Interleukin (IL)-17 enhances tumor necrosis factor-α-stimulated IL-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts

Journal of Cellular Biochemistry

Volumn 91, Issue 5, 2004, Pages 1053-1061

  Tokuda, Haruhiko ^a,b   Kanno, Yosuke ^b,c   Ishisaki, Akira ^b   Takenaka, Motoki ^b   Harada, Atsushi ^a   Kozawa, Osamu ^b  

^a CHUBU NATIONAL HOSPITAL   (Japan)

^b GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

IL 17; IL 6; Osteoblast; p38 MAP kinase; TNF

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 NITROPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANISOMYCIN; INTERLEUKIN 17; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; TUMOR NECROSIS FACTOR ALPHA; DRUG DERIVATIVE; IMIDAZOLE DERIVATIVE; LYSOPHOSPHOLIPID; PYRIDINE DERIVATIVE; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1-PHOSPHATE;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; DRUG ACTIVITY; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PROTEOMICS; ANIMAL; CELL LINE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PHOSPHORYLATION;

ANIMALIA;

ANIMALS; ANISOMYCIN; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; IMIDAZOLES; INTERLEUKIN-17; INTERLEUKIN-6; LYSOPHOSPHOLIPIDS; MICE; OSTEOBLASTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRIDINES; SPHINGOSINE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 8544251170     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.20004     Document Type: Article

References (35)

