-
1
-
-
0037176727
-
A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing
-
Weidemann, A., Eggert, S., Reinhard, F. B., Vogel, M., Paliga, K., Baier, G., Masters, C. L., Beyreuther, K. and Evin, G. (2002) A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing. Biochemistry 41, 2825-2835.
-
(2002)
Biochemistry
, vol.41
, pp. 2825-2835
-
-
Weidemann, A.1
Eggert, S.2
Reinhard, F.B.3
Vogel, M.4
Paliga, K.5
Baier, G.6
Masters, C.L.7
Beyreuther, K.8
Evin, G.9
-
2
-
-
0037007140
-
A physiologic signaling role for the gamma-secretase-derived intracellular fragment of APP
-
Leissring, M. A., Murphy, M. P., Mead, T. R., Akbari, Y., Sugarman, M. C., Jannatipour, M., Anliker, B., Muller, U., Saftig, P., De Strooper, B. et al. (2002) A physiologic signaling role for the gamma-secretase-derived intracellular fragment of APP. Proc. Natl. Acad. Sci. USA 99, 4697-4702.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 4697-4702
-
-
Leissring, M.A.1
Murphy, M.P.2
Mead, T.R.3
Akbari, Y.4
Sugarman, M.C.5
Jannatipour, M.6
Anliker, B.7
Muller, U.8
Saftig, P.9
De Strooper, B.10
-
3
-
-
3943092621
-
Pathways towards and away from Alzheimer's disease
-
Mattson, M. P. (2004) Pathways towards and away from Alzheimer's disease. Nature 430, 631-639.
-
(2004)
Nature
, vol.430
, pp. 631-639
-
-
Mattson, M.P.1
-
4
-
-
10944259134
-
Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein
-
Zhao, G., Mao, G., Tan, J., Dong, J., Cui, M. Z., Kim, S. H. and Xu, X. (2004) Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein. J. Biol. Chem. 279, 50647-50650.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 50647-50650
-
-
Zhao, G.1
Mao, G.2
Tan, J.3
Dong, J.4
Cui, M.Z.5
Kim, S.H.6
Xu, X.7
-
5
-
-
27844441278
-
γ-Cleavage is dependent on ζ-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain
-
Zhao, G., Cui, M. Z., Mao, G., Dong, Y., Tan, J., Sun, L. and Xu, X. (2005) γ-Cleavage is dependent on ζ-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain. J. Biol. Chem. 280, 37689-37697.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 37689-37697
-
-
Zhao, G.1
Cui, M.Z.2
Mao, G.3
Dong, Y.4
Tan, J.5
Sun, L.6
Xu, X.7
-
6
-
-
0029896354
-
Mechanisms of neuronal degeneration in Alzheimer's disease
-
Yankner, B. A. (1996). Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 16, 921-932.
-
(1996)
Neuron
, vol.16
, pp. 921-932
-
-
Yankner, B.A.1
-
7
-
-
33745236883
-
Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices
-
Shahani, N., Subramaniam, S., Wolf, T., Tackenberg, C. and Brandt, R. (2006) Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices. J. Neurosci. 26, 6130-6134.
-
(2006)
J. Neurosci
, vol.26
, pp. 6130-6134
-
-
Shahani, N.1
Subramaniam, S.2
Wolf, T.3
Tackenberg, C.4
Brandt, R.5
-
8
-
-
34249862316
-
The role of tau phosphorylation and cleavage in neuronal cell death
-
Chun, W. and Johnson, G. V. ( 2007) The role of tau phosphorylation and cleavage in neuronal cell death. Front. Biosci. 12, 733-756.
-
(2007)
Front. Biosci
, vol.12
, pp. 733-756
-
-
Chun, W.1
Johnson, G.V.2
-
9
-
-
84880186196
-
Segregation of a missense mutation in the amyloid beta-protein precursor gene familial Alzheimer's disease
-
Goate, A. (2006) Segregation of a missense mutation in the amyloid beta-protein precursor gene familial Alzheimer's disease. J. Alzheimer Dis. 9, 341-347.
-
(2006)
J. Alzheimer Dis
, vol.9
, pp. 341-347
-
-
Goate, A.1
-
10
-
-
4143091289
-
Apolipoprotein E: Diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease
-
Huang, Y., Weisgraber, K. H., Mucke, L. and Mahley, R. W. (2004) Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease. J. Mol. Neurosci. 23, 189-204.
-
(2004)
J. Mol. Neurosci
, vol.23
, pp. 189-204
-
-
Huang, Y.1
Weisgraber, K.H.2
Mucke, L.3
Mahley, R.W.4
-
11
-
-
33947201115
-
Loss-of-function presenilin mutations in Alzheimer's disease. Talking point on the role of presenilin mutations in Alzheimer disease
-
8, 141-146
-
De Strooper, B. (2007) Loss-of-function presenilin mutations in Alzheimer's disease. Talking point on the role of presenilin mutations in Alzheimer disease. EMBO Rep. 8, 141-146.
-
(2007)
EMBO Rep
-
-
De Strooper, B.1
-
12
-
-
33947644871
-
Protein oxidation and lipid peroxidation in brain of subjects with Alzheimer's disease: Insights into mechanism of neurodegeneration from redox proteomics
-
Sultana, R., Perluigi, M. and Butterfield, D. A. (2006) Protein oxidation and lipid peroxidation in brain of subjects with Alzheimer's disease: insights into mechanism of neurodegeneration from redox proteomics. Antiox. Redox Signal. 8, 2021-2037.
