-
1
-
-
0029981526
-
Neuropathology of Parkinson's disease
-
Forno, L. S. (1996) Neuropathology of Parkinson's disease. J. Neuropathol. Exp. Neurol. 55, 259-272.
-
(1996)
J. Neuropathol. Exp. Neurol
, vol.55
, pp. 259-272
-
-
Forno, L.S.1
-
2
-
-
26444544353
-
α-Synuclein dysfunction in Lewy body diseases
-
Tofaris, G. K. and Spillantini, M. G. (2005) α-Synuclein dysfunction in Lewy body diseases. Mov. Disorders 20, S37-S44.
-
(2005)
Mov. Disorders
, vol.20
-
-
Tofaris, G.K.1
Spillantini, M.G.2
-
3
-
-
0034704386
-
Pure autonomic failure in association with human α-synucleinopathy
-
Arai, K., Kato, N., Kashiwado, K. and Hattori, T. (2000) Pure autonomic failure in association with human α-synucleinopathy. Neurosci. Lett. 296, 171-173.
-
(2000)
Neurosci. Lett
, vol.296
, pp. 171-173
-
-
Arai, K.1
Kato, N.2
Kashiwado, K.3
Hattori, T.4
-
4
-
-
0031721278
-
Lewy body in neurodegeneration with brain iron accumulation type 1 is immunoreactive for α-synuclein
-
Arawaka, S., Saito, Y., Murayama, S. and Mori, H. (1998) Lewy body in neurodegeneration with brain iron accumulation type 1 is immunoreactive for α-synuclein. Neurology 51, 887-889.
-
(1998)
Neurology
, vol.51
, pp. 887-889
-
-
Arawaka, S.1
Saito, Y.2
Murayama, S.3
Mori, H.4
-
5
-
-
0032719237
-
Widespread occurrence of α-synuclein/NACP- immunoreactive neuronal inclusions in juvenile and adult-onset Hallervorden-Spatz disease with Lewy bodies
-
Wakabayashi, K., Yoshimoto, M., Fukushima, T., Koide, R., Horikawa, Y. and Takahashi, H. (1999) Widespread occurrence of α-synuclein/NACP- immunoreactive neuronal inclusions in juvenile and adult-onset Hallervorden-Spatz disease with Lewy bodies. Neuropathol. Appl. Neurobiol. 25, 363-368.
-
(1999)
Neuropathol. Appl. Neurobiol
, vol.25
, pp. 363-368
-
-
Wakabayashi, K.1
Yoshimoto, M.2
Fukushima, T.3
Koide, R.4
Horikawa, Y.5
Takahashi, H.6
-
6
-
-
0033936784
-
α-Synuclein inclusions in amygdala in the brains of patients with the Parkinsonism-Dementia complex of Guam
-
Yamazaki, M., Arai, Y., Baba, M., Iwatsubo, T., Mori, O., Katayama, Y. and Oyanagi, K. (2000) α-Synuclein inclusions in amygdala in the brains of patients with the Parkinsonism-Dementia complex of Guam. J. Neuropathol. Exp. Neurol. 59, 585-591.
-
(2000)
J. Neuropathol. Exp. Neurol
, vol.59
, pp. 585-591
-
-
Yamazaki, M.1
Arai, Y.2
Baba, M.3
Iwatsubo, T.4
Mori, O.5
Katayama, Y.6
Oyanagi, K.7
-
7
-
-
0032990543
-
Antibodies to α-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimers disease
-
Lippa, C. F., Schmidt, M. L., Lee, V. M.-Y. and Trojanowski, J. Q. (1999) Antibodies to α-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimers disease. Ann. Neurol. 45, 353-357.
-
(1999)
Ann. Neurol
, vol.45
, pp. 353-357
-
-
Lippa, C.F.1
Schmidt, M.L.2
Lee, V.M.-Y.3
Trojanowski, J.Q.4
-
8
-
-
0032584686
-
Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies
-
Spillantini, M. G., Crowther, R. A., Jakes, R., Cairns, N. J., Lantos, P. L. and Goedert, M. (1998) Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci. Lett. 251, 205-208.
-
(1998)
Neurosci. Lett
, vol.251
, pp. 205-208
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
Cairns, N.J.4
Lantos, P.L.5
Goedert, M.6
-
9
-
-
33846989334
-
Adult-onset neurodegeneration with brain iron accumulation and cortical α-synuclein and tau pathology: A distinct clinico-pathological entity
-
Tofaris, G. K, Revesz, T., Jacques, T., Papacostas, S. and Chataway, J. (2007) Adult-onset neurodegeneration with brain iron accumulation and cortical α-synuclein and tau pathology: a distinct clinico-pathological entity. Arch. Neurol. 64, 280-282.
-
(2007)
Arch. Neurol
, vol.64
, pp. 280-282
-
-
Tofaris, G.K.1
Revesz, T.2
Jacques, T.3
Papacostas, S.4
Chataway, J.5
-
10
-
-
0035169488
-
Lewy body pathology in Alzheimer's disease
-
Kotzbauer, P. T., Trojanowski, J. Q. and Lee, V. M.-Y. (2001) Lewy body pathology in Alzheimer's disease. J. Mol. Neurosci. 17, 225-232.
-
(2001)
J. Mol. Neurosci
, vol.17
, pp. 225-232
-
-
Kotzbauer, P.T.1
Trojanowski, J.Q.2
Lee, V.M.-Y.3
-
11
-
-
0029904487
-
NACP, a protein implicated in Alzheimer's disease and learning is natively unfolded
-
Weinreb, P. H., Zhen, W., Poon, A. W., Conway, K. A. and Lansbury, P. T (1996) NACP, a protein implicated in Alzheimer's disease and learning is natively unfolded. Biochemistry 35, 13709-13715.
