Genotoxic and non-genotoxic pathways of p53 induction

Cancer Letters

Volumn 174, Issue 1, 2001, Pages 1-15

  Pluquet, Olivier ^a   Hainaut, Pierre ^a  

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

DNA damage; Hypoxia; Non genotoxic stress; p14arf; p53; Phosphorylation

Indexed keywords

PROTEIN P53;

DNA DAMAGE; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME REGULATION; GENE ACTIVATION; GENOTOXICITY; HUMAN; HYPOXIA; ONCOGENE; PRIORITY JOURNAL; PROTEIN MODIFICATION; SHORT SURVEY; STRESS;

EID: 0035841951     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(01)00698-X     Document Type: Review

References (132)

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6. DNA strand breaks: The DNA template alterations that trigger p53- dependent DNA damage response pathways
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13. Allosteric activation of latent p53 tetramers
14. Regulation of p53 stability by Mdm2
15. Mdm2 promotes the rapid degradation of p53
16. JNK targets p53 ubiquitination and degradation in nonstressed cells
17. Mdm2 association with p53 targets its ubiquitination
18. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
19. MDM2-arbiter of p53's destruction
20. Amplification of a gene encoding a p53-associated protein in human sarcomas
21. Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2- mediated degradation of p53
22. The p53-mdm-2 autoregulatory feedback loop
23. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
24. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
25. Overproduction of MDM2 in vivo disrupts S phase independent of E2F1
26. Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53
27. The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter
28. MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice
29. MEKK1/JNK signaling stabilizes and activates p53
30. Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress
31. Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development
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33. Stress-activated kinases regulate protein stability
34. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system
35. The complexity of p53 modulation: Emerging patterns from divergent signals
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37. The dual role model for p53 in maintaining genomic integrity
38. Signaling to p53: Breaking the posttranslational modification code
39. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
40. DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage
41. Synergistic activation of transcription by CBP and p53
42. Binding and modulation of p53 by p300/CBP coactivators
43. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
44. ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins
45. Protein kinase C inhibitor and irradiation-induced apoptosis: Relevance of the cytochrome c-mediated caspase-9 death pathway
46. SUMO-1 modification activates the transcriptional response of p53
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48. Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome- mediated degradation
49. Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination
50. ATM-dependent phosphorylation of Mdm2 on serine 395: Role in p53 activation by DNA damage
51. Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage
52. SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53
53. Defective induction but normal activation and function of p53 in mouse cells lacking poly-ADP-ribose polymerase
54. Poly(ADP-ribose) polymerase, a major determinant of early cell response to ionizing radiation
55. Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis
56. Hypoxia induces accumulation of p53 protein, but activation of a G1- phase checkpoint by low-oxygen conditions is independent of p53 status
57. The INK4a/ARF tumor suppressor: One gene-two products-two pathways
58. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
59. Complex structure and regulation of the P16 (MTS1) locus
60. The CDKN2A (p16) gene and human cancer
61. MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
62. The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2
63. Association of p19 (ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
64. Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
65. p19ARF prevents G1 cyclin-dependent kinase activation by interacting with MDM2 and activating p53 in mouse fibroblasts
66. P19 (ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2
67. Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53
68. Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus
69. Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation
70. Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion
71. Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation
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77. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
78. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
79. Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
80. p53 inhibits hypoxia-inducible factor-stimulated transcription
81. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia- inducible factor 1alpha
82. Redox regulation of p53 during hypoxia
83. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
84. Cellular adhesion regulates p53 protein levels in primary human keratinocytes
85. p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest
86. p53 activation in response to microtubule disruption is mediated by integrin-Erk signaling
87. Increased p53 phosphorylation after microtubule disruption is mediated in a microtubule inhibitor- and cell-specific manner
88. Radiation-induced p53 and p21WAF-1/CIP1 expression in the murine intestinal epithelium: Apoptosis and cell cycle arrest
89. Phosphorylation of the p53 tumour-suppressor protein at three N- terminal sites by a novel casein kinase I-like enzyme
90. Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding
91. Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53
92. Enhanced phosphorylation of p53 by ATM in response to DNA damage
93. A role for ATR in the DNA damage-induced phosphorylation of p53
94. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
95. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
96. p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner
97. The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro
98. ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation
99. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
100. Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2
101. Cdk2 kinase phosphorylates serine 315 of human p53 in vitro
102. Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein
103. Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases
104. Phosphorylation of p53 at the casein kinase II site selectively regulates p53-dependent transcriptional repression but not transactivation
105. Phosphorylation of human p53 on Thr-55
106. DNA damage activates p53 through a phosphorylation-acetylation cascade
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109. U.v.-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle
110. p53 accumulation in various organs of rats after whole-body exposure to low-dose X-ray irradiation
111. p53 accumulation in the organs of low-dose X-ray-irradiated mice
112. Alpha-particle-induced p53 protein expression in a rat lung epithelial cell strain
113. p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines
114. Cadmium induces conformational modifications of wild-type p53 and suppresses p53 response to DNA damage in cultured cells
115. Increases in sequence specific DNA binding by p53 following treatment with chemotherapeutic and DNA damaging agents
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117. Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents
118. Distinct p53-mediated G1/S checkpoint responses in two NIH3T3 subclone cells following treatment with DNA-damaging agents
119. DNA strand breaks: The DNA template alterations that trigger p53- dependent DNA damage response pathways
120. Accumulation of p53 protein as a possible predictor of response to adjuvant combination chemotherapy with cyclophosphamide, methotrexate, fluorouracil, and prednisone for breast cancer
121. Phorbol esters attenuate the expression of p53 in cells treated with doxorubicin and protect TS-P53/K562 from apoptosis
122. Increased expression of p34cdc2 and its kinase activity in human gastric and colonic carcinomas
123. A p53-dependent mouse spindle checkpoint
124. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
125. Hypoxia induces accumulation of p53 protein, but activation of a G1- phase checkpoint by low-oxygen conditions is independent of p53 status
126. Cytokine-induced modulation of tumor suppressor gene expression in ovarian cancer cells: Up-regulation of p53 gene expression and induction of apoptosis by tumor necrosis factor-alpha
127. Tumor necrosis factor-induced apoptosis stimulates p53 accumulation and p21WAF1 proteolysis in ME-180 cells
128. p53-dependent induction of WAF1 by heat treatment in human glioblastoma cells
129. In vivo ubiquitination and proteasome-mediated degradation of p53(1)
130. Escape from senescence in human diploid fibroblasts induced directly by mutant p53
131. Polyamine analogue induction of the p53-p21WAF1/CIP1-Rb pathway and G1 arrest in human melanoma cells