The herbicide paraquat induces dopaminergic nigral apoptosis through sustained activation of the JNK pathway

Journal of Biological Chemistry

Volumn 279, Issue 31, 2004, Pages 32626-32632

  Peng, Jun ^a   Mao, Xiao Ou ^a   Stevenson, Fang Feng ^a   Hsu, Michael ^b   Andersen, Julie K ^a,b  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; HERBICIDES; LIVING SYSTEMS STUDIES; OXIDATION; STRESSES;

MOLECULAR LINKAGE; PARKINSON'S DISEASE;

BIOCHEMISTRY;

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTIOXIDANT; DOPAMINE; HERBICIDE; MANGANESE DERIVATIVE; MANGANESE TETRAKIS(4 BENZOIC ACID)PORPHYRIN; PARAQUAT; PORPHYRIN DERIVATIVE; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; DOPAMINERGIC NERVE CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; MALE; MOUSE; MOUSE STRAIN; NERVE CELL NECROSIS; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SUBSTANTIA NIGRA;

ANIMALS; ANTHRACENES; ANTIOXIDANTS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASES; CELL DEATH; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FREE RADICAL SCAVENGERS; HERBICIDES; IMMUNOHISTOCHEMISTRY; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE KINASE 4; METALLOPORPHYRINS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PARAQUAT; PHOSPHORYLATION; RATS; RECEPTORS, DOPAMINE; SUBSTANTIA NIGRA; TIME FACTORS;

ANIMALIA;

EID: 3543011314     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M404596200     Document Type: Article

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