-
1
-
-
10844266734
-
Transplantation 50 years later - Progress, challenges, and promises
-
Sayegh, M. H. & Carpenter, C. B. Transplantation 50 years later - progress, challenges, and promises. N. Engl. J. Med. 351, 2761-2766 (2004).
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 2761-2766
-
-
Sayegh, M.H.1
Carpenter, C.B.2
-
2
-
-
10244255039
-
Satisfaction (not) guaranteed: Re-evaluating the use of animal models of type 1 diabetes
-
Roep, B. O., Atkinson, M. & von Herrath, M. Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes. Nature Rev. Immunol. 4, 989-997 (2004).
-
(2004)
Nature Rev. Immunol.
, vol.4
, pp. 989-997
-
-
Roep, B.O.1
Atkinson, M.2
Von Herrath, M.3
-
3
-
-
34247638876
-
Immunotherapy of type 1 diabetes: Lessons for other autoimmune diseases
-
Bach, J. F. Immunotherapy of type 1 diabetes: lessons for other autoimmune diseases. Arthritis Res. 4 (suppl. 3), S3-S15 (2002).
-
(2002)
Arthritis Res.
, vol.4
, Issue.SUPPL. 3
-
-
Bach, J.F.1
-
4
-
-
0035036525
-
Chronic relapsing homologous collagen-induced arthritis in DBA/1 mice as a model for testing disease-modifying and remission-inducing therapies
-
Malfait, A. M., Williams, R. O., Malik, A. S., Maini, R. N. & Feldmann, M. Chronic relapsing homologous collagen-induced arthritis in DBA/1 mice as a model for testing disease-modifying and remission-inducing therapies. Arthritis Rheum. 44, 1215-1224 (2001).
-
(2001)
Arthritis Rheum.
, vol.44
, pp. 1215-1224
-
-
Malfait, A.M.1
Williams, R.O.2
Malik, A.S.3
Maini, R.N.4
Feldmann, M.5
-
5
-
-
0036584028
-
Development of anti-TNF therapy for rheumatoid arthritis
-
Feldmann, M. Development of anti-TNF therapy for rheumatoid arthritis. Nature Rev. Immunol. 2, 364-371 (2002).
-
(2002)
Nature Rev. Immunol.
, vol.2
, pp. 364-371
-
-
Feldmann, M.1
-
6
-
-
0037413467
-
A controlled trial of natalizumab for relapsing multiple sclerosis
-
Miller, D. H. et al. A controlled trial of natalizumab for relapsing multiple sclerosis. N. Engl. J. Med. 348, 15-23 (2003).
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 15-23
-
-
Miller, D.H.1
-
8
-
-
0142041982
-
Lasker clinical medical research award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases
-
Feldmann, M. & Maini, R. N. Lasker clinical medical research award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nature Med. 9, 1245-1250 (2003).
-
(2003)
Nature Med.
, vol.9
, pp. 1245-1250
-
-
Feldmann, M.1
Maini, R.N.2
-
9
-
-
0026506799
-
Prevention of experimental autoimmune encephalomyelitis by antibodies against α4 β 1 integrin
-
Yednock, T. A. et al. Prevention of experimental autoimmune encephalomyelitis by antibodies against α4 β1 integrin. Nature 356, 63-66 (1992).
-
(1992)
Nature
, vol.356
, pp. 63-66
-
-
Yednock, T.A.1
-
10
-
-
0037413468
-
Natalizumab for active Crohn's disease
-
Ghosh, S. et al. Natalizumab for active Crohn's disease. N. Engl. J. Med. 348, 24-32 (2003).
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 24-32
-
-
Ghosh, S.1
-
11
-
-
3042847542
-
Immune therapy for autoimmune diseases
-
Steinman, L. Immune therapy for autoimmune diseases. Science 305, 212-216 (2004).
-
(2004)
Science
, vol.305
, pp. 212-216
-
-
Steinman, L.1
-
13
-
-
0028024182
-
Repeated treatment with chimeric anti-CD4 antibody in multiple sclerosis
-
Lindsey, J. W. et al. Repeated treatment with chimeric anti-CD4 antibody in multiple sclerosis. Ann. Neurol. 36, 183-189 (1994).
-
(1994)
Ann. Neurol.