-
(1996)
Biochemistry
, vol.35
, pp. 13709-13715
-
-
Weinreb, P.H.1
Zhen, W.2
Poon, A.W.3
Conway, K.A.4
Lansbury, P.T.5
-
12
-
-
0032540327
-
Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes
-
Davidson, W. S., Jonas, A., Clayton, D. F. and George, J. M. (1998) Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes. J. Biol. Chem. 273, 9443-9449.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 9443-9449
-
-
Davidson, W.S.1
Jonas, A.2
Clayton, D.F.3
George, J.M.4
-
13
-
-
0032492689
-
Regulation of phospholipase D2: Selective inhibition of mammalian phospholipase D isoenzymes by α- and β-synucleins
-
Jenco, J. M., Rawlingson, A., Daniels, B. and Morris, A. J. (1998) Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by α- and β-synucleins. Biochemistry 37, 4901-4909.
-
(1998)
Biochemistry
, vol.37
, pp. 4901-4909
-
-
Jenco, J.M.1
Rawlingson, A.2
Daniels, B.3
Morris, A.J.4
-
14
-
-
0034077041
-
Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system
-
Abeliovich, A., Schmitz, Y., Farinas, I., Choi-Lundberg, D., Ho, W. H., Castillo, P. E. Shinsky, N., Verdugo, J. M., Armanini, M., Ryan, A et al. (2000) Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25, 239-252.
-
(2000)
Neuron
, vol.25
, pp. 239-252
-
-
Abeliovich, A.1
Schmitz, Y.2
Farinas, I.3
Choi-Lundberg, D.4
Ho, W.H.5
Castillo, P.E.6
Shinsky, N.7
Verdugo, J.M.8
Armanini, M.9
Ryan, A.10
-
15
-
-
0034193399
-
Synucleins are developmentally expressed and α-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons
-
Murphy, D. D., Rueter, S. M., Trojanowski, J. Q. and Lee, V. M.-Y. (2000) Synucleins are developmentally expressed and α-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons. J. Neurosci. 20, 3214-3220.
-
(2000)
J. Neurosci
, vol.20
, pp. 3214-3220
-
-
Murphy, D.D.1
Rueter, S.M.2
Trojanowski, J.Q.3
Lee, V.M.-Y.4
-
16
-
-
0029127954
-
Characterization of a novel protein regulated during the critical period for song learning in the zebra finch
-
George, J. M., Jin, H., Woods, W. S. and Clayton, D. F. (1995) Characterization of a novel protein regulated during the critical period for song learning in the zebra finch. Neuron 15, 361-372.
-
(1995)
Neuron
, vol.15
, pp. 361-372
-
-
George, J.M.1
Jin, H.2
Woods, W.S.3
Clayton, D.F.4
-
17
-
-
27544507306
-
alpha-Synuclein cooperates with CSPalpha in preventing neurodegeneration
-
Chandra, S., Gallardo, G., Fernandez-Chacon, R., Schluter, O. M. and Sudhof, T. C. (2005) alpha-Synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 123, 383-396.
-
(2005)
Cell
, vol.123
, pp. 383-396
-
-
Chandra, S.1
Gallardo, G.2
Fernandez-Chacon, R.3
Schluter, O.M.4
Sudhof, T.C.5
-
18
-
-
0038460184
-
Part II: α-synuclein and its molecular pathophysiological role in neurodegenerative disease
-
Dev, K. K., Hofele, K., Barbieri, S., Buchman, V. L. and van der Putten, H. (2003) Part II: α-synuclein and its molecular pathophysiological role in neurodegenerative disease. Neuropharmacolology 45, 14-44.
-
(2003)
Neuropharmacolology
, vol.45
, pp. 14-44
-
-
Dev, K.K.1
Hofele, K.2
Barbieri, S.3
Buchman, V.L.4
van der Putten, H.5
-
19
-
-
0032952414
-
Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions
-
Engelender, S., Kaminsky, Z., Guo, X., Sharp, A. H., Amaravi, R. K., Kleiderlein, J. J., Margolis, R. L., Troncoso, J. C., Lanahan, A. A., Worley, P. F. et al. (1999) Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions. Nat. Genet. 22, 110-114.
-
(1999)
Nat. Genet
, vol.22
, pp. 110-114
-
-
Engelender, S.1
Kaminsky, Z.2
Guo, X.3
Sharp, A.H.4
Amaravi, R.K.5
Kleiderlein, J.J.6
Margolis, R.L.7
Troncoso, J.C.8
Lanahan, A.A.9
Worley, P.F.10
-
20
-
-
0033565874
-
α-Synuclein shares physical and functional homology with 14-3-3 proteins
-
Ostrerova-Golts, N., Petrucelli, L., Farer, M., Mehta, N., Alexander, P., Choi, P., Palacino J, Hardy, J., Lee, J. M. and Wolozin, B. (1999) α-Synuclein shares physical and functional homology with 14-3-3 proteins. J. Neurosci. 19, 5782-5791.
