The IL-17 Cytokine Family

Vitamins and Hormones

Volumn 74, Issue , 2006, Pages 255-282

  Gaffen, Sarah L ^a,b   Kramer, Jill M ^a   Yu, Jeffrey J ^b   Shen, Fang ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IL17R PROTEIN, HUMAN; INTERLEUKIN 17; INTERLEUKIN 17 RECEPTOR;

ANIMAL; AUTOIMMUNE DISEASE; COMMUNICABLE DISEASE; GENETICS; HUMAN; IMMUNOLOGY; IN VITRO STUDY; NEOPLASM; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; AUTOIMMUNE DISEASES; COMMUNICABLE DISEASES; HUMANS; INTERLEUKIN-17; NEOPLASMS; RECEPTORS, INTERLEUKIN-17; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS;

EID: 33947732240     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0083-6729(06)74010-9     Document Type: Review

References (139)

1. Aggarwal S., Ghilardi N., Xie M.H., De Sauvage F.J., and Gurney A.L. Interleukin 23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin 17. J. Biol. Chem. 3 (2002) 1910-1914
2. Aggarwal S., and Gurney A.L. IL-17: A prototype member of an emerging family. J. Leukoc. Biol. 71 (2002) 1-8
3. Albanesi C., Cavani A., and Girolomoni G. IL-17 is produced by nickel-specific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: Synergistic or antagonistic effects with IFN-γ and TNF-α. J. Immunol. 162 (1999) 494-502
4. Andoh A., Fujino S., Bamba S., Araki Y., Okuno T., Bamba T., and Fujiyama Y. IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts. J. Immunol. 169 (2002) 1683-1687
5. Arican O., Aral M., Sasmaz S., and Ciragil P. Serum Levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity. Mediators Inflamm. 2005 (2005) 273-279
6. Attur M.G., Patel R.N., Abramson S.B., and Amin A.R. Interleukin-17 up-regulation of nitric oxide production in human osteoarthritis cartilage. Arthritis Rheum. 40 (1997) 1050-1053
7. Awane M., Andres P.G., Li D.J., and Reinecker H.C. NF-kappa B-inducing kinase is a common mediator of IL-17-, TNF-alpha-, and IL-1 beta-induced chemokine promoter activation in intestinal epithelial cells. J. Immunol. 162 (1999) 5337-5344
8. Bamba S., Andoh A., Yasui H., Araki Y., Bamba T., and Fujiyama Y. Matrix metalloproteinase-3 secretion from human colonic subepithelial myofibroblasts: Role of interleukin-17. J. Gastroenterol. 38 (2003) 548-554
9. Benchetrit F., Ciree A., Vives V., Warnier G., Gey A., Sautes-Fridman C., Fossiez F., Haicheur N., Fridman W.H., and Tartour E. Interleukin-17 inhibits tumor cell growth by means of a T-cell-dependent mechanism. Blood 99 (2002) 2114-2121
10. Bettelli E., and Kuchroo V.K. IL-12- and IL-23-induced T helper cell subsets: Birds of the same feather flock together. J. Exp. Med. 201 (2005) 169-171
11. H17 and regulatory T cells. Nature 441 (2006) 235-238
12. Chabaud M., Fossiez F., Taupin J.L., and Miossec P. Enhancing effect of IL-17 on IL-1-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis, synoviocytes and its regulation by Th2 cytokines. J. Immunol. 161 (1998) 409-414
13. Chabaud M., Garnero P., Dayer J.M., Guerne P.A., Fossiez F., and Miossec P. Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis. Cytokine 12 (2000) 1092-1099
14. Chan F.K., Chun H.J., Zheng L., Siegel R.M., Bui K.L., and Lenardo M.J. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science 288 (2000) 2351-2354
15. Chen A., Laurence A., Kanno Y., Pacher-Zavisin M., Zhu B.-M., Tato C., Yoshimura A., Hennighausen L., and O'Shea J.J. Selective regulatory function of Socs3 in the formation of IL-17-secreting cells. Proc. Natl. Acad. Sci. USA 103 (2006) 8137-8142