, vol.36
, pp. 183-189
-
-
Lindsey, J.W.1
-
14
-
-
0037313086
-
CD8-specific antibody-induced active tolerance: From bench to bedside
-
Chatenoud, L. CD8-specific antibody-induced active tolerance: from bench to bedside. Nature Rev. Immunol. 3, 123-132 (2003).
-
(2003)
Nature Rev. Immunol.
, vol.3
, pp. 123-132
-
-
Chatenoud, L.1
-
15
-
-
0037198420
-
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
-
Herold, K. C. et al. Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N. Engl. J. Med. 346, 1692-1698 (2002).
-
(2002)
N. Engl. J. Med.
, vol.346
, pp. 1692-1698
-
-
Herold, K.C.1
-
16
-
-
0027076729
-
Evidence that antihuman tumor necrosis factor monoclonal antibody prevents OKT3-induced acute syndrome
-
Charpentier, B. et al. Evidence that antihuman tumor necrosis factor monoclonal antibody prevents OKT3-induced acute syndrome. Transplantation 54, 997-1002 (1992).
-
(1992)
Transplantation
, vol.54
, pp. 997-1002
-
-
Charpentier, B.1
-
17
-
-
0032546352
-
Dendritic cells and the control of immunity
-
Banchereau, J. & Steinman, R. M. Dendritic cells and the control of immunity. Nature 392, 245-252 (1998).
-
(1998)
Nature
, vol.392
, pp. 245-252
-
-
Banchereau, J.1
Steinman, R.M.2
-
18
-
-
0021034058
-
Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity
-
Bottazzo, G. F., Pujol-Borrell, R., Hanafusa, T. & Feldmann, M. Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet 2, 1115-1119 (1983).
-
(1983)
Lancet
, vol.2
, pp. 1115-1119
-
-
Bottazzo, G.F.1
Pujol-Borrell, R.2
Hanafusa, T.3
Feldmann, M.4
-
19
-
-
0023512697
-
Monoclonal anti-Ia antibody therapy in animal models of autoimmune disease
-
McDevitt, H. O., Perry, R. & Steinman, L. A. Monoclonal anti-Ia antibody therapy in animal models of autoimmune disease. Ciba Found. Symp. 129, 184-193 (1987).
-
(1987)
Ciba Found. Symp.
, vol.129
, pp. 184-193
-
-
McDevitt, H.O.1
Perry, R.2
Steinman, L.A.3
-
20
-
-
0242574700
-
Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA 4Ig
-
Kremer, J. M. et al. Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. N. Engl. J. Med. 349, 1907-1915 (2003).
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 1907-1915
-
-
Kremer, J.M.1
-
21
-
-
0142218995
-
A critical role for OX40 in T cell-mediated immunopathology during lung viral infection
-
Humphreys, I. R. et al. A critical role for OX40 in T cell-mediated immunopathology during lung viral infection. J. Exp. Med. 198, 1237-1242 (2003).
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1237-1242
-
-
Humphreys, I.R.1
-
22
-
-
4444355794
-
Regulatory/suppressor T cells in health and disease
-
Shevach, E. M. Regulatory/suppressor T cells in health and disease. Arthritis Rheum. 50, 2721-2724 (2004).
-
(2004)
Arthritis Rheum.
, vol.50
, pp. 2721-2724
-
-
Shevach, E.M.1
-
23
-
-
5144222918
-
+ antigen-specific regulatory T cells
-
+ antigen-specific regulatory T cells. Proc. Natl. Acad. Sci. USA 101 (suppl. 2), 14622-14626 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, Issue.SUPPL. 2
, pp. 14622-14626
-
-
Bluestone, J.A.1
Tang, Q.2
-
24
-
-
3342930614
-
Anti B cell therapy (rituximab) in the treatment of autoimmune diseases
-
Kazkaz, H. & Isenberg, D. Anti B cell therapy (rituximab) in the treatment of autoimmune diseases. Curr. Opin. Pharmacol. 4, 398-402 (2004).
-
(2004)
Curr. Opin. Pharmacol.
, vol.4
, pp. 398-402
-
-
Kazkaz, H.1
Isenberg, D.2
-
25
-
-
0011713902
-
-
(eds Oppenheim, J. J. & Feldmann, M.) (Academic, London)
-
Oppenheim, J. J. & Feldmann, M. in Cytokine Reference, Vol. 1: Ligands (eds Oppenheim, J. J. & Feldmann, M.) 3-20 (Academic, London, 2001).
