-
1
-
-
0035142665
-
Activation of Stat proteins and growth control
-
Concise overview of the role of Stats in proliferation and growth control, •
-
Bromberg JF. Activation of Stat proteins and growth control. BioEssays 23, 161-169 (2001). • Concise overview of the role of Stats in proliferation and growth control.
-
(2001)
BioEssays
, vol.23
, pp. 161-169
-
-
Bromberg, J.F.1
-
2
-
-
0028234529
-
Jak-STAT pathway and transcriptional activation in response to IFNs and other extracellular signaling proteins
-
Darnell JE Jr, Kerr IM, Stark GR. Jak-STAT pathway and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264(5164), 1415-1421 (1994).
-
(1994)
Science
, vol.264
, Issue.5164
, pp. 1415-1421
-
-
Darnell Jr, J.E.1
Kerr, I.M.2
Stark, G.R.3
-
3
-
-
0033976059
-
The Jak-Stat pathway in normal and perturbed hematopoiesis
-
Ward AC, Touw I, Yoshimura A. The Jak-Stat pathway in normal and perturbed hematopoiesis. Blood 95(1), 19-29 (2000).
-
(2000)
Blood
, vol.95
, Issue.1
, pp. 19-29
-
-
Ward, A.C.1
Touw, I.2
Yoshimura, A.3
-
4
-
-
33846903838
-
-
O'Sullivan LA, Liongue C, Lewis RS, Stephenson SE, Ward AC. Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease. Mol. Immunol. 44(10), 2497-2506 (2007). • Recent comprehensive review of the role of the Jak-Stat-Socs pathway in cytokine signaling and disease
-
O'Sullivan LA, Liongue C, Lewis RS, Stephenson SE, Ward AC. Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease. Mol. Immunol. 44(10), 2497-2506 (2007). • Recent comprehensive review of the role of the Jak-Stat-Socs pathway in cytokine signaling and disease
-
-
-
-
5
-
-
0034801684
-
SOCS proteins: Negative regulators of cytokine signaling
-
Krebs DL, Hilton DJ. SOCS proteins: negative regulators of cytokine signaling. Stem Cells 19(5), 378-387 (2001).
-
(2001)
Stem Cells
, vol.19
, Issue.5
, pp. 378-387
-
-
Krebs, D.L.1
Hilton, D.J.2
-
6
-
-
1542493212
-
Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases
-
Hanada T, Kinjyo I, Inagaki-Ohara K, Yoshimura A. Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases. Rev. Physiol. Biochem. Pharmacol. 149, 72-86 (2003).
-
(2003)
Rev. Physiol. Biochem. Pharmacol
, vol.149
, pp. 72-86
-
-
Hanada, T.1
Kinjyo, I.2
Inagaki-Ohara, K.3
Yoshimura, A.4
-
7
-
-
13044263097
-
The conserved Socs box motif in suppressors of cytokine signalling binds to elongins B and C and may couple bound proteins to proteasomal degradation
-
Zhang JG, Farley A, Nicholson SE et al. The conserved Socs box motif in suppressors of cytokine signalling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc. Natl Acad. Sci. USA 96, 2071-2076 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 2071-2076
-
-
Zhang, J.G.1
Farley, A.2
Nicholson, S.E.3
-
8
-
-
0029157421
-
Distribution of the mammalian Stat gene family in mouse chromosomes
-
Copeland NG, Gilbert DJ, Schindler C et al. Distribution of the mammalian Stat gene family in mouse chromosomes. Genomics 29, 225-228 (1995).
-
(1995)
Genomics
, vol.29
, pp. 225-228
-
-
Copeland, N.G.1
Gilbert, D.J.2
Schindler, C.3
-
9
-
-
0027993605
-
Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription
-
Gouilleux F, Wakao H, Mundt M, Groner B. Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. EMBO J. 13(18), 4361-4369 (1994).
-
(1994)
EMBO J
, vol.13
, Issue.18
, pp. 4361-4369
-
-
Gouilleux, F.1
Wakao, H.2
Mundt, M.3
Groner, B.4
-
10
-
-
0030052617
-
Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets
-
Miyakawa Y, Oda A, Druker BJ et al. Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets. Blood 87, 439-446 (1996).
-
(1996)
Blood
, vol.87
, pp. 439-446
-
-
Miyakawa, Y.1
Oda, A.2
Druker, B.J.3
-
11
-
-
0029010473
-
Thrombopoietin activates a STAT5-like factor in hematopoietic cells
-
Pallard C, Gouilleux F, Benit L et al. Thrombopoietin activates a STAT5-like factor in hematopoietic cells. EMBO J. 14, 2847-2856 (1995).
-
(1995)
EMBO J
, vol.14
, pp. 2847-2856
-
-
Pallard, C.1
Gouilleux, F.2
Benit, L.3
-
12
-
-
0030929322
-
Stat5 activation correlates with erythropoietin receptor-mediated erythroid differentiation of an erythroleukemia cell line
-
Iwatsuki K, Endo T, Misawa H et al. Stat5 activation correlates with erythropoietin receptor-mediated erythroid differentiation of an erythroleukemia cell line. J. Biol. Chem. 272, 8149-8152 (1997).
-
(1997)
J. Biol. Chem
, vol.272
, pp. 8149-8152
-
-
Iwatsuki, K.1
Endo, T.2
Misawa, H.3
-
13
-
-
0029758109
-
Differential activation of Stat3 and Stat5 by distinct regions of the growth hormone receptor
-
Sotiropoulos A, Moutoussamy S, Renaudie F et al. Differential activation of Stat3 and Stat5 by distinct regions of the growth hormone receptor. Mol. Endocrinol. 10, 998-1009 (1996).
-
(1996)
Mol. Endocrinol
, vol.10
, pp. 998-1009
-
-
Sotiropoulos, A.1
Moutoussamy, S.2
Renaudie, F.3
-
15
-
-
0035400054
-
Cutting edge: The common γ-chain is an indispensable subunit of the IL-21 receptor complex
-
Asao H, Okuyama C, Kumaki S et al. Cutting edge: the common γ-chain is an indispensable subunit of the IL-21 receptor complex. J. Immunol. 167(1), 1-5 (2001).
-
(2001)
J. Immunol
, vol.167
, Issue.1
, pp. 1-5
-
-
Asao, H.1
Okuyama, C.2
Kumaki, S.3
-
16
-
-
0037138370
-
-
Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW. Signaling through the JAK/STAT pathway: recent advances and future challenges. Gene 285, 1-24 (2002). • Comprehensive analysis of the Jak-Stat literature.
-
Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW. Signaling through the JAK/STAT pathway: recent advances and future challenges. Gene 285, 1-24 (2002). • Comprehensive analysis of the Jak-Stat literature.
-
-
-
-
17
-
-
0030916177
-
Signaling of type II oncostatin M receptor
-
Auguste P, Guillet C, Fourcin M et al. Signaling of type II oncostatin M receptor. J. Biol. Chem. 272(25), 15760-15764 (1997).
-
(1997)
J. Biol. Chem
, vol.272
, Issue.25
, pp. 15760-15764
-
-
Auguste, P.1
Guillet, C.2
Fourcin, M.3
-
18
-
-
4143150831
-
Characterization of the signaling capacities of the novel gp130-like cytokine receptor
-
Dreuw A, Radtke S, Pflanz S, Lippok BE, Heinrich PC, Hermanns HM. Characterization of the signaling capacities of the novel gp130-like cytokine receptor. J. Biol. Chem. 279(34), 36112-36120 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, Issue.34
, pp. 36112-36120
-
-
Dreuw, A.1
Radtke, S.2
Pflanz, S.3
Lippok, B.E.4
Heinrich, P.C.5
Hermanns, H.M.6
-
19
-
-
0034882530
-
Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation
-
Quentmeier H, Drexler HG, Fleckenstein D et al. Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. Leukemia 15(8), 1286-1292 (2001).
