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Volumn 11, Issue 3-4, 2007, Pages 219-240

Model fusion: The next phase in developing animal models for Parkinson's disease

Author keywords

Animal modeling; Environment; Genes; MPTP; Parkinson's disease; Transgenic animals

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ALPHA SYNUCLEIN; DJ 1 PROTEIN; LEUCINE RICH REPEAT KINASE 2; PARAQUAT; PARKIN; ROTENONE; NEUROTOXIN;

EID: 34548400209     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03033569     Document Type: Review
Times cited : (54)

References (151)
  • 1
    • 0037126181 scopus 로고    scopus 로고
    • Rotenone destroys dopa-minergic neurons and induces parkinsonian symptoms in rats
    • Alam M and WJ Schmidt (2002) Rotenone destroys dopa-minergic neurons and induces parkinsonian symptoms in rats. Behav. Brain Res. 136(1), 317-324.
    • (2002) Behav. Brain Res. , vol.136 , Issue.1 , pp. 317-324
    • Alam, M.1    Schmidt, W.J.2
  • 8
    • 0001496694 scopus 로고
    • A primate model of parkinsonism, selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • Burns RS, CC Chiueh, SP Markey, MH Ebert, DM Jacobowitz and IJ Kopin (1983) A primate model of parkinsonism, selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc. Natl. Acad. Sci. USA 80, 4546-4550.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 4546-4550
    • Burns, R.S.1    Chiueh, C.C.2    Markey, S.P.3    Ebert, M.H.4    Jacobowitz, D.M.5    Kopin, I.J.6
  • 11
    • 0027321004 scopus 로고
    • 2-deoxyglucose enhances 1-methyl-4-pheny1-1, 2,3,6-tetrahydropyridine-induced ATP loss in the mouse brain
    • Chan P, JW Langston, I Irwin, LE DeLanney and DA Di Monte (1993) 2-deoxyglucose enhances 1-methyl-4-pheny1-1, 2,3,6-tetrahydropyridine-induced ATP loss in the mouse brain. J. Neurochem. 61(2), 610-616.
    • (1993) J. Neurochem. , vol.61 , Issue.2 , pp. 610-616
    • Chan, P.1    Langston, J.W.2    Irwin, I.3    DeLanney, L.E.4    Di Monte, D.A.5
  • 12
    • 27544507306 scopus 로고    scopus 로고
    • Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration
    • Chandra S, G Gallardo, R Fernandez-Chacon, OM Schluter and TC Sudhof (2005) Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 123(3), 383-396.
    • (2005) Cell , vol.123 , Issue.3 , pp. 383-396
    • Chandra, S.1    Gallardo, G.2    Fernandez-Chacon, R.3    Schluter, O.M.4    Sudhof, T.C.5
  • 15
    • 10444253306 scopus 로고    scopus 로고
    • Parkin and Hsp70 sacked by BAG5
    • Chung KK and TM Dawson (2004) Parkin and Hsp70 sacked by BAG5. Neuron 44(6), 899-901.
    • (2004) Neuron , vol.44 , Issue.6 , pp. 899-901
    • Chung, K.K.1    Dawson, T.M.2
  • 16
    • 2542534741 scopus 로고    scopus 로고
    • S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function
    • Chung KK, B Thomas, X Li, O Pletnikova, JC Troncoso, L Marsh, VL Dawson and TM Dawson (2004) S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. Science 304(5675), 1328-13231.
    • (2004) Science , vol.304 , Issue.5675 , pp. 1328-13231
    • Chung, K.K.1    Thomas, B.2    Li, X.3    Pletnikova, O.4    Troncoso, J.C.5    Marsh, L.6    Dawson, V.L.7    Dawson, T.M.8
  • 17
    • 0026598930 scopus 로고
    • Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium, evidence for free radical involvement
    • Cleeter MW, JM Cooper and AH Schapira (1992) Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium, evidence for free radical involvement. J. Neurochem. 58(2), 786-789.
    • (1992) J. Neurochem. , vol.58 , Issue.2 , pp. 786-789
    • Cleeter, M.W.1    Cooper, J.M.2    Schapira, A.H.3
  • 19
    • 0023896746 scopus 로고
    • Energy-driven uptake of the neurotoxin 1-methyl-4-phenylpyridinium into chromaffin granules via the catecholamine transporter
    • Daniels AJ and JF Reinhard Jr (1988) Energy-driven uptake of the neurotoxin 1-methyl-4-phenylpyridinium into chromaffin granules via the catecholamine transporter. J. Biol. Chem. 263(11), 5034-5036.
    • (1988) J. Biol. Chem. , vol.263 , Issue.11 , pp. 5034-5036
    • Daniels, A.J.1    Reinhard Jr., J.F.2
  • 21
    • 3542993306 scopus 로고    scopus 로고
    • Mice lacking alpha-synuclein have an attenuated loss of striatal dopamine following prolonged chronic MPTP administration
    • Drolet RE, B Behrouz, KJ Lookingland and JL Goudreau (2004) Mice lacking alpha-synuclein have an attenuated loss of striatal dopamine following prolonged chronic MPTP administration. Neurotoxicology 25 (5), 761-769.
