The potentiating effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on paraquat-induced neurochemical and behavioral changes in mice

Pharmacology Biochemistry and Behavior

Volumn 83, Issue 3, 2006, Pages 349-359

  Shepherd, K Raviie ^a   Lee, Eun Sook Y ^a   Schmued, Larry ^c   Jiao, Yun ^d   Ali, Syed F ^c   Oriaku, Ebenezer T ^a   Lamango, Nazarius S ^a   Soliman, Karam F A ^a   Charlton, Clivel G ^b  

^a FLORIDA A AND M UNIVERSITY   (United States)

^b MEHARRY MEDICAL COLLEGE   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Dopamine; Methylation; MPTP; Paraquat; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 3,4 DIHYDROXYPHENYLACETIC ACID; ADENOSYLHOMOCYSTEINASE; DOPAMINE; HOMOVANILLIC ACID; PARAQUAT; S ADENOSYLMETHIONINE; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; IMMUNOREACTIVITY; LOCOMOTION; MALE; METHYLATION; MOUSE; NEUROCHEMISTRY; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PRIORITY JOURNAL; SUBSTANTIA NIGRA;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; 3,4-DIHYDROXYPHENYLACETIC ACID; ANIMALS; BEHAVIOR, ANIMAL; DOPAMINE; DRUG SYNERGISM; HERBICIDES; HOMOVANILLIC ACID; HUMANS; MALE; METHYLATION; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; MPTP POISONING; NEUROTOXINS; PARAQUAT;

EID: 33747373586     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2006.02.013     Document Type: Article

References (74)