-
(2001)
Leukemia
, vol.15
, Issue.8
, pp. 1286-1292
-
-
Quentmeier, H.1
Drexler, H.G.2
Fleckenstein, D.3
-
20
-
-
0034657336
-
The role of STATs in transcriptional control and their impact on cellular function
-
Bromberg J, Darnell JE Jr. The role of STATs in transcriptional control and their impact on cellular function. Oncogene 19(21), 2468-2473 (2000).
-
(2000)
Oncogene
, vol.19
, Issue.21
, pp. 2468-2473
-
-
Bromberg, J.1
Darnell Jr., J.E.2
-
21
-
-
18844480398
-
Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21WAF/CIP1 by Stat5
-
Matsumura I, Ishikawa J, Nakajima K et al. Thrombopoietin-induced differentiation of a human megakaryoblastic leukemia cell line, CMK, involves transcriptional activation of p21WAF/CIP1 by Stat5. Mol. Cell. Biol. 17, 2933-2943 (1997).
-
(1997)
Mol. Cell. Biol
, vol.17
, pp. 2933-2943
-
-
Matsumura, I.1
Ishikawa, J.2
Nakajima, K.3
-
22
-
-
0344629668
-
STAT5 and Oct-1 form a stable complex that modulates cyclin D1 expression
-
Magne S, Caron S, Charon M, Rouyez M, Dusanter-Fourt I. STAT5 and Oct-1 form a stable complex that modulates cyclin D1 expression. Mol. Cell. Biol. 23, 8934-8945 (2003).
-
(2003)
Mol. Cell. Biol
, vol.23
, pp. 8934-8945
-
-
Magne, S.1
Caron, S.2
Charon, M.3
Rouyez, M.4
Dusanter-Fourt, I.5
-
23
-
-
33745621927
-
Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells
-
Tomita M, Kawakami H, Uchihara JN et al. Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells. Retrovirology 3, 22 (2006).
-
(2006)
Retrovirology
, vol.3
, pp. 22
-
-
Tomita, M.1
Kawakami, H.2
Uchihara, J.N.3
-
24
-
-
0037034858
-
Activation of STAT5 triggers proliferation and contributes to anti-apoptotic signalling mediated by the oncogenic Xmrk kinase
-
Morcinek JC, Weisser C, Geissinger E, Schartl M, Wellbrock C. Activation of STAT5 triggers proliferation and contributes to anti-apoptotic signalling mediated by the oncogenic Xmrk kinase. Oncogene 21(11), 1668-1678 (2002).
-
(2002)
Oncogene
, vol.21
, Issue.11
, pp. 1668-1678
-
-
Morcinek, J.C.1
Weisser, C.2
Geissinger, E.3
Schartl, M.4
Wellbrock, C.5
-
25
-
-
21644458365
-
Anti-apoptotic role of STAT5 in haematopoietic cells and in the pathogenesis of malignancies
-
Debierre-Grockiego F. Anti-apoptotic role of STAT5 in haematopoietic cells and in the pathogenesis of malignancies. Apoptosis 9(6), 717-728 (2004).
-
(2004)
Apoptosis
, vol.9
, Issue.6
, pp. 717-728
-
-
Debierre-Grockiego, F.1
-
26
-
-
0033595087
-
IL-3 dependent regulation of Bcl-xL gene expression by STAT5 in a bone marrow derived cell line
-
Dumon S, Santos SC, Debierre-Grockiego F et al. IL-3 dependent regulation of Bcl-xL gene expression by STAT5 in a bone marrow derived cell line. Oncogene 18(29), 4191-4199 (1999).
-
(1999)
Oncogene
, vol.18
, Issue.29
, pp. 4191-4199
-
-
Dumon, S.1
Santos, S.C.2
Debierre-Grockiego, F.3
-
27
-
-
0034163579
-
The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2, and bcl-x genes through the trans-activation domain of Stat5
-
Lord JD, McIntosh BC, Greenberg PD, Nelson BH. The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2, and bcl-x genes through the trans-activation domain of Stat5. J. Immunol. 164(5), 2533-2541 (2000).
-
(2000)
J. Immunol
, vol.164
, Issue.5
, pp. 2533-2541
-
-
Lord, J.D.1
McIntosh, B.C.2
Greenberg, P.D.3
Nelson, B.H.4
-
28
-
-
1242272047
-
A permissive role for phosphatidylinositol 3-kinase in the Stat5-mediated expression of cyclin D2 by the interleukin-2 receptor
-
Moon JJ, Rubio ED, Martino A, Krumm A, Nelson BH. A permissive role for phosphatidylinositol 3-kinase in the Stat5-mediated expression of cyclin D2 by the interleukin-2 receptor. J. Biol. Chem. 279(7), 5520-5527 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, Issue.7
, pp. 5520-5527
-
-
Moon, J.J.1
Rubio, E.D.2
Martino, A.3
Krumm, A.4
Nelson, B.H.5
-
29
-
-
35548981401
-
Human telomerase is regulated by erythropoietin and transforming growth factor-β in human erythroid progenitor cells
-
Prade-Houdellier N, Frebet E, Demur C et al. Human telomerase is regulated by erythropoietin and transforming growth factor-β in human erythroid progenitor cells. Leukemia 21(11), 2304-2310 (2007).
-
(2007)
Leukemia
, vol.21
, Issue.11
, pp. 2304-2310
-
-
Prade-Houdellier, N.1
Frebet, E.2
Demur, C.3
-
30
-
-
0031057929
-
Stat5a is mandatory for adult mammary gland development and lactogenesis
-
Liu X, Robinson GW, Wagner K-U, Garrett L, Wynshaw-Boris A, Hennighausen L. Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev. 11, 179-186 (1997).
-
(1997)
Genes Dev
, vol.11
, pp. 179-186
-
-
Liu, X.1
Robinson, G.W.2
Wagner, K.-U.3
Garrett, L.4
Wynshaw-Boris, A.5
Hennighausen, L.6
-
31
-
-
0000943469
-
Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
-
Teglund S, McKay C, Schuetz E et al. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 93, 841-850 (1998).
-
(1998)
Cell
, vol.93
, pp. 841-850
-
-
Teglund, S.1
McKay, C.2
Schuetz, E.3
-
32
-
-
0030930196
-
STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression
-
Feldman GM, Rosenthal LA, Liu X et al. STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression. Blood 90, 1768-1776 (1997).
-
(1997)
Blood
, vol.90
, pp. 1768-1776
-
-
Feldman, G.M.1
Rosenthal, L.A.2
Liu, X.3
-
33
-
-
0031433362
-
An indirect effect of Stat5a in IL-2-induced proliferation: A critical role for Stat5a in IL-2-mediated IL-2 receptor α chain induction
-
Nakajima H, Liu XW, Wynshaw-Boris A et al. An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor α chain induction. Immunity 7, 691-701 (1997).
-
(1997)
Immunity
, vol.7
, pp. 691-701
-
-
Nakajima, H.1
Liu, X.W.2
Wynshaw-Boris, A.3
-
34
-
-
0030833570
-
Requirement of Stat5b for sexual dimorphism of body growth rates and liver gene expression
-
Udy GB, Towers RP, Snell RG et al. Requirement of Stat5b for sexual dimorphism of body growth rates and liver gene expression. Proc. Natl Acad. Sci. USA 94, 7239-7244 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 7239-7244
-
-
Udy, G.B.1
Towers, R.P.2
Snell, R.G.3
-
35
-
-
0029032210
-
Intermittent plasma growth hormone triggers tyrosine phosphorylation and nuclear translocation of a liver-expressed, Stat 5-related DNA binding protein. Proposed role as an intracellular regulator of male-specific liver gene transcription
-
Waxman DJ, Ram PA, Park SH, Choi HK. Intermittent plasma growth hormone triggers tyrosine phosphorylation and nuclear translocation of a liver-expressed, Stat 5-related DNA binding protein. Proposed role as an intracellular regulator of male-specific liver gene transcription. J. Biol. Chem. 270(22), 13262-13270 (1995).