    • (2004) Neurotoxicology , vol.25 , Issue.5 , pp. 761-769
    • Drolet, R.E.1    Behrouz, B.2    Lookingland, J.K.3    Goudreau, J.L.4
  • 26
    • 0031005815 scopus 로고    scopus 로고
    • Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra
    • Ferrante RJ, JB Schulz, NW Kowall and MF Beal (1997) Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra. Brain Res. 753(1), 157-162.
    • (1997) Brain Res. , vol.753 , Issue.1 , pp. 157-162
    • Ferrante, R.J.1    Schulz, J.B.2    Kowall, N.W.3    Beal, M.F.4
  • 30
    • 0022466381 scopus 로고
    • Locus ceruleus lesions and eosinophilic inclusions in MPTP-treated monkeys
    • Forno LS, JW Langston, LE DeLanney, I Irwin and GA Ricaurte (1986) Locus ceruleus lesions and eosinophilic inclusions in MPTP-treated monkeys. Ann. Neurol. 20(4), 449-455.
    • (1986) Ann. Neurol. , vol.20 , Issue.4 , pp. 449-455
    • Forno, L.S.1    Langston, J.W.2    DeLanney, L.E.3    Irwin, I.4    Ricaurte, G.A.5
  • 34
    • 0035109738 scopus 로고    scopus 로고
    • Synuclein-opathies, clinical and pathological implications
    • Galvin JE, VM Lee and JQ Trojanowski (2001) Synuclein-opathies, clinical and pathological implications. Arch. Neurol. 58(2), 186-190.
    • (2001) Arch. Neurol. , vol.58 , Issue.2 , pp. 186-190
    • Galvin, J.E.1    Lee, V.M.2    Trojanowski, J.Q.3
  • 36
    • 0037118259 scopus 로고    scopus 로고
    • Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein
    • Giasson BI, JE Duda, SM Quinn, B Zhang, JQ Trojanowski and VM Lee (2002) Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron 34(4), 521-533.
    • (2002) Neuron , vol.34 , Issue.4 , pp. 521-533
    • Giasson, B.I.1    Duda, J.E.2    Quinn, S.M.3    Zhang, B.4    Trojanowski, J.Q.5    Lee, V.M.6
  • 42
    • 0035693854 scopus 로고    scopus 로고
    • Is methamphetamine abuse a risk factor in parkinsonism?
    • Guilarte TR (2001) Is methamphetamine abuse a risk factor in parkinsonism? Neurotoxicology 22(6), 725-731.
    • (2001) Neurotoxicology , vol.22 , Issue.6 , pp. 725-731
    • Guilarte, T.R.1
  • 44
    • 0021280826 scopus 로고    scopus 로고
    • 1984 Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydro-pyridine in mice
    • Heikkila RE, A Hess and RC Duvoisin (1984) Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydro-pyridine in mice. Science 224(4656), 1451-1453.
    • Science , vol.224 , Issue.4656 , pp. 1451-1453
    • Heikkila, R.E.1    Hess, A.2    Duvoisin, R.C.3
  • 48
    • 0000340348 scopus 로고
    • Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine, uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity
    • Javitch JA, RJ D'Amato, SM Strittmatter and SH Snyder (1985) Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine, uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc. Natl. Acad. Sci. USA 82(7), 2173-7.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , Issue.7 , pp. 2173-2177
    • Javitch, J.A.1    D'Amato, R.J.2    Strittmatter, S.M.3    Snyder, S.H.4
  • 49
    • 0034527763 scopus 로고    scopus 로고
    • Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein
    • Kahle PJ, M Neumann, L Ozmen and C Haass (2000a) Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein. Ann. NY Acad. Sci. 920, 33-41.
    • (2000) Ann. NY Acad. Sci. , vol.920 , pp. 33-41
    • Kahle, P.J.1    Neumann, M.2    Ozmen, L.3    Haass, C.4
  • 52
    • 0032707654 scopus 로고    scopus 로고
    • Increased expression of rat synuclein in the substantia nigra pars compacta identified by mRNA differential display in a model of developmental target injury
    • Kholodilov NG, M Neystat, TF Oo, SE Lo, KE Larsen, D Sulzer and RE Burke (1999) Increased expression of rat synuclein in the substantia nigra pars compacta identified by mRNA differential display in a model of developmental target injury. J. Neurochem. 73(6), 2586-2599.
    • (1999) J. Neurochem. , vol.73 , Issue.6 , pp. 2586-2599
    • Kholodilov, N.G.1    Neystat, M.2    Oo, T.F.3    Lo, S.E.4    Larsen, K.E.5    Sulzer, D.6    Burke, R.E.7
  • 53
    • 0032717232 scopus 로고    scopus 로고
    • Synuclein expression is decreased in rat substantia nigra following induction of apoptosis by intrastriatal 6-hydroxydopamine
    • Kholodilov NG, TF Oo and RE Burke (1999) Synuclein expression is decreased in rat substantia nigra following induction of apoptosis by intrastriatal 6-hydroxydopamine. Neurosci. Lett. 275(2), 105-108.
