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Volumn 9, Issue 12, 2007, Pages 2345-2355

ER stress signaling and the BCL-2 family of proteins: From adaptation to irreversible cellular damage

Author keywords

[No Author keywords available]

Indexed keywords

BH3 PROTEIN; BIM PROTEIN; CALCIUM; CASPASE; CASPASE 12; DYNEIN ADENOSINE TRIPHOSPHATASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PROTEIM BNIP2; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL W; PROTEIN BCL XL; PROTEIN BID; PROTEIN BLK; PROTEIN BMF; PROTEIN BNIP1; PROTEIN BNIP3; PROTEIN IRE1; PROTEIN MCL 1; PROTEIN NOXA; PROTEIN NR 13; PROTEIN PUMA; PROTEIN SERINE THREONINE KINASE; PROTEIN SPIKE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG; UNINDEXED DRUG; X BOX BINDING PROTEIN 1;

EID: 35848969791     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2007.1793     Document Type: Review
Times cited : (99)

References (116)
  • 2
    • 33750619845 scopus 로고    scopus 로고
    • How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane?
    • Antignani A and Youle RJ. How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane? Curr Opin Cell Biol 18: 685-689, 2006.
    • (2006) Curr Opin Cell Biol , vol.18 , pp. 685-689
    • Antignani, A.1    Youle, R.J.2
  • 4
    • 1842472069 scopus 로고    scopus 로고
    • Phosphorylation of BCL-2 regulates ER Ca(2+) homeostasis and apoptosis
    • Bassik MC, Scorrano L, Oakes SA, Pozzan T, and Korsmeyer SJ. Phosphorylation of BCL-2 regulates ER Ca(2+) homeostasis and apoptosis. EMBO J 23: 1207-1216, 2004.
    • (2004) EMBO J , vol.23 , pp. 1207-1216
    • Bassik, M.C.1    Scorrano, L.2    Oakes, S.A.3    Pozzan, T.4    Korsmeyer, S.J.5
  • 5
    • 0033782015 scopus 로고    scopus 로고
    • Dynamic interaction of Bip and ER stress transducers in the unfolded-protein response
    • Bertolotti A, Zhang Y, Hendershot LM, Harding HP, and Ron D. Dynamic interaction of Bip and ER stress transducers in the unfolded-protein response. Nat Cell Biol 2: 326-332, 2000.
    • (2000) Nat Cell Biol , vol.2 , pp. 326-332
    • Bertolotti, A.1    Zhang, Y.2    Hendershot, L.M.3    Harding, H.P.4    Ron, D.5
  • 6
    • 33645154135 scopus 로고    scopus 로고
    • Cellular response to endoplasmic reticulum stress: A matter of life or death
    • Boyce M and Yuan J. Cellular response to endoplasmic reticulum stress: a matter of life or death. Cell Death Differ 13: 363-373, 2006.
    • (2006) Cell Death Differ , vol.13 , pp. 363-373
    • Boyce, M.1    Yuan, J.2
  • 8
    • 0041534405 scopus 로고    scopus 로고
    • Calcium dynamics and endoplasmic reticular function in the regulation of protein synthesis: Implications for cell growth and adaptability
    • Brostrom MA and Brostrom CO. Calcium dynamics and endoplasmic reticular function in the regulation of protein synthesis: implications for cell growth and adaptability. Cell Calcium 34: 345-363, 2003.
    • (2003) Cell Calcium , vol.34 , pp. 345-363
    • Brostrom, M.A.1    Brostrom, C.O.2
  • 10
    • 0345059069 scopus 로고    scopus 로고
    • Evolutionarily conserved cytoprotection provided by Bax inhibitor-1 homologs from animals, plants, and yeast
    • Chae HJ, Ke N, Kim HR, Chen S, Godzik A, Dickman M, and Reed JC. Evolutionarily conserved cytoprotection provided by Bax inhibitor-1 homologs from animals, plants, and yeast. Gene 323: 101-113, 2003.
    • (2003) Gene , vol.323 , pp. 101-113
    • Chae, H.J.1    Ke, N.2    Kim, H.R.3    Chen, S.4    Godzik, A.5    Dickman, M.6    Reed, J.C.7
  • 11
    • 4143087106 scopus 로고    scopus 로고
    • Chae HJ, Kim HR, Xu C, Bailly-Maitre B, Krajewska M, Krajewski S, Banares S, Cui J, Digicaylioglu M, Ke N, Kitada S, Monosov E, Thomas M, Kress CL, Babendure JR, Tsien RY, Lipton SA, and Reed JC. BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress. Mol Cell 15: 355-366, 2004.
