-
1
-
-
0028834902
-
Rescue of embryonic lethality in MDM2-deficient mice by absence of p53
-
Jones SJ, Roe AE, Donehower LA, Bradley A. Rescue of embryonic lethality in MDM2-deficient mice by absence of p53. Nature 1995; 378:206-208.
-
(1995)
Nature
, vol.378
, pp. 206-208
-
-
Jones, S.J.1
Roe, A.E.2
Donehower, L.A.3
Bradley, A.4
-
2
-
-
0028823020
-
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
-
Montes de Oca Luna R, Wagner DS, Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 1995; 378:203-206.
-
(1995)
Nature
, vol.378
, pp. 203-206
-
-
Montes De Oca Luna, R.1
Wagner, D.S.2
Lozano, G.3
-
3
-
-
0034863683
-
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
-
Parant J, Chavez-Reves A, Little NA, Yan W, Reinke V, Jochemsen AG, Lozano G. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nature Genet 2001; 29:92-95.
-
(2001)
Nature Genet
, vol.29
, pp. 92-95
-
-
Parant, J.1
Chavez-Reves, A.2
Little, N.A.3
Yan, W.4
Reinke, V.5
Jochemsen, A.G.6
Lozano, G.7
-
4
-
-
0032535715
-
Loss of atm radisensitizes multiple p53 null tissues
-
Westphal CH, Hoyes KP, Canman CE, Huang X, Kastan MB, Hendry JH, Leder P. Loss of atm radisensitizes multiple p53 null tissues. Cancer Res 1998; 58:5637-5639.
-
(1998)
Cancer Res
, vol.58
, pp. 5637-5639
-
-
Westphal, C.H.1
Hoyes, K.P.2
Canman, C.E.3
Huang, X.4
Kastan, M.B.5
Hendry, J.H.6
Leder, P.7
-
5
-
-
0037220737
-
Mdm2 is critical for inhibition of p53 during lymphopoiesis and the response to ionizing radiation
-
Mendrysa SM, McElwee MK, Michalowski J, O'Leary KA, Young KM, Perry ME. Mdm2 is critical for inhibition of p53 during lymphopoiesis and the response to ionizing radiation. Mol Cell Biol 2003; 23:462-473.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 462-473
-
-
Mendrysa, S.M.1
McElwee, M.K.2
Michalowski, J.3
O'Leary, K.A.4
Young, K.M.5
Perry, M.E.6
-
6
-
-
0037011958
-
P53 mutant mice that display early ageing-associated phenotypes
-
Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, Lu X, Soron G, Cooper B, Brayton C, Park SH, Thompson T, Karsenty, G, Bradley A, Donehower L. P53 mutant mice that display early ageing-associated phenotypes. Nature 2002; 415:45-53.
-
(2002)
Nature
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
Venkatachalam, S.2
Choi, J.3
Jones, S.4
Ghebranious, N.5
Igelmann, H.6
Lu, X.7
Soron, G.8
Cooper, B.9
Brayton, C.10
Park, S.H.11
Thompson, T.12
Karsenty, G.13
Bradley, A.14
Donehower, L.15
-
7
-
-
1042266548
-
Modulation of mammalian life span by the short isoform of p53
-
Maier B, Gluba W, Bernier B, Turner T, Mohammad K, Guise T, Sutherland A, Thorner M, Scrable H. Modulation of mammalian life span by the short isoform of p53. Genes & Dev 2004; 18:306-319.
-
(2004)
Genes & Dev
, vol.18
, pp. 306-319
-
-
Maier, B.1
Gluba, W.2
Bernier, B.3
Turner, T.4
Mohammad, K.5
Guise, T.6
Sutherland, A.7
Thorner, M.8
Scrable, H.9
-
8
-
-
12344273381
-
Variation in the human TP53 gene affects old age survival and cancer mortality
-
Van Heemst D, Mooijaart, SP, Beekman M, Schreuder J., de Craen AJM, Brandt BW, Slagboom PE, Westendorp, RGJ. Variation in the human TP53 gene affects old age survival and cancer mortality. Exp Gerontology 2005; 40:11-15.
-
(2005)
Exp Gerontology
, vol.40
, pp. 11-15
-
-
Van Heemst, D.1
Mooijaart, S.P.2
Beekman, M.3
Schreuder, J.4
De Craen, A.J.M.5
Brandt, B.W.6
Slagboom, P.E.7
Westendorp, R.G.J.8
-
9
-
-
8844278362
-
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans
-
Bond GL, Hu W, Bond EE, Robins H, Lutzker SG, Arva NC, Bargonetti J, Bartel F, Taubert H, Wuerl P, Onel K, Yip L, Hwang, S-J, Strong LC, Lozano G, Levine AJ. A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell 2004; 119:591-602.
