Iron-mediated generation of the neurotoxin 6-hydroxydopamine quinone by reaction of fatty acid hydroperoxides with dopamine: A possible contributory mechanism for neuronal degeneration in parkinson's disease

Journal of Medicinal Chemistry

Volumn 40, Issue 14, 1997, Pages 2211-2216

  Pezzella, Alessandro ^a   D'Ischia, Marco ^a   Napolitano, Alessandra ^a   Misuraca, Giovanna ^a   Prota, Giuseppe ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BENZOQUINONE; DOPAMINE; FERROUS ION; HYDROGEN PEROXIDE; HYDROPEROXIDE; LINOLEIC ACID; NEUROTOXIN; OXIDOPAMINE;

ARTICLE; CHEMICAL REACTION KINETICS; DOPAMINE METABOLISM; DOPAMINERGIC NERVE CELL; NERVE CELL DEGENERATION; NEUROTOXICITY; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS;

DOPAMINE; EDETIC ACID; HUMANS; HYDROXYDOPAMINES; IRON; KINETICS; LINOLEIC ACIDS; LIPID PEROXIDES; NERVE DEGENERATION; NEUROTOXINS; PARKINSON DISEASE; QUINONES;

EID: 0030790785     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970099t     Document Type: Article

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