    • (1999) Neurosci. Lett. , vol.275 , Issue.2 , pp. 105-108
    • Kholodilov, N.G.1    Oo, T.F.2    Burke, R.E.3
  • 58
    • 33749583553 scopus 로고    scopus 로고
    • α-Synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity
    • Kontopoulos E., JD Parvin and MB Feany (2006) α-Synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. Hum. Mol. Genet. 15 (20), 3012-3023.
    • (2006) Hum. Mol. Genet. , vol.15 , Issue.20 , pp. 3012-3023
    • Kontopoulos, E.1    Parvin, J.D.2    Feany, M.B.3
  • 59
    • 33750357866 scopus 로고    scopus 로고
    • Proposed animal model of severe Parkinson's disease, neonatal 6-hydroxydopamine lesion of dopaminergic innervation of striatum
    • Kostrzewa RM, JP Kostrzewa, R Brus, RA Kostrzewa and P Nowak (2006) Proposed animal model of severe Parkinson's disease, neonatal 6-hydroxydopamine lesion of dopaminergic innervation of striatum. J. Neural Transm. Suppl. 70, 277-279.
    • (2006) J. Neural Transm. Suppl. , vol.70 , pp. 277-279
    • Kostrzewa, R.M.1    Kostrzewa, J.P.2    Brus, R.3    Kostrzewa, R.A.4    Nowak, P.5
  • 62
    • 0030864433 scopus 로고    scopus 로고
    • Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice
    • Lan J and DH Jiang (1997) Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice. J. Neural Transm. 104(4-5), 469-481.
    • (1997) J. Neural Transm. , vol.104 , Issue.4-5 , pp. 469-481
    • Lan, J.1    Jiang, D.H.2
  • 63
    • 33645755812 scopus 로고    scopus 로고
    • The Parkinson's complex, parkinsonism is just the tip of the iceberg
    • Langston JW (2006) The Parkinson's complex, parkinsonism is just the tip of the iceberg. Ann. Neurol. 59(4), 591-6.
    • (2006) Ann. Neurol. , vol.59 , Issue.4 , pp. 591-596
    • Langston, J.W.1
  • 64
    • 0020680904 scopus 로고
    • Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
    • Langston JW, P Ballard, JW Tetrud and I Irwin (1983) Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219(4587), 979-980.
    • (1983) Science , vol.219 , Issue.4587 , pp. 979-980
    • Langston, J.W.1    Ballard, P.2    Tetrud, J.W.3    Irwin, I.4
  • 65
    • 0021337873 scopus 로고
    • Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey
    • Langston JW, LS Forno, CS Rebert and I Irwin (1984) Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey. Brain Res. 292(2), 390-394.
    • (1984) Brain Res. , vol.292 , Issue.2 , pp. 390-394
    • Langston, J.W.1    Forno, L.S.2    Rebert, C.S.3    Irwin, I.4
  • 67
    • 0037173006 scopus 로고    scopus 로고
    • Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 -> Thr mutation causes neuro-degenerative disease with alpha-synuclein aggregation in transgenic mice
    • Lee MK, W Stirling, Y Xu, X Xu, D Qui, AS Mandir, TM Dawson, NG Copeland, NA Jenkins and DL Price (2002) Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 -> Thr mutation causes neuro-degenerative disease with alpha-synuclein aggregation in transgenic mice. Proc. Natl. Acad. Sci. USA 99(13), 8968-8973.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , Issue.13 , pp. 8968-8973
    • Lee, M.K.1    Stirling, W.2    Xu, Y.3    Xu, X.4    Qui, D.5    Mandir, A.S.6    Dawson, T.M.7    Copeland, N.G.8    Jenkins, N.A.9    Price, D.L.10
  • 68
    • 1342323484 scopus 로고    scopus 로고
    • Combined toxicity of prenatal bacterial endotoxin exposure and postnatal 6-hydroxydopamine in the adult rat midbrain
    • Ling ZD, Q Chang, JW Lipton, CW Tong, TM Landers and PM Carvey (2004) Combined toxicity of prenatal bacterial endotoxin exposure and postnatal 6-hydroxydopamine in the adult rat midbrain. Neuroscience 124(3), 619-628.
    • (2004) Neuroscience , vol.124 , Issue.3 , pp. 619-628
    • Ling, Z.D.1    Chang, Q.2    Lipton, J.W.3    Tong, C.W.4    Landers, T.M.5    Carvey, P.M.6
  • 69
    • 33745243255 scopus 로고    scopus 로고
    • Progressive dopamine neuron loss following supra-nigral lipopolysaccharide (LPS) infusion into rats exposed to LPS prenatally
    • Ling Z, Y Zhu, C Tong, JA Snyder, JW Lipton and PM Carvey (2006) Progressive dopamine neuron loss following supra-nigral lipopolysaccharide (LPS) infusion into rats exposed to LPS prenatally. Exp Neurol. 199(2), 499-512.