-
(2004)
Cell
, vol.119
, pp. 591-602
-
-
Bond, G.L.1
Hu, W.2
Bond, E.E.3
Robins, H.4
Lutzker, S.G.5
Arva, N.C.6
Bargonetti, J.7
Bartel, F.8
Taubert, H.9
Wuerl, P.10
Onel, K.11
Yip, L.12
Hwang, S.-J.13
Strong, L.C.14
Lozano, G.15
Levine, A.J.16
-
10
-
-
27644571181
-
MDM2 promoter variation and age of diagnosis of acute lymphocytic leukaemia
-
Swinney RM, Hsu SC, Hirschman BA, Chen TT-C, Tomlinson GE. MDM2 promoter variation and age of diagnosis of acute lymphocytic leukaemia. Leukemia 2005; 19:1996-1998.
-
(2005)
Leukemia
, vol.19
, pp. 1996-1998
-
-
Swinney, R.M.1
Hsu, S.C.2
Hirschman, B.A.3
Chen, T.T.-C.4
Tomlinson, G.E.5
-
11
-
-
0345268720
-
Mdm2 haploinsufficiency profoundly inhibits Myc-induced lymphomagenesis
-
Alt JR, Greiner TC, Cleveland JL, Eischen CM. Mdm2 haploinsufficiency profoundly inhibits Myc-induced lymphomagenesis. EMBO J 2003; 22:1442-1450.
-
(2003)
EMBO J
, vol.22
, pp. 1442-1450
-
-
Alt, J.R.1
Greiner, T.C.2
Cleveland, J.L.3
Eischen, C.M.4
-
12
-
-
14744278462
-
Small molecule antagonists of the MDM2 oncoprotein as anticancer agents
-
Buolamwini JK, Addo J, Kamath S, Patil S, Mason D, Ores M. Small molecule antagonists of the MDM2 oncoprotein as anticancer agents. Current Cancer Drug Targets 2005; 5:57-68.
-
(2005)
Current Cancer Drug Targets
, vol.5
, pp. 57-68
-
-
Buolamwini, J.K.1
Addo, J.2
Kamath, S.3
Patil, S.4
Mason, D.5
Ores, M.6
-
13
-
-
0036548741
-
Antisense anti-MDM2 mixed-backbone oligonucleotides enhance therapeutic efficacy of topoisomerase I inhibitor irinotecan in nude mice bearing human cancer xenografts: In vivo activity and mechanisms
-
Wang H, Wang S, Nan L, Yu D, Agrawal S, Zhang R. Antisense anti-MDM2 mixed-backbone oligonucleotides enhance therapeutic efficacy of topoisomerase I inhibitor irinotecan in nude mice bearing human cancer xenografts: In vivo activity and mechanisms. Int J of Oncology 2002; 20:745-752.
-
(2002)
Int J of Oncology
, vol.20
, pp. 745-752
-
-
Wang, H.1
Wang, S.2
Nan, L.3
Yu, D.4
Agrawal, S.5
Zhang, R.6
-
14
-
-
23844474160
-
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
-
Song E, Zhu P, Lee S-K, Chowdhury D, Kussman S, Dykxhoorn DM, Feng Y, Palliser D, Weiner DB, Shankar P, Marasco WA, Lieberman J. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nature Biotech 2005; 23:709-717.
-
(2005)
Nature Biotech
, vol.23
, pp. 709-717
-
-
Song, E.1
Zhu, P.2
Lee, S.-K.3
Chowdhury, D.4
Kussman, S.5
Dykxhoorn, D.M.6
Feng, Y.7
Palliser, D.8
Weiner, D.B.9
Shankar, P.10
Marasco, W.A.11
Lieberman, J.12
-
15
-
-
11144315535
-
Small molecule RITA bindstop53, blocks p3-HDM-2 interaction and activates p53 function in tumors
-
Issaeva N, Bozko P, Enge M, Protopopova M, Verhoef LGGC, Masucci M, Pramanik A, Selivanova G. Small molecule RITA bindstop53, blocks p3-HDM-2 interaction and activates p53 function in tumors. Nature Med 2004; 10:1321-1328.
-
(2004)
Nature Med
, vol.10
, pp. 1321-1328
-
-
Issaeva, N.1
Bozko, P.2
Enge, M.3
Protopopova, M.4
Verhoef, L.G.G.C.5
Masucci, M.6
Pramanik, A.7
Selivanova, G.8
-
16
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong N, Kammlott U, Lukacs C, Klein C, Fotouhi N, Liu E. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004; 303:844-848.