    • Chae HJ, Kim HR, Xu C, Bailly-Maitre B, Krajewska M, Krajewski S, Banares S, Cui J, Digicaylioglu M, Ke N, Kitada S, Monosov E, Thomas M, Kress CL, Babendure JR, Tsien RY, Lipton SA, and Reed JC. BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress. Mol Cell 15: 355-366, 2004.
  • 13
    • 0030297537 scopus 로고    scopus 로고
    • A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response
    • Cox JS and Walter P. A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell 87: 391-404, 1996.
    • (1996) Cell , vol.87 , pp. 391-404
    • Cox, J.S.1    Walter, P.2
  • 15
    • 33748972664 scopus 로고    scopus 로고
    • Autophagy in neurons: It is not all about food
    • Cuervo AM. Autophagy in neurons: it is not all about food. Trends Mol Med 12: 461-464, 2006.
    • (2006) Trends Mol Med , vol.12 , pp. 461-464
    • Cuervo, A.M.1
  • 16
    • 0041357164 scopus 로고    scopus 로고
    • Danial NN, Gramm CF, Scorrano L, Zhang CY, Krauss S, Ranger AM, Datta SR, Greenberg ME, Licklider LJ, Lowell BB, Gygi SP, and Korsmeyer SJ. BAD # Nature 424: 952-956, 2003.
    • Danial NN, Gramm CF, Scorrano L, Zhang CY, Krauss S, Ranger AM, Datta SR, Greenberg ME, Licklider LJ, Lowell BB, Gygi SP, and Korsmeyer SJ. BAD # Nature 424: 952-956, 2003.
  • 17
    • 0842281645 scopus 로고    scopus 로고
    • Cell death: Critical control points
    • Danial NN and Korsmeyer SJ. Cell death: critical control points. Cell 116: 205-219, 2004.
    • (2004) Cell , vol.116 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 18
    • 22044435410 scopus 로고    scopus 로고
    • The dynamic ER: Experimental approaches and current questions
    • Federovitch CM, Ron D, and Hampton RY. The dynamic ER: experimental approaches and current questions. Curr Opin Cell Biol 17: 409-414, 2005.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 409-414
    • Federovitch, C.M.1    Ron, D.2    Hampton, R.Y.3
  • 19
    • 0035736259 scopus 로고    scopus 로고
    • Organelle-specific initiation of cell death pathways
    • Ferri KF and Kroemer G. Organelle-specific initiation of cell death pathways. Nat Cell Biol 3: E255-E263, 2001.
    • (2001) Nat Cell Biol , vol.3
    • Ferri, K.F.1    Kroemer, G.2
  • 20
    • 12844266066 scopus 로고    scopus 로고
    • Identification of a network involved in thapsigargin-induced apoptosis using a library of small interfering RNA expression vectors
    • Futami T, Miyagishi M, and Taira K. Identification of a network involved in thapsigargin-induced apoptosis using a library of small interfering RNA expression vectors. J Biol Chem 280: 826-831, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 826-831
    • Futami, T.1    Miyagishi, M.2    Taira, K.3
  • 21
    • 0037124113 scopus 로고    scopus 로고
    • Germain M, Mathai JP, and Shore GC. BH-3-only bik functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria. J Biol Chem 277: 18053-18060, 2002.
    • Germain M, Mathai JP, and Shore GC. BH-3-only bik functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria. J Biol Chem 277: 18053-18060, 2002.
  • 22
    • 33646166316 scopus 로고    scopus 로고
    • The role of the endoplasmic reticulum in the accumulation of beta-amyloid peptide in alzheimer's disease
    • Ghribi O. The role of the endoplasmic reticulum in the accumulation of beta-amyloid peptide in alzheimer's disease. Curr Mol Med 6: 119-133, 2006.
    • (2006) Curr Mol Med , vol.6 , pp. 119-133
    • Ghribi, O.1
  • 23
    • 0035234534 scopus 로고    scopus 로고
    • Ire1p: A kinase and site-specific endoribonuclease
    • Gonzalez TN and Walter P. Ire1p: a kinase and site-specific endoribonuclease. Methods Mol Biol 160: 25-36, 2001.