-
(2006)
Antiox. Redox Signal
, vol.8
, pp. 2021-2037
-
-
Sultana, R.1
Perluigi, M.2
Butterfield, D.A.3
-
13
-
-
0036592758
-
The role of the metabolic lesion in Alzheimer's disease
-
Blass, J. P., Gibson, G. E. and Hoyer, S. (2002) The role of the metabolic lesion in Alzheimer's disease. J. Alzheimer Dis. 4, 225-232.
-
(2002)
J. Alzheimer Dis
, vol.4
, pp. 225-232
-
-
Blass, J.P.1
Gibson, G.E.2
Hoyer, S.3
-
14
-
-
22144492630
-
-
Kawahara, M. (2004) Disruption of calcium homeostasis in the pathogenesis of Alzheimer's disease and other conformational diseases. Curr. Alzheimer Res. 1, 87-95.
-
Kawahara, M. (2004) Disruption of calcium homeostasis in the pathogenesis of Alzheimer's disease and other conformational diseases. Curr. Alzheimer Res. 1, 87-95.
-
-
-
-
15
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R. et al. (1999) Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
-
16
-
-
0034529080
-
A furin-like convertase mediates propeptide cleavage of BACE the Alzheimer's beta secretase
-
Bennett, B. D., Denis, P., Haniu, M., Teplow, D. B., Kahn, S., Louis, J. C. Citron, M. and Vassar, R. (2000) A furin-like convertase mediates propeptide cleavage of BACE the Alzheimer's beta secretase. J. Biol. Chem. 275, 37712-37717.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 37712-37717
-
-
Bennett, B.D.1
Denis, P.2
Haniu, M.3
Teplow, D.B.4
Kahn, S.5
Louis, J.C.6
Citron, M.7
Vassar, R.8
-
17
-
-
0035830897
-
Processing of beta-secretase by furin and other members of the proprotein convertase family
-
Creemers, J. W., Ines Dominguez, D., Plets, E., Serneels, L., Taylor, N. A., Multhaup, G., Craessaerts, K. M., Annaert, W. and De Strooper, B. (2001) Processing of beta-secretase by furin and other members of the proprotein convertase family. J. Biol. Chem. 276, 4211-4217.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 4211-4217
-
-
Creemers, J.W.1
Ines Dominguez, D.2
Plets, E.3
Serneels, L.4
Taylor, N.A.5
Multhaup, G.6
Craessaerts, K.M.7
Annaert, W.8
De Strooper, B.9
-
18
-
-
0035805592
-
Phosphorylation regulates intracellular trafficking of beta-secretase
-
Walter, J., Fluhrer, R., Hartung, B., Willem, M., Kaether, C., Capell, A., Lammich, S., Multhaup, G. and Haass, C. (2001) Phosphorylation regulates intracellular trafficking of beta-secretase. J. Biol. Chem. 276, 14634-14641.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 14634-14641
-
-
Walter, J.1
Fluhrer, R.2
Hartung, B.3
Willem, M.4
Kaether, C.5
Capell, A.6
Lammich, S.7
Multhaup, G.8
Haass, C.9
-
19
-
-
0034613345
-
Maturation and pro-peptide cleavage of beta secretase
-
Capell, A., Steiner, H., Willem, M., Kaiser, H., Meyer, C., Walter, J., Lammich, S., Multhaup, G. and Haass, C. (2000) Maturation and pro-peptide cleavage of beta secretase. J. Biol. Chem. 275, 30949-30854.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 30949-30854
-
-
Capell, A.1
Steiner, H.2
Willem, M.3
Kaiser, H.4
Meyer, C.5
Walter, J.6
Lammich, S.7
Multhaup, G.8
Haass, C.9
-
20
-
-
0035815635
-
Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production
-
Benjannet, S., Elagoz, A., Wuickham, L., Mamarbachi, M., Munzer, J. S., Basak, A., Lazure, C., Cromlish, J. A., Sisodia, S., Checler, C. et al. (2001) Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production. J. Biol. Chem. 276, 10879-10887.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 10879-10887
-
-
Benjannet, S.1
Elagoz, A.2
Wuickham, L.3
Mamarbachi, M.4
Munzer, J.S.5
Basak, A.6
Lazure, C.7
Cromlish, J.A.8
Sisodia, S.9
Checler, C.10
-
21
-
-
0034721842
-
Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase
-
Huse, J. T., Pijak, D. S., Leslie, G. J., Lee, V. M. and Doms, R. W. (2000) Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase. J. Biol. Chem. 275, 33729-33737.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 33729-33737
-
-
Huse, J.T.1
Pijak, D.S.2
Leslie, G.J.3
Lee, V.M.4
Doms, R.W.5
-
22
-
-
0036200884
-
The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta)
-
Pastorino, L., Ikin, A. F., Nairn, A. C., Pursnani, A. and Buxbaum, J. D. (2002) The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta). Mol. Cell. Neurosci. 19, 175-185.