-
(1995)
J. Biol. Chem
, vol.270
, Issue.22
, pp. 13262-13270
-
-
Waxman, D.J.1
Ram, P.A.2
Park, S.H.3
Choi, H.K.4
-
36
-
-
0033082138
-
Stat5 is required for IL-2 induced cell cycle progression of peripheral T cells
-
Moriggl R, Topham DJ, Teglund S et al. Stat5 is required for IL-2 induced cell cycle progression of peripheral T cells. Immunity 10, 249-259 (1999).
-
(1999)
Immunity
, vol.10
, pp. 249-259
-
-
Moriggl, R.1
Topham, D.J.2
Teglund, S.3
-
37
-
-
0031774896
-
Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity
-
Imada K, Bloom ET, Nakajima K et al. Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity. J. Exp. Med. 188, 2067-2074 (1998).
-
(1998)
J. Exp. Med
, vol.188
, pp. 2067-2074
-
-
Imada, K.1
Bloom, E.T.2
Nakajima, K.3
-
38
-
-
0034665676
-
Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but ABL- and BCR/ABL-induced transformation are independent of Stat5
-
Sexl V, Piekorz R, Moriggl R et al. Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but ABL- and BCR/ABL-induced transformation are independent of Stat5. Blood 96(6), 2277-2283 (2000).
-
(2000)
Blood
, vol.96
, Issue.6
, pp. 2277-2283
-
-
Sexl, V.1
Piekorz, R.2
Moriggl, R.3
-
39
-
-
32244444750
-
-
Yao Z, Cui Y, Watford WT et al. Stat5a/b are essential for normal lymphoid development and differentiation. Proc. Natl Acad. Sci. USA 104, 1000-1004 (2006). • Informative paper, which has provided tremendous new insights into the requirement of Stat5 in vivo.
-
Yao Z, Cui Y, Watford WT et al. Stat5a/b are essential for normal lymphoid development and differentiation. Proc. Natl Acad. Sci. USA 104, 1000-1004 (2006). • Informative paper, which has provided tremendous new insights into the requirement of Stat5 in vivo.
-
-
-
-
40
-
-
33745111882
-
Clarifying the role of Stat5 in lymphoid development and Abelson induced transformation
-
Hoelbl A, Kovavic B, Kerenyi MA et al. Clarifying the role of Stat5 in lymphoid development and Abelson induced transformation. Blood 107, 4898-4906 (2006).
-
(2006)
Blood
, vol.107
, pp. 4898-4906
-
-
Hoelbl, A.1
Kovavic, B.2
Kerenyi, M.A.3
-
41
-
-
0036251154
-
Stat proteins and oncogenesis
-
Bromberg JF. Stat proteins and oncogenesis. J. Clin. Invest. 109, 1139-1142 (2002).
-
(2002)
J. Clin. Invest
, vol.109
, pp. 1139-1142
-
-
Bromberg, J.F.1
-
42
-
-
0038820386
-
Signal transducer and activator of transcription proteins in leukemias
-
Well-written review on the role of Stats in hematological malignancy, •
-
Benekli M, Baer MR, Baumann H, Wetzler M. Signal transducer and activator of transcription proteins in leukemias. Blood 101(8), 2940-2954 (2003). • Well-written review on the role of Stats in hematological malignancy.
-
(2003)
Blood
, vol.101
, Issue.8
, pp. 2940-2954
-
-
Benekli, M.1
Baer, M.R.2
Baumann, H.3
Wetzler, M.4
-
43
-
-
0034660463
-
Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6
-
Schuringa JJ, Wierenga AT, Kruijer W, Vellenga E. Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6. Blood 95(12), 3765-3770 (2000).
-
(2000)
Blood
, vol.95
, Issue.12
, pp. 3765-3770
-
-
Schuringa, J.J.1
Wierenga, A.T.2
Kruijer, W.3
Vellenga, E.4
-
44
-
-
33846620183
-
Bone marrow phospho-STAT5 expression in non-CML chronic myeloproliferative disorders correlates with JAK2 V617F mutation and provides evidence of in vivo JAK2 activation
-
Aboudola S, Murugesan G, Szpurka H et al. Bone marrow phospho-STAT5 expression in non-CML chronic myeloproliferative disorders correlates with JAK2 V617F mutation and provides evidence of in vivo JAK2 activation. Am. J. Surg. Pathol. 31(2), 233-239 (2007).
-
(2007)
Am. J. Surg. Pathol
, vol.31
, Issue.2
, pp. 233-239
-
-
Aboudola, S.1
Murugesan, G.2
Szpurka, H.3
-
45
-
-
34247354963
-
Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage
-
Cain JA, Xiang Z, O'Neal J et al. Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage. Blood 109(9), 3906-3914 (2007).
-
(2007)
Blood
, vol.109
, Issue.9
, pp. 3906-3914
-
-
Cain, J.A.1
Xiang, Z.2
O'Neal, J.3
-
46
-
-
0001639195
-
Some speculations on the myeloproliferative syndromes
-
Dameshek W. Some speculations on the myeloproliferative syndromes. Blood 6(4), 372-375 (1951).
-
(1951)
Blood
, vol.6
, Issue.4
, pp. 372-375
-
-
Dameshek, W.1
-
47
-
-
17844383458
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
James C, Ugo V, Le Couedic JP et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 434(7037), 1144-1148 (2005).
-
(2005)
Nature
, vol.434
, Issue.7037
, pp. 1144-1148
-
-
James, C.1
Ugo, V.2
Le Couedic, J.P.3
-
48
-
-
17644424955
-
A gain-of-function mutation of JAK2 in myeloproliferative disorders
-
Kralovics R, Passamonti F, Buser AS et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N. Engl. J. Med. 352(17), 1779-1790 (2005).
-
(2005)
N. Engl. J. Med
, vol.352
, Issue.17
, pp. 1779-1790
-
-
Kralovics, R.1
Passamonti, F.2
Buser, A.S.3
-
49
-
-
0035902180
-
Oncogenic kinase signalling
-
Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature 411, 355-365 (2001).
-
(2001)
Nature
, vol.411
, pp. 355-365
-
-
Blume-Jensen, P.1
Hunter, T.2
-
50
-
-
0029784886
-
Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines
-
Definitive study on the specific activation of Stats in primary patient samples, •
-
Weber-Nordt RM, Egen C, Wehinger J et al. Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines. Blood 88(3), 809-816 (1996). • Definitive study on the specific activation of Stats in primary patient samples.
-
(1996)
Blood
, vol.88
, Issue.3
, pp. 809-816
-
-
Weber-Nordt, R.M.1
Egen, C.2
Wehinger, J.3
-
51
-
-
13344279401
-
STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients
-
Gouilleux-Gruart V, Gouilleux F, Desaint C et al. STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood 87(5), 1692-1697 (1996).
-
(1996)
Blood
, vol.87
, Issue.5
, pp. 1692-1697
-
-
Gouilleux-Gruart, V.1
Gouilleux, F.2
Desaint, C.3
-
52
-
-
0037838661
-
Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells
-
Spiekermann K, Bagrintseva K, Schwab R, Schmieja K, Hiddemann W. Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells. Clin. Cancer Res. 9(6), 2140-2150 (2003).
-
(2003)
Clin. Cancer Res
, vol.9
, Issue.6
, pp. 2140-2150
-
-
Spiekermann, K.1
Bagrintseva, K.2
Schwab, R.3
Schmieja, K.4
Hiddemann, W.5
-
53
-
-
0142219889
-
Constitutive activation of Stat5b contributes to carcinogenesis in vivo
-
Xi S, Zhang Q, Gooding WE, Smithgall TE, Grandis JR. Constitutive activation of Stat5b contributes to carcinogenesis in vivo. Cancer Res. 63, 6763-6771 (2003).
