Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast

Molecular Cell

Volumn 1, Issue 3, 1998, Pages 337-346

  Xu, Qunli ^a   Reed, John C ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BAX PROTEIN, HUMAN; CARCINOGEN; COMPLEMENTARY DNA; ETOPOSIDE; FAS ANTIGEN; GROWTH PROMOTOR; MEMBRANE PROTEIN; ONCOPROTEIN; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; STAUROSPORINE; TEGT PROTEIN, HUMAN;

ANIMAL; APOPTOSIS; ARTICLE; CELL STRAIN COS1; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; FIBROBLAST; GENE EXPRESSION REGULATION; GENE LIBRARY; GENETIC SCREENING; GENETIC TRANSFECTION; GENETICS; HUMAN; INTRACELLULAR MEMBRANE; MAMMAL; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; PHENOTYPE; PHYSIOLOGY; SEQUENCE HOMOLOGY; YEAST;

ANIMALS; ANTIGENS, CD95; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOGENS; COS CELLS; DNA, ANTISENSE; DNA, COMPLEMENTARY; ETOPOSIDE; FIBROBLASTS; GENE EXPRESSION REGULATION, FUNGAL; GENE LIBRARY; GENETIC SCREENING; GROWTH SUBSTANCES; HUMANS; INTRACELLULAR MEMBRANES; MAMMALS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PHENOTYPE; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SEQUENCE HOMOLOGY, AMINO ACID; STAUROSPORINE; TRANSFECTION; YEASTS;

EID: 0031993255     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80034-9     Document Type: Article

References (54)