-
(2002)
Mol. Cell. Neurosci
, vol.19
, pp. 175-185
-
-
Pastorino, L.1
Ikin, A.F.2
Nairn, A.C.3
Pursnani, A.4
Buxbaum, J.D.5
-
23
-
-
15744380393
-
GGA proteins mediate the recycling of memapsin 2 (BACE)
-
He, X., Li, F., Chang, W. P. and Tang, J. (2005) GGA proteins mediate the recycling of memapsin 2 (BACE). J. Biol. Chem. 280, 11696-11703.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 11696-11703
-
-
He, X.1
Li, F.2
Chang, W.P.3
Tang, J.4
-
24
-
-
0642371716
-
Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP)
-
Marlow, L., Cain, M., Pappolla, M. A. and Sambamurti, K. (2003) Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP). J. Mol. Neurosci. 20, 233-239.
-
(2003)
J. Mol. Neurosci
, vol.20
, pp. 233-239
-
-
Marlow, L.1
Cain, M.2
Pappolla, M.A.3
Sambamurti, K.4
-
25
-
-
32544432195
-
Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme
-
Spoelgen, R., von Arnim, C. A., Thomas, A. V., Peltan, I. D., Koker, M., Deng, A., Irizzarry, M. C., Andersen, O. M., Willnow, T. E. and Hyman, B. T. (2006) Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme. J. Neurosci. 26, 418-428.
-
(2006)
J. Neurosci
, vol.26
, pp. 418-428
-
-
Spoelgen, R.1
von Arnim, C.A.2
Thomas, A.V.3
Peltan, I.D.4
Koker, M.5
Deng, A.6
Irizzarry, M.C.7
Andersen, O.M.8
Willnow, T.E.9
Hyman, B.T.10
-
26
-
-
0035159756
-
The beta-secretase, BACE: A prime target for Alzheimer's disease
-
Vassar, R. (2001) The beta-secretase, BACE: a prime target for Alzheimer's disease. J. Mol. Neurosci. 17, 157-170.
-
(2001)
J. Mol. Neurosci
, vol.17
, pp. 157-170
-
-
Vassar, R.1
-
27
-
-
17344388652
-
BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: Implications for Alzheimer's disease therapeutics
-
Roberds, S. L., Anderson, J., Basi, G., Bienkowski, M. J., Branstetter, D. G., Chen, K. S., Freedman, S. B., Frigon, N. L., Games, D., Hu, K. et al. (2001) BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum. Mol. Genet. 10, 1317-1324.
-
(2001)
Hum. Mol. Genet
, vol.10
, pp. 1317-1324
-
-
Roberds, S.L.1
Anderson, J.2
Basi, G.3
Bienkowski, M.J.4
Branstetter, D.G.5
Chen, K.S.6
Freedman, S.B.7
Frigon, N.L.8
Games, D.9
Hu, K.10
-
28
-
-
33750455150
-
Control of peripheral nerve myelination by the b-secretase BACE1
-
Willem, M., Garratt, A. N., Novak, B., Citron, M., Kaufmann, S., Rittger, A., DeStrooper, B., Saftig, P., Birchmeier, C. and Haass, C. (2006) Control of peripheral nerve myelination by the b-secretase BACE1. Science 314, 664-666.
-
(2006)
Science
, vol.314
, pp. 664-666
-
-
Willem, M.1
Garratt, A.N.2
Novak, B.3
Citron, M.4
Kaufmann, S.5
Rittger, A.6
DeStrooper, B.7
Saftig, P.8
Birchmeier, C.9
Haass, C.10
-
29
-
-
15844425969
-
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
-
Thinakaran, G., Borchelt, D. R., Lee, M. K., Slunt, H. H., Spitzer, L., Kim, G., Ratovitsky, T., Davenport, F., Nordstedt, C., Seeger, M. et al. (1996) Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17, 181-190.
-
(1996)
Neuron
, vol.17
, pp. 181-190
-
-
Thinakaran, G.1
Borchelt, D.R.2
Lee, M.K.3
Slunt, H.H.4
Spitzer, L.5
Kim, G.6
Ratovitsky, T.7
Davenport, F.8
Nordstedt, C.9
Seeger, M.10
-
30
-
-
20944440679
-
The structure and functions of the presenilins
-
Dewji, N. N. (2005) The structure and functions of the presenilins. Cell. Mol. Life Sci. 62, 1109-1119.
-
(2005)
Cell. Mol. Life Sci
, vol.62
, pp. 1109-1119
-
-
Dewji, N.N.1
-
31
-
-
33947609757
-
The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid
-
Verdile, G., Gandy, S. E. and Martins, R. N. (2007) The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid. Neurochem. Res. 32, 609-623.
-
(2007)
Neurochem. Res
, vol.32
, pp. 609-623
-
-
Verdile, G.1
Gandy, S.E.2
Martins, R.N.3
-
32
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K. and Van Leuven, F. (1998) Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391, 387-390.