-
(2003)
Cancer Res
, vol.63
, pp. 6763-6771
-
-
Xi, S.1
Zhang, Q.2
Gooding, W.E.3
Smithgall, T.E.4
Grandis, J.R.5
-
54
-
-
2542619062
-
The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells
-
Baskiewicz-Masiuk M, Machalinski B. The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells. Eur. J. Haematol. 72, 420-429 (2004).
-
(2004)
Eur. J. Haematol
, vol.72
, pp. 420-429
-
-
Baskiewicz-Masiuk, M.1
Machalinski, B.2
-
55
-
-
14644425319
-
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia
-
Ren R. Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat. Rev. Cancer 5(3), 172-183 (2005).
-
(2005)
Nat. Rev. Cancer
, vol.5
, Issue.3
, pp. 172-183
-
-
Ren, R.1
-
57
-
-
0027368352
-
BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein
-
Pendergast AM, Quilliam LA, Cripe LD et al. BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. Cell 75(1), 175-185 (1993).
-
(1993)
Cell
, vol.75
, Issue.1
, pp. 175-185
-
-
Pendergast, A.M.1
Quilliam, L.A.2
Cripe, L.D.3
-
58
-
-
0030710188
-
Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway
-
Skorski T, Bellacosa A, Nieborowska-Skorska M et al. Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway. EMBO J. 16(20), 6151-6161 (1997).
-
(1997)
EMBO J
, vol.16
, Issue.20
, pp. 6151-6161
-
-
Skorski, T.1
Bellacosa, A.2
Nieborowska-Skorska, M.3
-
59
-
-
0000506439
-
P210 and P190 (Bcr-Abl) induce the tyrosine phsophorylation and DNA binding activity of multiple specific STAT family members
-
Ilaria R, Jr. Van Etten RA. P210 and P190 (Bcr-Abl) induce the tyrosine phsophorylation and DNA binding activity of multiple specific STAT family members. J. Biol. Chem. 271, 31701-31710 (1996).
-
(1996)
J. Biol. Chem
, vol.271
, pp. 31701-31710
-
-
Ilaria Jr, R.1
Van Etten, R.A.2
-
60
-
-
0029810923
-
Constitutive activation of Stat5 by the Bcr-Abl oncogene in chronic myelogenous leukemia
-
Shuai K, Halpern J, ten Hoeve J, Rao X, Sawyers CL. Constitutive activation of Stat5 by the Bcr-Abl oncogene in chronic myelogenous leukemia. Oncogene 13, 247-254 (1996).
-
(1996)
Oncogene
, vol.13
, pp. 247-254
-
-
Shuai, K.1
Halpern, J.2
ten Hoeve, J.3
Rao, X.4
Sawyers, C.L.5
-
61
-
-
18544372618
-
Functional cooperation among Ras, STAT5, and phosphatidylinositol 3-kinase is required for full oncogenic activities of BCR/ABL in K562 cells
-
Sonoyama J, Matsumura I, Ezoe S et al. Functional cooperation among Ras, STAT5, and phosphatidylinositol 3-kinase is required for full oncogenic activities of BCR/ABL in K562 cells. J. Biol. Chem. 277(10), 8076-8082 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, Issue.10
, pp. 8076-8082
-
-
Sonoyama, J.1
Matsumura, I.2
Ezoe, S.3
-
62
-
-
0037069942
-
Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells
-
Huang M, Dorsey JF, Epling-Burnette PK et al. Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells. Oncogene 21(57), 8804-8816 (2002).
-
(2002)
Oncogene
, vol.21
, Issue.57
, pp. 8804-8816
-
-
Huang, M.1
Dorsey, J.F.2
Epling-Burnette, P.K.3
-
63
-
-
0034653929
-
STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells
-
Sillaber C, Gesbert F, Frank DA, Sattler M, Griffin JD. STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells. Blood 95(6), 2118-2125 (2000).
-
(2000)
Blood
, vol.95
, Issue.6
, pp. 2118-2125
-
-
Sillaber, C.1
Gesbert, F.2
Frank, D.A.3
Sattler, M.4
Griffin, J.D.5
-
64
-
-
33745057158
-
STAT5 signaling is required for the efficient induction and maintenance of CML in mice
-
Ye D, Wolff N, Li L, Zhang S, Ilaria RL Jr. STAT5 signaling is required for the efficient induction and maintenance of CML in mice. Blood 107(12), 4917-4925 (2006).
-
(2006)
Blood
, vol.107
, Issue.12
, pp. 4917-4925
-
-
Ye, D.1
Wolff, N.2
Li, L.3
Zhang, S.4
Ilaria Jr, R.L.5
-
65
-
-
33746139407
-
Janus kinase 2: A critical target in chronic myelogenous leukemia
-
Samanta AK, Lin H, Sun T, Kantarjian H, Arlinghaus RB. Janus kinase 2: a critical target in chronic myelogenous leukemia. Cancer Res. 66(13), 6468-6472 (2006).
-
(2006)
Cancer Res
, vol.66
, Issue.13
, pp. 6468-6472
-
-
Samanta, A.K.1
Lin, H.2
Sun, T.3
Kantarjian, H.4
Arlinghaus, R.B.5
-
66
-
-
15444339209
-
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
-
Lacronique V, Boureux A, Valle VD et al. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 278(5341), 1309-1312 (1997).
-
(1997)
Science
, vol.278
, Issue.5341
, pp. 1309-1312
-
-
Lacronique, V.1
Boureux, A.2
Valle, V.D.3
-
67
-
-
0030852328
-
-
Peeters P, Raynaud SD, Cools J et al. Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase Jak2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood 90(7), 2535-2540 (1997).
-
Peeters P, Raynaud SD, Cools J et al. Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase Jak2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood 90(7), 2535-2540 (1997).
-
-
-
-
68
-
-
0032530972
-
Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes
-
Schwaller J, Frantsve J, Aster J et al. Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes. EMBO J. 17(18), 5321-5333 (1998).
-
(1998)
EMBO J
, vol.17
, Issue.18
, pp. 5321-5333
-
-
Schwaller, J.1
Frantsve, J.2
Aster, J.3
-
69
-
-
0344517071
-
Fusion of the ets transcription factor TEL to Jak2 results in constitutive Jak-Stat signaling
-
Ho JM, Beattie BK, Squire JA, Frank DA, Barber DL. Fusion of the ets transcription factor TEL to Jak2 results in constitutive Jak-Stat signaling. Blood 93(12), 4354-4364 (1999).
-
(1999)
Blood
, vol.93
, Issue.12
, pp. 4354-4364
-
-
Ho, J.M.1
Beattie, B.K.2
Squire, J.A.3
Frank, D.A.4
Barber, D.L.5
-
70
-
-
0034660270
-
TEL-JAK2 transgenic mice develop T-cell leukemia
-
Carron C, Cormier F, Janin A et al. TEL-JAK2 transgenic mice develop T-cell leukemia. Blood 95(12), 3891-3899 (2000).
-
(2000)
Blood
, vol.95
, Issue.12
, pp. 3891-3899
-
-
Carron, C.1
Cormier, F.2
Janin, A.3
-
71
-
-
0035542766
-
The TEL/PDGFβR fusion in chronic myelomonocytic leukemia signals through STAT5-dependent and STAT5-independent pathways
-
Sternberg DW, Tomasson MH, Carroll M et al. The TEL/PDGFβR fusion in chronic myelomonocytic leukemia signals through STAT5-dependent and STAT5-independent pathways. Blood 98(12), 3390-3397 (2001).
-
(2001)
Blood
, vol.98
, Issue.12
, pp. 3390-3397
-
-
Sternberg, D.W.1
Tomasson, M.H.2
Carroll, M.3
-
72
-
-
0033639119
-
Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2
-
Schwaller J, Parganas E, Wang D et al. Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2. Mol. Cell. 6, 693-704 (2000).
-
(2000)
Mol. Cell
, vol.6
, pp. 693-704
-
-
Schwaller, J.1
Parganas, E.2
Wang, D.3
-
73
-
-
34347401419
-
Activation mechanisms of STAT5 by oncogenic Flt3-ITD
-
Choudhary C, Brandts C, Schwable J et al. Activation mechanisms of STAT5 by oncogenic Flt3-ITD. Blood 110(1), 370-374 (2007).