16. Ciree A., Michel L., Camilleri-Broet S., Jean Louis F., Oster M., Flageul B., Senet P., Fossiez F., Fridman W.H., Bachelez H., and Tartour E. Expression and activity of IL-17 in cutaneous T-cell lymphomas (mycosis fungoides and Sezary syndrome). Int. J. Cancer 112 (2004) 113-120
17. Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., et al. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: A bioinformatics assessment. Genome Res. 13 (2003) 2265-2270
18. Dong C., and Nurieva R.I. Regulation of immune and autoimmune responses by ICOS. J. Autoimmunity 21 (2003) 255-260
19. Eberl M. Don't count your interleukins before they've hatched. Trends Immunol. 23 (2002) 341-342
20. Faour W.H., Mancini A., He Q.W., and Di Battista J.A. T-cell-derived interleukin-17 regulates the level and stability of cyclooxygenase-2 (COX-2) mRNA through restricted activation of the p38 mitogen-activated protein kinase cascade: Role of distal sequences in the 3′-untranslated region of COX-2 mRNA. J. Biol. Chem. 278 (2003) 26897-26907
21. Flo T.H., Smith K.D., Sato S., Rodriguez D.J., Holmes M.A., Strong R.K., Akira S., and Aderem A. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 432 (2004) 917-921
22. Forlow S.B., Schurr J.R., Kolls J.K., Bagby G.J., Schwarzenberger P.O., and Ley K. Increased granulopoiesis through interleukin-17 and granulocyte colony-stimulating factor in leukocyte adhesion molecule-deficient mice. Blood 98 (2001) 3309-3314
23. Fort M.M., Cheung J., Yen D., Li J., Zurawski S.M., Lo S., Menon S., Clifford T., Hunte B., Lesley R., Muchamuel T., Hurst S.D., et al. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity 15 (2001) 985-995
24. Fossiez F., Djossou O., Chomarat P., Flores-Romo L., Ait-Yahia S., Maat C., Pin J.-J., Garrone P., Garcia E., Saeland S., Blanchard D., Gaillard C., et al. T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J. Exp. Med. 183 (1996) 2593-2603
25. Fujino S., Andoh A., Bamba S., Ogawa A., Hata K., Araki Y., Bamba T., and Fujiyama Y. Increased expression of interleukin 17 in inflammatory bowel disease. Gut 52 (2003) 65-70
26. Gaffen S.L. Interleukin-17: A unique inflammatory cytokine with roles in bone biology and arthritis. Arth. Res. Ther. 6 (2004) 240-247
27. Ghilardi N., Kljavin N., Chen Q., Lucas S., Gurney A., and de Sauvage F.J. Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice. J. Immunol. 172 (2004) 2827-2833
28. Happel K.I., Lockhart E.A., Mason C.M., Porretta E., Keoshkerian E., Odden A.R., Nelson S., and Ramsay A.J. Pulmonary interleukin-23 gene delivery increases local T-cell immunity and controls growth of Mycobacterium tuberculosis in the lungs. Infect. Immun. 73 (2005) 5782-5788
29. Happel K.I., Zheng M., Young E., Quinton L.J., Lockhart E., Ramsay A.J., Shellito J.E., Schurr J.R., Bagby G.J., Nelson S., and Kolls J.K. Cutting Edge: Roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae Infection. J. Immunol. 170 (2003) 4432-4436
30. Harrington L.E., Hatton R.D., Mangan P.R., Turner H., Murphy T.L., Murphy K.M., and Weaver C.T. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6 (2005) 1123-1132
31. Hata K., Andoh A., Shimada M., Fujino S., Bamba S., Araki Y., Okuno T., Fujiyama Y., and Bamba T. IL-17 stimulates inflammatory responses via NF-kappaB and MAP kinase pathways in human colonic myofibroblasts. Am. J. Physiol. Gastrointest. Liver Physiol. 282 (2002) G1035-G1044
32. Haudenschild D., Moseley T., Rose L., and Reddi A.H. Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer. J. Biol. Chem. 277 (2002) 4309-4316
33. Henness S., Johnson C.K., Ge Q., Armour C.L., Hughes J.M., and Ammit A.J. IL-17A augments TNF-alpha-induced IL-6 expression in airway smooth muscle by enhancing mRNA stability. J. Allergy Clin. Immunol. 114 (2004) 958-964
