Interaction with phospholipids modulates α-synuclein nitration and lipid-protein adduct formation

Biochemical Journal

Volumn 393, Issue 1, 2006, Pages 343-349

  Trostchansky, Andrés ^a   Lind, Summer ^b   Hodara, Roberto ^b   Oe, Tomoyuki ^c   Blair, Ian A ^c   Ischiropoulos, Harry ^b   Rubbo, Homero ^a   Souza, José M ^a  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

synuclein; Lipid protein adduct; Neurodegenerative disorder; Nitration; Parkinson's disease; Peroxynitrite

Indexed keywords

BIOMARKERS; FATTY ACIDS; LIQUID CHROMATOGRAPHY; NITRATION; OXIDATION; PATHOLOGY; PHOSPHOLIPIDS;

Α-SYNUCLEIN; LIPID-PROTEIN ADDUCT; NEURODEGENERATIVE DISORDER; PARKINSON'S DISEASE; PEROXYNITRITE;

PROTEINS;

ALPHA SYNUCLEIN; GLYCOSYLPHOSPHATIDYLINOSITOL; PEROXYNITRITE;

ARTICLE; DEGENERATIVE DISEASE; LIPID OXIDATION; LIPID PEROXIDATION; LIQUID CHROMATOGRAPHY; MOLECULAR MECHANICS; NERVE DEGENERATION; NITRATION; NONHUMAN; PARKINSON DISEASE; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; PROTEIN MODIFICATION; PROTEIN STRUCTURE;

ALDEHYDES; ALPHA-SYNUCLEIN; GENE EXPRESSION REGULATION; HUMANS; LIPID PEROXIDATION; NITRATES; OXIDATION-REDUCTION; PEROXYNITROUS ACID; PHOSPHOLIPIDS;

ANIMALIA;

EID: 30044439773     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20051277     Document Type: Article

References (27)