    • (2006) Exp Neurol , vol.199 , Issue.2 , pp. 499-512
    • Ling, Z.1    Zhu, Y.2    Tong, C.3    Snyder, J.A.4    Lipton, J.W.5    Carvey, P.M.6
  • 70
    • 0030878320 scopus 로고    scopus 로고
    • Environmental risk factors and Parkinson's disease, a case-control study in Taiwan
    • Liou HH, MC Tsai, CJ Chen, JS Jeng, YC Chang, SY Chen and RC Chen (1997) Environmental risk factors and Parkinson's disease, a case-control study in Taiwan. Neurology 48(6), 1583-1588.
    • (1997) Neurology , vol.48 , Issue.6 , pp. 1583-1588
    • Liou, H.H.1    Tsai, M.C.2    Chen, C.J.3    Jeng, J.S.4    Chang, Y.C.5    Chen, S.Y.6    Chen, R.C.7
  • 71
    • 1842441089 scopus 로고    scopus 로고
    • It's a double knock-out! The quaking mouse is a spontaneous deletion of parkin and parkin co-regulated gene (PACRG)
    • Lockhart PJ, CA O'Farrell and MJ Farrer (2004) It's a double knock-out! The quaking mouse is a spontaneous deletion of parkin and parkin co-regulated gene (PACRG). Mov. Disord. 19(1), 101-104.
    • (2004) Mov. Disord. , vol.19 , Issue.1 , pp. 101-104
    • Lockhart, P.J.1    O'Farrell, C.A.2    Farrer, M.J.3
  • 72
    • 0037127197 scopus 로고    scopus 로고
    • The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice, paraquat and α-synuclein
    • Manning-Boǧn AB, AL McCormack, J Li, VN Uversky, AL Fink and DA Di Monte (2002) The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice, paraquat and α-synuclein. J. Biol. Chem. 277, 1641-1644.
    • (2002) J. Biol. Chem. , vol.277 , pp. 1641-1644
    • Manning-Boǧn, A.B.1    McCormack, A.L.2    Li, J.3    Uversky, V.N.4    Fink, A.L.5    Di Monte, D.A.6
  • 75
    • 0034681471 scopus 로고    scopus 로고
    • Dopaminergic loss and inclusion body formation in alpha-synuclein mice, implications for neurodegenerative disorders
    • Masliah E, E Rockenstein, I Veinbergs, M Mallory, M Hashimoto, A Takeda, Y Sagara, A Sisk and L Mucke (2000) Dopaminergic loss and inclusion body formation in alpha-synuclein mice, implications for neurodegenerative disorders. Science 287(5456), 1265-1269.
    • (2000) Science , vol.287 , Issue.5456 , pp. 1265-1269
    • Masliah, E.1    Rockenstein, E.2    Veinbergs, I.3    Mallory, M.4    Hashimoto, M.5    Takeda, A.6    Sagara, Y.7    Sisk, A.8    Mucke, L.9
  • 78
    • 0037380982 scopus 로고    scopus 로고
    • Effects of L-dopa and other amino acids against paraquat-induced nigros-triatal degeneration
    • McCormack AL and DA Di Monte (2003) Effects of L-dopa and other amino acids against paraquat-induced nigros-triatal degeneration. J. Neurochem. 85(1), 82-86.
    • (2003) J. Neurochem. , vol.85 , Issue.1 , pp. 82-86
    • McCormack, A.L.1    Di Monte, D.A.2
  • 80
    • 0033030440 scopus 로고    scopus 로고
    • Immunochemical analysis of vesicular monoamine transporter (VMAT2) protein in Parkinson's disease
    • Miller GW, JD Erickson, JT Perez, SN Penland, DC Mash, DB Rye and AI Levey (1999) Immunochemical analysis of vesicular monoamine transporter (VMAT2) protein in Parkinson's disease. Exp. Neurol. 156(1), 138-148.
    • (1999) Exp. Neurol. , vol.156 , Issue.1 , pp. 138-148
    • Miller, G.W.1    Erickson, J.D.2    Perez, J.T.3    Penland, S.N.4    Mash, D.C.5    Rye, D.B.6    Levey, A.I.7
  • 81
    • 0028266425 scopus 로고
    • Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahy-dropyridine (MPTP)-induced hemiparkinsonian monkeys
    • Mochizuki H, H Imai, K Endo, K Yokomizo, Y Murata, N Hattori and Y Mizuno (1994) Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahy-dropyridine (MPTP)-induced hemiparkinsonian monkeys. Neurosci. Lett. 168, 251-253.
    • (1994) Neurosci. Lett. , vol.168 , pp. 251-253
    • Mochizuki, H.1    Imai, H.2    Endo, K.3    Yokomizo, K.4    Murata, Y.5    Hattori, N.6    Mizuno, Y.7
  • 82
    • 0346434141 scopus 로고    scopus 로고
    • A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization
    • Moore DJ, L Zhang, TM Dawson and VL Dawson (2003) A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization. J. Neurochem. 87(6), 1558-1567.