    • (2001) Methods Mol Biol , vol.160 , pp. 25-36
    • Gonzalez, T.N.1    Walter, P.2
  • 25
    • 0032693671 scopus 로고    scopus 로고
    • Mammalian Transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
    • Haze K, Yoshida H, Yanagi H, Yura T, and Mori K. Mammalian Transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol Biol Cell 10: 3787-3799, 1999.
    • (1999) Mol Biol Cell , vol.10 , pp. 3787-3799
    • Haze, K.1    Yoshida, H.2    Yanagi, H.3    Yura, T.4    Mori, K.5
  • 27
    • 0142105406 scopus 로고    scopus 로고
    • Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein
    • Hetz C, Russelakis-Carneiro M, Maundrell K, Castilla J, and Soto C. Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein. EMBO J 22: 5435-5445, 2003.
    • (2003) EMBO J , vol.22 , pp. 5435-5445
    • Hetz, C.1    Russelakis-Carneiro, M.2    Maundrell, K.3    Castilla, J.4    Soto, C.5
  • 30
    • 84864508805 scopus 로고    scopus 로고
    • Emerging roles of the unfolded protein response signaling in physiology and disease
    • Hetz CA and Soto C. Emerging roles of the unfolded protein response signaling in physiology and disease. Curr Mol Med 6: 1, 2006.
    • (2006) Curr Mol Med , vol.6 , pp. 1
    • Hetz, C.A.1    Soto, C.2
  • 31
    • 33646175291 scopus 로고    scopus 로고
    • Stressing out protein response in prion-related disorders
    • Hetz CA and Soto C. Stressing out protein response in prion-related disorders. Curr Mol Med 6: 37-43, 2006.
    • (2006) Curr Mol Med , vol.6 , pp. 37-43
    • Hetz, C.A.1    Soto, C.2
  • 32
    • 0038143287 scopus 로고    scopus 로고
    • Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons
    • Holtz WA and O'Malley KL. Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons. J Biol Chem 278: 19367-19377, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 19367-19377
    • Holtz, W.A.1    O'Malley, K.L.2
  • 33
    • 33645815074 scopus 로고    scopus 로고
    • Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated nf-kappab activation and down-regulation of traf2 expression
    • Hu P, Han Z, Couvillon AD, Kaufman RJ, and Exton JH. Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated nf-kappab activation and down-regulation of traf2 expression. Mol Cell Biol 26: 3071-3084, 2006.
    • (2006) Mol Cell Biol , vol.26 , pp. 3071-3084
    • Hu, P.1    Han, Z.2    Couvillon, A.D.3    Kaufman, R.J.4    Exton, J.H.5
  • 34
    • 3242806002 scopus 로고    scopus 로고
    • BAX Inhibitor-1, an ancient cell death suppressor in animals and plants with prokaryotic relatives
    • Huckelhoven R. BAX Inhibitor-1, an ancient cell death suppressor in animals and plants with prokaryotic relatives. Apoptosis 9: 299-307, 2004.
    • (2004) Apoptosis , vol.9 , pp. 299-307
    • Huckelhoven, R.1
  • 36
    • 0034329418 scopus 로고    scopus 로고
    • Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, and Yoshimori T. LC3, a mammalian homologue of yeast apg8p, is localized in autophagosome membranes after processing. EMBO J 19: 5720-5728, 2000.
    • Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, and Yoshimori T. LC3, a mammalian homologue of yeast apg8p, is localized in autophagosome membranes after processing. EMBO J 19: 5720-5728, 2000.
  • 40
  • 41
    • 8444250981 scopus 로고    scopus 로고
    • A role for bip as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1
    • Kimata Y, Oikawa D, Shimizu Y, Ishiwata-Kimata Y, and Kohno K. A role for bip as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1. J Cell Biol 167: 445-456, 2004.
    • (2004) J Cell Biol , vol.167 , pp. 445-456
    • Kimata, Y.1    Oikawa, D.2    Shimizu, Y.3    Ishiwata-Kimata, Y.4    Kohno, K.5
  • 42
    • 14744281338 scopus 로고    scopus 로고
    • Bcl-X(L) specifically activates Bak to induce swelling and restructuring of the endoplasmic reticulum
    • Klee M and Pimentel-Muinos FX. Bcl-X(L) specifically activates Bak to induce swelling and restructuring of the endoplasmic reticulum. J Cell Biol 168: 723-734, 2005.