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
Kong, N.7
Kammlott, U.8
Lukacs, C.9
Klein, C.10
Fotouhi, N.11
Liu, E.12
-
17
-
-
13944274061
-
Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells
-
Grasberger BL, Lu T, Schubert C, Parks DJ, Carver TE, Koblish HK, Cummings MD, LaFrance LV, Milkiewicz KL, Calvo RR, Maguire D, Lattanze J, Franks CF, Zhao S, Ramachandren K, Bylebyl GR, Zhang M, Manthey CL, Patrella EC, Pantoliano MW, Deckman IC, Spurlino JC, Maroney AC, Tomczuk BE, Molloy CJ, Bone RF. Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells. J Med Chem 2005; 48:909-912.
-
(2005)
J Med Chem
, vol.48
, pp. 909-912
-
-
Grasberger, B.L.1
Lu, T.2
Schubert, C.3
Parks, D.J.4
Carver, T.E.5
Koblish, H.K.6
Cummings, M.D.7
LaFrance, L.V.8
Milkiewicz, K.L.9
Calvo, R.R.10
Maguire, D.11
Lattanze, J.12
Franks, C.F.13
Zhao, S.14
Ramachandren, K.15
Bylebyl, G.R.16
Zhang, M.17
Manthey, C.L.18
Patrella, E.C.19
Pantoliano, M.W.20
Deckman, I.C.21
Spurlino, J.C.22
Maroney, A.C.23
Tomczuk, B.E.24
Molloy, C.J.25
Bone, R.F.26
more..
-
18
-
-
20444369867
-
Small molecular inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
-
Yang Y, Ludwig RL, Jensen JP, Pierre SA, Medaglia MV, Davydov IV, Safiran YJ, Oberoi P, Kenten JH, Phillips AC, Weissman AM, Vousden KH. Small molecular inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell 2005; 7:547-559.
-
(2005)
Cancer Cell
, vol.7
, pp. 547-559
-
-
Yang, Y.1
Ludwig, R.L.2
Jensen, J.P.3
Pierre, S.A.4
Medaglia, M.V.5
Davydov, I.V.6
Safiran, Y.J.7
Oberoi, P.8
Kenten, J.H.9
Phillips, A.C.10
Weissman, A.M.11
Vousden, K.H.12
-
19
-
-
29944447632
-
Tumor suppression and normal aging in mice with constitutively high p53 activity
-
Mendrysa SM, O'Leary KA, McElwee MK, Michalowski J, Eisenman RN, Powell DA, Perry ME. Tumor suppression and normal aging in mice with constitutively high p53 activity. Genes Dev 2006; 20:16-21.
-
(2006)
Genes Dev
, vol.20
, pp. 16-21
-
-
Mendrysa, S.M.1
O'Leary, K.A.2
McElwee, M.K.3
Michalowski, J.4
Eisenman, R.N.5
Powell, D.A.6
Perry, M.E.7
-
20
-
-
0025015168
-
A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
-
Moser AR, Pitot HC, Dove WF. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 1990; 247:322-324.
-
(1990)
Science
, vol.247
, pp. 322-324
-
-
Moser, A.R.1
Pitot, H.C.2
Dove, W.F.3
-
21
-
-
0037013154
-
A senescence program controlled by p53 and p16ink4a contributes to the outcome of cancer therapy
-
Schmitt CA, Fridman JS, Yang M, Lee S, Baranov E, Hoffman RM, Lowe SW. A senescence program controlled by p53 and p16ink4a contributes to the outcome of cancer therapy. Cell 2002; 109:335-346.
-
(2002)
Cell
, vol.109
, pp. 335-346
-
-
Schmitt, C.A.1
Fridman, J.S.2
Yang, M.3
Lee, S.4
Baranov, E.5
Hoffman, R.M.6
Lowe, S.W.7
-
22
-
-
0037439071
-
Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform
-
Cao L, Li W, Kim S, Brodie SG, Deng C-X. Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. Genes Dev 2003; 17:201-213.
-
(2003)
Genes Dev
, vol.17
, pp. 201-213
-
-
Cao, L.1
Li, W.2
Kim, S.3
Brodie, S.G.4
Deng, C.-X.5
-
23
-
-
0034106125
-
Analysis of ku80-mutant mice and cells with deficient levels of p53
-
Lim D-S, Vogel H, Willerford DM, Sands AT, Platt KA, Hasty P. Analysis of ku80-mutant mice and cells with deficient levels of p53. Mol Cell Biol 2000; 20:3772-3780.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 3772-3780
-
-
Lim, D.-S.1
Vogel, H.2
Willerford, D.M.3
Sands, A.T.4
Platt, K.A.5
Hasty, P.6
-
24
-
-
85047689866
-
Telomeres, stem cells senescence and cancer
-
Sharpless NE, DePinho RA. Telomeres, stem cells senescence and cancer. J Clinical Invest 2004; 113:160-168.