-
(2001)
Cytokine Reference, Vol. 1: Ligands
, vol.1
, pp. 3-20
-
-
Oppenheim, J.J.1
Feldmann, M.2
-
26
-
-
3843048717
-
-
(eds Oppenheim, J. J. & Feldmann, M.) (Academic, London)
-
Feldmann, M. & Brennan, F. M. in Cytokine Reference, Vol. 1: Ligands (eds Oppenheim, J. J. & Feldmann, M.) 35-41 (Academic, London, 2001).
-
(2001)
Cytokine Reference, Vol. 1: Ligands
, vol.1
, pp. 35-41
-
-
Feldmann, M.1
Brennan, F.M.2
-
27
-
-
0029876121
-
Role of cytokines in rheumatoid arthritis
-
Feldmann, M., Brennan, F. M. & Maini, R. N. Role of cytokines in rheumatoid arthritis. Annu. Rev. Immunol. 14, 397-440 (1996).
-
(1996)
Annu. Rev. Immunol.
, vol.14
, pp. 397-440
-
-
Feldmann, M.1
Brennan, F.M.2
Maini, R.N.3
-
28
-
-
0027438710
-
Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha
-
Elliott, M. J. et al. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha. Arthritis Rheum. 36, 1681-1690 (1993).
-
(1993)
Arthritis Rheum.
, vol.36
, pp. 1681-1690
-
-
Elliott, M.J.1
-
29
-
-
0031660364
-
Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis
-
Maini, R. N. et al. Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. Arthritis Rheum. 41, 1552-1563 (1998).
-
(1998)
Arthritis Rheum.
, vol.41
, pp. 1552-1563
-
-
Maini, R.N.1
-
30
-
-
2342658406
-
Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: A randomized, placebo-controlled, 52-week trial
-
Keystone, E. C. et al. Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: a randomized, placebo-controlled, 52-week trial. Arthritis Rheum. 50, 1400-1411 (2004).
-
(2004)
Arthritis Rheum.
, vol.50
, pp. 1400-1411
-
-
Keystone, E.C.1
-
31
-
-
0013511183
-
Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein
-
Moreland, L. W. et al. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N. Engl. J. Med. 337, 141-147 (1997).
-
(1997)
N. Engl. J. Med.
, vol.337
, pp. 141-147
-
-
Moreland, L.W.1
-
32
-
-
0035056003
-
Anti-TNFα therapy of rheumatoid arthritis: What have we learned?
-
Feldmann, M. & Maini, R. N. Anti-TNFα therapy of rheumatoid arthritis: what have we learned? Annu. Rev. Immunol. 19, 163-196 (2001).
-
(2001)
Annu. Rev. Immunol.
, vol.19
, pp. 163-196
-
-
Feldmann, M.1
Maini, R.N.2
-
33
-
-
3342892420
-
Inhibition of IL-6 for the treatment of inflammatory diseases
-
Nishimoto, N. & Kishimoto, T. Inhibition of IL-6 for the treatment of inflammatory diseases. Curr. Opin. Pharmacol. 4, 386-391 (2004).
-
(2004)
Curr. Opin. Pharmacol.
, vol.4
, pp. 386-391
-
-
Nishimoto, N.1
Kishimoto, T.2
-
34
-
-
0029617952
-
Modulation of proinflammatory cytoklne release in rheumatoid synovial membrane cell cultures. Comparison of monoclonal anti TNF-alpha antibody with the interleukin-1 receptor antagonist
-
Butler, D. M., Maini, R. N., Feldmann, M. & Brennan, F. M. Modulation of proinflammatory cytoklne release in rheumatoid synovial membrane cell cultures. Comparison of monoclonal anti TNF-alpha antibody with the interleukin-1 receptor antagonist. Eur. Cytakine Netw. 6, 225-230 (1995).
-
(1995)
Eur. Cytakine Netw.
, vol.6
, pp. 225-230
-
-
Butler, D.M.1
Maini, R.N.2
Feldmann, M.3
Brennan, F.M.4
-
35
-
-
17444394445
-
Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist
-
Bresnihan, B. et al. Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arthritis Rheum. 41, 2196-2204 (1998).
-
(1998)
Arthritis Rheum.
, vol.41
, pp. 2196-2204
-
-
Bresnihan, B.1
-
36
-
-
3342897676
-
Interleukin-15: A new cytokine target for the treatment of inflammatory diseases
-
McInnes, I. B. & Gracie, J. A. Interleukin-15: a new cytokine target for the treatment of inflammatory diseases. Curr. Opin. Pharmacol. 4, 392-397 (2004).