1. Bagetta G., Corasaniti M.I., Iannone M., Nistico G., and Stephenson J.D. Production of limbic motor seizures and brain damage by systemic and intracerebral injections of paraquat in rats. Pharmacol Toxicol 71 (1992) 443-448
2. Barbeau A., Roy M., Cloutier T., Plasse L., and Paris S. Environmental and genetic factors in the etiology of Parkinson's disease. Adv Neurol 45 (1987) 299-306
3. Berman S.B., and Hastings TG. Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: implications for Parkinson's disease. J Neurochem 73 (1999) 1127-1137
4. Brooks A.I., Chadwick C.A., Gelbard H.A., Cory-Slechta D.A., and Federoff H.J. Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss. Brain Res 823 (1999) 1-10
5. Bus J.S., Cagen S.Z., Olgaard M., and Gibson J.E. A mechanism of paraquat toxicity in mice and rats. Toxicol Appl Pharmacol 35 (1976) 501-513
6. Chan P., Di Monte D.A., Langston J.W., and Janson A.M. (+) MK-801 does not prevent MPTP-induced loss of nigral neurons in mice. J Pharmacol Exp Ther 280 (1997) 439-446
7. Charlton C.G. A parallel relationship between Parkinson's disease and an excess of S-adenosyl methionine-dependent biological methylation in the brain. In: Nagatsu T., Fisher A., and Yoshida M. (Eds). Basic clinical and therapeutic aspects of Alzheimer's and Parkinson's disease vol. 1 (1990), Plenum, New York 333-339
8. Charlton C.G., and Mack J. Substantia nigra degeneration and tyrosine hydroxylase depletion caused by excess S-adenosyl methionine in the rat brain. Mol Neurobiol 9 (1994) 149-161
9. Charlton C.G., and Way E.L. Tremor induced by S-adenosyl-l-methionine: possible relation to l-DOPA effects. J Pharm Pharmacol 30 (1978) 819-820
10. Collins M.A., Neafsey E.J., Matsubara K., Cobuzzi Jr. R.J., and Rollema H. Indole-N-methylated B-carbolinium ions as potential brain-bioactivated neurotoxins. Brain Res 570 (1992) 154-160
11. Corrigan F.M., Wienburg C.L., Shore R.F., Daniel S.E., and Mann D. Organochlorine insecticides in substantia nigra in Parkinson's disease. J Toxicol Environ Health A 59 (2000) 229-234
12. Crews F.T., Hirata F., and Axelrod J. Identification and properties of methyltransferases that synthesize phosphatidylcholine in rat brain synaptosomes. J Neurochem 34 (1980) 1491-1498
13. Crowell Jr. B.G., Benson R., Shockley D., and Charlton C.G. S-adenosyl-l-methionine decreases motor activity in the rat: similar to Parkinson's disease-like symptoms. Behav Neural Biol 59 (1993) 186-193
14. Davis G.C., Williams A.C., Markey S.P., Ebert M.H., Caine E.D., Reichert C.M., et al. Chronic Parkinsonism secondary to intravenous injection of meperidine analogues. Psychiatry Res 1 (1979) 9249-9254
15. DeMaria J.E., Lerant A.A., and Freeman M.E. Prolactin activates all three populations of hypothalamic neuroendocrine dopaminergic neurons in ovariectomized rats. Brain Res 837 (1999) 236-241
16. Dey M.S., Breeze R.G., Hayton W.L., Karara A.H., and Krieger R.I. Paraquat pharmacokinetics using a subcutaneous toxic low-dose in the rat. Fundam Appl Toxicol 14 (1990) 208-216
17. Di Monte D.A., McCormack A., Petzinger G., Janson A.M., Quik M., and Langston J.W. Relationship among nigrostriatal denervation, parkinsonism, and dyskinesias in the MPTP primate model. Mov Disord 15 (2000) 459-466
18. Duvoisin R.C., Heikkila R.E., Nicklas W.J., and Hess A. Dopaminergic neurotoxicity of MPTP in the mouse: a murine model of Parkinsonism. In: Fahn S. (Ed). Recent development in Parkinson's disease (1986), Raven Press, New York 147-154
19. Fabisiak J.P., Kagan V.E., Ritov V.B., Johnson D.E., and Lazo J.S. Bcl-2 inhibits selective oxidation and externalization of phosphatidylserine during paraquat-induced apoptosis. Am J Physiol 272 (1997) C675-C684 [Pt2]
20. Fahn S. Parkinsonism. In: Wyngaarden J.B., and Smith Jr. L.H. (Eds). Cecil's textbook of medicine (1988), Saunders, Philadelphia [PA] 2143-2147
21. Frederickson C.J. Neurobiology of zinc and zinc-containing neurons. Int Rev Neurobiol 31 (1989) 145-238
22. Fredriksson A., Fredriksson M., and Eriksson P. Neonatal exposure to paraquat or MPTP induces permanent changes in striatum dopamine and behavior in adult mice. Toxicol Appl Pharmacol 122 (1993) 258-264
23. Freyaldenhoven T.E., Ali S.F., and Hart R.W. MPTP- and MPP+-induced effects on body temperature exhibit age-and strain-dependence in mice. Brain Res 688 (1995) 161-170