    • (2005) J Cell Biol , vol.168 , pp. 723-734
    • Klee, M.1    Pimentel-Muinos, F.X.2
  • 44
    • 33646167400 scopus 로고    scopus 로고
    • ER stress, hypoxia tolerance and tumor progression
    • Koumenis C. ER stress, hypoxia tolerance and tumor progression. Curr Mol Med 6: 55-69, 2006.
    • (2006) Curr Mol Med , vol.6 , pp. 55-69
    • Koumenis, C.1
  • 47
    • 13944277343 scopus 로고    scopus 로고
    • Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, and Newmeyer DD. BH3 domains of bh3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell 17: 525-535, 2005.
    • Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, and Newmeyer DD. BH3 domains of bh3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell 17: 525-535, 2005.
  • 48
    • 33745962416 scopus 로고    scopus 로고
    • Labi V, Erlacher M, Kiessling S, and Villunger A. BH3-only proteins in cell death initiation, malignant disease and anticancer therapy. Cell Death Differ 13: 1325-1338, 2006.
    • Labi V, Erlacher M, Kiessling S, and Villunger A. BH3-only proteins in cell death initiation, malignant disease and anticancer therapy. Cell Death Differ 13: 1325-1338, 2006.
  • 49
    • 29244448729 scopus 로고    scopus 로고
    • XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands
    • Lee AH, Chu GC, Iwakoshi NN, and Glimcher LH. XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands. EMBO J 24: 4368-4380, 2005.
    • (2005) EMBO J , vol.24 , pp. 4368-4380
    • Lee, A.H.1    Chu, G.C.2    Iwakoshi, N.N.3    Glimcher, L.H.4
  • 50
    • 0142059951 scopus 로고    scopus 로고
    • XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
    • Lee AH, Iwakoshi NN, and Glimcher LH. XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol 23: 7448-7459, 2003.
    • (2003) Mol Cell Biol , vol.23 , pp. 7448-7459
    • Lee, A.H.1    Iwakoshi, N.N.2    Glimcher, L.H.3
  • 51
    • 0037083755 scopus 로고    scopus 로고
    • IRE1-mediated unconventional mrna splicing and s2p-mediated atf6 cleavage merge to regulate xbp1 in signaling the unfolded protein response
    • Lee K, Tirasophon W, Shen X, Michalak M, Prywes R, Okada T, Yoshida H, Mori K, and Kaufman RJ. IRE1-mediated unconventional mrna splicing and s2p-mediated atf6 cleavage merge to regulate xbp1 in signaling the unfolded protein response. Genes Dev 16: 452-466, 2002.
    • (2002) Genes Dev , vol.16 , pp. 452-466
    • Lee, K.1    Tirasophon, W.2    Shen, X.3    Michalak, M.4    Prywes, R.5    Okada, T.6    Yoshida, H.7    Mori, K.8    Kaufman, R.J.9
  • 52
    • 26444558130 scopus 로고    scopus 로고
    • Pharmacological manipulation of bcl-2 family members to control cell death
    • Letai A. Pharmacological manipulation of bcl-2 family members to control cell death. J Clin Invest 115: 2648-2655, 2005.
    • (2005) J Clin Invest , vol.115 , pp. 2648-2655
    • Letai, A.1
  • 53
    • 0036728834 scopus 로고    scopus 로고
    • Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
    • Letai A, Bassik MC, Walensky LD, Sorcinelli MD, Weiler S, and Korsmeyer SJ. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2: 183-192, 2002.
    • (2002) Cancer Cell , vol.2 , pp. 183-192
    • Letai, A.1    Bassik, M.C.2    Walensky, L.D.3    Sorcinelli, M.D.4    Weiler, S.5    Korsmeyer, S.J.6
  • 54
    • 12944308330 scopus 로고    scopus 로고
    • Eating oneself and uninvited guests: Autophagy-related pathways in cellular defense
    • Levine B. Eating oneself and uninvited guests: autophagy-related pathways in cellular defense. Cell 120: 159-162, 2005.
    • (2005) Cell , vol.120 , pp. 159-162
    • Levine, B.1
  • 55
    • 25144506835 scopus 로고    scopus 로고
    • Autophagy in cell death: An innocent convict?
    • Levine B and Yuan J. Autophagy in cell death: an innocent convict? J Clin Invest 115: 2679-2688, 2005.