-
(2004)
Curr. Opin. Pharmacol.
, vol.4
, pp. 392-397
-
-
McInnes, I.B.1
Gracie, J.A.2
-
37
-
-
3042814921
-
HMGB1 in the immunology of sepsis (not septic shock) and arthritis
-
Czura, C. J., Yang, H., Amelia, C. A. & Tracey, K. J. HMGB1 in the immunology of sepsis (not septic shock) and arthritis. Adv. Immunol. 84, 181-200 (2004).
-
(2004)
Adv. Immunol.
, vol.84
, pp. 181-200
-
-
Czura, C.J.1
Yang, H.2
Amelia, C.A.3
Tracey, K.J.4
-
38
-
-
3342982829
-
A single-dose placebo-controlled study of AMG162, a fully human monoclonal antibody to RANKL, in postmenopausal women
-
Bekker, P. J. et al. A single-dose placebo-controlled study of AMG162, a fully human monoclonal antibody to RANKL, in postmenopausal women. J. Bone Miner. Res. 19, 1059-1066 (2004).
-
(2004)
J. Bone Miner. Res.
, vol.19
, pp. 1059-1066
-
-
Bekker, P.J.1
-
39
-
-
0033645975
-
Reflections on chemokines
-
Baggiolini, M. Reflections on chemokines. Immunol. Rev. 177, 5-7 (2000).
-
(2000)
Immunol. Rev.
, vol.177
, pp. 5-7
-
-
Baggiolini, M.1
-
40
-
-
0027982876
-
Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
-
Springer, T. A. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76, 301-314 (1994).
-
(1994)
Cell
, vol.76
, pp. 301-314
-
-
Springer, T.A.1
-
41
-
-
0029975898
-
A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: A basis for peptide-specific therapy after onset of clinical disease
-
Yu, M., Johnson, J. M. & Tuohy, V. K. A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease. J. Exp. Med. 183, 1777-1788 (1996).
-
(1996)
J. Exp. Med.
, vol.183
, pp. 1777-1788
-
-
Yu, M.1
Johnson, J.M.2
Tuohy, V.K.3
-
42
-
-
0033023195
-
The concept of specific immune treatment against autoimmune diseases
-
Sela, M. The concept of specific immune treatment against autoimmune diseases. Int. Rev. Immunol. 18, 201-216 (1999).
-
(1999)
Int. Rev. Immunol.
, vol.18
, pp. 201-216
-
-
Sela, M.1
-
43
-
-
0030069797
-
Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein
-
Brocke, S. et al. Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. Nature 379, 343-346 (1996).
-
(1996)
Nature
, vol.379
, pp. 343-346
-
-
Brocke, S.1
-
44
-
-
0033791462
-
Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial
-
The altered peptide ligand in relapsing MS study group
-
Kappos, L. et al. Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. The altered peptide ligand in relapsing MS study group. Nature Med. 6, 1176-1182 (2000).
-
(2000)
Nature Med.
, vol.6
, pp. 1176-1182
-
-
Kappos, L.1
-
45
-
-
0033786776
-
Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
-
Bielekova, B. et al. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nature Med. 6, 1167-1175 (2000).
-
(2000)
Nature Med.
, vol.6
, pp. 1167-1175
-
-
Bielekova, B.1
-
46
-
-
0033559521
-
Suppressive immunization with DNA encoding a self-peptide prevents autoimmune disease: Modulation of T cell co-stimulation
-
Ruiz, P. J. et al. Suppressive immunization with DNA encoding a self-peptide prevents autoimmune disease: modulation of T cell co-stimulation. J. Immunol. 162, 3336-3341 (1999).
-
(1999)
J. Immunol.
, vol.162
, pp. 3336-3341
-
-
Ruiz, P.J.1
-
47
-
-
0035944844
-
Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, phase II trial
-
Raz, I. et al. Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. Lancet 358, 1749-1753 (2001).
-
(2001)
Lancet
, vol.358
, pp. 1749-1753
-
-
Raz, I.1
-
48
-
-
10744231057
-
Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis
-
Robinson, W. H. et al. Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis. Nature Biotechnol. 21, 1033-1039 (2003).
-
(2003)
Nature Biotechnol.