-
(2007)
Blood
, vol.110
, Issue.1
, pp. 370-374
-
-
Choudhary, C.1
Brandts, C.2
Schwable, J.3
-
74
-
-
0032867588
-
The signal transducer and activator of transcription Stat5b gene is a new partner of retinoic acid receptor α in acute promyelocytic leukemia
-
Arnould C, Phillipe C, Bourdon V, Gregoire MJ, Berger R, Jonveaux P. The signal transducer and activator of transcription Stat5b gene is a new partner of retinoic acid receptor α in acute promyelocytic leukemia. Hum. Mol. Genet. 8, 1741-1749 (1999).
-
(1999)
Hum. Mol. Genet
, vol.8
, pp. 1741-1749
-
-
Arnould, C.1
Phillipe, C.2
Bourdon, V.3
Gregoire, M.J.4
Berger, R.5
Jonveaux, P.6
-
75
-
-
0037088996
-
Interactions of Stat5b-RAR α, a novel promyelocytic leukemia fusion protein, with retinoic acid receptor and Stat3 signaling pathways
-
Dong S, Tweardy DJ. Interactions of Stat5b-RAR α, a novel promyelocytic leukemia fusion protein, with retinoic acid receptor and Stat3 signaling pathways. Blood 99, 2637-2646 (2002).
-
(2002)
Blood
, vol.99
, pp. 2637-2646
-
-
Dong, S.1
Tweardy, D.J.2
-
76
-
-
0029794132
-
A decade of molecular biology of retinoic acid receptors
-
Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J. 10(9), 940-954 (1996).
-
(1996)
FASEB J
, vol.10
, Issue.9
, pp. 940-954
-
-
Chambon, P.1
-
77
-
-
0038546657
-
SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia
-
Chen CY, Tsay W, Tang JL et al. SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia. Genes Chromosomes Cancer 37(3), 300-305 (2003).
-
(2003)
Genes Chromosomes Cancer
, vol.37
, Issue.3
, pp. 300-305
-
-
Chen, C.Y.1
Tsay, W.2
Tang, J.L.3
-
78
-
-
0344530291
-
Epigenetic alteration of the SOCS1 gene in chronic myeloid leukaemia
-
Liu TC, Lin SF, Chang JG, Yang MY, Hung SY, Chang CS. Epigenetic alteration of the SOCS1 gene in chronic myeloid leukaemia. Br. J. Haematol. 123(4), 654-661 (2003).
-
(2003)
Br. J. Haematol
, vol.123
, Issue.4
, pp. 654-661
-
-
Liu, T.C.1
Lin, S.F.2
Chang, J.G.3
Yang, M.Y.4
Hung, S.Y.5
Chang, C.S.6
-
79
-
-
35948966315
-
STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression
-
Zhang Q, Wang HY, Liu X, Wasik MA. STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression. Nat. Med. 13(11), 1341-1348 (2007).
-
(2007)
Nat. Med
, vol.13
, Issue.11
, pp. 1341-1348
-
-
Zhang, Q.1
Wang, H.Y.2
Liu, X.3
Wasik, M.A.4
-
80
-
-
0037088997
-
The Stat5-RARα fusion protein represses transcription and differentiation through interaction with a corepressor complex
-
Maurer AB, Wichmann C, Gross A et al. The Stat5-RARα fusion protein represses transcription and differentiation through interaction with a corepressor complex. Blood 99(8), 2647-2652 (2002).
-
(2002)
Blood
, vol.99
, Issue.8
, pp. 2647-2652
-
-
Maurer, A.B.1
Wichmann, C.2
Gross, A.3
-
81
-
-
0037114625
-
Polycythemia vera: Myths, mechanisms, and management
-
Spivak JL. Polycythemia vera: myths, mechanisms, and management. Blood 100(13), 4272-4290 (2002).
-
(2002)
Blood
, vol.100
, Issue.13
, pp. 4272-4290
-
-
Spivak, J.L.1
-
82
-
-
0016391236
-
Letter: Bone-marrow responses in polycythemia vera
-
Prchal JF, Axelrad AA. Letter: bone-marrow responses in polycythemia vera. N. Engl. J. Med. 290(24), 1382 (1974).
-
(1974)
N. Engl. J. Med
, vol.290
, Issue.24
, pp. 1382
-
-
Prchal, J.F.1
Axelrad, A.A.2
-
83
-
-
2542454747
-
PRV-1 mRNA expression discriminates two types of essential thrombocythemia
-
Griesshammer M, Klippel S, Strunck E et al. PRV-1 mRNA expression discriminates two types of essential thrombocythemia. Ann. Hematol. 83(6), 364-370 (2004).
-
(2004)
Ann. Hematol
, vol.83
, Issue.6
, pp. 364-370
-
-
Griesshammer, M.1
Klippel, S.2
Strunck, E.3
-
84
-
-
33344471678
-
V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis
-
Campbell PJ, Griesshammer M, Dohner K et al. V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis. Blood 107(5), 2098-2100 (2006).
-
(2006)
Blood
, vol.107
, Issue.5
, pp. 2098-2100
-
-
Campbell, P.J.1
Griesshammer, M.2
Dohner, K.3
-
85
-
-
33645400695
-
X-inactivation-based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis
-
Levine RL, Belisle C, Wadleigh M et al. X-inactivation-based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis. Blood 107(10), 4139-4141 (2006).
-
(2006)
Blood
, vol.107
, Issue.10
, pp. 4139-4141
-
-
Levine, R.L.1
Belisle, C.2
Wadleigh, M.3
-
86
-
-
34548714666
-
The gain-of-function JAK2 V617F mutation shifts the phenotype of essential thrombocythemia and chronic idiopathic myelofibrosis to more "erythremic" and less "thrombocythemic": A molecular, histologic, and clinical study
-
Rudzki Z, Sacha T, Stoj A et al. The gain-of-function JAK2 V617F mutation shifts the phenotype of essential thrombocythemia and chronic idiopathic myelofibrosis to more "erythremic" and less "thrombocythemic": a molecular, histologic, and clinical study. Int. J. Hematol. 86(2), 130-136 (2007).
-
(2007)
Int. J. Hematol
, vol.86
, Issue.2
, pp. 130-136
-
-
Rudzki, Z.1
Sacha, T.2
Stoj, A.3
-
87
-
-
20244369569
-
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
-
Levine RL, Wadleigh M, Cools J et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 7(4), 387-397 (2005).
-
(2005)
Cancer Cell
, vol.7
, Issue.4
, pp. 387-397
-
-
Levine, R.L.1
Wadleigh, M.2
Cools, J.3
-
88
-
-
20144363192
-
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
-
Baxter EJ, Scott LM, Campbell PJ et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 365(9464), 1054-1061 (2005).
-
(2005)
Lancet
, vol.365
, Issue.9464
, pp. 1054-1061
-
-
Baxter, E.J.1
Scott, L.M.2
Campbell, P.J.3
-
89
-
-
0034012330
-
Regulation of the Jak2 tyrosine kinase by its pseudokinase domain
-
Saharinen P, Takaluoma K, Silvennoinen O. Regulation of the Jak2 tyrosine kinase by its pseudokinase domain. Mol. Cell. Biol. 20(10), 3387-3395 (2000).
-
(2000)
Mol. Cell. Biol
, vol.20
, Issue.10
, pp. 3387-3395
-
-
Saharinen, P.1
Takaluoma, K.2
Silvennoinen, O.3
-
90
-
-
33846921639
-
The role of the granulocyte colony-stimulating factor receptor (G-CSF-R) in disease
-
Ward AC. The role of the granulocyte colony-stimulating factor receptor (G-CSF-R) in disease. Front. Biosci. 12, 608-618 (2007).