    • (2005) J Clin Invest , vol.115 , pp. 2679-2688
    • Levine, B.1    Yuan, J.2
  • 56
    • 33646373219 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-induced apoptosis: Multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by P53
    • Li J, Lee B, and Lee AS. Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by P53. J Biol Chem 281: 7260-7270, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 7260-7270
    • Li, J.1    Lee, B.2    Lee, A.S.3
  • 58
    • 33747368704 scopus 로고    scopus 로고
    • Lin SS, Bassik MC, Suh H, Nishino M, Arroyo JD, Hahn WC, Korsmeyer SJ, and Roberts TM. PP2A regulates bcl-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. J Biol Chem 281: 23003-23012, 2006.
    • Lin SS, Bassik MC, Suh H, Nishino M, Arroyo JD, Hahn WC, Korsmeyer SJ, and Roberts TM. PP2A regulates bcl-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. J Biol Chem 281: 23003-23012, 2006.
  • 59
    • 33646166752 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-induced apoptosis and auto-immunity in diabetes
    • Lipson KL, Fonseca SG, and Urano F. Endoplasmic reticulum stress-induced apoptosis and auto-immunity in diabetes. Curr Mol Med 6: 71-77, 2006.
    • (2006) Curr Mol Med , vol.6 , pp. 71-77
    • Lipson, K.L.1    Fonseca, S.G.2    Urano, F.3
  • 60
    • 27144453741 scopus 로고    scopus 로고
    • Transcriptional upregulation of PUMA modulates endoplasmic reticulum calcium pool depletion-induced apoptosis via Bax activation
    • Luo X, He Q, Huang Y, and Sheikh MS. Transcriptional upregulation of PUMA modulates endoplasmic reticulum calcium pool depletion-induced apoptosis via Bax activation. Cell Death Differ 12: 1310-1318, 2005.
    • (2005) Cell Death Differ , vol.12 , pp. 1310-1318
    • Luo, X.1    He, Q.2    Huang, Y.3    Sheikh, M.S.4
  • 62
    • 21244462014 scopus 로고    scopus 로고
    • Mathai JP, Germain M, and Shore GC. BH3-only BIK regulates BAX,BAK-dependent release of ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death. J Biol Chem 280: 23829-23836, 2005.
    • Mathai JP, Germain M, and Shore GC. BH3-only BIK regulates BAX,BAK-dependent release of ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death. J Biol Chem 280: 23829-23836, 2005.
  • 63
    • 33646267694 scopus 로고    scopus 로고
    • Conformational diseases and er stress-mediated cell death: Apoptotic cell death and autophagic cell death
    • Momoi T. Conformational diseases and er stress-mediated cell death: apoptotic cell death and autophagic cell death. Curr Mol Med 6: 111-118, 2006.
    • (2006) Curr Mol Med , vol.6 , pp. 111-118
    • Momoi, T.1
  • 64
    • 9644295726 scopus 로고    scopus 로고
    • Translocation of bim to the endoplasmic reticulum (ER) mediates ER stress signaling for activation of caspase-12 during ER stress-induced apoptosis
    • Morishima N, Nakanishi K, Tsuchiya K, Shibata T, and Seiwa E. Translocation of bim to the endoplasmic reticulum (ER) mediates ER stress signaling for activation of caspase-12 during ER stress-induced apoptosis. J Biol Chem 279: 50375-50381, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 50375-50381
    • Morishima, N.1    Nakanishi, K.2    Tsuchiya, K.3    Shibata, T.4    Seiwa, E.5
  • 65
    • 0034698878 scopus 로고    scopus 로고
    • Cross-talk between two cysteine protease families: Activation of caspase-12 by calpain in apoptosis
    • Nakagawa T and Yuan J. Cross-talk between two cysteine protease families: activation of caspase-12 by calpain in apoptosis. J Cell Biol 150: 887-894, 2000.
    • (2000) J Cell Biol , vol.150 , pp. 887-894
    • Nakagawa, T.1    Yuan, J.2
  • 67
    • 0036606540 scopus 로고    scopus 로고
    • ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
    • Nishitoh H, Matsuzawa A, Tobiume K, Saegusa K, Takeda K, Inoue K, Hori S, Kakizuka A, and Ichijo H. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev 16: 1345-1355, 2002.