24. Gharib A., Sarda N., Chabannes B., Cronenberger L., and Pacheco H. The regional concentrations of s-adenosyl-l-methionine, s-adenosyl-l-homocysteine, and adenosine in rat brain. J Neurochem 38 (1982) 810-815
25. Greenamyre J.T., Betarbet R., and Sherer T.B. The rotenone model of Parkinson's disease: genes, environment and mitochondria. Parkinsonism Relat Disord 9 (2003) S59-S64
26. Hallman H., Lange J., Olson L., Stromberg I., and Jonsson G. Neurochemical and histochemical characterization of neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on brain catecholamine neurons in the mouse. J Neurochem 44 (1985) 117-127
27. Harvey D.C., Lacan G., Tanious S.P., and Melega W.P. Recovery from methamphetamine induced long-term nigrostriatal dopaminergic deficits without substantia nigra cell loss. Brain Res 871 (2000) 259-270
28. Hochman A., Sternin H., Gorodin S., Korsmeyer S., Ziv I., Melamed E., et al. Enhanced oxidative stress and altered antioxidants in brains of Bcl-2 deficient mice. J Neurochem 71 (1998) 741-748
29. Hornykiewicz O. Dopamine (3-hydroxytyramine) and brain function. Pharmacol Rev 18 (1966) 925-964
30. Imaizumi Y. Geographical variations in mortality from Parkinson's disease in Japan, 1977-1985. Acta Neurol Scand 91 (1995) 311-316
31. Kadiiska M.B., Hanna P.M., and Mason R.P. In vivo ESR spin trapping evidence for hydroxyl radical-mediated toxicity of paraquat and copper in rats. Toxicol Appl Pharmacol 123 (1993) 187-192
32. Langston J.W. Epidemiology versus genetics in Parkinson's disease: progress in resolving an age-old debate. Ann Neurol 44 (1998) S45-S52
33. Langston J.W., Ballard P.A., Tetrud J.W., and Irwin I. Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219 (1983) 979-980
34. Lanska D.J. The geographic distribution of Parkinson's disease mortality in the United States. J Neurol Sci 150 (1997) 63-70
35. Lee E.S., and Charlton C. 1-Methyl-4-phenyl-pyridinium increases S-adenosyl-l-methionine dependent phospholipid methylation. Pharmacol Biochem Behav 70 (2001) 105-114
36. Lee E.S., Chen H., Shepherd K.R., Lamango N.S., Soliman K.F., and Charlton C.G. Inhibitory effect of Lysophosphatidylcholine on the dopaminergic system. Neurochem Res 29 (2004) 1333-1342
37. Lewin R. Parkinson's disease: an environmental cause?. Science 229 (1985) 257-258
38. Lindquist N.G., Larsson B.S., and Lyden-Sokolowski A. Autoradiography of 14C Paraquat or 14C Diquat in frogs and mice: accumulation in neuromelanin. Neurosci Lett 93 (1988) 1-6
39. Liou H.H., Tsai M.C., Chen C.J., Jeng J.S., Chang Y.C., Chen S.Y., et al. Environmental risk factors and Parkinson's disease: a case-control study in Taiwan. Neurology 48 (1997) 1583-1588
40. Mannisto P.T., and Kaakkola S. Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors. Pharmacol Rev 51 (1999) 593-628
41. Markey S.P., Weisz A., and Bacon J.P. Reduced paraquat does not exhibit MPTP-like neurotoxicity. J Anal Toxicol 10 (1986) 257
42. Matsubara K., Kobayashi S., Kobayashi Y., Yamashita K., Koide H., Hatta M., et al. B-carbolinium cations, endogenous MPP+ analogs, in the lumbar cerebrospinal fluid of parkinsonian patients. Neurology 45 (1995) 2240-2245
43. Mays L.L., Borek E., and Finch C.E. Glycine N-methyltransferase is a regulatory enzyme which increases in ageing animals. Nature 243 5407 (1973) 411-413
44. McCormack A.L., Thiruchelvam M., Manning-Bog A.B., Thiffault C., Langston J.W., Cory-Slechta D.A., et al. Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat. Neurobiol Dis 10 (2002) 119-127
45. McGrew D.M., Irwin I., and Langston J.W. Ethylenebisdithiocarbamate enhances MPTP-induced striatal dopamine depletion in mice. Neurotoxicology 21 (2000) 309-312
46. McNaught K.S., Thull U., Carrup A., Altomare C., Cellamare S., Carotti A., et al. Inhibition of complex I by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP). Biochem Pharmacol 50 (1995) 1903-1911
47. Miller D.B., Reinhard J.F., Daniels A.J., and O'Callaghan JP. Diethyldithiocarbamate potentiates the neurotoxicity of in vivo 1-methyl-4-phenyl-1,2,3,6-tettrahydropyridine and of in vitro 1-methyl-4-phenylpyridinium. J Neurochem 57 (1991) 541-549
48. Moghal S., Rajput AH., D'Arcy C., and Rajput R. Prevalence of movement disorders in elderly community residents. Neuroepidemiology 13 (1994) 175-178