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Guhde, G.5
Annaert, W.6
Von Figura, K.7
Van Leuven, F.8
-
33
-
-
13044278313
-
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
-
Herreman, A., Hartmann, D., Annaert, W., Saftig, P., Craessaerts, K., Serneels, L., Umans, L., Schrijvers, V., Checler, F., Vanderstichele, H. et al. (1999) Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc. Natl. Acad. Sci. USA 96, 11872-11877.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 11872-11877
-
-
Herreman, A.1
Hartmann, D.2
Annaert, W.3
Saftig, P.4
Craessaerts, K.5
Serneels, L.6
Umans, L.7
Schrijvers, V.8
Checler, F.9
Vanderstichele, H.10
-
34
-
-
21144447065
-
Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases
-
Mastrangelo, P., Mathews, P. M., Chishti, M. A., Schmidt, S. D., Gu, Y., Yang, J., Mazzella, M. J., Coomaraswamy, J., Horne, P., Strome, B. et al. (2005) Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases. Proc. Natl. Acad. Sci. USA 102, 8972-8977.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 8972-8977
-
-
Mastrangelo, P.1
Mathews, P.M.2
Chishti, M.A.3
Schmidt, S.D.4
Gu, Y.5
Yang, J.6
Mazzella, M.J.7
Coomaraswamy, J.8
Horne, P.9
Strome, B.10
-
35
-
-
0037173115
-
Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation
-
Edbauer, D., Winkler, E., Haass, C. and Steiner, H. (2002) Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation. Proc. Natl. Acad. Sci. USA 99, 8666-8671.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 8666-8671
-
-
Edbauer, D.1
Winkler, E.2
Haass, C.3
Steiner, H.4
-
36
-
-
18444417998
-
Aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation
-
Francis, R., McGrath, G., Zhang, J., Ruddy, D. A., Sym, M., Apfeld, J., Nicoll, M., Maxwell, M., Hai, B., Ellis, M. C. et al. (2002) Aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev. Cell 3, 85-97.
-
(2002)
Dev. Cell
, vol.3
, pp. 85-97
-
-
Francis, R.1
McGrath, G.2
Zhang, J.3
Ruddy, D.A.4
Sym, M.5
Apfeld, J.6
Nicoll, M.7
Maxwell, M.8
Hai, B.9
Ellis, M.C.10
-
37
-
-
0034080403
-
Aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling
-
Goutte, C., Hepler, W., Mickey, K. M. and Priess, J. R. (2000) Aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling. Development 127, 2481-2492.
-
(2000)
Development
, vol.127
, pp. 2481-2492
-
-
Goutte, C.1
Hepler, W.2
Mickey, K.M.3
Priess, J.R.4
-
38
-
-
0038360879
-
Different cofactor activities in gamma-secretase assembly: Evidence for a nicastrin-Aph-1 subcomplex
-
Hu, Y. and Fortini, M. E. (2003) Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex. J. Cell Biol. 161, 685-690.
-
(2003)
J. Cell Biol
, vol.161
, pp. 685-690
-
-
Hu, Y.1
Fortini, M.E.2
-
39
-
-
0037468759
-
The role of presenilin cofactors in the gamma-secretase complex
-
Takasugi, N., Tomita, T., Hayashi, I., Tsuruoka, M., Niimura, M., Takahashi, Y., Thinakaran, G. and Iwatsubo, T. (2003) The role of presenilin cofactors in the gamma-secretase complex. Nature 422, 438-441.
-
(2003)
Nature
, vol.422
, pp. 438-441
-
-
Takasugi, N.1
Tomita, T.2
Hayashi, I.3
Tsuruoka, M.4
Niimura, M.5
Takahashi, Y.6
Thinakaran, G.7
Iwatsubo, T.8
-
40
-
-
0036260892
-
Increased expression of the amyloid precursor beta-secretase in Alzheimer's Disease
-
Holsinger, R. M., McLean, C. A, Beyreuther, K., Masters, C. L. and Evin, G. (2002) Increased expression of the amyloid precursor beta-secretase in Alzheimer's Disease. Ann. Neurol. 51, 783-786.
-
(2002)
Ann. Neurol
, vol.51
, pp. 783-786
-
-
Holsinger, R.M.1
McLean, C.A.2
Beyreuther, K.3
Masters, C.L.4
Evin, G.5
-
41
-
-
0036718272
-
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease
-
Fukumoto, H., Cheung, B. S., Hyman, B. T. and Irizarry, M. C. (2002) Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease. Arch. Neurol. 59, 1381-1389.
-
(2002)
Arch. Neurol
, vol.59
, pp. 1381-1389
-
-
Fukumoto, H.1
Cheung, B.S.2
Hyman, B.T.3
Irizarry, M.C.4
-
42
-
-
0037236622
-
Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease
-
Yang, L. B., Lindholm, K., Yan, R., Citron, M., Xia, W., Yang, X. L., Beach, T., Sue, L., Wong, P., Price, D. et al. (2003) Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease. Nat. Med. 9, 3-4.
-
(2003)
Nat. Med
, vol.9
, pp. 3-4
-
-
Yang, L.B.1
Lindholm, K.2
Yan, R.3
Citron, M.4
Xia, W.5
Yang, X.L.6
Beach, T.7
Sue, L.8
Wong, P.9
Price, D.10
-
43
-
-
0028180518
-
Amodel for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: Relevance to Alzheimer disease
-
Hensley, K., Carney, J. M., Mattson, M. P., Aksenova, M., Harris, M., Wu, J. F., Floyd, R. A. and Butterfield, D. A. (1994) Amodel for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. Proc. Natl. Acad. Sci. USA 91, 3270-3274.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 3270-3274
-
-
Hensley, K.1
Carney, J.M.2
Mattson, M.P.3
Aksenova, M.4
Harris, M.5
Wu, J.F.6
Floyd, R.A.7
Butterfield, D.A.8
-
44
-
-
0036751954
-
Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases
-
Floyd, R. A. and Hensley, K. (2002) Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases. Neurobiol. Aging 23, 795-807.