, vol.21
, pp. 1033-1039
-
-
Robinson, W.H.1
-
49
-
-
0032100767
-
Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen
-
Gutgemann, I., Fahrer, A. M., Altman, J. D., Davis, M. M. & Chien, Y. H. Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen. Immunity 8, 667-673 (1998).
-
(1998)
Immunity
, vol.8
, pp. 667-673
-
-
Gutgemann, I.1
Fahrer, A.M.2
Altman, J.D.3
Davis, M.M.4
Chien, Y.H.5
-
50
-
-
0028037782
-
Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
-
Chen, Y., Kuchroo, V. K., Inobe, J., Hafler, D. A. & Weiner, H. L. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265, 1237-1240 (1994).
-
(1994)
Science
, vol.265
, pp. 1237-1240
-
-
Chen, Y.1
Kuchroo, V.K.2
Inobe, J.3
Hafler, D.A.4
Weiner, H.L.5
-
51
-
-
0142213193
-
Oral tolerance in the treatment of rheumatoid arthritis
-
Toussirot, E. A. Oral tolerance in the treatment of rheumatoid arthritis. Curr. Drug Targets Inflamm. Allergy 1, 45-52 (2002).
-
(2002)
Curr. Drug Targets Inflamm. Allergy
, vol.1
, pp. 45-52
-
-
Toussirot, E.A.1
-
52
-
-
0027361432
-
Construction and initial characterization of a mouse-human chimeric anti-TNF antibody
-
Knight, D. M. et al. Construction and initial characterization of a mouse-human chimeric anti-TNF antibody. Mol. Immunol. 30, 1443-1453 (1993).
-
(1993)
Mol. Immunol.
, vol.30
, pp. 1443-1453
-
-
Knight, D.M.1
-
53
-
-
0027962758
-
Making antibodies by phage display technology
-
Winter, G., Griffiths, A. D., Hawkins, R. E. & Hoogenboom, H. R. Making antibodies by phage display technology. Annu. Rev. Immunol. 12, 433-455 (1994).
-
(1994)
Annu. Rev. Immunol.
, vol.12
, pp. 433-455
-
-
Winter, G.1
Griffiths, A.D.2
Hawkins, R.E.3
Hoogenboom, H.R.4
-
54
-
-
0014760032
-
Cellular sites of immunologic unresponsiveness
-
Chiller, J. M., Habicht, G. S. & Weigle, W. O. Cellular sites of immunologic unresponsiveness. Proc. Natl Acad. Sci. USA 65, 551-556 (1970).
-
(1970)
Proc. Natl. Acad. Sci. USA
, vol.65
, pp. 551-556
-
-
Chiller, J.M.1
Habicht, G.S.2
Weigle, W.O.3
-
55
-
-
0034735827
-
A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis
-
Bathon, J. M. et al. A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis. N. Engl. J. Med. 343, 1586-1593 (2000).
-
(2000)
N. Engl. J. Med.
, vol.343
, pp. 1586-1593
-
-
Bathon, J.M.1
-
56
-
-
0029959940
-
Interleukin-10 inhibition of the progression of established collagen-induced arthritis
-
Walmsley, M. et al. Interleukin-10 inhibition of the progression of established collagen-induced arthritis. Arthritis Rheum. 39, 495-503 (1996).
-
(1996)
Arthritis Rheum.
, vol.39
, pp. 495-503
-
-
Walmsley, M.1
-
57
-
-
0242353920
-
Targeting cytokines to inflammation sites
-
Adams, G., Vessillier, S., Dreja, H. & Chernajovsky, Y. Targeting cytokines to inflammation sites. Nature Biotechnol. 21, 1314-1320 (2003).
-
(2003)
Nature Biotechnol.
, vol.21
, pp. 1314-1320
-
-
Adams, G.1
Vessillier, S.2
Dreja, H.3
Chernajovsky, Y.4
-
58
-
-
0242353927
-
Engineering better cytokines
-
Steinman, L. Engineering better cytokines. Nature Biotechnol. 21, 1293-1294 (2003).
-
(2003)
Nature Biotechnol.
, vol.21
, pp. 1293-1294
-
-
Steinman, L.1
-
59
-
-
0141758383
-
Interferon-beta in the treatment of relapsing-remitting multiple sclerosis
-
Revel, M. Interferon-beta in the treatment of relapsing-remitting multiple sclerosis. Pharmacol. Ther. 100, 49-62 (2003).
-
(2003)
Pharmacol. Ther.