34. Hirahara N., Nio Y., Sasaki S., Minari Y., Takamura M., Iguchi C., Dong M., Yamasawa K., and Tamura K. Inoculation of human interleukin-17 gene-transfected Meth-A fibrosarcoma cells induces T cell-dependent tumor-specific immunity in mice. Oncology 61 (2001) 79-89
35. Honorati M.C., Neri S., Cattini L., and Facchini A. IL-17 enhances the susceptibility of U-2 OS osteosarcoma cells to NK cell lysis. Clin. Exp. Immunol. 133 (2003) 344-349
36. Hsieh H.G., Loong C.C., and Lin C.Y. Interleukin-17 induces src/MAPK cascades activation in human renal epithelial cells. Cytokine 19 (2002) 159-174
37. Huang W., Na L., Fidel P.L., and Schwarzenberger P. Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J. Infect. Dis. 190 (2004) 624-631
38. Hurst S.D., Muchamuel T., Gorman D.M., Gilbert J.M., Clifford T., Kwan S., Menon S., Seymour B., Jackson C., Kung T.T., Brieland J.K., Zurawski S.M., et al. New IL-17 family members promote Th1 or Th2 responses in the lung: In vivo function of the novel cytokine IL-25. J. Immunol. 169 (2002) 443-453
39. Hwang S.Y., Kim J.Y., Kim K.W., Park M.K., Moon Y., Kim W.U., and Kim H.Y. IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kappaB- and PI3-kinase/Akt-dependent pathways. Arthritis Res. Ther. 6 (2004) R120-R128
40. Hymowitz S.G., Filvaroff E.H., Yin J.P., Lee J., Cai L., Risser P., Maruoka M., Mao W., Foster J., Kelley R.F., Pan G., Gurney A.L., et al. IL-17s adopt a cystine knot fold: Structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMBO J. 20 (2001) 5332-5341
41. Johnson R.B., Wood N., and Serio F.G. Interleukin-11 and IL-17 and the pathogenesis of periodontal disease. J. Periodontol. 75 (2004) 37-43
42. Jovanovic D.V., Martel-Pelletier J., Di Battista J.A., Mineau F., Jolicoeur F.-C., Benderdour M., and Pelletier J.-P. Stimulation of 92-kD gelatinase (matrix metalloproteinase 9) production by interleukin-17 in human monocyte/macrophages. Arthritis Rheum. 43 (2000) 1134-1144
43. Kane L.P., Shapiro V.S., Stokoe D., and Weiss A. Induction of NF-kappaB by the Akt/PKB kinase. Curr. Biol. 9 (1999) 601-604
44. Kantarci A., Oyaizu K., and Van Dyke T.E. Neutrophil-mediated tissue injury in periodontal disease pathogenesis: Findings from localized aggressive periodontitis. J. Periodontol. 74 (2003) 66-75
45. Kao C.Y., Chen Y., Thai P., Wachi S., Huang F., Kim C., Harper R.W., and Wu R. IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J. Immunol. 173 (2004) 3482-3491
46. Kato T., Furumoto H., Ogura T., Onishi Y., Irahara M., Yamano S., Kamada M., and Aono T. Expression of IL-17 mRNA in ovarian cancer. Biochem. Biophys. Res. Commun. 282 (2001) 735-738
47. Kelly M.N., Kolls J.K., Happel K., Schwartzman J.D., Schwarzenberger P., Combe C., Moretto M., and Khan I.A. Interleukin-17/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection. Infect. Immun. 73 (2005) 617-621
48. Khader S.A., Pearl J.E., Sakamoto K., Gilmartin L., Bell G.K., Jelley-Gibbs D.M., Ghilardi N., deSauvage F., and Cooper A.M. IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available. J. Immunol. 175 (2005) 788-795
49. Kim M.R., Manoukian R., Yeh R., Silbiger S.M., Danilenko D.M., Scully S., Sun J., DeRose M.L., Stolina M., Chang D., Van G.Y., Clarkin K., et al. Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production. Blood 100 (2002) 2330-2340
50. Knappe A., Hiller C., Niphuis H., Fossiez F., Thurau M., Wittmann S., Kuhn E.M., Lebecque S., Banchereau J., Rosenwirth B., Fleckenstein B., Heeney J., et al. The interleukin-17 gene of herpesvirus saimiri. J. Virol. 72 (1998) 5797-5801