-
(2002)
Neurobiol. Aging
, vol.23
, pp. 795-807
-
-
Floyd, R.A.1
Hensley, K.2
-
45
-
-
0031020476
-
A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid betapeptide
-
Mark, R. J., Lovell, M. A., Markesbery, W. R., Uchida, K. and Mattson, M. P. (1997) A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid betapeptide. J. Neurochem. 68, 255-264.
-
(1997)
J. Neurochem
, vol.68
, pp. 255-264
-
-
Mark, R.J.1
Lovell, M.A.2
Markesbery, W.R.3
Uchida, K.4
Mattson, M.P.5
-
46
-
-
27744542593
-
Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer's disease and familial British dementia
-
Tabner, B. J., El-Agnaf, O. M., Turnbull, S., German, M. J., Paleologou, K. E., Hayashi, Y., Cooper, L. J., Fullwood, N. J. and Allsop D (2005) Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer's disease and familial British dementia. J. Biol. Chem. 280, 35789-35792.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 35789-35792
-
-
Tabner, B.J.1
El-Agnaf, O.M.2
Turnbull, S.3
German, M.J.4
Paleologou, K.E.5
Hayashi, Y.6
Cooper, L.J.7
Fullwood, N.J.8
Allsop, D.9
-
47
-
-
27544511750
-
Formation and stabilization model of the 42-mer Abeta radical: Implications for the long-lasting oxidative stress in Alzheimer's disease
-
Murakami, K., Irie, K., Ohigashi, H., Hara, H., Nagao, M., Shimizu, T. and Shirasawa T(2005) Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease. J. Am. Chem. Soc. 127, 15168-15174.
-
(2005)
J. Am. Chem. Soc
, vol.127
, pp. 15168-15174
-
-
Murakami, K.1
Irie, K.2
Ohigashi, H.3
Hara, H.4
Nagao, M.5
Shimizu, T.6
Shirasawa, T.7
-
48
-
-
0034673209
-
Oxidative stress induces increase in intracellular amyloid beta-protein production and selective activation of betaI and betaII PKCs in NT2 cells
-
Paola, D., Domenicotti, C., Nitti, M., Vitali, A., Borghi, R., Cottalasso, D., Zaccheo, D., Odetti, P., Strocchi, P., Marinari, U. M. et al. (2000) Oxidative stress induces increase in intracellular amyloid beta-protein production and selective activation of betaI and betaII PKCs in NT2 cells. Biochem. Biophys. Res. Commun. 268, 642-646.
-
(2000)
Biochem. Biophys. Res. Commun
, vol.268
, pp. 642-646
-
-
Paola, D.1
Domenicotti, C.2
Nitti, M.3
Vitali, A.4
Borghi, R.5
Cottalasso, D.6
Zaccheo, D.7
Odetti, P.8
Strocchi, P.9
Marinari, U.M.10
-
49
-
-
19944433845
-
Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways
-
Tamagno, E., Parola, M., Bardini, P., Piccini, A., Borghi, R., Guglielmotto, M., Santoro, G., Davit, A., Danni, O., Smith, M. A., Perry, G. and Tabaton, M. (2005) Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways. J. Neurochem. 92, 628-636.
-
(2005)
J. Neurochem
, vol.92
, pp. 628-636
-
-
Tamagno, E.1
Parola, M.2
Bardini, P.3
Piccini, A.4
Borghi, R.5
Guglielmotto, M.6
Santoro, G.7
Davit, A.8
Danni, O.9
Smith, M.A.10
Perry, G.11
Tabaton, M.12
-
50
-
-
20944444768
-
Oxidative stress potentiates BACE1 gene expression and Abeta generation
-
Tong, Y., Zhou, W., Fung, V., Christensen, M. A., Qing, H., Sun, X. and Song, W. (2005) Oxidative stress potentiates BACE1 gene expression and Abeta generation. J. Neural. Transm. 112, 455-469.
-
(2005)
J. Neural. Transm
, vol.112
, pp. 455-469
-
-
Tong, Y.1
Zhou, W.2
Fung, V.3
Christensen, M.A.4
Qing, H.5
Sun, X.6
Song, W.7
-
51
-
-
0036403838
-
Oxidative stress increases expression and activity of BACE in NT2 neurons
-
Tamagno, E., Bardini, P., Obbili, A., Vitali, A., Borghi, R., Zaccheo, D., Pronzato, M. A., Danni, O., Smith, M. A., Perry, G. et al. (2002) Oxidative stress increases expression and activity of BACE in NT2 neurons. Neurobiol. Dis. 10, 279-288.
-
(2002)
Neurobiol. Dis
, vol.10
, pp. 279-288
-
-
Tamagno, E.1
Bardini, P.2
Obbili, A.3
Vitali, A.4
Borghi, R.5
Zaccheo, D.6
Pronzato, M.A.7
Danni, O.8
Smith, M.A.9
Perry, G.10
-
52
-
-
0142219838
-
Dehydroepiandrosterone reduces expression and activity of BACE in NT2 neurons exposed to oxidative stress
-
Tamagno, E., Guglielmotto, M., Bardini, P., Santoro, G., Davit, A., Di Simone, D., Danni O. and Tabaton, M. (2003) Dehydroepiandrosterone reduces expression and activity of BACE in NT2 neurons exposed to oxidative stress. Neurobiol. Dis. 14, 291-301.