    • (2002) Genes Dev , vol.16 , pp. 1345-1355
    • Nishitoh, H.1    Matsuzawa, A.2    Tobiume, K.3    Saegusa, K.4    Takeda, K.5    Inoue, K.6    Hori, S.7    Kakizuka, A.8    Ichijo, H.9
  • 68
    • 33646183455 scopus 로고    scopus 로고
    • The control of endoplasmic reticulum-initiated apoptosis by the bcl-2 family of proteins
    • Oakes SA, Lin SS, and Bassik MC. The control of endoplasmic reticulum-initiated apoptosis by the bcl-2 family of proteins. Curr Mol Med 6: 99-109, 2006.
    • (2006) Curr Mol Med , vol.6 , pp. 99-109
    • Oakes, S.A.1    Lin, S.S.2    Bassik, M.C.3
  • 72
    • 0038393112 scopus 로고    scopus 로고
    • Opferman JT, and Korsmeyer SJ. Apoptosis in the development and maintenance of the immune system. Nat Immunol 4: 410-415, 2003.
    • Opferman JT, and Korsmeyer SJ. Apoptosis in the development and maintenance of the immune system. Nat Immunol 4: 410-415, 2003.
  • 74
    • 33745958168 scopus 로고    scopus 로고
    • Bcl-2 And Ca2+ homeostasis in the endoplasmic reticulum
    • Pinton P and Rizzuto R. Bcl-2 And Ca2+ homeostasis in the endoplasmic reticulum. Cell Death Differ 13: 1409-1418, 2006.
    • (2006) Cell Death Differ , vol.13 , pp. 1409-1418
    • Pinton, P.1    Rizzuto, R.2
  • 77
    • 7744232493 scopus 로고    scopus 로고
    • Misfolded proteins, endoplasmic reticulum stress and neurodegeneration
    • Rao RV and Bredesen DE. Misfolded proteins, endoplasmic reticulum stress and neurodegeneration. Curr Opin Cell Biol 16: 653-662, 2004.
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 653-662
    • Rao, R.V.1    Bredesen, D.E.2
  • 78
    • 33645141178 scopus 로고    scopus 로고
    • Coupling endoplasmic reticulum stress to the cell-death program: A novel hsp90-independent role for the small chaperone protein P23
    • Rao RV, Niazi K, Mollahan P, Mao X, Crippen D, Poksay KS, Chen S, and Bredesen DE. Coupling endoplasmic reticulum stress to the cell-death program: a novel hsp90-independent role for the small chaperone protein P23. Cell Death Differ 13: 415-425, 2006.
    • (2006) Cell Death Differ , vol.13 , pp. 415-425
    • Rao, R.V.1    Niazi, K.2    Mollahan, P.3    Mao, X.4    Crippen, D.5    Poksay, K.S.6    Chen, S.7    Bredesen, D.E.8
  • 79
    • 33745957572 scopus 로고    scopus 로고
    • Proapoptotic multidomain bcl-2/bax-family proteins: Mechanisms, physiological roles, and therapeutic opportunities
    • Reed JC. Proapoptotic multidomain bcl-2/bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities. Cell Death Differ 13: 1378-1386, 2006.
    • (2006) Cell Death Differ , vol.13 , pp. 1378-1386
    • Reed, J.C.1
  • 80
    • 0042477717 scopus 로고    scopus 로고
    • Gene expression during er stress-induced apoptosis in neurons: Induction of the bh3-only protein bbc3/puma and activation of the mitochondrial apoptosis pathway
    • Reimertz C, Kogel D, Rami A, Chittenden T, and Prehn JH. Gene expression during er stress-induced apoptosis in neurons: induction of the bh3-only protein bbc3/puma and activation of the mitochondrial apoptosis pathway. J Cell Biol 162: 587-597, 2003.
    • (2003) J Cell Biol , vol.162 , pp. 587-597
    • Reimertz, C.1    Kogel, D.2    Rami, A.3    Chittenden, T.4    Prehn, J.H.5
  • 82
    • 33750363298 scopus 로고    scopus 로고
    • The roles of intracellular protein-degradation pathways In Neurodegeneration
    • Rubinsztein DC. The roles of intracellular protein-degradation pathways In Neurodegeneration. Nature 443: 780-786, 2006.
    • (2006) Nature , vol.443 , pp. 780-786
    • Rubinsztein, D.C.1
  • 83
    • 17644371025 scopus 로고    scopus 로고
    • Proapoptotic BAX and BAK control multiple initiator caspases
    • Ruiz-Vela A, Opferman JT, Cheng EH, and Korsmeyer SJ. Proapoptotic BAX and BAK control multiple initiator caspases. EMBO Rep 6: 379-385, 2005.