-
(2004)
J Clinical Invest
, vol.113
, pp. 160-168
-
-
Sharpless, N.E.1
DePinho, R.A.2
-
25
-
-
23844535164
-
Complicating the role of p53 in aging
-
Gentry A, Venkatachalam S. Complicating the role of p53 in aging. Aging Cell 2005; 4:157-160.
-
(2005)
Aging Cell
, vol.4
, pp. 157-160
-
-
Gentry, A.1
Venkatachalam, S.2
-
26
-
-
27844596799
-
Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span
-
Bauer JH, Poon PC, Glatt-Deeley H, Abrams JM, Helfand SL. Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span, Curr Biol 2005; 15:2063-2068.
-
(2005)
Curr Biol
, vol.15
, pp. 2063-2068
-
-
Bauer, J.H.1
Poon, P.C.2
Glatt-Deeley, H.3
Abrams, J.M.4
Helfand, S.L.5
-
27
-
-
0024431245
-
High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene
-
Lavigueur A, Maltby V, Mock D, Rossant J, Pawson T, Bernstein A. High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene. Mol Cell Biol 1989; 9:3982-3991.
-
(1989)
Mol Cell Biol
, vol.9
, pp. 3982-3991
-
-
Lavigueur, A.1
Maltby, V.2
Mock, D.3
Rossant, J.4
Pawson, T.5
Bernstein, A.6
-
28
-
-
0037112844
-
"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally
-
Garcia-Cao I, Garcia-Cao M, Martin-Caballero J, Criado LM, Klatt P, Flores JM, Weill JC, Blasco MA, Serrano M. "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J 2002; 21:6225-6235.
-
(2002)
EMBO J
, vol.21
, pp. 6225-6235
-
-
Garcia-Cao, I.1
Garcia-Cao, M.2
Martin-Caballero, J.3
Criado, L.M.4
Klatt, P.5
Flores, J.M.6
Weill, J.C.7
Blasco, M.A.8
Serrano, M.9
-
29
-
-
32044435126
-
Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways
-
Levine AJ, Feng Z, Mak TW, You H, Jin S. Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev 2006; 20:267-275.
-
(2006)
Genes Dev
, vol.20
, pp. 267-275
-
-
Levine, A.J.1
Feng, Z.2
Mak, T.W.3
You, H.4
Jin, S.5
-
30
-
-
17244372678
-
The role of insulin-like signalling in the regulation of ageing
-
Holzenberger, M. The role of insulin-like signalling in the regulation of ageing. Horm Res 2004; 62 Suppl 1:89-92.
-
(2004)
Horm Res
, vol.62
, Issue.1 SUPPL.
, pp. 89-92
-
-
Holzenberger, M.1
-
31
-
-
24344447780
-
P63 deficiency activates a program of cellular senescence and leads to accelerated aging
-
Keyes WM, Wu Y, Vogel H, Guo X, Lowe S, Mills AA. P63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev 2005; 19:1986-1999.
-
(2005)
Genes Dev
, vol.19
, pp. 1986-1999
-
-
Keyes, W.M.1
Wu, Y.2
Vogel, H.3
Guo, X.4
Lowe, S.5
Mills, A.A.6
-
32
-
-
0142039901
-
Cell type- and promoter-specific roles of ser18 phosphorylation in regulating p53
-
Chao C, Hergenhahn M, Kaeser M.D, Wu Z, Saito S, Iggo R, Hollstein M, Appella E, Xu Y. Cell type- and promoter-specific roles of ser18 phosphorylation in regulating p53. J Biol Chem 2003; 278:41028-41033.
-
(2003)
J Biol Chem
, vol.278
, pp. 41028-41033
-
-
Chao, C.1
Hergenhahn, M.2
Kaeser, M.D.3
Wu, Z.4
Saito, S.5
Iggo, R.6
Hollstein, M.7
Appella, E.8
Xu, Y.9
-
33
-
-
22844445705
-
Temporal dissection of p53 function in vitro and in vivo
-
Christophorou MA, Martin-Zanca D, Soucek L, Lawler ER, Brown-Swigart L, Verschuren EW, Evan GI. Temporal dissection of p53 function in vitro and in vivo. Nature Genet 2005; 37: 718-726.
-
(2005)
Nature Genet
, vol.37
, pp. 718-726
-
-
Christophorou, M.A.1
Martin-Zanca, D.2
Soucek, L.3
Lawler, E.R.4
Brown-Swigart, L.5
Verschuren, E.W.6
Evan, G.I.7
|