chemokine secretion in human fetal intestinal epithelial cells. Clin Exp Immunol 125 (2001) 56-63
137. Benderdour M., Tardif G., Pelletier J.P., Di Battista J.A., Reboul P., Ranger P., et al. Interleukin 17 (IL-17) induces collagenase-3 production in human osteoarthritic chondrocytes via AP-1 dependent activation: differential activation of AP-1 members by IL-17 and IL-1beta. J Rheumatol 29 (2002) 1262-1272
138. Granet C., and Miossec P. Combination of the pro-inflammatory cytokines IL-1, TNF-alpha and IL-17 leads to enhanced expression and additional recruitment of AP-1 family members, Egr-1 and NF-kappaB in osteoblast-like cells. Cytokine 26 (2004) 169-177
139. Granet C., Maslinski W., and Miossec P. Increased AP-1 and NF-kappaB activation and recruitment with the combination of the proinflammatory cytokines IL-1beta, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocytes. Arthritis Res Ther 6 (2004) R190-R198
140. de Haij S., Bakker A.C., van der Geest R.N., Haegeman G., Vanden Berghe W., Aarbiou J., et al. NF-kappaB mediated IL-6 production by renal epithelial cells is regulated by c-jun NH2-terminal kinase. J Am Soc Nephrol 16 (2005) 1603-1611
141. Subramaniam S.V., Cooper R.S., and Adunyah S.E. Evidence for the involvement of JAK/STAT pathway in the signaling mechanism of interleukin-17. Biochem Biophys Res Commun 262 (1999) 14-19
142. Samardzic T., Jankovic V., Stosic-Grujicic S., and Trajkovic V. STAT1 is required for iNOS activation, but not IL-6 production in murine fibroblasts. Cytokine 13 (2001) 179-182
143. Miggin S., and O'Neill L. New insights into the regulation of TLR signaling. J Leukoc Biol 80 (2006) 220-226
144. Pullen S.S., Dang T.T., Crute J.J., and Kehry M.R. CD40 signaling through tumor necrosis factor receptor-associated factors (TRAFs). Binding site specificity and activation of downstream pathways by distinct TRAFs. J Biol Chem 274 (1999) 14246-14254
145. Rong Z., Cheng L., Ren Y., Li Z., Li Y., Li X., et al. Interleukin-17F signaling requires ubiquitination of interleukin-17 receptor via TRAF6. Cell Signal 19 (2007) 1514-1520
146. Li X., Commane M., Nie H., Hua X., Chatterjee-Kishore M., Wald D., et al. Act1, an NF-kappa B-activating protein. Proc Natl Acad Sci USA 97 (2000) 10489-10493
147. Leonardi A., Chariot A., Claudio E., Cunningham K., and Siebenlist U. CIKS, a connection to Ikappa B kinase and stress-activated protein kinase. Proc Natl Acad Sci USA 97 (2000) 10494-10499
148. Qian Y., Qin J., Cui G., Naramura M., Snow E.C., Ware C.F., et al. Act1, a negative regulator in CD40- and BAFF-mediated B cell survival. Immunity 21 (2004) 575-587
149. Qian Y., Liu C., Hartupee J., Altuntas C.Z., Gulen M.F., Jane-Wit D., et al. The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease. Nat Immunol 8 (2007) 247-256
150. Linden A. A role for the cytoplasmic adaptor proteins Act1 in mediating IL-17 signaling. Sci STKE re4 (2007) 1-8
151. Xu Y., Tao X., Shen B., Horng T., Medzhitov R., Manley J., et al. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 408 (2000) 111-115
152. Rock F., Hardiman G., Timans J., Kastelein R., and Bazan J. A family of human receptors structurally related to Drosophila Toll. Proc Natl Acad Sci USA 95 (1998) 588-593
153. Toshchakov V., and Vogel S. Cell-penetrating TIR BB loop decoy peptides: a novel class of TLR signaling inhibitors and a tool to study topology of TIR-TIR interactions. Expert Opin. Biol. Ther. 7 (2007) 1035-1050
154. Toshchakov V.Y., Fenton M.J., and Vogel S.N. Cutting edge: differential inhibition of TLR signaling pathways by cell-permeable peptides representing BB loops of TLRs. J Immunol 178 (2007) 2655-2660
155. Poltorak A., He X., Smirnova I., Liu M.Y., Van Huffel C., Du X., et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282 (1998) 2085-2088
156. Tsang M., Friesel R., Kudoh T., and Dawid I. Identification of Sef, a novel modulator of FGF signalling. Nature Cell Biol 4 (2002) 165-169
157. Numasaki M., Watanabe M., Suzuki T., Takahashi H., Nakamura A., McAllister F., et al. IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J Immunol 175 (2005) 6177-6189
158. Woltman A.M., de Haij S., Boonstra J.G., Gobin S.J., Daha M.R., and van Kooten C. Interleukin-17 and CD40-ligand synergistically enhance cytokine and chemokine production by renal epithelial cells. J Am Soc Nephrol 11 (2000) 2044-2055
159. Kim K.W., Cho M.L., Kim H.R., Ju J.H., Park M.K., Oh H.J., et al. Up-regulation of stromal cell-derived factor 1 (CXCL12) production in rheumatoid synovial fibroblasts through interactions with T lymphocytes: role of interleukin-17 and CD40L-CD40 interaction. Arthritis Rheum 56 (2007) 1076-1086
160. Laan M., Prause O., Miyamoto M., Sjostrand M., Hytonen A.M., Kaneko T., et al. A role of GM-CSF in the accumulation of neutrophils in the airways caused by IL-17 and TNF-alpha. Eur Respir J 21 (2003) 387-393