-
(2003)
Neurobiol. Dis
, vol.14
, pp. 291-301
-
-
Tamagno, E.1
Guglielmotto, M.2
Bardini, P.3
Santoro, G.4
Davit, A.5
Di Simone, D.6
Danni, O.7
Tabaton, M.8
-
53
-
-
0030917601
-
Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: Involvement of calcium and oxyradicals
-
Guo, Q., Sopher, B. L., Furukawa, K., Pham, D. G., Robinson, N., Martin, G. M. and Mattson, M. P. (1997) Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals. J. Neurosci. 17, 4212-4222.
-
(1997)
J. Neurosci
, vol.17
, pp. 4212-4222
-
-
Guo, Q.1
Sopher, B.L.2
Furukawa, K.3
Pham, D.G.4
Robinson, N.5
Martin, G.M.6
Mattson, M.P.7
-
54
-
-
0033168352
-
Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB
-
Weihl, C. C., Ghadge, G. D., Kennedy, S. G., Hay, N., Miller, R. J. and Roos, R. P. (1999) Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB. J. Neurosci. 19, 5360-5369.
-
(1999)
J. Neurosci
, vol.19
, pp. 5360-5369
-
-
Weihl, C.C.1
Ghadge, G.D.2
Kennedy, S.G.3
Hay, N.4
Miller, R.J.5
Roos, R.P.6
-
55
-
-
18444391830
-
Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production
-
Moehlmann, T., Winkler, E., Xia, X., Edbauer, D., Murrell, J., Capell, A., Kaether, C., Zheng, H., Ghetti, B., Haass, C. et al. (2002) Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production. Proc. Natl. Acad. Sci. USA 99, 8025-8030.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 8025-8030
-
-
Moehlmann, T.1
Winkler, E.2
Xia, X.3
Edbauer, D.4
Murrell, J.5
Capell, A.6
Kaether, C.7
Zheng, H.8
Ghetti, B.9
Haass, C.10
-
56
-
-
33749521100
-
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: Potential factors in amyloid plaque formation
-
Oakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L. et al. (2006) Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J. Neurosci. 26, 10129-10140.
-
(2006)
J. Neurosci
, vol.26
, pp. 10129-10140
-
-
Oakley, H.1
Cole, S.L.2
Logan, S.3
Maus, E.4
Shao, P.5
Craft, J.6
Guillozet-Bongaarts, A.7
Ohno, M.8
Disterhoft, J.9
Van Eldik, L.10
-
57
-
-
2442664058
-
Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice
-
Sadowski, M., Pankiewicz, J., Scholtzova, H., Ji, Y., Quartermain, D., Jensen, C. H., Duff, K., Nixon, R. A., Gruen, R. J. and Wisniewski, T. (2004) Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice. J. Neuropathol. Exp. Neurol. 63, 418-428.
-
(2004)
J. Neuropathol. Exp. Neurol
, vol.63
, pp. 418-428
-
-
Sadowski, M.1
Pankiewicz, J.2
Scholtzova, H.3
Ji, Y.4
Quartermain, D.5
Jensen, C.H.6
Duff, K.7
Nixon, R.A.8
Gruen, R.J.9
Wisniewski, T.10
-
58
-
-
0029803744
-
Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities
-
Citron, M., Diehl, T. S., Gordon, G., Biere, A. L., Seubert, P. and Selkoe, D. J. (1996) Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities. Proc. Natl. Acad. Sci. USA 93, 13170-13175.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 13170-13175
-
-
Citron, M.1
Diehl, T.S.2
Gordon, G.3
Biere, A.L.4
Seubert, P.5
Selkoe, D.J.6
-
59
-
-
33644653041
-
Aging sensitizes toward ROS formation and lipid peroxidation in PS1M146L transgenic mice
-
Schuessel, K., Frey, C., Jourdan, C., Keil, U., Weber, C. C., Muller-Spahn, F., Muller, W. E. and Eckert, A. (2006) Aging sensitizes toward ROS formation and lipid peroxidation in PS1M146L transgenic mice. Free Radic. Biol. Med. 40, 850-862.
-
(2006)
Free Radic. Biol. Med
, vol.40
, pp. 850-862
-
-
Schuessel, K.1
Frey, C.2
Jourdan, C.3
Keil, U.4
Weber, C.C.5
Muller-Spahn, F.6
Muller, W.E.7
Eckert, A.8
-
60
-
-
0032972922
-
Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice
-
Begley, J. G., Duan, W., Chan, S., Duff, K. and Mattson, M. P. (1999) Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice. J. Neurochem. 72, 1030-1039.
-
(1999)
J. Neurochem
, vol.72
, pp. 1030-1039
-
-
Begley, J.G.1
Duan, W.2
Chan, S.3
Duff, K.4
Mattson, M.P.5
-
61
-
-
4444304720
-
APP and PS-1 mutations induce brain oxidative stress independent of dietary cholesterol: Implications for Alzheimer's disease
-
Mohmmad Abdul, H., Wenk, G. L., Gramling, M., Hauss-Wegrzyniak, B. and Butterfield, D. A. (2004) APP and PS-1 mutations induce brain oxidative stress independent of dietary cholesterol: implications for Alzheimer's disease. Neurosci. Lett. 368, 148-150
-
(2004)
Neurosci. Lett
, vol.368
, pp. 148-150
-
-
Mohmmad Abdul, H.1
Wenk, G.L.2
Gramling, M.3
Hauss-Wegrzyniak, B.4
Butterfield, D.A.5
-
62
-
-
0037435545
-
Pure spastic paraparesis associated with a novel presenilin 1 R278K mutation
-
Assini, A., Terreni, L., Borghi, R., Giliberto, L., Piccini, A., Loqui, D., Fogliarino, S., Forloni, G. and Tabaton, M. (2003) Pure spastic paraparesis associated with a novel presenilin 1 R278K mutation. Neurology 60, 150-151.