    • (2005) EMBO Rep , vol.6 , pp. 379-385
    • Ruiz-Vela, A.1    Opferman, J.T.2    Cheng, E.H.3    Korsmeyer, S.J.4
  • 84
    • 0037114971 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease
    • Ryu EJ, Harding HP, Angelastro JM, Vitolo OV, Ron D, and Greene LA. Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. J Neurosci 22: 10690-10698, 2002.
    • (2002) J Neurosci , vol.22 , pp. 10690-10698
    • Ryu, E.J.1    Harding, H.P.2    Angelastro, J.M.3    Vitolo, O.V.4    Ron, D.5    Greene, L.A.6
  • 86
    • 22244446505 scopus 로고    scopus 로고
    • the mammalian unfolded protein response
    • Schroder M and Kaufman RJ. the mammalian unfolded protein response. Annu Rev Biochem 74: 739-789, 2005.
    • (2005) Annu Rev Biochem , vol.74 , pp. 739-789
    • Schroder, M.1    Kaufman, R.J.2
  • 87
    • 13944257800 scopus 로고    scopus 로고
    • Transcription, apoptosis and p53: Catch-22
    • Schuler M and Green DR. Transcription, apoptosis and p53: catch-22. Trends Genet 21: 182-187, 2005.
    • (2005) Trends Genet , vol.21 , pp. 182-187
    • Schuler, M.1    Green, D.R.2
  • 89
    • 33845478357 scopus 로고    scopus 로고
    • The inflammatory caspases: Guardians against infections and sepsis
    • Scott AM and Saleh M. The inflammatory caspases: guardians against infections and sepsis. Cell Death Differ 14: 23-31, 2007.
    • (2007) Cell Death Differ , vol.14 , pp. 23-31
    • Scott, A.M.1    Saleh, M.2
  • 90
    • 33646190885 scopus 로고    scopus 로고
    • The ask1-map kinase signaling in ER stress and neurodegenerative diseases
    • Sekine Y, Takeda K, and Ichijo H. The ask1-map kinase signaling in ER stress and neurodegenerative diseases. Curr Mol Med 6: 87-97, 2006.
    • (2006) Curr Mol Med , vol.6 , pp. 87-97
    • Sekine, Y.1    Takeda, K.2    Ichijo, H.3
  • 91
    • 0029903049 scopus 로고    scopus 로고
    • Oligomerization and phosphorylation of the ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus
    • Shamu CE and Walter P. Oligomerization and phosphorylation of the ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. EMBO J 15: 3028-3039, 1996.
    • (1996) EMBO J , vol.15 , pp. 3028-3039
    • Shamu, C.E.1    Walter, P.2
  • 93
    • 0030954870 scopus 로고    scopus 로고
    • The transmembrane kinase ire1p is a site-specific endonuclease that initiates mrna splicing in the unfolded protein response
    • Sidrauski C and Walter P. The transmembrane kinase ire1p is a site-specific endonuclease that initiates mrna splicing in the unfolded protein response. Cell 90: 1031-1039, 1997.
    • (1997) Cell , vol.90 , pp. 1031-1039
    • Sidrauski, C.1    Walter, P.2
  • 95
    • 14944348965 scopus 로고    scopus 로고
    • The role of bh3-only proteins in the immune system
    • Strasser A. The role of bh3-only proteins in the immune system. Nat Rev Immunol 5: 189-200, 2005.
    • (2005) Nat Rev Immunol , vol.5 , pp. 189-200
    • Strasser, A.1
  • 97
    • 33646176558 scopus 로고    scopus 로고
    • ER stress and upr in familial amyotrophic lateral sclerosis
    • Turner BJ and Atkin JD. ER stress and upr in familial amyotrophic lateral sclerosis. Curr Mol Med 6: 79-86, 2006.
    • (2006) Curr Mol Med , vol.6 , pp. 79-86
    • Turner, B.J.1    Atkin, J.D.2
  • 98
    • 0034723235 scopus 로고    scopus 로고
    • Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
    • Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, and Ron D. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287: 664-666, 2000.
    • (2000) Science , vol.287 , pp. 664-666
    • Urano, F.1    Wang, X.2    Bertolotti, A.3    Zhang, Y.4    Chung, P.5    Harding, H.P.6    Ron, D.7
  • 99
    • 34548860810 scopus 로고
    • Autopoiesis: Living systems, its characterization and a model
    • Varela FG, Maturana HR, and Uribe R. Autopoiesis: living systems, its characterization and a model. Curr Mod Biol 5: 187-196, 1974.