    • (2003) J. Neurochem. , vol.87 , Issue.6 , pp. 1558-1567
    • Moore, D.J.1    Zhang, L.2    Dawson, T.M.3    Dawson, V.L.4
  • 85
    • 0021810979 scopus 로고
    • Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
    • Nicklas WJ, I Vyas and RE Heikkila (1985) Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sci. 36(26), 2503-2508.
    • (1985) Life Sci. , vol.36 , Issue.26 , pp. 2503-2508
    • Nicklas, W.J.1    Vyas, I.2    Heikkila, R.E.3
  • 89
    • 0024848034 scopus 로고
    • Abnormalities of the electron transport chain in idiopathic Parkinson's disease
    • Parker WD Jr, S J Boyson and JK Parks (1989) Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann. Neurol. 26(6), 719-723.
    • (1989) Ann. Neurol. , vol.26 , Issue.6 , pp. 719-723
    • Parker Jr., W.D.1    Boyson, S.J.2    Parks, J.K.3
  • 90
    • 3543011314 scopus 로고    scopus 로고
    • The herbicide paraquat induces dopaminergic nigral apoptosis through sustained activation of the JNK pathway
    • Epub 2004 May 20
    • Peng J, XO Mao, FF Stevenson, M Hsu and JK Andersen (2004) The herbicide paraquat induces dopaminergic nigral apoptosis through sustained activation of the JNK pathway. J. Biol. Chem. 279 (31), 32626-32632. Epub 2004 May 20.
    • (2004) J. Biol. Chem. , vol.279 , Issue.31 , pp. 32626-32632
    • Peng, J.1    Mao, X.O.2    Stevenson, F.F.3    Hsu, M.4    Andersen, J.K.5
  • 91
    • 13844313915 scopus 로고    scopus 로고
    • Parkin-deficient mice are not a robust model of parkinsonism
    • Perez FA and RD Palmiter (2005) Parkin-deficient mice are not a robust model of parkinsonism. Proc. Natl. Acad. Sci. USA 102(6), 2174-2179.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , Issue.6 , pp. 2174-2179
    • Perez, F.A.1    Palmiter, R.D.2
  • 92
    • 30344450813 scopus 로고    scopus 로고
    • Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity
    • Perez FA, WR Curtis and RD Palmiter (2005) Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity. BMC Neurosci. 6, 71.
    • (2005) BMC Neurosci. , vol.6 , pp. 71
    • Perez, F.A.1    Curtis, W.R.2    Palmiter, R.D.3
  • 93
    • 0022445973 scopus 로고
    • Paraquat and two endogenous analogues of the neurotoxic substance N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine do not damage dopaminergic nigrostriatal neurons in the mouse
    • Perry TL, VW Yong, RA Wall and K Jones (1986) Paraquat and two endogenous analogues of the neurotoxic substance N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine do not damage dopaminergic nigrostriatal neurons in the mouse. Neurosci. Lett. 69(3), 285-289.
    • (1986) Neurosci. Lett. , vol.69 , Issue.3 , pp. 285-289
    • Perry, T.L.1    Yong, V.W.2    Wall, R.A.3    Jones, K.4
  • 94
    • 0035960066 scopus 로고    scopus 로고
    • Mouse model of Parkinsonism, a comparison between subacute MPTP and chronic MPTP/probenecid treatment
    • Petroske E, GE Meredith, S Callen, S Totterdell and YS Lau (2001) Mouse model of Parkinsonism, a comparison between subacute MPTP and chronic MPTP/probenecid treatment. Neuroscience 106(3), 589-601.
    • (2001) Neuroscience , vol.106 , Issue.3 , pp. 589-601
    • Petroske, E.1    Meredith, G.E.2    Callen, S.3    Totterdell, S.4    Lau, Y.S.5
  • 95
    • 0030790785 scopus 로고    scopus 로고
    • Iron-mediated generation of the neurotoxin 6-hydroxydopamine quinone by reaction of fatty acid hydroperoxides with dopamine, a possible contributory mechanism for neuronal degeneration in Parkinson's disease
    • Pezzella A, M d'Ischia, A Napolitano, G Misuraca and G Prota (1997) Iron-mediated generation of the neurotoxin 6-hydroxydopamine quinone by reaction of fatty acid hydroperoxides with dopamine, a possible contributory mechanism for neuronal degeneration in Parkinson's disease. J. Med. Chem. 40(14), 2211-2216.
    • (1997) J. Med. Chem. , vol.40 , Issue.14 , pp. 2211-2216
    • Pezzella, A.1    d'Ischia, M.2    Napolitano, A.3    Misuraca, G.4    Prota, G.5
  • 98
    • 33846308531 scopus 로고    scopus 로고
    • Microglial activation as a priming event leading to paraquat-induced dopaminergic cell degeneration
    • Purisai MG, AL McCormack, S Cumine, J Li, MZ Isla and DA Di Monte (2007) Microglial activation as a priming event leading to paraquat-induced dopaminergic cell degeneration. Neurobiol. Dis. 25(2), 392-400.