-
(1999)
J. Neurosci
, vol.19
, pp. 5782-5791
-
-
Ostrerova-Golts, N.1
Petrucelli, L.2
Farer, M.3
Mehta, N.4
Alexander, P.5
Choi, P.6
Palacino, J.7
Hardy, J.8
Lee, J.M.9
Wolozin, B.10
-
21
-
-
0035976959
-
α-Synuclein affects the MAP kinase pathway and accelerates cell death
-
Iwata, A., Maruyama, M., Kanazawa, I. and Nukina, N. (2001) α-Synuclein affects the MAP kinase pathway and accelerates cell death. J. Biol. Chem. 276, 45320-45329.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 45320-45329
-
-
Iwata, A.1
Maruyama, M.2
Kanazawa, I.3
Nukina, N.4
-
22
-
-
0034604583
-
Wild-type but not Parkinson's disease-related Ala-53-Thr mutant α-synuclein protects neuronal cells from apoptotic stimuli
-
Alves da Costa, C., Ancolio, K. and Checler, F. (2000) Wild-type but not Parkinson's disease-related Ala-53-Thr mutant α-synuclein protects neuronal cells from apoptotic stimuli. J. Biol. Chem. 275, 24065-24069.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 24065-24069
-
-
Alves da Costa, C.1
Ancolio, K.2
Checler, F.3
-
23
-
-
0035109909
-
Effect of the over-expression of wild-type or mutant alpha-synuclein on cell susceptibility to insult
-
Lee, M., Hyun, D., Halliwell, B. and Jenner, P. (2001) Effect of the over-expression of wild-type or mutant alpha-synuclein on cell susceptibility to insult. J. Neurochem. 76, 998-1009
-
(2001)
J. Neurochem
, vol.76
, pp. 998-1009
-
-
Lee, M.1
Hyun, D.2
Halliwell, B.3
Jenner, P.4
-
24
-
-
0037192865
-
α-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress signalling pathway in neuronal cells
-
Hashimoto, M., Hsu, L. J., Rockenstein, E., Takenouchi, T., Mallory, M. and Masliah, E. (2002) α-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress signalling pathway in neuronal cells. J. Biol. Chem. 277, 11465-11472.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 11465-11472
-
-
Hashimoto, M.1
Hsu, L.J.2
Rockenstein, E.3
Takenouchi, T.4
Mallory, M.5
Masliah, E.6
-
25
-
-
34548341065
-
The effect of truncated human α-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease
-
in press
-
Michell, A. W., Tofaris, G. K., Gossage, H., Tyers, P., Spillantini, M. G. and Barker, R. A. (2007) The effect of truncated human α-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease. Cell Transplant., in press.
-
(2007)
Cell Transplant
-
-
Michell, A.W.1
Tofaris, G.K.2
Gossage, H.3
Tyers, P.4
Spillantini, M.G.5
Barker, R.A.6
-
26
-
-
34247139885
-
-
Hum. Mol. Genet. Epub ahead of print
-
Schneider, B. L., Seehus, C. R., Capowski, E. E., Aebischer, P., Zhang, S. C. and Svendsen, C. N. (2007) Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation. Hum. Mol. Genet. Epub ahead of print.
-
(2007)
Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation
-
-
Schneider, B.L.1
Seehus, C.R.2
Capowski, E.E.3
Aebischer, P.4
Zhang, S.C.5
Svendsen, C.N.6
-
27
-
-
0034614415
-
Constitutive phosphorylation of the Parkinson's disease associated α-synuclein
-
Okochi, M., Walter, J., Koyama, A., Nakajo, S., Baba, M., Iwatsubo, T., Meijer, L., Kahle, P. J. and Haass, C. (2000) Constitutive phosphorylation of the Parkinson's disease associated α-synuclein. J. Biol. Chem. 275, 390-397.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 390-397
-
-
Okochi, M.1
Walter, J.2
Koyama, A.3
Nakajo, S.4
Baba, M.5
Iwatsubo, T.6
Meijer, L.7
Kahle, P.J.8
Haass, C.9
-
28
-
-
0034714204
-
Synucleins are a novel class of substrates for G protein-coupled receptor kinases
-
Pronin, A. N., Morris, A. J., Surguchov, A. and Benovic, J. L. (2000) Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J. Biol. Chem. 275, 26515-26522.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 26515-26522
-
-
Pronin, A.N.1
Morris, A.J.2
Surguchov, A.3
Benovic, J.L.4
-
29
-
-
0036484302
-
Multiple phosphorylation of α-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation
-
Negro, A., Brunati, A. M., Donella-Deana, A. Massimino, M. L. and Pinna, L. A. (2002) Multiple phosphorylation of α-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation. FASEB J. 16, 210-212.
-
(2002)
FASEB J
, vol.16
, pp. 210-212
-
-
Negro, A.1
Brunati, A.M.2
Donella-Deana, A.3
Massimino, M.L.4
Pinna, L.A.5
-
30
-
-
0030882856
-
α-synuclein in Lewy Bodies
-
Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R. and Goedert, M. (1997) α-synuclein in Lewy Bodies. Nature 338, 839-840.
-
(1997)
Nature
, vol.338
, pp. 839-840
-
-
Spillantini, M.G.1
Schmidt, M.L.2
Lee, V.M.-Y.3
Trojanowski, J.Q.4
Jakes, R.5
Goedert, M.6
-
31
-
-
0032568534
-
α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
-
Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M. and Goedert, M. (1998) α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95, 6469-6473.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 6469-6473
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
Hasegawa, M.4
Goedert, M.5
-
32
-
-
0030744876
-
Mutation in α-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos, M. H., Lavendan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R. et al. (1997) Mutation in α-synuclein gene identified in families with Parkinson's disease. Science 276, 2045-2047.
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavendan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
-
33
-
-
0031990490
-
Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease
-
Kruger, R., Kuhn, W., Muller, T., Woitalla, D., Graeber, M., Kosel, S., Przuntek, H., Epplen, J. T., Schos, L. and Riess, O. (1998) Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nat. Genet. 18, 106-108.
