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Volumn 5, Issue 7, 2006, Pages 714-717

Tumor suppression by p53 without accelerated aging: Just enough of a good thing?

Author keywords

Aging; Cancer therapy; Chemoprevention; Mdm2; p53; Tumor suppression

Indexed keywords

PROTEIN INHIBITOR; PROTEIN MDM2; PROTEIN MDM2 INHIBITOR; PROTEIN P53; REGULATOR PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

EID: 33645711615     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.5.7.2632     Document Type: Review
Times cited : (14)

References (33)
  • 1
    • 0028834902 scopus 로고
    • Rescue of embryonic lethality in MDM2-deficient mice by absence of p53
    • Jones SJ, Roe AE, Donehower LA, Bradley A. Rescue of embryonic lethality in MDM2-deficient mice by absence of p53. Nature 1995; 378:206-208.
    • (1995) Nature , vol.378 , pp. 206-208
    • Jones, S.J.1    Roe, A.E.2    Donehower, L.A.3    Bradley, A.4
  • 2
    • 0028823020 scopus 로고
    • Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
    • Montes de Oca Luna R, Wagner DS, Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 1995; 378:203-206.
    • (1995) Nature , vol.378 , pp. 203-206
    • Montes De Oca Luna, R.1    Wagner, D.S.2    Lozano, G.3
  • 3
    • 0034863683 scopus 로고    scopus 로고
    • Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
    • Parant J, Chavez-Reves A, Little NA, Yan W, Reinke V, Jochemsen AG, Lozano G. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nature Genet 2001; 29:92-95.
    • (2001) Nature Genet , vol.29 , pp. 92-95
    • Parant, J.1    Chavez-Reves, A.2    Little, N.A.3    Yan, W.4    Reinke, V.5    Jochemsen, A.G.6    Lozano, G.7
  • 11
    • 0345268720 scopus 로고    scopus 로고
    • Mdm2 haploinsufficiency profoundly inhibits Myc-induced lymphomagenesis
    • Alt JR, Greiner TC, Cleveland JL, Eischen CM. Mdm2 haploinsufficiency profoundly inhibits Myc-induced lymphomagenesis. EMBO J 2003; 22:1442-1450.
    • (2003) EMBO J , vol.22 , pp. 1442-1450
    • Alt, J.R.1    Greiner, T.C.2    Cleveland, J.L.3    Eischen, C.M.4
  • 13
    • 0036548741 scopus 로고    scopus 로고
    • Antisense anti-MDM2 mixed-backbone oligonucleotides enhance therapeutic efficacy of topoisomerase I inhibitor irinotecan in nude mice bearing human cancer xenografts: In vivo activity and mechanisms
    • Wang H, Wang S, Nan L, Yu D, Agrawal S, Zhang R. Antisense anti-MDM2 mixed-backbone oligonucleotides enhance therapeutic efficacy of topoisomerase I inhibitor irinotecan in nude mice bearing human cancer xenografts: In vivo activity and mechanisms. Int J of Oncology 2002; 20:745-752.
    • (2002) Int J of Oncology , vol.20 , pp. 745-752
    • Wang, H.1    Wang, S.2    Nan, L.3    Yu, D.4    Agrawal, S.5    Zhang, R.6
  • 20
    • 0025015168 scopus 로고
    • A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
    • Moser AR, Pitot HC, Dove WF. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 1990; 247:322-324.
    • (1990) Science , vol.247 , pp. 322-324
    • Moser, A.R.1    Pitot, H.C.2    Dove, W.F.3
  • 21
    • 0037013154 scopus 로고    scopus 로고
    • A senescence program controlled by p53 and p16ink4a contributes to the outcome of cancer therapy
    • Schmitt CA, Fridman JS, Yang M, Lee S, Baranov E, Hoffman RM, Lowe SW. A senescence program controlled by p53 and p16ink4a contributes to the outcome of cancer therapy. Cell 2002; 109:335-346.
    • (2002) Cell , vol.109 , pp. 335-346
    • Schmitt, C.A.1    Fridman, J.S.2    Yang, M.3    Lee, S.4    Baranov, E.5    Hoffman, R.M.6    Lowe, S.W.7
  • 22
    • 0037439071 scopus 로고    scopus 로고
    • Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform
    • Cao L, Li W, Kim S, Brodie SG, Deng C-X. Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. Genes Dev 2003; 17:201-213.
    • (2003) Genes Dev , vol.17 , pp. 201-213
    • Cao, L.1    Li, W.2    Kim, S.3    Brodie, S.G.4    Deng, C.-X.5
  • 24
    • 85047689866 scopus 로고    scopus 로고
    • Telomeres, stem cells senescence and cancer
    • Sharpless NE, DePinho RA. Telomeres, stem cells senescence and cancer. J Clinical Invest 2004; 113:160-168.
    • (2004) J Clinical Invest , vol.113 , pp. 160-168
    • Sharpless, N.E.1    DePinho, R.A.2
  • 25
    • 23844535164 scopus 로고    scopus 로고
    • Complicating the role of p53 in aging
    • Gentry A, Venkatachalam S. Complicating the role of p53 in aging. Aging Cell 2005; 4:157-160.
    • (2005) Aging Cell , vol.4 , pp. 157-160
    • Gentry, A.1    Venkatachalam, S.2
  • 26
    • 27844596799 scopus 로고    scopus 로고
    • Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span
    • Bauer JH, Poon PC, Glatt-Deeley H, Abrams JM, Helfand SL. Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span, Curr Biol 2005; 15:2063-2068.
    • (2005) Curr Biol , vol.15 , pp. 2063-2068
    • Bauer, J.H.1    Poon, P.C.2    Glatt-Deeley, H.3    Abrams, J.M.4    Helfand, S.L.5
  • 27
    • 0024431245 scopus 로고
    • High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene
    • Lavigueur A, Maltby V, Mock D, Rossant J, Pawson T, Bernstein A. High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene. Mol Cell Biol 1989; 9:3982-3991.
    • (1989) Mol Cell Biol , vol.9 , pp. 3982-3991
    • Lavigueur, A.1    Maltby, V.2    Mock, D.3    Rossant, J.4    Pawson, T.5    Bernstein, A.6
  • 29
    • 32044435126 scopus 로고    scopus 로고
    • Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways
    • Levine AJ, Feng Z, Mak TW, You H, Jin S. Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev 2006; 20:267-275.
    • (2006) Genes Dev , vol.20 , pp. 267-275
    • Levine, A.J.1    Feng, Z.2    Mak, T.W.3    You, H.4    Jin, S.5
  • 30
    • 17244372678 scopus 로고    scopus 로고
    • The role of insulin-like signalling in the regulation of ageing
    • Holzenberger, M. The role of insulin-like signalling in the regulation of ageing. Horm Res 2004; 62 Suppl 1:89-92.
    • (2004) Horm Res , vol.62 , Issue.1 SUPPL. , pp. 89-92
    • Holzenberger, M.1
  • 31
    • 24344447780 scopus 로고    scopus 로고
    • P63 deficiency activates a program of cellular senescence and leads to accelerated aging
    • Keyes WM, Wu Y, Vogel H, Guo X, Lowe S, Mills AA. P63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev 2005; 19:1986-1999.
    • (2005) Genes Dev , vol.19 , pp. 1986-1999
    • Keyes, W.M.1    Wu, Y.2    Vogel, H.3    Guo, X.4    Lowe, S.5    Mills, A.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.