-
(2007)
Front. Biosci
, vol.12
, pp. 608-618
-
-
Ward, A.C.1
-
91
-
-
33751226932
-
Multiple pathways contribute to the hyperproliferative responses from truncated granulocyte colony-stimulating factor receptors
-
Gits J, van Leeuwen D, Carroll HP, Touw IP, Ward AC. Multiple pathways contribute to the hyperproliferative responses from truncated granulocyte colony-stimulating factor receptors. Leukemia 20(12), 2111-2118 (2006).
-
(2006)
Leukemia
, vol.20
, Issue.12
, pp. 2111-2118
-
-
Gits, J.1
van Leeuwen, D.2
Carroll, H.P.3
Touw, I.P.4
Ward, A.C.5
-
92
-
-
0025885417
-
Autosomal dominant erythrocytosis caused by increased sensitivity to erythropoietin
-
Juvonen E, Ikkala E, Fyhrquist F, Ruutu T. Autosomal dominant erythrocytosis caused by increased sensitivity to erythropoietin. Blood 78(11), 3066-3069 (1991).
-
(1991)
Blood
, vol.78
, Issue.11
, pp. 3066-3069
-
-
Juvonen, E.1
Ikkala, E.2
Fyhrquist, F.3
Ruutu, T.4
-
93
-
-
0022217637
-
Autosomal dominant polycythemia
-
Prchal JT, Crist WM, Goldwasser E, Perrine G, Prchal JF. Autosomal dominant polycythemia. Blood 66(5), 1208-1214 (1985).
-
(1985)
Blood
, vol.66
, Issue.5
, pp. 1208-1214
-
-
Prchal, J.T.1
Crist, W.M.2
Goldwasser, E.3
Perrine, G.4
Prchal, J.F.5
-
94
-
-
0035106628
-
Pathogenetic mechanisms of polycythemia vera and congenital polycythemic disorders
-
Prchal JT. Pathogenetic mechanisms of polycythemia vera and congenital polycythemic disorders. Semin. Hematol. 38(1 Suppl. 2), 10-20 (2001).
-
(2001)
Semin. Hematol
, vol.38
, Issue.1 SUPPL. 2
, pp. 10-20
-
-
Prchal, J.T.1
-
95
-
-
0033050680
-
A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation
-
Arcasoy MO, Harris KW, Forget BG. A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation. Exp. Hematol. 27(1), 63-74 (1999).
-
(1999)
Exp. Hematol
, vol.27
, Issue.1
, pp. 63-74
-
-
Arcasoy, M.O.1
Harris, K.W.2
Forget, B.G.3
-
96
-
-
33746437130
-
MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
-
Pikman Y, Lee BH, Mercher T et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med. 3(7), e270 (2006).
-
(2006)
PLoS Med
, vol.3
, Issue.7
-
-
Pikman, Y.1
Lee, B.H.2
Mercher, T.3
-
97
-
-
1342304116
-
Critical role of STAT5 activation in transformation mediated by ZNF198-FGFR1
-
Heath C, Cross NC. Critical role of STAT5 activation in transformation mediated by ZNF198-FGFR1. J. Biol. Chem. 279(8), 6666-6673 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, Issue.8
, pp. 6666-6673
-
-
Heath, C.1
Cross, N.C.2
-
98
-
-
0036202064
-
The 8p11 myeloproliferative syndrome: A distinct clinical entity caused by constitutive activation of FGFR1
-
Macdonald D, Reiter A, Cross NC. The 8p11 myeloproliferative syndrome: a distinct clinical entity caused by constitutive activation of FGFR1. Acta. Haematol. 107(2), 101-107 (2002).
-
(2002)
Acta. Haematol
, vol.107
, Issue.2
, pp. 101-107
-
-
Macdonald, D.1
Reiter, A.2
Cross, N.C.3
-
99
-
-
17344373285
-
FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome
-
Xiao S, Nalabolu SR, Aster JC et al. FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome. Nat. Genet. 18(1), 84-87 (1998).
-
(1998)
Nat. Genet
, vol.18
, Issue.1
, pp. 84-87
-
-
Xiao, S.1
Nalabolu, S.R.2
Aster, J.C.3
-
100
-
-
0032170974
-
Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome
-
Reiter A, Sohal J, Kulkarni S et al. Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome. Blood 92(5), 1735-1742 (1998).
-
(1998)
Blood
, vol.92
, Issue.5
, pp. 1735-1742
-
-
Reiter, A.1
Sohal, J.2
Kulkarni, S.3
-
101
-
-
0033206227
-
ZNF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS 1 and 5
-
Smedley D, Demiroglu A, Abdul-Rauf M et al. ZNF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS 1 and 5. Neoplasia 1(4), 349-355 (1999).
-
(1999)
Neoplasia
, vol.1
, Issue.4
, pp. 349-355
-
-
Smedley, D.1
Demiroglu, A.2
Abdul-Rauf, M.3
-
102
-
-
0344987881
-
A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome
-
Cools J, DeAngelo DJ, Gotlib J et al. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N. Engl. J. Med. 348(13), 1201-1214 (2003).
-
(2003)
N. Engl. J. Med
, vol.348
, Issue.13
, pp. 1201-1214
-
-
Cools, J.1
DeAngelo, D.J.2
Gotlib, J.3
-
103
-
-
33750609891
-
Newly identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and rapamycin
-
Corbacioglu S, Kilic M, Westhoff MA, Reinhardt D, Fulda S, Debatin KM. Newly identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and rapamycin. Blood 108(10), 3504-3513 (2006).
-
(2006)
Blood
, vol.108
, Issue.10
, pp. 3504-3513
-
-
Corbacioglu, S.1
Kilic, M.2
Westhoff, M.A.3
Reinhardt, D.4
Fulda, S.5
Debatin, K.M.6
-
104
-
-
19944431828
-
-
Moriggl R, Sexl V, Kenner L et al. Stat5 tetramer formation is associated with leukemogenesis. Cancer Cell 7, 87-99 (2005). • Important study on the mechanisms underlying pathogenesis mediated via Stat5.
-
Moriggl R, Sexl V, Kenner L et al. Stat5 tetramer formation is associated with leukemogenesis. Cancer Cell 7, 87-99 (2005). • Important study on the mechanisms underlying pathogenesis mediated via Stat5.
-
-
-
-
105
-
-
31844435122
-
Constitutively-active zebrafish stat5 expands hematopoietic cell populations in vivo
-
Lewis RS, Stephenson SEM, Ward AC. Constitutively-active zebrafish stat5 expands hematopoietic cell populations in vivo. Exp. Hematol. 34, 179-187 (2006).
-
(2006)
Exp. Hematol
, vol.34
, pp. 179-187
-
-
Lewis, R.S.1
Stephenson, S.E.M.2
Ward, A.C.3
-
106
-
-
22344444393
-
Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis
-
Kato T, Iwama A, Tadokoro Y et al. Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis. J. Exp. Med. 202, 169-179 (2005).
-
(2005)
J. Exp. Med
, vol.202
, pp. 169-179
-
-
Kato, T.1
Iwama, A.2
Tadokoro, Y.3
-
107
-
-
33947267129
-
Constitutive activation of Flt3 and STAT5A enhances self-renewal and alters differentiation of hematopoietic stem cells
-
Moore MA, Dorn DC, Schuringa JJ, Chung KY, Morrone G. Constitutive activation of Flt3 and STAT5A enhances self-renewal and alters differentiation of hematopoietic stem cells. Exp. Hematol. 35(4 Suppl. 1), 105-116 (2007).
-
(2007)
Exp. Hematol
, vol.35
, Issue.4 SUPPL. 1
, pp. 105-116
-
-
Moore, M.A.1
Dorn, D.C.2
Schuringa, J.J.3
Chung, K.Y.4
Morrone, G.5
-
108
-
-
85117738201
-
-
Schepers H, van Gosliga D, Wierenga AT, Eggen BJ, Schuringa JJ, Vellenga E. STAT5 is required for long-term maintenance of normal and leukemic human stem/progenitor cells. Blood 110(8), 2880-2888 (2007). • Key paper providing compelling evidence for the role of Stat5 in leukemia.