1. Akira S, Hirano T, Taga T, Kishimoto T. 1990. Biology of multifunctional cytokines: IL-6 and related molecules (IL-1 and TNF). FASEB J 4:2860-2867.
2. Bezooijen RLV, Farih-Sips HCM, Papapoulos SE, Lowik CWGM. 1999. Interleukin-17: A new bone acting cytokine in vitro. J Bone Miner Res 14:1513-1521.
3. Cuenda A, Rouse J, Doza YN, Meier R, Cohen P, Gallagher TF, Young PR, Lee JC. 1995. SB203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEES Lett 364:229-233.
4. Feldmann M, Brennan FM, Maini RN. 1996. Rheumatoid arthritis. Cell 85:307-310.
5. Flescher E, Garrett IR, Mundy GR, Talal N. 1990. Induction of bone resorbing activity by normal and rheumatoid arthritis T cells. CHn Immunol Immunopathol 56:210-218.
6. Fussiez FD, Djossou O, Chomarat P, Flores-Romo L, Ait-Yahia S, Maat C, Pin J-J, Garrone P, Garcia E, Sealand S, Blanchard D, Gaillard C, Mahapatra BD, Rouvier E, Golstein P, Banchereau J, Lebecque S. 1996. T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med 183:2593-2603.
7. Gowen M. 1991. Cytokines regulate bone cell function. Rheumatol Rev 1:43-50.
8. Helle M, Brakenhoff JPJ, DeGroot ER, Aarden LA. 1988. Interleukin-6 is involved in interleukin-1-induced activities. Eur J Immunol 18:957-959.
9. Ishimi Y, Miyaura C, Jin CH, Akatsu T, Abe E, Nakamura Y, Yamaguchi Y, Yoshiki S, Matsuda T, Hirano T, Kishimoto T, Suda T. 1990. IL-6 is produced by osteoblasts and induces bone resorption. J Immunol 145:3297-3303.
10. Komine M, Kukita A, Kukita T, Ogata Y, Hotokebuchi T, Kohashi O. 2001. Tumor necrosis factor-α cooperates with receptor activator of nuclear factor kB ligand in generation of osteoclasts in stromal cell-depleted rat bone marrow cell culture. Bone 28:474-483.
11. Kotake S, Udagawa N, Takahashi N, Matsuzaki K, Itoh K, Ishiyama S, Saito S, Inoue K, Kamatani N, Gillespie MT, Martin TJ, Suda T. 1999. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 103:1345-1352.
12. Kozawa O, Suzuki A, Kaida T, Tokuda H, Uematsu T. 1997a. Tumor necrosis factor-α autoregulates interleukin-6 synthesis via activation of protein kinase C: Function of sphingosine 1-phosphate and phosphatidylcholine-specific phospholipase C. J Biol Chem 272:25099-25104.
13. 2α stimulates interleukin-6 synthesis via activation of PKC in osteoblast-like cells. Am J Physiol 272:E208-E211.
14. Kozawa O, Tokuda H, Matsuno H, Uematsu T. 1997c. Activation of mitogen-activated protein kinase is involved in sphingosine 1-phosphate- stimulated interleukin-6 synthesis in osteoblasts. FEBS Lett 418:149-151.
15. Kummar JL, Rao PK, Heidenreich KA. 1997. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. J Biol Chem 282:20490-20494.
16. Laan M, Lotvall J, Chung KF, Linden A. 2001. IL-17-induced cytokine release in human bronchial epithelial cells in vitro: Role of mitogen-activated protein (MAP) kinases. Br J Pharmacol 133:200-206.
17. Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage. Nature 227:680-685.
18. Littlewood AJ, Russil J, Harvey GR, Hughes DE, Russel RGG, Gowen M. 1991. The modulation of the expression of IL-6 and its receptor in human osteoblasts in vitro. Endocrinology 129:1513-1520.
19. Lubberts E, van den Bersselaar L, Oppers-Walgreen B, Schwarzenberger P, Coenen-de Roo CJJ, Kolls JK, Joosten LAB, van den Berg WM. 2003. IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kB ligand/osteoprotegerin balance. J Immunol 170:2655-2662.
20. Mahadevan LC, Edwards DR. 1991. Signalling and super-induction. Nature 28:747-748.
21. Manolagas SC. 1995. Role of cytokines in bone resorption. Bone 17:63S-67S.
22. Martel-Pelletier J, Mineau F, Jovanovic D, Di Battista JA, Pelletier JP. 1999. Mitogen-activated protein kinase and nuclear factor kappaB together regulate interleukin-17-induced nitric oxide production in human osteoarthritic chondrocytes: Possible role of transactivating factor mitogen-activated protein kinase-activated proten kinase (MAPKAPK). Arth Rheum 42:2399-2409.
23. Miwa M, Kozawa O, Tokuda H, Uematsu T. 1999. Mitogen-activated protein (MAP) kinases are involved in interleukin-1 (IL-1)-induced IL-6 synthesis in osteoblasts: Modulation not of p38 MAP kinase, but of p42/p44 MAP kinase by IL-1-activated protein kinase C. Endocrinology 140:5120-5125.
24. Mundy GR. 1993. Role of cytokines in bone resorption. J Cell Biochem 53:296-300.
25. Nijweide PJ, Burger EH, Feyen JHM. 1986. Cells of bone: Proliferation, differentiation, and hormonal regulation. Physiol Rev 86:855-886.
26. 3 or parathyroid hormone. J Biol Chem 274:19301-19308.
27. Raingeaud J, Gupta S, Rogers JS, Dickens M, Han J, Ulevitch RJ, David RJ. 1995. Proinflammatory cytokines and enviromental stress cause p38 MAP kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem 270:7420-7426.
28. Roodman GD. 1992. Interleukin-6: An osteotropic factor? J Bone Miner Res 7:475-478.
29. Shalom-Barak T, Quach J, Lotz M. 1998. Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-κB. J Biol Chem 273:27467-27473.
30. Snick JV. 1990. Interleukin-6; an overview. Annual Review of Immunology 8:253-297.
31. Spriggs MK. 1997. Interleukin-17 and its receptor. J Clin Immunol 17:366-369.
32. Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ. 1999. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 20:345-357.
33. Sudo H, Kodama H, Amagai Y, Yamamoto S, Kasai S. 1983. In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. J Cell Biol 96:191-198.
34. Widmann C, Gibson S, Jarpe MB, Johnson GL. 1999. Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to human. Physiol Rev 79:143-180.
35. Yao Z, Painter SL, Fanslow WC, Ulrich D, Macduff BM, Spriggs MK, Armitage RJ. 1995. Human IL-17: A novel cytokine derived from T cells. J Immunol 155:5483-5486.