51. Kobayashi S.D., Voyich J.M., Braughton K.R., and DeLeo F.R. Down-regulation of proinflammatory capacity during apoptosis in human polymorphonuclear leukocytes. J. Immunol. 170 (2003) 3357-3368
52. Koenders M.I., Kolls J.K., Oppers-Walgreen B., van den Bersselaar L., Joosten L.A., Schurr J.R., Schwarzenberger P., van den Berg W.B., and Lubberts E. Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis. Arthritis Rheum. 52 (2005) 3239-3247
53. Kolls J.K., and Linden A. Interleukin-17 family members and inflammation. Immunity 21 (2004) 467-476
54. Koshy P.J., Henderson N., Logan C., Life P.F., Cawston T.E., and Rowan A.D. Interleukin 17 induces cartilage collagen breakdown: Novel synergistic effects in combination with proinflammatory cytokines. Ann. Rheum. Dis. 61 (2002) 704-713
55. Kotake S., Udagawa N., Takahashi N., Matsuzaki K., Itoh K., Ishiyama S., Saito S., Inoue K., Kamatani N., Gillespie M.T., Martin T.J., and Suda T. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J. Clin. Invest. 103 (1999) 1345-1352
56. Kramer J., Yi L., Shen F., Maitra A., Jiao X., Jin T., and Gaffen S. Cutting edge: Evidence for ligand-independent multimerization of the IL-17 receptor. J. Immunol. 176 (2006) 711-715
57. Laan M., Cui A.-H., Hoshino H., Lötvall J., Sjöstrand M., Gruenert D.C., Skoogh B.-E., and Lindén A. Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J. Immunol. 162 (1999) 2347-2352
58. Laan M., Lotvall J., Chung K.F., and Linden A. IL-17-induced cytokine release in human bronchial epithelial cells in vitro: Role of mitogen-activated protein (MAP) kinases. Br. J. Pharmacol. 133 (2001) 200-206
59. Laan M., Prause O., Miyamoto M., Sjostrand M., Hytonen A.M., Kaneko T., Lotvall J., and Linden A. A role of GM-CSF in the accumulation of neutrophils in the airways caused by IL-17 and TNF-alpha. Eur. Respir. J. 21 (2003) 387-393
60. Langrish C.L., Chen Y., Blumenschein W.M., Mattson J., Basham B., Sedgwick J.D., McClanahan T., Kastelein R.A., and Cua D.J. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201 (2005) 233-240
61. Lee J., Ho W.H., Maruoka M., Corpuz R.T., Baldwin D.T., Foster J.S., Goddard A.D., Yansura D.G., Vandlen R.L., Wood W.I., and Gurney A.L. IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. J. Biol. Chem. 276 (2001) 1660-1664
62. LeGrand A., Fermor B., Fink C., Pisetsky D.S., Weinberg J.B., Vail T.P., and Guilak F. Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci. Arthritis Rheum. 44 (2001) 2078-2083
63. Li H., Chen J., Huang A., Stinson J., Heldens S., Foster J., Dowd P., Gurney A.L., and Wood W.I. Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 family. Proc. Natl. Acad. Sci. USA 97 (2000) 773-778
64. Liacini A., Sylvester J., Li W.Q., and Zafarullah M. Mithramycin downregulates proinflammatory cytokine-induced matrix metalloproteinase gene expression in articular chondrocytes. Arthritis Res. Ther. 7 (2005) R777-R783
65. Liacini A., Sylvester J., and Zafarullah M. Triptolide suppresses proinflammatory cytokine-induced matrix metalloproteinase and aggrecanase-1 gene expression in chondrocytes. Biochem. Biophys. Res. Commun. 327 (2005) 320-327
66. Liew F.Y., and McInnes I.B. A fork in the pathway to inflammation and arthritis. Nat. Med. 11 (2005) 601-602
67. Lin X., and Wang D. The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling. Semin. Immunol. 16 (2004) 429-435
68. Linden A., Laan M., and Anderson G. Neutrophils, interleukin-17A and lung disease. Eur. Respir. J. 25 (2005) 159-172