, vol.100
, pp. 49-62
-
-
Revel, M.1
-
60
-
-
0141757326
-
Inactivation of TNF signaling by rationally designed dominant-negative TNF variants
-
Steed, P. M. et al. Inactivation of TNF signaling by rationally designed dominant-negative TNF variants. Science 301, 1895-1898 (2003).
-
(2003)
Science
, vol.301
, pp. 1895-1898
-
-
Steed, P.M.1
-
61
-
-
19944431840
-
Very early treatment with infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal: Results from a twelve-month randomized, double-blind, placebo-controlled trial
-
Quinn, M. A. et al. Very early treatment with infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal: results from a twelve-month randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 52, 27-35 (2005).
-
(2005)
Arthritis Rheum.
, vol.52
, pp. 27-35
-
-
Quinn, M.A.1
-
62
-
-
0034735842
-
Infliximab and methotrexate in the treatment of rheumatoid arthritis
-
Antitumor necrosis factor trial in rheumatoid arthritis with concomitant therapy study group
-
Lipsky, P. E. et al. Infliximab and methotrexate in the treatment of rheumatoid arthritis. Antitumor necrosis factor trial in rheumatoid arthritis with concomitant therapy study group. N. Engl. J. Med. 343, 1594-1602 (2000).
-
(2000)
N. Engl. J. Med.
, vol.343
, pp. 1594-1602
-
-
Lipsky, P.E.1
-
63
-
-
10744223002
-
Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: Double-blind randomised controlled trial
-
Klareskog, L. et al. Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial. Lancet 363, 675-681 (2004).
-
(2004)
Lancet
, vol.363
, pp. 675-681
-
-
Klareskog, L.1
-
64
-
-
0035846326
-
Tuberculosis associated with infliximab, a tumor necrosis factor α-neutralizing agent
-
Keane, J. et al. Tuberculosis associated with infliximab, a tumor necrosis factor α-neutralizing agent. N. Engl. J. Med. 345, 1098-1104 (2001).
-
(2001)
N. Engl. J. Med.
, vol.345
, pp. 1098-1104
-
-
Keane, J.1
-
65
-
-
0037116867
-
Adverse reactions to TNF-α inhibitors in rheumatoid arthritis
-
Day, R. Adverse reactions to TNF-α inhibitors in rheumatoid arthritis. Lancet 359, 540-541 (2002).
-
(2002)
Lancet
, vol.359
, pp. 540-541
-
-
Day, R.1
-
66
-
-
0035852136
-
Progress in the treatment of rheumatoid arthritis
-
Pisetsky, D. S. & St Clair, E. W. Progress in the treatment of rheumatoid arthritis. JAMA 286, 2787-2790 (2001).
-
(2001)
JAMA
, vol.286
, pp. 2787-2790
-
-
Pisetsky, D.S.1
St. Clair, E.W.2
-
67
-
-
0036164274
-
Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells
-
Brennan, F. M. et al. Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells. Arthritis Rheum. 46, 31-41 (2002).
-
(2002)
Arthritis Rheum.
, vol.46
, pp. 31-41
-
-
Brennan, F.M.1
-
68
-
-
0033763979
-
Assessment of antibodies to double-stranded DNA induced in rheumatoid arthritis patients following treatment with infliximab, a monoclonal antibody to tumor necrosis factor α
-
Charles, P. J., Smeenk, R. J. T., DeJong, J., Feldmann, M. & Maini, R. N. Assessment of antibodies to double-stranded DNA induced in rheumatoid arthritis patients following treatment with infliximab, a monoclonal antibody to tumor necrosis factor α. Arthritis Rheum. 43, 2383-2390 (2000).
-
(2000)
Arthritis Rheum.
, vol.43
, pp. 2383-2390
-
-
Charles, P.J.1
Smeenk, R.J.T.2
DeJong, J.3
Feldmann, M.4
Maini, R.N.5
-
69
-
-
1942435932
-
Rheumatoid arthritis and malignant lymphomas
-
Baecklund, E., Askling, J., Rosenquist, R., Ekbom, A. & Klareskog, L. Rheumatoid arthritis and malignant lymphomas. Curr. Opin. Rheumatol. 16, 254-261 (2004).
-
(2004)
Curr. Opin. Rheumatol.
