Effects of L-dopa and other amino acids against paraquat-induced nigrostriatal degeneration

Journal of Neurochemistry

Volumn 85, Issue 1, 2003, Pages 82-86

  McCormack, Alison L ^a   Di Monte, Donato A ^a  

^a PARKINSON S INSTITUTE   (United States)

Author keywords

Amino acid transporter; Blood brain barrier; Parkinson's disease; Pesticides; Substantia nigra; synuclein

Indexed keywords

AMINO ACID; BENSERAZIDE; CARRIER PROTEIN; LEVODOPA METHYL ESTER; LYSINE; PARAQUAT; THIOFLAVINE; VALINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DIET; DOPAMINERGIC NERVE CELL; DRUG EFFECT; DRUG TARGETING; DRUG TRANSPORT; IMMUNOREACTIVITY; MALE; MESENCEPHALON; MOUSE; NEUROPATHOLOGY; NEUROPHARMACOLOGY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; STRIATONIGRAL DEGENERATION;

ANIMALIA; PARKINSONIA;

EID: 0037380982     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01621.x     Document Type: Article

References (15)

1. Audus K. L. and Borchardt R. T. (1986) Characteristics of the large neutral amino acid transport system of bovine brain microvessel endothelial cell monolayers. J. Neurochem. 47, 484-488.
2. Bart J., Groen H. J., Hendrikse N. H., van der Graaf W. T., Vaalburg W. and de Vries E. G. (2000) The blood-brain barrier and oncology: new insights into function and modulation. Cancer Treat. Rev. 26, 449-462.
3. Betarbet R., Sherer T. B., MacKenzie G., Garcia-Osuna M., Panov A. V. and Greenamyre J. T. (2000) Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat. Neurosci. 3, 1301-1306.
4. Boado R. J., Li J. Y., Nagaya M., Zhang C. and Pardridge W. M. (1999) Selective expression of the large neutral amino acid transporter at the blood-brain barrier. Proc. Natl Acad. Sci. USA 96, 12079-12084.
5. Di Monte D. A. (2001) The role of environmental agents in Parkinson's disease. Clin. Neurosci. Res. 1, 419-426.
6. Furuno T., Landi M. T., Ceroni M., Caporaso N., Bernucci I., Nappi G., Martignoni E., Schaeffeler E., Eichelbaum M., Schwab M. and Zanger U. M. (2002) Expression polymorphism of the blood-brain barrier component P-glycoprotein (MDR1) in relation to Parkinson's disease. Pharmacogenetics 12, 529-534.
7. Kageyama T., Nakamura M., Matsuo A., Yamasaki Y., Takakura Y., Hashida M., Kanai Y., Naito M., Tsuruo T., Minato N. and Shimohama S. (2000) The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier. Brain Res. 879, 115-121.
8. Koller W. C. (1986) Paraquat and Parkinson's disease. Neurology 36, 1147.
9. McCormack A. L., Thiruchelvam M., Manning-Bog A. B., Thiffault C., Langston J. W., Cory-Slechta D. A. and Di Monte D. A. (2002) Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat. Neurobiol. Dis. 10, 119-127.
10. Manning-Bog A. B., McCormack A. L., Li J., Uversky V. N., Fink A. L. and Di Monte D. A. (2002) The herbicide paraquat causes up-regulation and aggregation of α-synuclein in mice. J. Biol. Chem. 277, 1641-1644.
11. Schmidt M. L., Robinson K. A., Lee V. M. and Trojanowski J. Q. (1995) Chemical and immunological heterogeneity of fibrillar amyloid in plaques of Alzheimer's disease and Down's syndrome brains revealed by confocal microscopy. Am. J. Pathol. 147, 503-515.
12. Shimizu K., Ohtaki K., Matsubara K., Aoyama K., Uezono T., Saito O., Suno M., Ogawa K., Hayase N., Kimura K. and Shiono H. (2001) Carrier-mediated processes in blood-brain barrier penetration and neural uptake of paraquat. Brain. Res. 906, 135-142.
13. Smith Q. R. (2000) Transport of glutamate and other amino acids at the blood-brain barrier. J. Nutr. 130, 1016S-1022S.
14. Spillantini M. G., Crowther R. A., Jakes R., Hasegawa M. and Goedert M. (1998) α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies. Proc. Natl Acad. Sci. USA 95, 6469-6473.
15. Uversky V. N., Li J. and Fink A. L. (2001) Pesticides directly accelerate the rate of α-synuclein fibril formation: a possible factor in Parkinson's disease. FEBS Lett. 500, 105-108.