-
(1998)
Nat. Genet
, vol.18
, pp. 106-108
-
-
Kruger, R.1
Kuhn, W.2
Muller, T.3
Woitalla, D.4
Graeber, M.5
Kosel, S.6
Przuntek, H.7
Epplen, J.T.8
Schos, L.9
Riess, O.10
-
34
-
-
10744230149
-
The new mutation E46K of alpha-synucleincauses Parkinson and Lewy body Dementia
-
Zarranz, J. J., Alegre, J., Gomez-Esteban, J. C., Lezcano, E., Ros, R., Ampuero, I., Vidal, L., Hoenicka, J., Rodriguez, Atares, B. et al. (2004) The new mutation E46K of alpha-synucleincauses Parkinson and Lewy body Dementia. Ann. Neurol. 55, 164-173.
-
(2004)
Ann. Neurol
, vol.55
, pp. 164-173
-
-
Zarranz, J.J.1
Alegre, J.2
Gomez-Esteban, J.C.3
Lezcano, E.4
Ros, R.5
Ampuero, I.6
Vidal, L.7
Hoenicka, J.8
-
35
-
-
0033515471
-
Both familial Parkinson's disease mutations accelerate α-synuclein aggregation
-
Narhi, L., Wood, S. J., Steavenson, S., Jiang, Y., Wu, G. M., Anafi, D., Kaufman, S. A., Martin, F., Sitney, K., Denis, P. et al. (1999) Both familial Parkinson's disease mutations accelerate α-synuclein aggregation. J. Biol. Chem. 274, 9843-9846.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 9843-9846
-
-
Narhi, L.1
Wood, S.J.2
Steavenson, S.3
Jiang, Y.4
Wu, G.M.5
Anafi, D.6
Kaufman, S.A.7
Martin, F.8
Sitney, K.9
Denis, P.10
-
36
-
-
0034712918
-
Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross beta conformation
-
Serpell, L. C., Berriman, J., Jakes, R., Goedert, M. and Crowther, R. A. (2000) Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross beta conformation. Proc. Natl. Acad. Sci. USA 97, 4897-4902.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 4897-4902
-
-
Serpell, L.C.1
Berriman, J.2
Jakes, R.3
Goedert, M.4
Crowther, R.A.5
-
37
-
-
0034681163
-
Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy
-
Conway, K. A., Lee S.-L., Rochet, J. C., Ding, T. T., Williamson, R. E. and Lansbury, P. T. (2000) Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy. Proc Natl Acad Sci USA 97, 571-576.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 571-576
-
-
Conway, K.A.1
Lee, S.-L.2
Rochet, J.C.3
Ding, T.T.4
Williamson, R.E.5
Lansbury, P.T.6
-
38
-
-
6344228684
-
Mutation E46K increases phospholipids binding and assembly into filaments of human alpha-synuclein
-
Choi, W., Zibanee, S., Jakes, R., Serpell, L. C., Davletov, B., Crowther, R. A. and Goedert, M. (2004) Mutation E46K increases phospholipids binding and assembly into filaments of human alpha-synuclein. FEBS Lett. 576, 363-368.
-
(2004)
FEBS Lett
, vol.576
, pp. 363-368
-
-
Choi, W.1
Zibanee, S.2
Jakes, R.3
Serpell, L.C.4
Davletov, B.5
Crowther, R.A.6
Goedert, M.7
-
39
-
-
14844335694
-
The E46K mutation in alpha-synuclein increases amyloid fibril formation
-
Greenbaum, E. A., Graves, C. L., Mishizen-Eberz, A. J., Lupoli, M. A., Lynch, D. R., Englander, S. W., Axelsen, P. H. and Giasson, B. I. (2005) The E46K mutation in alpha-synuclein increases amyloid fibril formation. J. Biol. Chem. 280, 7800-7807.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 7800-7807
-
-
Greenbaum, E.A.1
Graves, C.L.2
Mishizen-Eberz, A.J.3
Lupoli, M.A.4
Lynch, D.R.5
Englander, S.W.6
Axelsen, P.H.7
Giasson, B.I.8
-
40
-
-
4644290985
-
alpha-Synuclein locus duplication as cause of familial Parkinson's disease
-
Chartier-Harlin, M. C., Kachergus, J., Roumier, C., Mouroux, V., Douay, X., Lincoln, S., Levecque, C., Larvor, L., Andrieux, J., Hulihan, M. et al. (2004) alpha-Synuclein locus duplication as cause of familial Parkinson's disease. Lancet 364, 1167-1169.
-
(2004)
Lancet
, vol.364
, pp. 1167-1169
-
-
Chartier-Harlin, M.C.1
Kachergus, J.2
Roumier, C.3
Mouroux, V.4
Douay, X.5
Lincoln, S.6
Levecque, C.7
Larvor, L.8
Andrieux, J.9
Hulihan, M.10
-
41
-
-
4644236043
-
Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease
-
Ibanez, P., Bonnet, A. M., Debarges, B., Lohmann, E., Tison, F., Pollak, P., Agid, Y., Durr, A., Brice, A. (2004) Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease. Lancet 364, 1169-1171
-
(2004)
Lancet
, vol.364
, pp. 1169-1171
-
-
Ibanez, P.1
Bonnet, A.M.2
Debarges, B.3
Lohmann, E.4
Tison, F.5
Pollak, P.6
Agid, Y.7
Durr, A.8
Brice, A.9
-
42
-
-
0242300619
-
alpha-Synuclein locus triplication causes Parkinson's disease
-
Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R. et al. (2003) alpha-Synuclein locus triplication causes Parkinson's disease. Science 302, 841.
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
Hulihan, M.7
Peuralinna, T.8
Dutra, A.9
Nussbaum, R.10
-
43
-
-
0037118259
-
Neuronal α-synucleinopathy with severe movement disorder in mice expressing A53T human a-synuclein
-
Giasson, B. I., Duda, J. E., Quinn, S. M., Zhang, B., Trojanowski, J. Q. and Lee, V. M.-Y. (2002) Neuronal α-synucleinopathy with severe movement disorder in mice expressing A53T human a-synuclein. Neuron 34, 521-533.