    • (2007) Neurobiol. Dis. , vol.25 , Issue.2 , pp. 392-400
    • Purisai, M.G.1    McCormack, A.L.2    Cumine, S.3    Li, J.4    Isla, M.Z.5    Di Monte, D.A.6
  • 100
    • 33847759064 scopus 로고    scopus 로고
    • Systemic LPS causes chronic neuroinflammation and progressive neurodegen-eration
    • Qin L, X Wu, ML Block, Y Liu, GR Breese, JS Hong, DJ Knapp and FT Crews (2007) Systemic LPS causes chronic neuroinflammation and progressive neurodegen-eration. Glia 55(5), 453-462.
    • (2007) Glia , vol.55 , Issue.5 , pp. 453-462
    • Qin, L.1    Wu, X.2    Block, M.L.3    Liu, Y.4    Breese, G.R.5    Hong, J.S.6    Knapp, D.J.7    Crews, F.T.8
  • 102
    • 0023001744 scopus 로고
    • Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria
    • Ramsay RR and TP Singer (1986) Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria. J. Biol. Chem. 261(17), 7585-7587.
    • (1986) J. Biol. Chem. , vol.261 , Issue.17 , pp. 7585-7587
    • Ramsay, R.R.1    Singer, T.P.2
  • 103
  • 104
    • 0035017068 scopus 로고    scopus 로고
    • Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice
    • Rathke-Hartlieb S, PJ Kahle, M Neumann, L Ozmen, S Haid, M Okochi, C Haas and JB Schulz (2001) Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice. J. Neurochem. 77(4), 1181-1184.
    • (2001) J. Neurochem. , vol.77 , Issue.4 , pp. 1181-1184
    • Rathke-Hartlieb, S.1    Kahle, P.J.2    Neumann, M.3    Ozmen, L.4    Haid, S.5    Okochi, M.6    Haas, C.7    Schulz, J.B.8
  • 108
    • 33847274641 scopus 로고    scopus 로고
    • Chronic rotenone treatment induces behavioral effects but no pathological signs of parkinsonism in mice
    • Richter F, M Hamann and A Richter (2007) Chronic rotenone treatment induces behavioral effects but no pathological signs of parkinsonism in mice. J. Neurosci. Res. 85(3), 681-691.
    • (2007) J. Neurosci. Res. , vol.85 , Issue.3 , pp. 681-691
    • Richter, F.1    Hamann, M.2    Richter, A.3
  • 110
    • 0036605566 scopus 로고    scopus 로고
    • Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters
    • Rockenstein E, M Mallory, M Hashimoto, D Song, CW Shults, I Lang and E Masliah (2002) Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters. J. Neurosci. Res. 68(5), 568-578.
    • (2002) J. Neurosci. Res. , vol.68 , Issue.5 , pp. 568-578
    • Rockenstein, E.1    Mallory, M.2    Hashimoto, M.3    Song, D.4    Shults, C.W.5    Lang, I.6    Masliah, E.7
  • 112
    • 4143125488 scopus 로고    scopus 로고
    • Parkin-positive autosomal recessive juvenile Parkinsonism with alpha-synuclein-positive inclusions
    • Sasaki S, A Shirata, K Yamane and M Iwata (2004) Parkin-positive autosomal recessive juvenile Parkinsonism with alpha-synuclein-positive inclusions. Neurology 63(4), 678-82.
    • (2004) Neurology , vol.63 , Issue.4 , pp. 678-682
    • Sasaki, S.1    Shirata, A.2    Yamane, K.3    Iwata, M.4
  • 113
    • 0028274216 scopus 로고
    • Evidence for mitochondrial dysfunction in Parkinson's disease - A critical appraisal
    • Schapira AH (1994) Evidence for mitochondrial dysfunction in Parkinson's disease - a critical appraisal. Mov. Disord. 9, 125-138.
    • (1994) Mov. Disord. , vol.9 , pp. 125-138
    • Schapira, A.H.1
  • 117
    • 15844397278 scopus 로고    scopus 로고
    • Neurotoxins and neurotoxic species implicated in neurodegeneration
    • Segura Aguilar J and RM Kostrzewa (2004) Neurotoxins and neurotoxic species implicated in neurodegeneration. Neurotox. Res. 6(7-8), 615-630.
    • (2004) Neurotox. Res. , vol.6 , Issue.7-8 , pp. 615-630
    • Segura Aguilar, J.1    Kostrzewa, R.M.2
  • 119
    • 13944267769 scopus 로고    scopus 로고
    • DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation
    • Shendelman S, A Jonason, C Martinat, T Leete and A Abeliovich (2004) DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation. PLoS Biol. 2(11), e362.
    • (2004) PLoS Biol. , vol.2 , Issue.11
    • Shendelman, S.1    Jonason, A.2    Martinat, C.3    Leete, T.4    Abeliovich, A.5
  • 121
    • 0037229425 scopus 로고    scopus 로고
    • Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation
    • Sherer TB, JH Kim, R Betarbet and JT Greenamyre (2003) Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation. Exp. Neurol. 179(1), 9-16.