    • (1974) Curr Mod Biol , vol.5 , pp. 187-196
    • Varela, F.G.1    Maturana, H.R.2    Uribe, R.3
  • 103
    • 14944347389 scopus 로고    scopus 로고
    • Westphalen BC, Wessig J, Leypoldt F, Arnold S, and Methner A. BI-1 protects cells from oxygen glucose deprivation by reducing the calcium content of the endoplasmic reticulum. Cell Death Differ 12: 304-306, 2005.
    • Westphalen BC, Wessig J, Leypoldt F, Arnold S, and Methner A. BI-1 protects cells from oxygen glucose deprivation by reducing the calcium content of the endoplasmic reticulum. Cell Death Differ 12: 304-306, 2005.
  • 105
    • 0031993255 scopus 로고    scopus 로고
    • Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast
    • Xu Q and Reed JC. Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. Mol Cell 1: 337-346, 1998.
    • (1998) Mol Cell , vol.1 , pp. 337-346
    • Xu, Q.1    Reed, J.C.2
  • 106
    • 0035957929 scopus 로고    scopus 로고
    • Activation Of Caspase-12, An endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress
    • Yoneda T, Imaizumi K, Oono K, Yui D, Gomi F, Katayama T, and Tohyama M. Activation Of Caspase-12, An endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress. J Biol Chem 276: 13935-13940, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 13935-13940
    • Yoneda, T.1    Imaizumi, K.2    Oono, K.3    Yui, D.4    Gomi, F.5    Katayama, T.6    Tohyama, M.7
  • 107
    • 33749579383 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress triggers autophagy
    • Yorimitsu T, Nair U, Yang Z, and Klionsky DJ. Endoplasmic reticulum stress triggers autophagy. J Biol Chem 281: 30299-30304, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 30299-30304
    • Yorimitsu, T.1    Nair, U.2    Yang, Z.3    Klionsky, D.J.4
  • 108
    • 0035966269 scopus 로고    scopus 로고
    • XBP1 mrna is induced by atf6 and spliced by ire1 in response to ER stress to produce a highly active transcription factor
    • Yoshida H, Matsui T, Yamamoto A, Okada T, and Mori K. XBP1 mrna is induced by atf6 and spliced by ire1 in response to ER stress to produce a highly active transcription factor. Cell 107: 881-891, 2001.
    • (2001) Cell , vol.107 , pp. 881-891
    • Yoshida, H.1    Matsui, T.2    Yamamoto, A.3    Okada, T.4    Mori, K.5
  • 109
    • 0033815971 scopus 로고    scopus 로고
    • ATF6 activated by proteolysis binds in the presence of nf-y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response
    • Yoshida H, Okada T, Haze K, Yanagi H, Yura T, Negishi M, and Mori K. ATF6 activated by proteolysis binds in the presence of nf-y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol Cell Biol 20: 6755-6767, 2000.
    • (2000) Mol Cell Biol , vol.20 , pp. 6755-6767
    • Yoshida, H.1    Okada, T.2    Haze, K.3    Yanagi, H.4    Yura, T.5    Negishi, M.6    Mori, K.7
  • 110
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • Yue Z, Jin S, Yang C, Levine AJ, and Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A 100: 15077-15082, 2003.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3    Levine, A.J.4    Heintz, N.5
  • 112
    • 33749233991 scopus 로고    scopus 로고
    • The crystal structure of human ire1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response
    • Zhou J, Liu CY, Back SH, Clark RL, Peisach D, Xu Z, and Kaufman RJ. The crystal structure of human ire1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proc Natl Acad Sci U S A 103: 14343-14348, 2006.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 14343-14348
    • Zhou, J.1    Liu, C.Y.2    Back, S.H.3    Clark, R.L.4    Peisach, D.5    Xu, Z.6    Kaufman, R.J.7
  • 113
    • 33745954330 scopus 로고    scopus 로고
    • BCL2 family in dna damage and cell cycle control
    • Zinkel S, Gross A, and Yang E. BCL2 family in dna damage and cell cycle control. Cell Death Differ 13: 1351-1359, 2006.
    • (2006) Cell Death Differ , vol.13 , pp. 1351-1359
    • Zinkel, S.1    Gross, A.2    Yang, E.3


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