49. Olanow C.W., and Tatton W.G. Etiology and pathogenesis of Parkinson's disease. Annu Rev Neurosci 22 (1999) 123-144
50. Oreland L. Monoamine oxidase, dopamine and Parkinson's disease. Acta Neurol Scand 84 Suppl. 136 (1991) 60-65
51. Perry T.L., Yong V.W., Wall R.A., and Jones K. Paraquat and two endogenous analogues of the neurotoxic substance N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine do not damage dopaminergic nigrostriatal neurons in the mouse. Neurosci Lett 69 (1986) 285-289
52. Sanchez-Ramos J.R., Hefti F., and Weiner W.J. Paraquat and Parkinson's disease. Neurology 37 (1987) 728
53. Sellinger O.Z., Kramer C.M., Conger A., and Duboff G.S. The carboxylmethylation of cerebral membrane-bound proteins increases with age. Mech Ageing Dev 43 (1988) 161-173
54. Shimada H., Hirai K.I., Simamura E., and Pan J. Mitochondrial NADH-quinone oxidoreductase of the outer membrane is responsible for paraquat cytotoxicity in rat livers. Arch Biochem Biophys 351 (1998) 75-81
55. Shimizu K., Matsubara K., Ohtaki K., Fujimaru S., Saito O., and Shiono H. Paraquat induces long-lasting dopamine overflow through the excitotoxic pathway in the striatum of freely moving rats. Brain (2003) 976243-976252
56. Standaert D.G., and Stern M.B. Update on the management of Parkinson's disease. Med Clin North Am 77 (1993) 169
57. Stramentinoli G., Gualano M., Catto E., and Algeri S.J. Tissue levels of s-adenosyl methionine in ageing rats. J Gerontol 32 (1977) 392-394
58. Tanner C.M. The role of environmental toxins in the etiology of Parkinson's disease. Brain Res 12 (1989) 49-54
59. Tanner C.M. Occupational and environmental causes of Parkinsonism. Occup Med 7 (1992) 503-513
60. Tanner CM., and Ben-Shlomo. Epidemiology of Parkinson's disease. Adv Neurol 80 (1999) 153-159
61. Tanner C.M., and Goldman S.M. Epidemiology of movement disorders. Curr Opin Neurol 7 (1994) 340-345
62. Tanner C.M., and Goldman S.M. Epidemiology of Parkinson's disease. Neuroepidemiology 14 (1996) 317-335
63. Tanner C.M., Ottman R., Goldman S.M., Ellenberg J., Chan P., Mayeux R., et al. J Am Med Assoc 281 (1999) 341-346
64. Thiruchelvam M., Brockel B.J., Richfield E.K., Baggs R.B., and Cory-Slechta D.A. Potentiated and preferential effects of combined paraquat and maneb on nigrostriatal dopamine systems: environmental risk factors for Parkinson's disease. Brain Res 873 (2000) 225-234
65. Thiruchelvam M., McCormack A., Richfield E.K., Baggs R.B., Tank A.W., Di Monte D.A., et al. Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype. Eur J Neurosci 18 (2003) 589-600
66. Thomas D.M., Walker P.D., Benjamins J.A., Geddes T.J., and Kuhn D.M. Methamphetamine neurotoxicity in dopamine nerve endings of the striatum is associated with microglial activation. J Pharmacol Exp Ther 31 1 (2004) 1-7
67. Trush M.A., Mimnaugh E.G., Ginsburg E., and Gram T.E. In vitro stimulation by paraquat of reactive oxygen-mediated lipid peroxidation in rat lung. Toxicol Appl Pharmacol 60 (1981) 279-286
68. Tuomisto L. Ontogenesis and regional distribution of histamine and histamine-N-methyltransferase in guinea pig brain. J Neurochem 28 (1977) 271-276
69. Walters T.L., Irwin I., Delfani K., Langston J.W., and Janson A.M. Diethyldithiocarbamate causes nigral cell loss and dopamine depletion with nontoxic doses of MPTP. Exp Neurol 156 (1999) 62-70
70. Westerink B.H., and Spaan S.J. Simultaneous determination of the formation rate of dopamine and its metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in various rat brain areas. Brain Res 252 (1982) 239-425
71. Widdowson P.S., Farnworth M.J., Simpson M.G., and Lock E.A. Influence on age on the passage of paraquat through the blood-brain barrier in rats: a distribution and pathological examination. Hum Exp Toxicol 15 (1996) 231-236
72. Williams A.C., Pall H.S., Steventon G.B., Green S., Buttrum S., Molloy H., et al. N-methylation of pyridines and Parkinson's disease. Adv Neurol 60 (1993) 194-196
73. Yang W.L., and Sun A.Y. Paraquat-induced free radical reaction in mouse brain microsomes. Neurochem Res 23 (1998) 47-53
74. Yassin M.S., Cheng H., Ekblom J., and Oreland L. Inhibitors of catecholamine metabolizing enzymes cause changes in S-adenosyl methionine and S-adenosyl homocysteine in the rat brain. Neurochemistry (1998) 3253-3259