-
(2003)
Neurology
, vol.60
, pp. 150-151
-
-
Assini, A.1
Terreni, L.2
Borghi, R.3
Giliberto, L.4
Piccini, A.5
Loqui, D.6
Fogliarino, S.7
Forloni, G.8
Tabaton, M.9
-
63
-
-
0031949628
-
A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1
-
Crook, R., Verkkoniemi, A., Perez-Tur, J., Mehta, N., Baker, M., Houlden, H., Farrer, M., Hutton, M., Lincoln, S., Hardy, J. et al. (1998) A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1. Nat Med. 4, 452-455.
-
(1998)
Nat Med
, vol.4
, pp. 452-455
-
-
Crook, R.1
Verkkoniemi, A.2
Perez-Tur, J.3
Mehta, N.4
Baker, M.5
Houlden, H.6
Farrer, M.7
Hutton, M.8
Lincoln, S.9
Hardy, J.10
-
64
-
-
8244260610
-
-
Kwok, J. B., Taddei, K., Hallupp, M., Fisher, C., Brooks, W. S., Broe, G. A., Hardy, J., Fulham, M. J., Nicholson, G. A., Stell, R. et al. (1997) Two novel (M233T and R278T) presenilin-1 mutations in early-onset Alzheimer's disease pedigrees and preliminary evidence for association of presenilin-1 mutations with a novel phenotype. Neuroreport 8, 1537-1542.
-
Kwok, J. B., Taddei, K., Hallupp, M., Fisher, C., Brooks, W. S., Broe, G. A., Hardy, J., Fulham, M. J., Nicholson, G. A., Stell, R. et al. (1997) Two novel (M233T and R278T) presenilin-1 mutations in early-onset Alzheimer's disease pedigrees and preliminary evidence for association of presenilin-1 mutations with a novel phenotype. Neuroreport 8, 1537-1542.
-
-
-
-
65
-
-
0034813045
-
-
Sodeyama, N., Iwata, T., Ishikawa, K., Mizusawa, H., Yamada, M., Itoh, Y., Otomo, E., Matsushita, M. and Komatsuzaki, Y. (2001) Very early onset Alzheimer's disease with spastic paraparesis associated with a novel presenilin 1 mutation (Phe237Ile). J. Neurol. Neurosurg. Psychiatry 71, 556-557.
-
Sodeyama, N., Iwata, T., Ishikawa, K., Mizusawa, H., Yamada, M., Itoh, Y., Otomo, E., Matsushita, M. and Komatsuzaki, Y. (2001) Very early onset Alzheimer's disease with spastic paraparesis associated with a novel presenilin 1 mutation (Phe237Ile). J. Neurol. Neurosurg. Psychiatry 71, 556-557.
-
-
-
-
66
-
-
0033762710
-
Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations
-
Houlden, H., Baker, M., McGowan, E., Lewis, P., Hutton, M., Crook, R., Wood, N. W., Kumar-Singh, S., Geddes, J., Swash, M. et al. (2000) Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations. Ann. Neurol. 48, 806-808.
-
(2000)
Ann. Neurol
, vol.48
, pp. 806-808
-
-
Houlden, H.1
Baker, M.2
McGowan, E.3
Lewis, P.4
Hutton, M.5
Crook, R.6
Wood, N.W.7
Kumar-Singh, S.8
Geddes, J.9
Swash, M.10
-
67
-
-
26644445247
-
Beta-amyloid is different in normal aging and in Alzheimer disease
-
Piccini, A., Russo, C., Gliozzi, A., Relini, A., Vitali, A., Borghi, R., Giliberto, L., Armirotti, A., D'Arrigo, C., Bachi, A. et al. (2005) Beta-amyloid is different in normal aging and in Alzheimer disease. J. Biol. Chem. 280, 34186-34192.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 34186-34192
-
-
Piccini, A.1
Russo, C.2
Gliozzi, A.3
Relini, A.4
Vitali, A.5
Borghi, R.6
Giliberto, L.7
Armirotti, A.8
D'Arrigo, C.9
Bachi, A.10
-
68
-
-
34249099116
-
A presenilin 1S170F mutation is associated with a novel Alzheimer's disease molecular phenotype
-
Piccini, A., Zanussi, G., Borghi, R., Novello, C., Monaco, S., Russo, R., Da Monte, G., Armirotti, A., Gelati, M., Giordano, R. et al. (2007) A presenilin 1S170F mutation is associated with a novel Alzheimer's disease molecular phenotype. Arch Neurosci. 64, 738-745.