    • (2003) Exp. Neurol. , vol.179 , Issue.1 , pp. 9-16
    • Sherer, T.B.1    Kim, J.H.2    Betarbet, R.3    Greenamyre, J.T.4
  • 124
    • 1542617769 scopus 로고    scopus 로고
    • Enhanced substantia nigra mitochondrial pathology in human α-synuclein transgenic mice after treatment with MPTP
    • Song DD, CW Shults, A Sisk, E Rockenstein and E Masliah (2004) Enhanced substantia nigra mitochondrial pathology in human α-synuclein transgenic mice after treatment with MPTP. Exp. Neurol. 186(2), 158-172.
    • (2004) Exp. Neurol. , vol.186 , Issue.2 , pp. 158-172
    • Song, D.D.1    Shults, C.W.2    Sisk, A.3    Rockenstein, E.4    Masliah, E.5
  • 125
    • 0032568534 scopus 로고    scopus 로고
    • α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies
    • Spillantini MG, RA Crowther, R Jakes, M Hasegawa and M Goedert (1998) α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies. Proc. Natl. Acad. Sci. USA 95(11), 6469-6473.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , Issue.11 , pp. 6469-6473
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Hasegawa, M.4    Goedert, M.5
  • 126
    • 0035097503 scopus 로고    scopus 로고
    • Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation
    • Spira PJ, DM Sharpe, G Halliday, J Cavanagh and GA Nicholson (2001) Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation. Ann. Neurol. 49(3), 313-319.
    • (2001) Ann. Neurol. , vol.49 , Issue.3 , pp. 313-319
    • Spira, P.J.1    Sharpe, D.M.2    Halliday, G.3    Cavanagh, J.4    Nicholson, G.A.5
  • 128
    • 0034624274 scopus 로고    scopus 로고
    • Increased striatal dopamine turnover following acute administration of rotenone to mice
    • Thiffault C, JW Langston and DA Di Monte (2000) Increased striatal dopamine turnover following acute administration of rotenone to mice. Brain Res. 885, 283-288.
    • (2000) Brain Res. , vol.885 , pp. 283-288
    • Thiffault, C.1    Langston, J.W.2    Di Monte, D.A.3
  • 129
    • 0042421940 scopus 로고    scopus 로고
    • Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype
    • Thiruchelvam M, A McCormack, EK Richfield, RB Baggs, AW Tank, DA Di Monte and DA Cory-Slechta (2003) Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype. Eur. J. Neurosci. 18(3), 589-600.
    • (2003) Eur. J. Neurosci. , vol.18 , Issue.3 , pp. 589-600
    • Thiruchelvam, M.1    McCormack, A.2    Richfield, E.K.3    Baggs, R.B.4    Tank, A.W.5    Di Monte, D.A.6    Cory-Slechta, D.A.7
  • 130
    • 0034671469 scopus 로고    scopus 로고
    • The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb, implications for Parkinson's disease
    • Thiruchelvam M, EK Richfield, RB Baggs, AW Tank and DA Cory-Slechta (2000) The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb, implications for Parkinson's disease. J. Neurosci. 20(24), 9207-9214.
    • (2000) J. Neurosci. , vol.20 , Issue.24 , pp. 9207-9214
    • Thiruchelvam, M.1    Richfield, E.K.2    Baggs, R.B.3    Tank, A.W.4    Cory-Slechta, D.A.5
  • 131
    • 1542359628 scopus 로고    scopus 로고
    • Risk factors for dopaminergic neuron loss in human alpha-synuclein transgenic mice
    • Thiruchelvam MJ, JM Powers, DA Cory-Slechta and EK Richfield (2004) Risk factors for dopaminergic neuron loss in human alpha-synuclein transgenic mice. Eur. J. Neurosci. 19(4), 845-854.
    • (2004) Eur. J. Neurosci. , vol.19 , Issue.4 , pp. 845-854
    • Thiruchelvam, M.J.1    Powers, J.M.2    Cory-Slechta, D.A.3    Richfield, E.K.4
  • 132
    • 33646097224 scopus 로고    scopus 로고
    • Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120), implications for Lewy body disorders
    • Tofaris GK, P Garcia Reitbock, T Humby, SL Lambourne, M O'Connell, B Ghetti, H Gossage, PC Emson, LS Wilkinson, M Goedert and MG Spillantini (2006) Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120), implications for Lewy body disorders. J. Neurosci. 26(15), 3942-3950.
    • (2006) J. Neurosci. , vol.26 , Issue.15 , pp. 3942-3950
    • Tofaris, G.K.1    Garcia Reitbock, P.2    Humby, T.3    Lambourne, S.L.4    O'Connell, M.5    Ghetti, B.6    Gossage, H.7    Emson, P.C.8    Wilkinson, L.S.9    Goedert, M.10    Spillantini, M.G.11
  • 135
    • 0033966487 scopus 로고    scopus 로고
    • Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP
    • Vila M, S Vukosavic, V Jackson-Lewis, M Neystat, M Jakowec and S Przedborski (2000) Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP. J. Neurochem. 74(2), 721-729.