69. Liu X., Lin X., and Gaffen S.L. Crucial role for nuclear factor of activated T cells (NFAT) in T cell receptor-mediated regulation of the human interleukin-17 gene. J. Biol. Chem. 279 (2004) 52762-52771
70. Liu X.K., Clements J.L., and Gaffen S.L. Signaling through the murine T cell receptor induces IL-17 production in the absence of costimulation, IL-23 or dendritic cells. Mol. Cells 20 (2005) 329-337
71. Lubberts E., van den Bersselaar L., Oppers-Walgreen B., Schwarzenberger P., Coenen-de Roo C.J., Kolls J.K., Joosten L.A., and van den Berg W.B. IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance. J. Immunol. 170 (2003) 2655-2662
72. Lubberts E., Koenders M.I., and van den Berg W.B. The role of T cell interleukin-17 in conducting destructive arthritis: Lessons from animal models. Arthritis Res. Ther. 7 (2005) 29-37
73. Lubberts E., Schwarzenberger P., Huang W., Schurr J.R., Peschon J.J., van den Berg W.B., and Kolls J.K. Requirement of IL-17 receptor signaling in radiation-resistant cells in the joint for full progression of destructive synovitis. J. Immunol. 175 (2005) 3360-3368
74. Maertzdorf J., Osterhaus A.D., and Verjans G.M. IL-17 expression in human herpetic stromal keratitis: Modulatory effects on chemokine production by corneal fibroblasts. J. Immunol. 169 (2002) 5897-5903
75. Maggio E., van den Berg A., Diepstra A., Kluiver J., Visser L., and Poppema S. Chemokines, cytokines and their receptors in Hodgkin's lymphoma cell lines and tissues. Ann. Oncol. 13 Suppl. 1 (2002) 52-56
76. H17 lineage. Nature 441 (2006) 231-234
77. Martel-Pelletier J., Mineau F., Jovanovic D., Di Battista J.A., and Pelletier J.P. Mitogen-activated protein kinase and nuclear factor kappaB together regulate interleukin-17-induced nitric oxide production in human osteoarthritic chondrocytes: Possible role of transactivating factor mitogen-activated protein kinase-activated protein kinase (MAPKAPK). Arthritis Rheum. 42 (1999) 2399-2409
78. Matusevicius D., Kivisakk P., He B., Kostulas N., Ozenci V., Fredrikson S., and Link H. Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult. Scler. 5 (1999) 101-104
79. McAllister F., Henry A., Kreindler J.L., Dubin P.J., Ulrich L., Steele C., Finder J.D., Pilewski J.M., Carreno B.M., Goldman S.J., Pirhonen J., and Kolls J.K. Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: Implications for airway inflammation in cystic fibrosis. J. Immunol. 175 (2005) 404-412
80. Miljkovic D., and Trajkovic V. Inducible nitric oxide synthase activation by interleukin-17. Cytokine Growth Factor Rev. 15 (2004) 21-32
81. Miljkovic D., Cvetkovic I., Momcilovic M., Maksimovic-Ivanic D., Stosic-Grujicic S., and Trajkovic V. Interleukin-17 stimulates inducible nitric oxide synthase-dependent toxicity in mouse beta cells. Cell. Mol. Life Sci 62 (2005) 2658-2668
82. Miossec P. Interleukin-17 in rheumatoid arthritis: If T cells were to contribute to inflammation and destruction through synergy. Arthritis Rheum. 48 (2003) 594-601
83. Moseley T.A., Haudenschild D.R., Rose L., and Reddi A.H. Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev. 14 (2003) 155-174
84. Nakae S., Nambu A., Sudo K., and Iwakura Y. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J. Immunol 171 (2003) 6173-6177
85. Nakae S., Saijo S., Horai R., Sudo K., Mori S., and Iwakura Y. IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc. Natl. Acad. Sci. USA 100 (2003) 5986-5990
86. Novatchkova M., Leibbrandt A., Werzowa J., Neubuser A., and Eisenhaber F. The STIR-domain superfamily in signal transduction, development and immunity. Trends Biochem. Sci. 28 (2003) 226-229