1. Duda, J. E., Giasson, B. I., Chen, Q., Gur, T. L., Hurtig, H. I., Stern, M. B., Gollomp, S. M., Ischiropoulos, H., Lee, V. M. and Trojanowski, J. Q. (2000) Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies. Am. J. Pathol. 157, 1439-1445
2. Spillantini, M. G., Schmidt, M. L., Lee, V. M., Trojanowski, J. Q., Jakes, R. and Goedert, M. (1997) Alpha-synuclein in Lewy bodies. Nature (London) 388, 839-840
3. Giasson, B. I., Uryu, K., Trojanowski, J. Q. and Lee, V. M. (1999) Mutant and wild type human alpha-synudeins assemble into elongated filaments with distinct morphologies in vitro. J. Biol. Chem. 274, 7619-7622
4. Davidson, W. S., Jonas, A., Clayton, D. F. and George, J. M. (1998) Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes. J. Biol. Chem. 273, 9443-9449
5. Jo, E., McLaurin, J., Yip, C. M., St George-Hyslop, P. and Fraser, P. E. (2000) Alpha-synuclein membrane interactions and lipid specificity. J. Biol. Chem. 275, 34328-34334
6. Giasson, B. I., Duda, J. E., Murray, I. V., Chen, Q., Souza, J. M., Hurtig, H. I., Ischiropoulos, H., Trojanowski, J. Q. and Lee, V. M. (2000) Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science 290, 985-989
7. Souza, J. M., Giasson, B. I., Chen, Q., Lee, V. M. and Ischiropoulos, H. (2000) Dityrosine cross-linking promotes formation of stable alpha-synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies. J. Biol. Chem. 275, 18344-18349
8. Norris, E. H., Giasson, B. I., Ischiropoulos, H. and Lee, V. M. (2003) Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications. J. Biol. Chem. 278, 27230-27240
9. Hodara, R., Norris, E. H., Giasson, B. I., Mishizen-Eberz, A. J., Lynch, D. R., Lee, V. M. and Ischiropoulos, H. (2004) Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation. J. Biol. Chem. 279, 47746-47753
10. Uchida, K., Sakai, K., Itakura, K., Osawa, T. and Toyokuni, S. (1997) Protein modification by lipid peroxidation products: formation of malondialdehyde-derived N(epsilon)-(2-propenol)lysine in proteins. Arch. Biochem. Biophys. 346, 45-52
11. Uchida, K. (2000) Role of reactive aldehyde in cardiovascular diseases. Free Radical Biol. Med. 28, 1685-1696
12. Trostchansky, A., Batthyany, C., Botti, H., Radi, R., Denicola, A. and Rubbo, H. (2001) Formation of lipid-protein adducts in low-density lipoprotein by fluxes of peroxynitrite and its inhibition by nitric oxide. Arch. Biochem. Biophys. 395, 225-232
13. Trostchansky, A., Ferrer-Sueta, G., Batthyany, C., Botti, H., Batinic-Haberle, I., Radi, R. and Rubbo, H. (2003) Peroxynitrite-mediated LDL oxidation is inhibited by manganese porphyris in the presence of uric acid. Free Radical Biol. Med. 35, 1293-1300
14. Perrin, R. J., Woods, W. S., Clayton, D. F. and George, J. M. (2000) Interaction of human alpha-synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis. J. Biol. Chem. 275, 34393-34398
15. Perrin, R. J., Woods, W. S., Clayton, D. F. and George, J. M. (2001) Exposure to long-chain polyunsaturated fatty acids triggers rapid multimerization of synucleins. J. Biol. Chem. 276, 41958-41962
16. Radi, R., Beckman, J. S., Bush, K. M. and Freeman, B. A. (1991) Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide. Arch. Biochem. Biophys. 288, 481-487
17. Radi, R., Denicola, A., Alvarez, B., Ferrer, G. and Rubbo, H. (2000) The biological chemistry of peroxynitrite. In Nitric Oxide Biology and Pathobiology (Ignarro, L. J., ed.), pp. 57-82, Academic Press, San Diego, CA
18. Takahashi, T., Yamashita, H., Nakamura, T., Nagano, Y. and Nakamura, S. (2002) Tyrosine 125 of alpha-synuclein plays a critical role for dimerization following nitrative stress. Brain Res. 938, 73-80
19. Paxinou, E., Chen, Q., Weisse, M., Giasson, B. I., Norris, E. H., Rueter, S. M., Trojanowski, J. Q., Lee, V. M. and Ischiropoulos, H. (2001) Induction of alpha-synuclein aggregation by intracellular nitrative insult. J. Neurosci. 21, 8053-8061
20. Andrekopoulos, C., Zhang, H., Joseph, J., Kalivendi, S. and Kalyanaraman, B. (2004) Bicarbonate enhances alpha-synuclein oligomerization and nitration: intermediacy of carbonate radical anion and nitrogen dioxide radical. Biochem. J. 378, 435-447
21. Weinreb, P. H., Zhen, W., Poon, A. W., Conway, K. A. and Lansbury, Jr, P. T. (1996) NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry 35, 13709-13715
22. Cole, N. B., Murphy, D. D., Grider, T., Rueter, S., Brasaemle, D. and Nussbaum, R. L. (2002) Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein. J. Biol. Chem. 277, 6344-6352
23. Segrest, J. P., Jones, M. K., De Loof, H., Brouillette, C. G., Venkatachalapathi, Y. V. and Anantharamaiah, G. M. (1992) The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function. J. Lipid Res. 33, 141-166
24. Uchida, K., Toyokuni, S., Nishikawa, K., Kawakishi, S., Oda, H., Hiai, H. and Stadtman, E. R. (1994) Michael addition-type 4-hydroxy-2-nonenal adducts in modified low-density lipoproteins: markers for atherosclerosis. Biochemistry 33, 12487-12494
25. Münch, G., Lüth, H. J., Wong, A., Arendt, T., Hirsch, E., Ravid, R. and Riederer, P. (2000) Crosslinking of alpha-synuclein by advanced glycation endproducts - an early pathophysiological step in Lewy body formation? J. Chem. Neuroanat. 20, 253-257
26. Rasia, R. M., Bertoncini, C. W., Marsh, D., Hoyer, W., Cherny, D., Zweckstetter, M., Griesinger, C., Jovin, T. M. and Fernandez, C. O. (2005) Structural characterization of copper(II) binding to alpha-synuclein: insights into the bioinorganic chemistry of Parkinson's disease. Proc. Natl. Acad. Sci. U.S.A. 102, 4294-4299
27. Norris, E. H., Giasson, B. I., Hodara, R., Xu, S., Trojanowski, J. Q., Ischiropoulos, H. and Lee, V. M. (2005) Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations. J. Biol. Chem. 280, 21212-21219