1. Alnemri, E.S., Robertson, N.M., Fernandas, T.F., Croce, C.M., and Litwack, G. (1992). Overexpressed full-length human bcl-2 extends the survival of baculovirus-infected Sf9 insect cells. Proc. Natl. Acad. Sci. USA 89, 7295-7299.
2. Altschul, S.F., Gish, W., Miller, W., Myers, E.W., and Lipman, D.J. (1990). Basic local alignment search tool. J. Mol. Biol. 215, 403-410.
3. Antonsson, B., Conti, F., Ciavatta, A., Montessuit, S., Lewis, S., Martinou, I., Bernasconi, L., Bernard, A., Mermod, J.-J., Mazzei, G., et al. (1997). Inhibition of Bax channel-forming activity by Bcl-2. Science 277, 370-372.
4. Ausubel, F.M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, A., and Struhl, K. (1991). Current Protocols in Molecular Biology. (New York: Wiley Interscience).
5. Baffy, G., Miyashita, T., Williamson, J.R., and Reed, J.C. (1993). Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production. J. Biol. Chem. 268, 6511-6519.
6. Bernardi, P., Broekemeier, K.M., and Pfeiffer, D.R. (1994). Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane. J. Bioenerg. Biomembr. 26, 509-517.
7. Catterall, W.A. (1995). Structure and function of voltage-gated ion channels. Annu. Rev. Biochem. 64, 493-531.
8. Cramer, W.A., Heymann, J.B., Schendel, S.L., Deriy, B.N., Cohen, F. S., Elkins, P.A., and Stauffacher, C.V. (1995). Structure-function of the channel-forming colicins. Annu. Rev. Biophys. Biomol. Struct. 24, 611-641.
9. Deveraux, Q., Takahashi, R., Salvesen, G.S., and Reed, J.C. (1997). X-linked IAP is a direct inhibitor of cell death proteases. Nature 388, 300-303.
10. Dingwall, C., and Laskey, R.A. (1991). Nuclear targeting sequences - a consensus? Trends Biochem. Sci. 16, 478-481.
11. Donovan, J.J., Simon, M.I., Draper, R.K., and Montal, M. (1981). Diphtheria toxin forms transmembrane channels in planar lipid bilayers. Proc. Natl. Acad. Sci. USA 78, 172-176.
12. González-Garcia, M., Pérez-Ballestero, R., Ding, L., Duan, L., Boise, L., Thompson, C., and Nuñez, G. (1994). bel-XL is the major bcl-X mRNA form expressed during murine development and its product localizes to mitochondria. Development 120, 3033-3042.
13. Greenhalf, W., Stephan, C., and Chaudhuri, B. (1996). Role of mitochondria and C-terminal membrane anchor of Bcl-2 in Bax induced growth arrest and mortality in Saccharomyces cerevisiae. FEBS Lett. 380, 169-175.
14. Guo, Q., Sopher, B.L., Furukawa, K., Pham, D.G., Robinson, N., Martin, G.M., and Mattson, M.P. (1997). Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals. J. Neurosci. 17, 4212-4222.
15. Han, J., Sabbatini, P., Perez, D., Rao, L., Modha, D., and White, E. (1996). The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein. Genes Dev. 10, 461-477.
16. Hengartner, M.O., and Horvitz, H.R. (1994). C. elegans cell survival gene ced-9 encodes a functional homolog of the mammlian protooncogene bcl-2. Cell 76, 665-676.
17. Hofmann, K., and Stoffel, W. (1993). A database of membrane-spanning protein segments. Biol. Chem. Hoppe Seyler 274, 166.
18. L during apoptosis. Proc. Natl. Acad. Sci. USA 94, 3668-3672.
19. Ink, B., Zornig, M., Baum, B., Hajibagheri, N., James, C., Chittenden, T., and Evan, G. (1997). Human bak induces cell death in Schizosaccharomyces pombe with morphological changes similiar to those with apoptosis in mammalian cells. Mol. Cell. Biol. 17, 2468-2474.
20. Jayaraman, T., and Marks, A.R. (1997). T cells deficient in inositol 1,4,5-trisphosphate receptor are resistant to apoptosis. Mol. Cell. Biol. 17, 3005-3012.
21. Jürgensmeier, J.M., Krajewski, S., Armstrong, R., Wilson, G.M., Oltersdorf, T., Fritz, L.C., Reed, J.C., and Ottilie, S. (1997). Bax-and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe. Mol. Biol. Cell 8, 325-329.
22. Kane, D.J., Sarafin, T.A., Auton, S., Hahn, H., Gralla, F.B., Valentine, J.C., Ord, T., and Bredesen, D.E. (1993). Bcl-2 inhibition of neural cell death: decreased generation of reactive oxygen species. Science 262, 1274-1276.
23. Kozak, M. (1997). Recognition of AUG and alternative initiator codons is augmented by G in position +4 but is not generally affected by the nucleotides in positions +5 and +6. EMBO J. 16, 2482-2492.
24. Krajewski, S., Tanaka, S., Takayama, S., Schibler, M.J., Fenton, W., and Reed, J.C. (1993). Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res. 53, 4701-4714.
25. Kroemer, G. (1997).The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat. Med. 3, 614-620.
26. Kroemer, G., Zamzami, N., and Susin, S.A. (1996). Mitochondrial control of apoptosis. Immunol. Today 18, 44-51.