87. Numasaki M., Fukushi J., Ono M., Narula S.K., Zavodny P.J., Kudo T., Robbins P.D., Tahara H., and Lotze M.T. Interleukin-17 promotes angiogenesis and tumor growth. Blood 101 (2003) 2620-2627
88. Numasaki M., Watanabe M., Suzuki T., Takahashi H., Nakamura A., McAllister F., Hishinuma T., Goto J., Lotze M.T., Kolls J.K., and Sasaki H. IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J. Immunol. 175 (2005) 6177-6189
89. Owyang A., Schmitz J., McClanahan T., Artis D., Kastelein R., and Cua D. IL-25 is required for the regulation of autoimmunity and immunity to parasites. Paper presented at Keystone Symposia: Cytokines, Disease and Therapeutic Intervention (2005) (Santa Fe, NM)
90. Ozaki K., and Leonard W.J. Cytokine and cytokine receptor pleiotropy and redundancy. J. Biol. Chem. 277 (2002) 29355-29358
91. Pan G., French D., Mao W., Maruoka M., Risser P., Lee J., Foster J., Aggarwal S., Nicholes K., Guillet S., Schow P., and Gurney A.L. Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice. J. Immunol. 167 (2001) 6559-6567
92. Pancer Z., Mayer W.E., Klein J., and Cooper M.D. Prototypic T cell receptor and CD4-like coreceptor are expressed by lymphocytes in the agnathan sea lamprey. Proc. Natl. Acad. Sci. USA 101 (2004) 13273-13278
93. Park H., Li Z., Yang X.O., Chang S.H., Nurieva R., Wang Y.H., Wang Y., Hood L., Zhu Z., Tian Q., and Dong C. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6 (2005) 1133-1141
94. Piwien Pilipuk G., Galigniana M.D., and Schwartz J. Subnuclear localization of C/EBP beta is regulated by growth hormone and dependent on MAPK. J. Biol. Chem. 278 (2003) 35668-35677
95. Prause O., Bozinovski S., Anderson G.P., and Linden A. Increased matrix metalloproteinase-9 concentration and activity after stimulation with interleukin-17 in mouse airways. Thorax 59 (2004) 313-317
96. Pullen S.S., Dang T.T., Crute J.J., and Kehry M.R. CD40 signaling through tumor necrosis factor receptor-associated factors (TRAFs). Binding site specificity and activation of downstream pathways by distinct TRAFs. J. Biol. Chem. 274 (1999) 14246-14254
97. Ramji D.P., and Foka P. CCAAT/enhancer-binding proteins: Structure, function and regulation. Biochem. J. 365 (2002) 561-575
98. Remy I., Wilson I.A., and Michnick S.W. Erythropietin receptor activation by a ligand-induced conformation change. Science 283 (1999) 990-993
99. Rouvier E., Luciani M.-F., Mattei M.-G., Denizot F., and Golstein P. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a Herpesvirus Saimiri gene. J. Immunol. 150 (1993) 5445-5456
100. Ruddy M.J., Shen F., Smith J., Sharma A., and Gaffen S.L. Interleukin-17 regulates expression of the CXC chemokine LIX/CXCL5 in osteoblasts: Implications for inflammation and neutrophil recruitment. J. Leukoc. Biol. 76 (2004) 135-144
101. Ruddy M.J., Wong G.C., Liu X.K., Yamamoto H., Kasayama S., Kirkwood K.L., and Gaffen S.L. Functional cooperation between interleukin-17 and tumor necrosis factor-α is mediated by CCAAT/enhancer-binding protein family members. J. Biol. Chem. 279 (2004) 2559-2567
102. Rutitzky L.I., Lopes da Rosa J.R., and Stadecker M.J. Severe CD4 T cell-mediated immunopathology in murine schistosomiasis is dependent on IL-12p40 and correlates with high levels of IL-17. J. Immunol. 175 (2005) 3920-3926
103. Samardzic T., Jankovic V., Stosic-Grujicic S., and Trajkovic V. STAT1 is required for iNOS activation, but not IL-6 production in murine fibroblasts. Cytokine 13 (2001) 179-182
104. Schwandner R., Yamaguchi K., and Cao Z. Requirement of tumor necrosis factor-associated factor (TRAF) 6 in interleukin 17 signal transduction. J. Exp. Med. 191 (2000) 1233-1239