-
Schepers H, van Gosliga D, Wierenga AT, Eggen BJ, Schuringa JJ, Vellenga E. STAT5 is required for long-term maintenance of normal and leukemic human stem/progenitor cells. Blood 110(8), 2880-2888 (2007). • Key paper providing compelling evidence for the role of Stat5 in leukemia.
-
-
-
-
109
-
-
33746859330
-
Constitutive STAT5 activation specifically cooperates with the loss of p53 function in B-cell lymphomagenesis
-
Joliot V, Cormier F, Medyouf H, Alcalde H, Ghysdael J. Constitutive STAT5 activation specifically cooperates with the loss of p53 function in B-cell lymphomagenesis. Oncogene 25(33), 4573-4584 (2006).
-
(2006)
Oncogene
, vol.25
, Issue.33
, pp. 4573-4584
-
-
Joliot, V.1
Cormier, F.2
Medyouf, H.3
Alcalde, H.4
Ghysdael, J.5
-
110
-
-
34548492241
-
Tyrosine-phosphorylated STAT5 accumulates on podosomes in Hck-transformed fibroblasts and chronic myeloid leukemia cells
-
Poincloux R, Cougoule C, Daubon T, Maridonneau-Parini I, Le Cabec V. Tyrosine-phosphorylated STAT5 accumulates on podosomes in Hck-transformed fibroblasts and chronic myeloid leukemia cells. J. Cell. Physiol. 213(1), 212-220 (2007).
-
(2007)
J. Cell. Physiol
, vol.213
, Issue.1
, pp. 212-220
-
-
Poincloux, R.1
Cougoule, C.2
Daubon, T.3
Maridonneau-Parini, I.4
Le Cabec, V.5
-
111
-
-
33846927933
-
Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias
-
Harir N, Pecquet C, Kerenyi M et al. Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias. Blood 109(4), 1678-1686 (2007).
-
(2007)
Blood
, vol.109
, Issue.4
, pp. 1678-1686
-
-
Harir, N.1
Pecquet, C.2
Kerenyi, M.3
-
112
-
-
38149004467
-
STAT5 is essential for Akt/p70S6 kinase activity during IL-2-induced lymphocyte proliferation
-
Lockyer HM, Tran E, Nelson BH. STAT5 is essential for Akt/p70S6 kinase activity during IL-2-induced lymphocyte proliferation. J. Immunol. 179(8), 5301-5308 (2007).
-
(2007)
J. Immunol
, vol.179
, Issue.8
, pp. 5301-5308
-
-
Lockyer, H.M.1
Tran, E.2
Nelson, B.H.3
-
113
-
-
0036635291
-
Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug
-
Capdeville R, Buchdunger E, Zimmermann J, Matter A. Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug. Nat. Rev. Drug Discov. 1(7), 493-502 (2002).
-
(2002)
Nat. Rev. Drug Discov
, vol.1
, Issue.7
, pp. 493-502
-
-
Capdeville, R.1
Buchdunger, E.2
Zimmermann, J.3
Matter, A.4
-
114
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
Druker BJ, Tamura S, Buchdunger E et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat. Med. 2(5), 561-566 (1996).
-
(1996)
Nat. Med
, vol.2
, Issue.5
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
-
115
-
-
34248166041
-
Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells
-
Nam S, Williams A, Vultur A et al. Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells. Mol. Cancer Ther. 6(4), 1400-1405 (2007).
-
(2007)
Mol. Cancer Ther
, vol.6
, Issue.4
, pp. 1400-1405
-
-
Nam, S.1
Williams, A.2
Vultur, A.3
-
116
-
-
34548412863
-
+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation
-
+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation. Mol. Pharmacol. 72(3), 788-795 (2007).
-
(2007)
Mol. Pharmacol
, vol.72
, Issue.3
, pp. 788-795
-
-
Rahmani, M.1
Nguyen, T.K.2
Dent, P.3
Grant, S.4
-
117
-
-
26944483583
-
Human leukemias with mutated FLT3 kinase are synergistically sensitive to FLT3 and Hsp90 inhibitors: The key role of the STAT5 signal transduction pathway
-
Yao Q, Nishiuchi R, Kitamura T, Kersey JH. Human leukemias with mutated FLT3 kinase are synergistically sensitive to FLT3 and Hsp90 inhibitors: the key role of the STAT5 signal transduction pathway. Leukemia 19(9), 1605-1612 (2005).
-
(2005)
Leukemia
, vol.19
, Issue.9
, pp. 1605-1612
-
-
Yao, Q.1
Nishiuchi, R.2
Kitamura, T.3
Kersey, J.H.4
-
118
-
-
33845582907
-
Downregulation of VEGF-A, STAT5 and AKT in acute myeloid leukemia blasts of patients treated with SU5416
-
Loges S, Tinnefeld H, Metzner A et al. Downregulation of VEGF-A, STAT5 and AKT in acute myeloid leukemia blasts of patients treated with SU5416. Leuk. Lymphoma 47(12), 2601-2609 (2006).
-
(2006)
Leuk. Lymphoma
, vol.47
, Issue.12
, pp. 2601-2609
-
-
Loges, S.1
Tinnefeld, H.2
Metzner, A.3
-
119
-
-
22144455380
-
Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412
-
Growney JD, Clark JJ, Adelsperger J et al. Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412. Blood 106(2), 721-724 (2005).
-
(2005)
Blood
, vol.106
, Issue.2
, pp. 721-724
-
-
Growney, J.D.1
Clark, J.J.2
Adelsperger, J.3
-
120
-
-
29644438937
-
Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemia
-
Rajasingh J, Raikwar HP, Muthian G, Johnson C, Bright JJ. Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemia. Biochem. Biophys. Res. Commun. 340(2), 359-368 (2006).
-
(2006)
Biochem. Biophys. Res. Commun
, vol.340
, Issue.2
, pp. 359-368
-
-
Rajasingh, J.1
Raikwar, H.P.2
Muthian, G.3
Johnson, C.4
Bright, J.J.5
-
121
-
-
0034665713
-
Structural mechanism for STI-571 inhibition of abelson tyrosine kinase
-
Schindler T, Bornmann W, Pellicena P, Miller WT, Clarkson B, Kuriyan J. Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. Science 289(5486), 1938-1942 (2000).
-
(2000)
Science
, vol.289
, Issue.5486
, pp. 1938-1942
-
-
Schindler, T.1
Bornmann, W.2
Pellicena, P.3
Miller, W.T.4
Clarkson, B.5
Kuriyan, J.6
-
122
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker BJ, Talpaz M, Resta DJ et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N. Engl. J. Med. 344(14), 1031-1037 (2001).
-
(2001)
N. Engl. J. Med
, vol.344
, Issue.14
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
-
123
-
-
0035810142
-
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
-
Druker BJ, Sawyers CL, Kantarjian H et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N. Engl. J. Med. 344(14), 1038-1042 (2001).
-
(2001)
N. Engl. J. Med
, vol.344
, Issue.14
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
-
124
-
-
0030031766
-
Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative
-
Buchdunger E, Zimmermann J, Mett H et al. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res. 56(1), 100-104 (1996).
-
(1996)
Cancer Res
, vol.56
, Issue.1
, pp. 100-104
-
-
Buchdunger, E.1
Zimmermann, J.2
Mett, H.3
-
125
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
Gorre ME, Mohammed M, Ellwood K et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293(5531), 876-880 (2001).
-
(2001)
Science
, vol.293
, Issue.5531
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
-
126
-
-
0036566540
-
High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
-
Branford S, Rudzki Z, Walsh S et al. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood 99(9), 3472-3475 (2002).
