Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

Molecular Cell

Volumn 14, Issue 1, 2004, Pages 95-104

  Venkatraman, Prasanna ^a   Wetzel, Ronald ^b   Tanaka, Motomasa ^c   Nukina, Nobuyuki ^c   Goldberg, Alfred L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TENNESSEE MEDICAL CENTER   (United States)

^c RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDASE; POLYGLUTAMINE; PROTEASOME; PROTEIN SUBUNIT;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPATHOLOGY; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ASSAY; EUKARYOSIS; NEUROPATHOLOGY; NONHUMAN; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN SECRETION;

ANIMALS; ARCHAEAL PROTEINS; CYSTEINE ENDOPEPTIDASES; FUNGAL PROTEINS; HUMANS; MULTIENZYME COMPLEXES; MYOGLOBIN; NEURODEGENERATIVE DISEASES; PEPTIDE FRAGMENTS; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; RECOMBINANT FUSION PROTEINS; REPETITIVE SEQUENCES, AMINO ACID;

ANIMALIA; ARCHAEA; EUKARYOTA;

EID: 1842766144     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(04)00151-0     Document Type: Article

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