-
(2002)
Neuron
, vol.34
, pp. 521-533
-
-
Giasson, B.I.1
Duda, J.E.2
Quinn, S.M.3
Zhang, B.4
Trojanowski, J.Q.5
Lee, V.M.-Y.6
-
44
-
-
0037173006
-
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala53Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice
-
Lee, M. K., Stirling, W., Xu, Y., Xu, X., Qui, D., Mandir, A. S., Dawson, T. M., Copeland, N. G., Jenkins, N. A. and Price, D. L. (2002) Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala53Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. Proc. Natl. Acad. Sci. USA 99, 8968-8973.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 8968-8973
-
-
Lee, M.K.1
Stirling, W.2
Xu, Y.3
Xu, X.4
Qui, D.5
Mandir, A.S.6
Dawson, T.M.7
Copeland, N.G.8
Jenkins, N.A.9
Price, D.L.10
-
45
-
-
0036855635
-
-
Neumann, M., Kahle, P. J., Giasson, B. I., Ozmen, L., Borroni, E., Spooren, W., Muller, V., Odoy, S., Fujiwara, H., Hasegawa, M. et al. C. (2002) Misfolded proteinase K-resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α- synucleinopathies. J. Clin. Invest. 110, 1429-1439.
-
Neumann, M., Kahle, P. J., Giasson, B. I., Ozmen, L., Borroni, E., Spooren, W., Muller, V., Odoy, S., Fujiwara, H., Hasegawa, M. et al. C. (2002) Misfolded proteinase K-resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α- synucleinopathies. J. Clin. Invest. 110, 1429-1439.
-
-
-
-
46
-
-
0034979314
-
Lack of nigral pathology in transgenic mice expressing human α-synuclein driven by the tyrosine hydroxylase promoter
-
Matsuoka, Y., Vila, M., Lincoln, S., McCormack, A., Dickson, D., Langston, W. J., McGowan, E., Farrer, M., Hardy, J., Duff, K. et al. (2001) Lack of nigral pathology in transgenic mice expressing human α-synuclein driven by the tyrosine hydroxylase promoter. Neurobiol. Dis. 8, 535-539.
-
(2001)
Neurobiol. Dis
, vol.8
, pp. 535-539
-
-
Matsuoka, Y.1
Vila, M.2
Lincoln, S.3
McCormack, A.4
Dickson, D.5
Langston, W.J.6
McGowan, E.7
Farrer, M.8
Hardy, J.9
Duff, K.10
-
47
-
-
0036550101
-
Parkinson-like neurodegeneration induced by targeted overexpression of α-synuclein in the nigrostriatal system
-
Kirik, D., Rosenblad, C., Burger, C., Lundberg, C., Johansen, T. E., Muzyczka, N., Mandel, R. J. and Bjorklund, A. (2002) Parkinson-like neurodegeneration induced by targeted overexpression of α-synuclein in the nigrostriatal system. J. Neurosci. 22, 2780-2791.
-
(2002)
J. Neurosci
, vol.22
, pp. 2780-2791
-
-
Kirik, D.1
Rosenblad, C.2
Burger, C.3
Lundberg, C.4
Johansen, T.E.5
Muzyczka, N.6
Mandel, R.J.7
Bjorklund, A.8
-
48
-
-
0036202813
-
Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra
-
Klein, R. L., King, M. A., Hamby, M. E. and Meyer, E. M. (2002) Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra. (2002) Hum. Gene Ther. 13, 605-612.
-
(2002)
Hum. Gene Ther
, vol.13
, pp. 605-612
-
-
Klein, R.L.1
King, M.A.2
Hamby, M.E.3
Meyer, E.M.4
-
49
-
-
0036679197
-
α-Synucleinopathy and selective dopaminergic neurone loss in a rat lentiviral-based model of Parkinson's disease
-
Lo Bianco, C., Ridet, J.-L., Schneider, B. L., Deglon, N. and Aebischer, P. (2002) α-Synucleinopathy and selective dopaminergic neurone loss in a rat lentiviral-based model of Parkinson's disease. Proc. Natl. Acad. Sci. USA 99, 10813-10818.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 10813-10818
-
-
Lo Bianco, C.1
Ridet, J.-L.2
Schneider, B.L.3
Deglon, N.4
Aebischer, P.5
-
50
-
-
0034704752
-
A Drosophila model of Parkinson's disease
-
Feany, M. B. and Bender, W. W. (2000)A Drosophila model of Parkinson's disease. Nature 404, 394-398.
-
(2000)
Nature
, vol.404
, pp. 394-398
-
-
Feany, M.B.1
Bender, W.W.2
-
51
-
-
0031787871
-
Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson's disease
-
Conway, K. A., Harper, J. D. and Lansbury, P. T. (1998) Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson's disease. Nat. Med. 4, 1318-1320.
-
(1998)
Nat. Med
, vol.4
, pp. 1318-1320
-
-
Conway, K.A.1
Harper, J.D.2
Lansbury, P.T.3
-
52
-
-
0034663039
-
The A53T α-synuclein mutation increases iron-dependent aggregation and toxicity
-
Ostrerova-Golts, N., Petrucelli, L., Hardy, J., Lee, J. M., Farer, M. and Wolozin, B. (2000) The A53T α-synuclein mutation increases iron-dependent aggregation and toxicity. J. Neurosci. 20, 6048-6054.