-
(2002)
Blood
, vol.99
, Issue.9
, pp. 3472-3475
-
-
Branford, S.1
Rudzki, Z.2
Walsh, S.3
-
127
-
-
13844251975
-
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
-
Weisberg E, Manley PW, Breitenstein W et al. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell 7(2), 129-141 (2005).
-
(2005)
Cancer Cell
, vol.7
, Issue.2
, pp. 129-141
-
-
Weisberg, E.1
Manley, P.W.2
Breitenstein, W.3
-
128
-
-
3142676436
-
Overriding imatinib resistance with a novel ABL kinase inhibitor
-
Shah NP, Tran C, Lee FY, Chen P, Norris D, Sawyers CL. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 305(5682), 399-401 (2004).
-
(2004)
Science
, vol.305
, Issue.5682
, pp. 399-401
-
-
Shah, N.P.1
Tran, C.2
Lee, F.Y.3
Chen, P.4
Norris, D.5
Sawyers, C.L.6
-
129
-
-
13844261144
-
A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance
-
Gumireddy K, Baker SJ, Cosenza SC et al. A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance. Proc. Natl Acad. Sci. USA 102(6), 1992-1997 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, Issue.6
, pp. 1992-1997
-
-
Gumireddy, K.1
Baker, S.J.2
Cosenza, S.C.3
-
130
-
-
30144436273
-
The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor
-
Lucet IS, Fantino E, Styles M et al. The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor. Blood 107(1), 176-183 (2006).
-
(2006)
Blood
, vol.107
, Issue.1
, pp. 176-183
-
-
Lucet, I.S.1
Fantino, E.2
Styles, M.3
-
131
-
-
23044495944
-
Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog
-
Boggon TJ, Li Y, Manley PW, Eck MJ. Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog. Blood 106(3), 996-1002 (2005).
-
(2005)
Blood
, vol.106
, Issue.3
, pp. 996-1002
-
-
Boggon, T.J.1
Li, Y.2
Manley, P.W.3
Eck, M.J.4
-
132
-
-
38149123436
-
JAK2 inhibitor therapy in myeloproliferative disorders: Rationale, preclinical studies and ongoing clinical trials
-
Pardanani A. JAK2 inhibitor therapy in myeloproliferative disorders: rationale, preclinical studies and ongoing clinical trials. Leukemia, (2007).
-
(2007)
Leukemia
-
-
Pardanani, A.1
-
133
-
-
33847407174
-
+ progenitors via JAK-2/STAT-5 pathway activation
-
+ progenitors via JAK-2/STAT-5 pathway activation. Blood 109(5), 2147-2155 (2007).
-
(2007)
Blood
, vol.109
, Issue.5
, pp. 2147-2155
-
-
Wang, Y.1
Cai, D.2
Brendel, C.3
-
134
-
-
33645745233
-
Enhanced sensitivity to inhibition of SHP2, STAT5, and Gab2 expression in chronic myeloid leukemia (CML)
-
Scherr M, Chaturvedi A, Battmer K et al. Enhanced sensitivity to inhibition of SHP2, STAT5, and Gab2 expression in chronic myeloid leukemia (CML). Blood 107(8), 3279-3287 (2006).
-
(2006)
Blood
, vol.107
, Issue.8
, pp. 3279-3287
-
-
Scherr, M.1
Chaturvedi, A.2
Battmer, K.3
-
135
-
-
33749515476
-
Targeting of CD44 eradicates human acute myeloid leukemic stem cells
-
Jin L, Hope KJ, Zhai Q, Smadja-Joffe F, Dick JE. Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat. Med. 12(10), 1167-1174 (2006).
-
(2006)
Nat. Med
, vol.12
, Issue.10
, pp. 1167-1174
-
-
Jin, L.1
Hope, K.J.2
Zhai, Q.3
Smadja-Joffe, F.4
Dick, J.E.5
-
136
-
-
33749521890
-
Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells
-
Krause DS, Lazarides K, von Andrian UH, Van Etten RA. Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells. Nat. Med. 12(10), 1175-1180 (2006).
-
(2006)
Nat. Med
, vol.12
, Issue.10
, pp. 1175-1180
-
-
Krause, D.S.1
Lazarides, K.2
von Andrian, U.H.3
Van Etten, R.A.4
-
137
-
-
0025990893
-
Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia
-
Klein B, Wijdenes J, Zhang XG et al. Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia. Blood 78(5), 1198-1204 (1991).
-
(1991)
Blood
, vol.78
, Issue.5
, pp. 1198-1204
-
-
Klein, B.1
Wijdenes, J.2
Zhang, X.G.3
-
138
-
-
20344385768
-
Combination therapy with interleukin-6 receptor superantagonist Sant7 and dexamethasone induces antitumor effects in a novel SCID-hu in vivo model of human multiple myeloma
-
Tassone P, Neri P, Burger R et al. Combination therapy with interleukin-6 receptor superantagonist Sant7 and dexamethasone induces antitumor effects in a novel SCID-hu in vivo model of human multiple myeloma. Clin. Cancer Res. 11(11), 4251-4258 (2005).
-
(2005)
Clin. Cancer Res
, vol.11
, Issue.11
, pp. 4251-4258
-
-
Tassone, P.1
Neri, P.2
Burger, R.3
-
139
-
-
0035068530
-
Gp130 and ras mediated signaling in human plasma cell line INA-6: A cytokine-regulated tumor model for plasmacytoma
-
Burger R, Guenther A, Bakker F et al. Gp130 and ras mediated signaling in human plasma cell line INA-6: a cytokine-regulated tumor model for plasmacytoma. Hematol. J. 2(1), 42-53 (2001).
-
(2001)
Hematol. J
, vol.2
, Issue.1
, pp. 42-53
-
-
Burger, R.1
Guenther, A.2
Bakker, F.3
-
140
-
-
0027502201
-
Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth
-
Sato K, Tsuchiya M, Saldanha J et al. Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth. Cancer Res. 53(4), 851-856 (1993).
-
(1993)
Cancer Res
, vol.53
, Issue.4
, pp. 851-856
-
-
Sato, K.1
Tsuchiya, M.2
Saldanha, J.3
-
141
-
-
23644442893
-
Tocilizumab inhibits signal transduction mediated by both mIL-6R and sIL-6R, but not by the receptors of other members of IL-6 cytokine family
-
Mihara M, Kasutani K, Okazaki M et al. Tocilizumab inhibits signal transduction mediated by both mIL-6R and sIL-6R, but not by the receptors of other members of IL-6 cytokine family. Int. Immunopharmacol. 5(12), 1731-1740 (2005).
-
(2005)
Int. Immunopharmacol
, vol.5
, Issue.12
, pp. 1731-1740
-
-
Mihara, M.1
Kasutani, K.2
Okazaki, M.3
-
142
-
-
0035977055
-
Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation
-
Turkson J, Ryan D, Kim JS et al. Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. J. Biol. Chem. 276(48), 45443-45455 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, Issue.48
, pp. 45443-45455
-
-
Turkson, J.1
Ryan, D.2
Kim, J.S.3
-
143
-
-
0037294154
-
Identification of a high-affinity phosphopeptide inhibitor of Stat3
-
Ren Z, Cabell LA, Schaefer TS, McMurray JS. Identification of a high-affinity phosphopeptide inhibitor of Stat3. Bioorg. Med. Chem. Lett. 13(4), 633-636 (2003).
-
(2003)
Bioorg. Med. Chem. Lett
, vol.13
, Issue.4
, pp. 633-636
-
-
Ren, Z.1
Cabell, L.A.2
Schaefer, T.S.3
McMurray, J.S.4
-
144
-
-
20844444135
-
-
Jing N, Tweardy DJ. Targeting Stat3 in cancer therapy. Anticancer Drugs 16(6), 601-607 (2005). • Useful review highlighting current strategies of targeting Stat3 in cancer therapy.
-
Jing N, Tweardy DJ. Targeting Stat3 in cancer therapy. Anticancer Drugs 16(6), 601-607 (2005). • Useful review highlighting current strategies of targeting Stat3 in cancer therapy.
-
-
-
|