-
(2007)
Arch Neurosci
, vol.64
, pp. 738-745
-
-
Piccini, A.1
Zanussi, G.2
Borghi, R.3
Novello, C.4
Monaco, S.5
Russo, R.6
Da Monte, G.7
Armirotti, A.8
Gelati, M.9
Giordano, R.10
-
69
-
-
0038751845
-
Secretion and intracellular generated of truncated Abeta in beta-site amyloid-beta precursors protein-cleaving enzyme expressing human neurons
-
Lee, E. B., Skovronsky, D. M., Abtahian, F., Doms, R. W. and Lee, V. M. (2003) Secretion and intracellular generated of truncated Abeta in beta-site amyloid-beta precursors protein-cleaving enzyme expressing human neurons. J. Biol. Chem. 278, 4458-4466.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 4458-4466
-
-
Lee, E.B.1
Skovronsky, D.M.2
Abtahian, F.3
Doms, R.W.4
Lee, V.M.5
-
70
-
-
0035818998
-
Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP
-
Kamal, A., Almenar-Queralt, A., LeBlanc, J. F., Roberts, E. A. and Goldstein, L. S. (2001) Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature 414, 643-648.
-
(2001)
Nature
, vol.414
, pp. 643-648
-
-
Kamal, A.1
Almenar-Queralt, A.2
LeBlanc, J.F.3
Roberts, E.A.4
Goldstein, L.S.5
-
71
-
-
33846167046
-
Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1)
-
Kuzuya, A., Uemura, K., Kitagawa, N., Aoyagi, N., Kihara, T., Ninomiya, H., Ishiura, S., Takahashi, R. and Shimohama, S. (2007) Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1). J. Neurosci. Res. 85, 153-165.
-
(2007)
J. Neurosci. Res
, vol.85
, pp. 153-165
-
-
Kuzuya, A.1
Uemura, K.2
Kitagawa, N.3
Aoyagi, N.4
Kihara, T.5
Ninomiya, H.6
Ishiura, S.7
Takahashi, R.8
Shimohama, S.9
-
72
-
-
33847714347
-
Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage
-
Minopoli, G., Stante, M., Napolitano, F., Telese, F., Aloia, L., De Felice, M., Di Lauro, R., Pacelli, R., Brunetti, A., Zambrano, N. et al. (2006) Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage. J. Biol. Chem. 282, 831-835.
-
(2006)
J. Biol. Chem
, vol.282
, pp. 831-835
-
-
Minopoli, G.1
Stante, M.2
Napolitano, F.3
Telese, F.4
Aloia, L.5
De Felice, M.6
Di Lauro, R.7
Pacelli, R.8
Brunetti, A.9
Zambrano, N.10
-
73
-
-
18744435477
-
Presenilin-1 mutations in Alzheimer's disease
-
Russo, C., Schettini, G., Saido, T. C., Hulette, C., Lippa, C., Lannfelt, L., Ghetti, B., Gambetti, P., Tabaton, M. and Teller, J. K. (2000) Presenilin-1 mutations in Alzheimer's disease. Nature 405, 531-532.
-
(2000)
Nature
, vol.405
, pp. 531-532
-
-
Russo, C.1
Schettini, G.2
Saido, T.C.3
Hulette, C.4
Lippa, C.5
Lannfelt, L.6
Ghetti, B.7
Gambetti, P.8
Tabaton, M.9
Teller, J.K.10
-
74
-
-
33745228920
-
The various aggregation states of beta-amyloid 1-42 mediate different effects on oxidative stress, neurodegeneration, and BACE-1 expression
-
Tamagno, E., Bardini, P., Guglielmotto, M., Danni, O. and Tabaton, M. (2006) The various aggregation states of beta-amyloid 1-42 mediate different effects on oxidative stress, neurodegeneration, and BACE-1 expression. Free Radic. Biol. Med. 41, 202-212.
-
(2006)
Free Radic. Biol. Med
, vol.41
, pp. 202-212
-
-
Tamagno, E.1
Bardini, P.2
Guglielmotto, M.3
Danni, O.4
Tabaton, M.5
-
75
-
-
0034763569
-
Differential effects of unaggregated and aggregated amyloid beta protein (1-40) on K(+) channel currents in primary cultures of rat cerebellar granule and cortical neurones
-
Ramsden, M., Plant, L. D., Webster, N. J., Vaughan, P. F., Henderson, Z. and Pearson, H. A. (2001) Differential effects of unaggregated and aggregated amyloid beta protein (1-40) on K(+) channel currents in primary cultures of rat cerebellar granule and cortical neurones. J. Neurochem. 79, 699-712.
-
(2001)
J. Neurochem
, vol.79
, pp. 699-712
-
-
Ramsden, M.1
Plant, L.D.2
Webster, N.J.3
Vaughan, P.F.4
Henderson, Z.5
Pearson, H.A.6
-
76
-
-
0038045587
-
The production of amyloid beta peptide is a critical requirement for the viability of central neurons
-
Plant, L. D., Boyle, J. P., Smith, I. F., Peers, C. and Pearson, H. A. (2003) The production of amyloid beta peptide is a critical requirement for the viability of central neurons. J. Neurosci. 23, 5531-5535.
-
(2003)
J. Neurosci
, vol.23
, pp. 5531-5535
-
-
Plant, L.D.1
Boyle, J.P.2
Smith, I.F.3
Peers, C.4
Pearson, H.A.5
-
77
-
-
0344672942
-
APP processing and synaptic function
-
Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., Sisodia, S. and Malinow, R. (2003) APP processing and synaptic function. Neuron 37, 925-937.
-
(2003)
Neuron
, vol.37
, pp. 925-937
-
-
Kamenetz, F.1
Tomita, T.2
Hsieh, H.3
Seabrook, G.4
Borchelt, D.5
Iwatsubo, T.6
Sisodia, S.7
Malinow, R.8
|