Synuclein expression is decreased in rat substantia nigra following induction of apoptosis by intrastriatal 6-hydroxydopamine

Neuroscience Letters

Volumn 275, Issue 2, 1999, Pages 105-108

  Kholodilov, Nikolai G ^a   Oo, Tinmarla F ^a   Burke, Robert E ^a  

^a New York Presbyterian Columbia University Medical Center   (United States)

Author keywords

6 Hydroxydopamine; Apoptosis; Parkinson's disease; Striatum; Substantia nigra; Synuclein

Indexed keywords

ALPHA SYNUCLEIN; OXIDOPAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; NERVE CELL NECROSIS; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SUBSTANTIA NIGRA;

ANIMALS; APOPTOSIS; BLOTTING, NORTHERN; CORPUS STRIATUM; IMMUNOHISTOCHEMISTRY; NERVE TISSUE PROTEINS; NEURONS; OXIDOPAMINE; RATS; RNA, MESSENGER; SUBSTANTIA NIGRA; SYNUCLEINS;

EID: 0032717232     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00740-5     Document Type: Article

References (20)

1. Clarke P.G.H., Oppenheim R.W. Neuron death in vertebrate development: in vivo methods. Schwartz L.M., Osborne B.A. Methods in Cell Biology: Cell Death. 1995;277-321 Academic Press, New York.
2. Clayton D.F., George J.M. The synucleins: a family of proteins involved in synaptic function, plasticity neurodegeneration and disease. Trends Neurosci. 21:1998;249-254.
3. George J.M., Jin H., Woods W.S., Clayton D.F. Characterization of a novel protein regulated during the critical period for song learning in the zebra finch. Neuron. 15:1995;361-372.
4. Irizarry M.C., Kim T.W., McNamara M., Tanzi R.E., George J.M., Clayton D.F., Hyman B.T. Characterization of the precursor protein of the non-A beta component of senile plaques (NACP) in the human central nervous system. J. Neuropath. Exp. Neurol. 55:1996;889-895.
5. Iwai A., Masliah E., Yoshimoto M., Ge N., Flanagan L., de Silva H.A.R., Kittel A., Saitoh T. The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron. 14:1995;467-475.
6. Jackson-Lewis V., Vukosavic S., Neystat M., Przedborski S. Synuclein upregulation following MPTP administration. Abstr. Soc. Neurosci. 24:1999;968.
7. Jensen P.H., Nielsen M.S., Jakes R., Dotti C.G., Goedert M. Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation. J. Biol. Chem. 273:1998;26292-26294.
8. Jeon B.S., Kholodilov N.G., Oo T.F., Kim S., Tomaselli K.J., Srinivasan A., Stefanis L., Burke R.E. Activation of caspase-3 in developmental models of programmed cell death in neurons of the substantia nigra. J. Neurochem. 73:1999;322-333.
9. Kholodilov N.G., Neystat M., Oo T.F., Lo S.E., Larsen K.E., Sulzer D., Burke R.E. Increased expression of rat synuclein1 in the substantia nigra pars compacta identified by differential display in a model of developmental target injury. J. Neurochem. 73:1999;. in press.
10. Macaya A., Munell F., Gubits R.M., Burke R.E. Apoptosis in substantia nigra following developmental striatal excitotoxic injury. Proc. Natl. Acad. Sci. USA. 91:1994;8117-8121.
11. Maroteaux L., Campanelli J.T., Scheller R.H. Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J. Neurosci. 8:1988;2804-2815.
12. Maroteaux L., Scheller R.H. The rat brain synucleins; family of proteins transiently associated with neuronal membrane. Mol. Brain Res. 11:1991;335-343.
13. Marti M.J., James C.J., Oo T.F., Kelly W.J., Burke R.E. Early developmental destruction of terminals in the striatal target induces apoptosis in dopamine neurons of the substantia nigra. J. Neurosci. 17:1997;2030-2039.
14. Oo T.F., Henchcliffe C., James D., Burke R.E. Expression of c-fos, c-jun and c-jun N-terminal kinase (JNK) in a developmental model of induced apoptotic death in neurons of the substantia nigra. J. Neurochem. 72:1999;557-564.
15. Ostrerova N., Petrucelli L., Farrer M., Mehta N., Choi P., Hardy J., Wolozin B. Alpha-synuclein shares physical and functional homology with 14-3-3 proteins. J. Neurosci. 19:1999;5782-5791.
16. Park D.S., Morris E.J., Stefanis L., Troy C.M., Shelanski M.L., Geller H.M., Greene L.A. Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation and oxidative stress. J. Neurosci. 18:1998;830-840.
17. Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E.S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W.G., Lazzarini A.M., Duvoisin R.C., Golbe L.I., Nussbaum R.L. Mutation in the α-synuclein gene identified in families with Parkinson's Disease. Science. 276:1997;2045-2047.
18. Spillantini M.G., Schmidt M.L., Lee V.M.Y., Trojanowski J.Q., Jakes R., Goedert M. α-Synuclein in Lewy bodies. Nature. 388:1997;839-840.
19. Stefanis L., Kholodilov N.G., Larsen K.E., Przedborski S., Sulzer D., Burke R., Greene L.A. Ubiquitinated inclusions in rat pheochromocytoma PC12 cells stably overexpressing the A53T mutant-synuclein. Neurology. 52:1999;A4.
20. Ueda K., Fukushima H., Masliah E., Xia Y., Iwai A., Yoshimoto M., Otero D.A.C., Kondo J., Ihara Y., Saitoh T. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA. 90:1993;11282-11286.