-
(2000)
J. Neurosci
, vol.20
, pp. 6048-6054
-
-
Ostrerova-Golts, N.1
Petrucelli, L.2
Hardy, J.3
Lee, J.M.4
Farer, M.5
Wolozin, B.6
-
53
-
-
0033681149
-
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
-
Betarbet, R., Sherer, T. B., McKenzie, G., Garcia-Osuna, M., Panov, A. V. and Greenamyre, J. T. (2001) Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat. Neurosci. 3, 1301-1306.
-
(2001)
Nat. Neurosci
, vol.3
, pp. 1301-1306
-
-
Betarbet, R.1
Sherer, T.B.2
McKenzie, G.3
Garcia-Osuna, M.4
Panov, A.V.5
Greenamyre, J.T.6
-
54
-
-
0034602442
-
Oxidative damage linked to neurodegeneration by selective α-synuclein nitration in synucleinopathy lesions
-
Giasson, B. I., Duda, J. E., Murray, I. V. J., Chen, Q., Souza, J. M., Hurting, H. I., Ischiropoulos, H., Trojanowski, J. Q. and Lee, V. M.-Y. (2000) Oxidative damage linked to neurodegeneration by selective α-synuclein nitration in synucleinopathy lesions. Science 290, 985-989.
-
(2000)
Science
, vol.290
, pp. 985-989
-
-
Giasson, B.I.1
Duda, J.E.2
Murray, I.V.J.3
Chen, Q.4
Souza, J.M.5
Hurting, H.I.6
Ischiropoulos, H.7
Trojanowski, J.Q.8
Lee, V.M.-Y.9
-
55
-
-
9144229591
-
Functional consequences of alpha-synuclein tyrosine nitration: Diminished binding to lipid vesicles and increased fibril formation
-
Hodara, R., Norris, E. H., Giasson, B. I., Mishizen-Eberz, A. J., Lynch, D. R., Lee, V. M. and Ischiropoulos, H. (2004) Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation. J. Biol. Chem. 279, 47746-47753.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 47746-47753
-
-
Hodara, R.1
Norris, E.H.2
Giasson, B.I.3
Mishizen-Eberz, A.J.4
Lynch, D.R.5
Lee, V.M.6
Ischiropoulos, H.7
-
56
-
-
0036174010
-
α-Synuclein is phosphorylated in synucleinopathy lesions
-
Fujiwara, H., Hasegawa, M., Dohmae, N., Kawashima, A., Masliah, E., Goldberg, M. S., Shen, J., Takio, K. and Iwatsubo, T. (2002) α-Synuclein is phosphorylated in synucleinopathy lesions. Nat. Cell. Biol. 4, 160-164.
-
(2002)
Nat. Cell. Biol
, vol.4
, pp. 160-164
-
-
Fujiwara, H.1
Hasegawa, M.2
Dohmae, N.3
Kawashima, A.4
Masliah, E.5
Goldberg, M.S.6
Shen, J.7
Takio, K.8
Iwatsubo, T.9
-
57
-
-
0031728689
-
Synthetic filaments assembled from C-terminally truncated α-synuclein
-
Crowther, R. A., Jakes, R., Spillantini, M. G. and Goedert, M. (1998) Synthetic filaments assembled from C-terminally truncated α-synuclein. FEBS Lett. 436, 309-312.
-
(1998)
FEBS Lett
, vol.436
, pp. 309-312
-
-
Crowther, R.A.1
Jakes, R.2
Spillantini, M.G.3
Goedert, M.4
-
58
-
-
0038116620
-
Role of alpha-synuclein carboxy-terminus on fibril formation in vitro
-
Murray, I. V., Giasson, B. I., Quinn, S. M., Koppaka, V., Axelsen, P. H., Ischiropoulos, H., Trojanowski, J. Q. and Lee, V.-M. Y. (2003) Role of alpha-synuclein carboxy-terminus on fibril formation in vitro. Biochemistry 42, 8530-8540.
-
(2003)
Biochemistry
, vol.42
, pp. 8530-8540
-
-
Murray, I.V.1
Giasson, B.I.2
Quinn, S.M.3
Koppaka, V.4
Axelsen, P.H.5
Ischiropoulos, H.6
Trojanowski, J.Q.7
Lee, V.-M.Y.8
-
59
-
-
0242666359
-
Ubiquitination of α-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function
-
Tofaris, G. K., Razzaq, A., Ghetti, B., Lilley, K. S. and Spillantini, M. G. (2003) Ubiquitination of α-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function. J. Biol. Chem. 278, 44405-44411.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 44405-44411
-
-
Tofaris, G.K.1
Razzaq, A.2
Ghetti, B.3
Lilley, K.S.4
Spillantini, M.G.5
-
60
-
-
33646097224
-
Pathological changes in dopaminergic neurons in mice transgenic for human α-synuclein (1-120): Implications for Lewy body disorders
-
Tofaris, G. K., Reitbock, P. G., Humpy, T., Limounsine, S., O'Connell, M., Ghetti, B., Wilkinson, L., Goedert, M. and Spillantini, M. G. (2006) Pathological changes in dopaminergic neurons in mice transgenic for human α-synuclein (1-120): implications for Lewy body disorders. J. Neurosci. 26, 3942-3950.