, vol.16
, pp. 254-261
-
-
Baecklund, E.1
Askling, J.2
Rosenquist, R.3
Ekbom, A.4
Klareskog, L.5
-
70
-
-
0027978457
-
Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis
-
Cope, A. P. et al. Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis. J. Clin. Invest. 94, 749-760 (1994).
-
(1994)
J. Clin. Invest.
, vol.94
, pp. 749-760
-
-
Cope, A.P.1
-
71
-
-
2642558925
-
Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: A multicenter, double-blind, placebo-controlled trial
-
Nishimoto, N. et al. Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum. 50, 1761-1769 (2004).
-
(2004)
Arthritis Rheum.
, vol.50
, pp. 1761-1769
-
-
Nishimoto, N.1
-
72
-
-
2442561768
-
Oral simvastatin treatment in relapsing-remitting multiple sclerosis
-
Vollmer, T. et al. Oral simvastatin treatment in relapsing-remitting multiple sclerosis. Lancet 363, 1607-1608 (2004).
-
(2004)
Lancet
, vol.363
, pp. 1607-1608
-
-
Vollmer, T.1
-
73
-
-
0034533147
-
Statins as a newly recognized type of immunomodulator
-
Kwak, B., Mulhaupt, F., Myit, S, & Mach, F. Statins as a newly recognized type of immunomodulator. Nature Med. 6, 1399-1402 (2000).
-
(2000)
Nature Med.
, vol.6
, pp. 1399-1402
-
-
Kwak, B.1
Mulhaupt, F.2
Myit, S.3
Mach, F.4
-
74
-
-
0034897403
-
Combination of gene delivery and DNA vaccination to protect from and reverse Th1 autoimmune disease via deviation to the Th2 pathway
-
Garren, H. et al. Combination of gene delivery and DNA vaccination to protect from and reverse Th1 autoimmune disease via deviation to the Th2 pathway. Immunity 15, 15-22 (2001).
-
(2001)
Immunity
, vol.15
, pp. 15-22
-
-
Garren, H.1
-
75
-
-
0037038402
-
The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease
-
Youssef, S. et al. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature 420, 78-84 (2002).
-
(2002)
Nature
, vol.420
, pp. 78-84
-
-
Youssef, S.1
-
76
-
-
2942670131
-
Trial of Atorvastatin in Rheumatoid Arthritis (TARA): Double-blind, randomised placebo-controlled trial
-
McCarey, D. W. et al. Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial. Lancet 363, 2015-2021 (2004).
-
(2004)
Lancet
, vol.363
, pp. 2015-2021
-
-
McCarey, D.W.1
-
77
-
-
11144357288
-
Peroxisome proliferator-activated receptor alpha agonists as therapy for autoimmune disease
-
Lovett-Racke, A. E. et al. Peroxisome proliferator-activated receptor alpha agonists as therapy for autoimmune disease. J. Immunol. 172, 5790-5798 (2004).
-
(2004)
J. Immunol.
, vol.172
, pp. 5790-5798
-
-
Lovett-Racke, A.E.1
-
78
-
-
12344308309
-
The non-thiol angiotensin-converting enzyme inhibitor quinapril suppresses inflammatory arthritis
-
Dalbeth, N., Edwards, J., Fairchild, S., Callan, M. & Hall, F. C. The non-thiol angiotensin-converting enzyme inhibitor quinapril suppresses inflammatory arthritis. Rheumatology (Oxford) 44, 24-31 (2005).
-
(2005)
Rheumatology (Oxford)
, vol.44
, pp. 24-31
-
-
Dalbeth, N.1
Edwards, J.2
Fairchild, S.3
Callan, M.4
Hall, F.C.5
-
79
-
-
0028226982
-
Synergy between anti-CD4 and anti-tumor necrosis factor in the amelioration of established collagen-induced arthritis
-
Williams, R. O., Mason, L. J., Feldmann, M. & Maini, R. N. Synergy between anti-CD4 and anti-tumor necrosis factor in the amelioration of established collagen-induced arthritis. Proc. Natl Acad. Sci. USA 91, 2762-2766 (1994).
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 2762-2766
-
-
Williams, R.O.1
Mason, L.J.2
Feldmann, M.3
Maini, R.N.4
-
80
-
-
2342551979
-
Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate
-
Genovese, M. C. et al. Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate. Arthritis Rheum. 50, 1412-1419 (2004).
-
(2004)
Arthritis Rheum.
, vol.50
, pp. 1412-1419
-
-
Genovese, M.C.1
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