105. Schwarzenberger P., La Russa V., Miller A., Ye P., Huang W., Zieske A., Nelson S., Bagby G.J., Stoltz D., Mynatt R.L., Spriggs M., and Kolls J.K. IL-17 stimulates granulopoiesis in mice: Use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines. J. Immunol. 161 (1998) 6383-6389
106. Shalom-Barak T., Quach J., and Lotz M. Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB. J. Biol. Chem. 273 (1998) 27467-27473
107. Shen F., Ruddy M.J., Plamondon P., and Gaffen S.L. Cytokines link osteoblasts and inflammation: Microarray analysis of interleukin-17- and TNF-alpha-induced genes in bone cells. J. Leukoc. Biol. 77 (2005) 388-399
108. Shen F., Hu Z., Goswami J., and Gaffen S.L. Identification of common transcriptional regulatory elements in interleukin-17 target gene. J. Biol. Chem. (2005) in press
109. Shi Y., Ullrich S.J., Zhang J., Connolly K., Grzegorzewski K.J., Barber M.C., Wang W., Wathen K., Hodge V., Fisher C.L., Olsen H., Ruben S.M., et al. A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity. J. Biol. Chem. 275 (2000) 19167-19176
110. Shimada M., Andoh A., Hata K., Tasaki K., Araki Y., Fujiyama Y., and Bamba T. IL-6 secretion by human pancreatic periacinar myofibroblasts in response to inflammatory mediators. J. Immunol. 168 (2002) 861-868
111. Shin H.C., Benbernou N., Esnault S., and Guenounou M. Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway. Cytokine 11 (1999) 257-266
112. Stark M.A., Huo Y., Burcin T.L., Morris M.A., Olson T.S., and Ley K. Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity 22 (2005) 285-294
113. Starnes T., Broxmeyer H.E., Robertson M.J., and Hromas R. Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis. J. Immunol. 169 (2002) 642-646
114. Steiner G.E., Newman M.E., Paikl D., Stix U., Memaran-Dagda N., Lee C., and Marberger M.J. Expression and function of pro-inflammatory interleukin IL-17 and IL-17 receptor in normal, benign hyperplastic, and malignant prostate. Prostate 56 (2003) 171-182
115. Subramaniam S.V., Cooper R.S., and Adunyah S.E. Evidence for the involvement of JAK/STAT pathway in the signaling mechanism of interleukin-17. Biochem. Biophys. Res. Commun. 262 (1999) 14-19
116. Takahashi K., Azuma T., Motohira H., Kinane D.F., and Kitetsu S. The potential role of interleukin-17 in the immunopathology of periodontal disease. J. Clin. Periodontol. 32 (2005) 369-374
117. Tang Q.Q., Gronborg M., Huang H., Kim J.W., Otto T.C., Pandey A., and Lane M.D. Sequential phosphorylation of CCAAT enhancer-binding protein beta by MAPK and glycogen synthase kinase 3beta is required for adipogenesis. Proc. Natl. Acad. Sci. USA 102 (2005) 9766-9771
118. Tartour E., Fossiez F., Joyeux I., Galinha A., Gey A., Claret E., Sastre-Garau X., Couturier J., Mosseri V., Vives V., Banchereau J., Fridman W.H., et al. Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice. Cancer Res. 59 (1999) 3698-3704
119. Teunissen M.B., Koomen C.W., de Waal Malefyt R., Wierenga E.A., and Bos J.D. Interleukin-17 and interferon-γ synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. J. Invest. Dermatol. 111 (1998) 645-649
120. Tian E., Sawyer J.R., Largaespada D.A., Jenkins N.A., Copeland N.G., and Shaughnessy J.D. Evi27 encodes a novel membrane protein with homology to the IL-17 receptor. Oncogene 19 (2000) 2098-2109
121. Tokuda H., Kanno Y., Ishisaki A., Takenaka M., Harada A., and Kozawa O. Interleukin (IL)-17 enhances tumor necrosis factor-alpha-stimulated IL-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts. J. Cell. Biochem. 91 (2004) 1053-1061