-
(2006)
J. Neurosci
, vol.26
, pp. 3942-3950
-
-
Tofaris, G.K.1
Reitbock, P.G.2
Humpy, T.3
Limounsine, S.4
O'Connell, M.5
Ghetti, B.6
Wilkinson, L.7
Goedert, M.8
Spillantini, M.G.9
-
61
-
-
0032879452
-
Role of cytochrome c as a stimulator of alpha-synuclein aggregation in Lewy body disease
-
Hashimoto, M., Takeda, A., Hsu, L. J., Takenouchi, T. and Masliah, E. (1999) Role of cytochrome c as a stimulator of alpha-synuclein aggregation in Lewy body disease. J. Biol. Chem. 274, 28849-2885.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 28849-22885
-
-
Hashimoto, M.1
Takeda, A.2
Hsu, L.J.3
Takenouchi, T.4
Masliah, E.5
-
62
-
-
0037474250
-
Cellular polyamines promote the aggregation of alpha-synuclein
-
Antony, T., Hoyer, W., Cherny, D., Heim, G., Jovin, T. M. and Subramaniam, V. (2003) Cellular polyamines promote the aggregation of alpha-synuclein., J. Biol. Chem. 278, 3235-3240.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 3235-3240
-
-
Antony, T.1
Hoyer, W.2
Cherny, D.3
Heim, G.4
Jovin, T.M.5
Subramaniam, V.6
-
63
-
-
2942584868
-
NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation
-
Fernandez, C. O., Hoyer, W., Zweckstetter, M., Jares-Erijman, E. A., Subramaniam, V., Griesinger, C. and Jovin, T. M. (2004) NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation. EMBO, J. 23, 2039-2046.
-
(2004)
EMBO, J
, vol.23
, pp. 2039-2046
-
-
Fernandez, C.O.1
Hoyer, W.2
Zweckstetter, M.3
Jares-Erijman, E.A.4
Subramaniam, V.5
Griesinger, C.6
Jovin, T.M.7
-
64
-
-
0037378356
-
Polycation-induced oligomerization and accelerated fibrillation of human alpha-synuclein in vitro
-
Goers, J., Uversky, V. N. and Fink, A. L. (2003) Polycation-induced oligomerization and accelerated fibrillation of human alpha-synuclein in vitro. Protein Sci. 12, 702-707.
-
(2003)
Protein Sci
, vol.12
, pp. 702-707
-
-
Goers, J.1
Uversky, V.N.2
Fink, A.L.3
-
65
-
-
20444401187
-
Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations
-
Norris, E. H., Giasson, B. I., Hodara, R., Xu, S., Trojanowski, J. Q., Ischiropoulos H and Lee, V. M. (2005) Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations. J. Biol. Chem. 280, 21212-2129.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 21212-22129
-
-
Norris, E.H.1
Giasson, B.I.2
Hodara, R.3
Xu, S.4
Trojanowski, J.Q.5
Ischiropoulos, H.6
Lee, V.M.7
-
66
-
-
0035947372
-
Impairment of the ubiquitin-proteasome system by protein aggregation
-
Bence, N. F., Sampat, R. M. and Kopito, R. R. (2001) Impairment of the ubiquitin-proteasome system by protein aggregation. Science 292, 1552-1555.
-
(2001)
Science
, vol.292
, pp. 1552-1555
-
-
Bence, N.F.1
Sampat, R.M.2
Kopito, R.R.3
-
67
-
-
1842766144
-
Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins
-
Venkatraman, P., Wetzel, R., Tanaka, M., Nukina, N. and Goldberg, A. L. (2004) Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins. Mol. Cell 14, 95-104.
-
(2004)
Mol. Cell
, vol.14
, pp. 95-104
-
-
Venkatraman, P.1
Wetzel, R.2
Tanaka, M.3
Nukina, N.4
Goldberg, A.L.5
-
68
-
-
1842424791
-
Proteasomal inhibition by alpha-synuclein filaments and oligomers
-
Lindersson, E., Beedholm, R., Hojrup, P., Moos, T., Gai, W., Hendil, K. B. and Jensen, P. H. (2004) Proteasomal inhibition by alpha-synuclein filaments and oligomers. J. Biol. Chem. 279, 12924-12934.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 12924-12934
-
-
Lindersson, E.1
Beedholm, R.2
Hojrup, P.3
Moos, T.4
Gai, W.5
Hendil, K.B.6
Jensen, P.H.7
-
69
-
-
0035976835
-
α-Synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome
-
Tofaris, G. K., Layfield, R. and Spillantini, M. G. (2001) α-Synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome. FEBS Lett. 509, 22-26.
-
(2001)
FEBS Lett
, vol.509
, pp. 22-26
-
-
Tofaris, G.K.1
Layfield, R.2
Spillantini, M.G.3
-
70
-
-
0037449572
-
Endoproteolytic activity of the proteasome
-
Liu, C.-W., Corboy, M. J., DeMartino, G. N. and Thomas, P. J. (2003) Endoproteolytic activity of the proteasome. Science 299, 408-411.
-
(2003)
Science
, vol.299
, pp. 408-411
-
-
Liu, C.-W.1
Corboy, M.J.2
DeMartino, G.N.3
Thomas, P.J.4
-
71
-
-
0036468432
-
Chaperone suppression of α-synuclein toxicity in a Drosophila Model for Parkinson's disease
-
Auluck, P. K., Chan, H. Y. E., Trojanowski, J. Q., Lee, V. M. and Bonini, N. M. (2002) Chaperone suppression of α-synuclein toxicity in a Drosophila Model for Parkinson's disease. Science 295, 865-868.