    • (2000) J. Neurochem. , vol.74 , Issue.2 , pp. 721-729
    • Vila, M.1    Vukosavic, S.2    Jackson-Lewis, V.3    Neystat, M.4    Jakowec, M.5    Przedborski, S.6
  • 138
    • 0033062725 scopus 로고    scopus 로고
    • Diethyldithiocarbamate causes nigral cell loss and dopamine depletion with nontoxic doses of MPTP
    • Walters TL, I Irwin, K Delfani, JW Langston and AM Janson (1999) Diethyldithiocarbamate causes nigral cell loss and dopamine depletion with nontoxic doses of MPTP. Exp. Neurol. 156(1), 62-70.
    • (1999) Exp. Neurol. , vol.156 , Issue.1 , pp. 62-70
    • Walters, T.L.1    Irwin, I.2    Delfani, K.3    Langston, J.W.4    Janson, A.M.5
  • 139
    • 0029739461 scopus 로고    scopus 로고
    • No changes in behaviour, nigro-striatal system neurochemistry or neuronal cell death following toxic multiple oral paraquat administration to rats
    • Widdowson PS, MJ Farnworth, R Upton and MG Simpson (1996) No changes in behaviour, nigro-striatal system neurochemistry or neuronal cell death following toxic multiple oral paraquat administration to rats. Hum. Exp. Toxicol. 15, 583-591.
    • (1996) Hum. Exp. Toxicol. , vol.15 , pp. 583-591
    • Widdowson, P.S.1    Farnworth, M.J.2    Upton, R.3    Simpson, M.G.4
  • 140
    • 0034647948 scopus 로고    scopus 로고
    • Mutation analysis and association studies of the UCHL1 gene in German Parkinson's disease patients
    • Wintermeyer P, R Kruger, W Kuhn, T Muller, D Woitalla, D Berg, G Becker, E Leroy, M Polymeropoulos, K Berger, H Przuntek, L Schols, JT Epplen and O Riess (2000) Mutation analysis and association studies of the UCHL1 gene in German Parkinson's disease patients. Neuroreport 11(10), 2079-2082.
    • (2000) Neuroreport , vol.11 , Issue.10 , pp. 2079-2082
    • Wintermeyer, P.1    Kruger, R.2    Kuhn, W.3    Muller, T.4    Woitalla, D.5    Berg, D.6    Becker7
  • 141
    • 20944437573 scopus 로고    scopus 로고
    • The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis
    • Xu J, N Zhong, H Wang, JE Elias, CY Kim, I Woldman, C Pifl, SP Gygi, C Geula and BA Yankner (2005) The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. Hum. Mol. Genet. 14(9), 1231-1241.
    • (2005) Hum. Mol. Genet. , vol.14 , Issue.9 , pp. 1231-1241
    • Xu, J.1    Zhong, N.2    Wang, H.3    Elias, J.E.4    Kim, C.Y.5    Woldman, I.6    Pifl, C.7    Gygi, S.P.8    Geula, C.9    Yankner, B.A.10
  • 142
    • 14544288232 scopus 로고    scopus 로고
    • Therapeutic potential of adenosine A(2A) receptor antagonists in Parkinson's disease
    • Xu K, E Bastia and M Schwarzschild (2005) Therapeutic potential of adenosine A(2A) receptor antagonists in Parkinson's disease. Pharmacol. Ther. 105(3), 267-310.
    • (2005) Pharmacol. Ther. , vol.105 , Issue.3 , pp. 267-310
    • Xu, K.1    Bastia, E.2    Schwarzschild, M.3
  • 144
    • 0027329926 scopus 로고
    • The role of iron in senescence of dopaminergic neurons in Parkinson's disease
    • Youdim MB and P Riederer (1993) The role of iron in senescence of dopaminergic neurons in Parkinson's disease. J. Neural Transm. Suppl. 40, 57-67.
    • (1993) J. Neural Transm. Suppl. , vol.40 , pp. 57-67
    • Youdim, M.B.1    Riederer, P.2
  • 146
    • 17144379764 scopus 로고    scopus 로고
    • The tau gene haplotype h1 confers a susceptibility to Parkinson's disease
    • Zhang J, Y Song, H Chen and D Fan (2005) The tau gene haplotype h1 confers a susceptibility to Parkinson's disease. Eur. Neurol. 53(1), 15-21.
    • (2005) Eur. Neurol. , vol.53 , Issue.1 , pp. 15-21
    • Zhang, J.1    Song, Y.2    Chen, H.3    Fan, D.4
  • 148
    • 30044449754 scopus 로고    scopus 로고
    • DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity
    • Zhou W and CR Freed (2005) DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity. J. Biol. Chem. 280(52), 43150-43158.
    • (2005) J. Biol. Chem. , vol.280 , Issue.52 , pp. 43150-43158
    • Zhou, W.1    Freed, C.R.2
  • 149
    • 31344464179 scopus 로고    scopus 로고
    • The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein
    • Zhou W, M Zhu, MA Wilson, GA Petsko and AL Fink (2006) The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein. J. Mol. Biol. 356(4), 1036-1048.
    • (2006) J. Mol. Biol. , vol.356 , Issue.4 , pp. 1036-1048
    • Zhou, W.1    Zhu, M.2    Wilson, M.A.3    Petsko, G.A.4    Fink, A.L.5


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