122. Toy D., Kugler D., Wolfson M., Bos T.V., Gurgel J., Tocker J., and Peschon J. Cutting Edge: IL-17 signals through a heteromeric receptor complex. J. Immunol. 117 (2006) 136-139
123. Trajkovic V., Stosic-Grujicic S., Samardzic T., Markovic M., Miljkovic D., Ramic Z., and Mostarica Stojkovic M. Interleukin-17 stimulates inducible nitric oxide synthase activation in rodent astrocytes. J. Neuroimmunol. 119 (2001) 183-191
124. Tsang M., and Dawid I. Promotion and attenuation of FGF signaling through the Ras-MAPK pathway. Sci. STKE 228 (2004) PE17
125. Tsang M., Friesel R., Kudoh T., and Dawid I. Identification of Sef, a novel modulator of FGF signalling. Nat. Cell. Biol. 4 (2002) 165-169
126. Van Bezooijen R.L., Farih-Sips H.C.M., Papapoulos S.E., and Löwik C.W.G.M. Interleukin-17: A new bone acting cytokine in vitro. J. Bone Min. Res. 14 (1999) 1513-1521
127. Van Bezooijen R.L., Van Der Wee-Pals L., Papapoulos S.E., and Lowik C.W. Interleukin 17 synergises with tumour necrosis factor alpha to induce cartilage destruction in vitro. Ann. Rheum. Dis. 61 (2002) 870-876
128. Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., and Stockinger B. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 (2006) 179-189
129. Wong C.K., Ho C.Y., Li E.K., and Lam C.W. Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus. Lupus 9 (2000) 589-593
130. Wynn T.A. T(H)-17: A giant step from T(H)1 and T(H)2. Nat. Immunol. 6 (2005) 1069-1070
131. Xiong S., Zhao Q., Rong Z., Huang G., Huang Y., Chen P., Zhang S., Liu L., and Chang Z. hSef inhibits PC-12 cell differentiation by interfering with Ras-mitogen-activated protein kinase MAPK signaling. J. Biol. Chem. 278 (2003) 50273-50282
132. Yamada T., Tsuchiya T., Osada S., Nishihara T., and Imagawa M. CCAAT/enhancer-binding protein δ gene expression is mediated by autoregulation through downstream binding sites. Biochem. Biophys. Res. Commun. 242 (1998) 88-92
133. Yang R.B., Ng C.K., Wasserman S.M., Komuves L.G., Gerritsen M.E., and Topper J.N. A novel interleukin-17 receptor-like protein identified in human umbilical vein endothelial cells antagonizes basic fibroblast growth factor-induced signaling. J. Biol. Chem. 278 (2003) 33232-33238
134. Yao Z., Fanslow W.C., Seldin M.F., Rousseau A.-M., Painter S.L., Comeau M.R., Cohen J.I., and Spriggs M.K. Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 3 (1995) 811-821
135. Yao Z., Spriggs M.K., Derry J.M.J., Strockbine L., Park L.S., VandenBos T., Zappone J., Painter S.L., and Armitage R.J. Molecular characterization of the human interleukin-17 receptor. Cytokine 9 (1997) 794-800
136. Ye P., Rodriguez F.H., Kanaly S., Stocking K.L., Schurr J., Schwarzenberger P., Oliver P., Huang W., Zhang P., Zhang J., Shellito J.E., Bagby G.J., et al. Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J. Exp. Med. 194 (2001) 519-527
137. Yen D., Cheung J., Scheeres H., Poulet F., McClanahan T., Mckenzie B., Kleinschek M.A., Owyang A., Mattson J., Blumenschein W., Murphy E., Sathe M., Cua D.J., Kastelein R.A., and Rennick D. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J. Clin. Invest. 116 (2006) 1310-1316
138. Zhang Z., Andoh A., Yasui H., Inatomi O., Hata K., Tsujikawa T., Kitoh K., Takayanagi A., Shimizu N., and Fujiyama Y. Interleukin-1beta and tumor necrosis factor-alpha upregulate interleukin-23 subunit p19 gene expression in human colonic subepithelial myofibroblasts. Int. J. Mol. Med. 15 (2005) 79-83
139. Ziolkowska M., Koc A., Luszczukiewicz G., Ksiezopolksa-Pietrzak K., Klimczak E., Chwalinska-Sadowska H., and Maslinski W. High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism. J. Immunol. 164 (2000) 2832-2838