-
(2002)
Science
, vol.295
, pp. 865-868
-
-
Auluck, P.K.1
Chan, H.Y.E.2
Trojanowski, J.Q.3
Lee, V.M.4
Bonini, N.M.5
-
72
-
-
21244499845
-
The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways
-
Shin, Y., Klucken, J., Patterson, C., Hyman, B. T. and McLean, P. J. (2005) The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways., J. Biol. Chem. 280, 23727-23734.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 23727-23734
-
-
Shin, Y.1
Klucken, J.2
Patterson, C.3
Hyman, B.T.4
McLean, P.J.5
-
73
-
-
0035834655
-
Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins
-
Perrin, R. J., Woods, W. S., Clayton, D. F. and George, J. M. (2001) Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins. J. Biol. Chem. 276, 41958-41962.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 41958-41962
-
-
Perrin, R.J.1
Woods, W.S.2
Clayton, D.F.3
George, J.M.4
-
74
-
-
0037456578
-
The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease
-
Sharon, R., Bar-Joseph, I., Frosch, M. P., Walsh, D. M., Hamilton, J. A. and Selkoe, D. J. (2003) The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron 37, 583-595.
-
(2003)
Neuron
, vol.37
, pp. 583-595
-
-
Sharon, R.1
Bar-Joseph, I.2
Frosch, M.P.3
Walsh, D.M.4
Hamilton, J.A.5
Selkoe, D.J.6
-
75
-
-
0035800097
-
Vesicle permeabilization for the pathogenesis and treatment of Parkinson's disease
-
Volles, M. J., Lee, S. J., Rochet, J. C., Shtilerman, M. D., Ding, T. T., Kessler, J. C. and Lansbury, P. T. (2001) Vesicle permeabilization for the pathogenesis and treatment of Parkinson's disease. Biochemistry 40, 7812-7819.
-
(2001)
Biochemistry
, vol.40
, pp. 7812-7819
-
-
Volles, M.J.1
Lee, S.J.2
Rochet, J.C.3
Shtilerman, M.D.4
Ding, T.T.5
Kessler, J.C.6
Lansbury, P.T.7
-
76
-
-
0141891097
-
The association of alpha-synuclein with membranes affects bilayer structure, stability and fibril formation
-
Zhu, M., Li, J. and Fink, A. L. (2003) The association of alpha-synuclein with membranes affects bilayer structure, stability and fibril formation. J. Biol. Chem. 278, 40186-40197.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 40186-40197
-
-
Zhu, M.1
Li, J.2
Fink, A.L.3
-
77
-
-
33748502763
-
Alpha-synuclein overexpression increases cytosolic catecholamine concentration
-
Mosharov, E. V., Staal, R. G., Bove, J., Prou, D., Hananiya, A., Markov, D., Poulsen, N., Larsen, K. E., Moore, C. M., Troyer, M. D. et al. (2006) Alpha-synuclein overexpression increases cytosolic catecholamine concentration. J. Neurosci. 26, 9304-9311.
-
(2006)
J. Neurosci
, vol.26
, pp. 9304-9311
-
-
Mosharov, E.V.1
Staal, R.G.2
Bove, J.3
Prou, D.4
Hananiya, A.5
Markov, D.6
Poulsen, N.7
Larsen, K.E.8
Moore, C.M.9
Troyer, M.D.10
-
78
-
-
0035834360
-
Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct
-
Conway, K. A., Rochet, J. C., Bieganski, R. M. and Lansbury, P. T. (2001) Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct. Science 294, 1346-1349.
-
(2001)
Science
, vol.294
, pp. 1346-1349
-
-
Conway, K.A.1
Rochet, J.C.2
Bieganski, R.M.3
Lansbury, P.T.4
-
79
-
-
33749170166
-
Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates
-
Mazzulli, J. R., Mishizen, A. J., Giasson, B. I., Lynch, D. R., Thomas, S. A., Nakashima, A., Nagatsu, T., Ota, A. and Ischiropoulos, H. (2006) Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates. J. Neurosci. 26, 10068-10078.
-
(2006)
J. Neurosci
, vol.26
, pp. 10068-10078
-
-
Mazzulli, J.R.1
Mishizen, A.J.2
Giasson, B.I.3
Lynch, D.R.4
Thomas, S.A.5
Nakashima, A.6
Nagatsu, T.7
Ota, A.8
Ischiropoulos, H.9
-
80
-
-
0036278335
-
Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson's disease
-
Xu, J., Kao, S.-Y., Lee, F. J. S., Song, W., Jin, L.-W. and Yanker, B. A. (2002) Dopamine-dependent neurotoxicity of α-synuclein: a mechanism for selective neurodegeneration in Parkinson's disease. Nat. Med. 8, 600-606.
-
(2002)
Nat. Med
, vol.8
, pp. 600-606
-
-
Xu, J.1
Kao, S.-Y.2
Lee, F.J.S.3
Song, W.4
Jin, L.-W.5
Yanker, B.A.6
-
81
-
-
0036468957
-
Overexpression of human α-synuclein causes dopamine neurone death in primary human mesencephalic culture
-
Zhou, W., Schaak, J., Zawada, W. M. and Freed, C. R. (2002) Overexpression of human α-synuclein causes dopamine neurone death in primary human mesencephalic culture. Brain Res. 926, 42-50.
-
(2002)
Brain Res
, vol.926
, pp. 42-50
-
-
Zhou, W.1
Schaak, J.2
Zawada, W.M.3
Freed, C.R.4
-
82
-
-
30044439773
-
Interaction with phospholipids modulates alpha-synuclein nitration and lipi-protein adduct formation
-
Trostchansky, A., Lind, S., Hodara, R., Oe, T., Blair, I. A., Ischiropoulos, H., Rubbo, H. and Souza, J. M. (2006) Interaction with phospholipids modulates alpha-synuclein nitration and lipi-protein adduct formation. Biochem. J. 393, 343-349.
-
(2006)
Biochem. J
, vol.393
, pp. 343-349
-
-
Trostchansky, A.1
Lind, S.2
Hodara, R.3
Oe, T.4
Blair, I.A.5
Ischiropoulos, H.6
Rubbo, H.7
Souza, J.M.8
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