27. Kyte, J., and Doolittle, R.F. (1982). A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157, 105-132.
28. Lam, M., Dubyak, G., Chen, L., Nuñez, G., Miesfeld, R.L., and Distelhorst, C.W. (1994). Evidence that Bcl-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes. Proc. Natl. Acad. Sci. USA 91, 6569-6573.
29. Lew, D.J., Dulic, V., and Reed, S.I. (1991). Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell 66, 1197-1206.
30. Manon, S., Chaudhuri, B., and Buérin, M. (1997). Release of cytochrome c and decrease of cytochrome c oxidase in Bax-expressing yeast cells, and prevention of these effects by coexpression of Bcl-XL. FEBS Lett. 415, 29-32.
31. 1-ATPase proton pump is required for function of proapoptotic protein Bax in yeast and mammalian cells. Mol. Cell 1, this issue, 327-336.
32. L forms an ion channel in synthetic lipid membranes. Nature 385, 353-357.
33. Muchmore, S.W., Sattler, M., Liang, H., Meadows, R.P., Harlan, J.E., Yoon, H.S., Nettesheim, D., Changs, B.S., Thompson, C.B., Wong, S., Ng, S., and Fesik, S.W. (1996). X-ray and NM R structure of human Bcl-XL, an inhibitor of programmed cell death. Nature 381, 335-341.
34. Reed, J.C. (1994). Bcl-2 and the regulation of programmed cell death. J. Cell Biol. 124, 1-6.
35. Reed, J.C. (1997a). Double identity for proteins of the Bcl-2 family. Nature 387, 773-776.
36. Reed, J.C. (1997b). Cytochrome c: can't live with it - can't live without it. Cell 91, 559-562.
37. Sato, T., Hanada, M., Bodrug, S., Irie, S., Iwama, N., Boise, L.H., Thompson, C.B., Golemis, E., Fong, L., Wang, H.-G., and Reed, J.C. (1994). Interactions among members of the bcl-2 protein family analyzed with a yeast two-hybrid system. Proc. Natl. Acad. Sci. USA 91, 9238-9242.
38. Schendel, S.L., Xie, Z., Montal, M.O., Matsuyama, S., Montal, M., and Reed, J.C. (1997). Channel formation by antiapoptotic protein Bcl-2. Proc. Natl. Acad. Sci. USA 94, 5113-5118.
39. Schlesinger, P., Gross, A., Yin, X.-M., Yamamoto, K., Saito, M., Waksman, G., and Korsmeyer, S. (1997). Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2. Proc. Natl. Acad. Sci. USA 94, 11357-11362.
40. Simonian, P.L., Grillot, D.A.M., Merino, R., and Nunez, G. (1996). Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL. J. Biol. Chem. 271, 22764-22772.
41. Tao, W., Kurschner, C., and Morgan, J.I. (1997). Modulation of cell death in yeast by the Bcl-2 family of proteins. J. Biol. Chem. 272, 15547-15552.
42. Teasdale, R.D., and Jackson, M.R. (1996). Signal-mediated sorting of membrane proteins between the endoplasmic reticulum and the golgi apparatus. Annu. Rev. Cell Dev. Biol. 12, 27-54.
43. Vaux, D.L., and Strasser, A. (1996). The molecular biology of apoptosis. Proc. Natl. Acad. Sci. USA 93, 2239-2244.
44. Vaux, D.L., Weissman, I.L., and Kim, S.K. (1992). Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2. Science 258, 1955-1957.
45. Walter, L., Dirks, B., Rothermel, E., Heyens, M., Szpirer, C., Levan, G., and Gunther, E. (1994). A novel, conserved gene of the rat that is developmentally regulated in the testis. Mamm. Genome 5, 216-221.
46. Walter, L., Marynen, P., Szpirer, J., Levan, G., and Gunther, E. (1995). Identification of a novel conserved human gene, TEGT. Genomics 28, 301-304.
47. Wang, H.-G., Millan, J.A., Cox, A.D., Der, C.J., Rapp, U.R., Beck, T., Zha, H., and Reed, J.C. (1995). R-ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism. J. Cell Biol. 129, 1103-1114.
48. Wang, H.G., Rapp, U.R., and Reed, J.C. (1996). Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell 87, 629-638.
49. White, E., and Cipriani, R. (1989). Specific disruption of intermediate filaments and the nuclear lamina by the 19-kDa product of the adenovirus E1B oncogene. Proc. Natl. Acad. Sci. USA 86, 9886-9890.
50. Wolozin, B., Iwasaki, K., Vito, P., Ganjei, J.K., Lacana, E., Sunderland, T., Zhao, B., Kusiak, J.W., Wasco, W., and D'Adamio, L. (1996). Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science 274, 1710-1713.
51. Yang, E., and Korsmeyer, S.J. (1996). Molecularthanatopsis: a discourse on the Bcl2 family and cell death. Blood 88, 386-401.
52. Zha, H., Fisk, H.A., Yaffe, M.P., Mahajan, N., Herman, B., and Reed, J.C. (1996). Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells. Mol. Cell. Biol. 16, 6494-6508.
53. Zha, H., and Reed, J.C. (1997). Heterodimerization-independent functions of cell death regulatory proteins Bax and Bcl-2 in yeast and mammalian cells. J. Biol. Chem. 272, 31482-31488.
54. Zhu, W., Cowie, A., Wasfy, L., Leber, B., and Andrews, D. (1996). Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types. EMBO J. 15, 4130-4141.