Structure-based approaches to drug discovery against tuberculosis

Current Protein and Peptide Science

Volumn 8, Issue 4, 2007, Pages 365-375

  Holton, Simon J ^a   Weiss, Manfred S ^a   Tucker, Paul A ^a   Wilmanns, Matthias ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

Acyl coA carboxylase; Amino acid biosynthesis; Bacillus Calmette Guerin; Mtb genome sequences; Open reading frame

Indexed keywords

1 (6 BROMO 2 METHOXY 3 QUINOLINYL) 4 DIMETHYLAMINO 2 (1 NAPHTHYL) 1 PHENYL 2 BUTANOL; AMINOSALICYLIC ACID; BACTERIAL PROTEIN; BCG VACCINE; COENZYME A; ENZYME INHIBITOR; ETHAMBUTOL; GATIFLOXACIN; HISTIDINE; ISONIAZID; KANAMYCIN; LEUCINE; MAXIFLOXACIN; MYCOLIC ACID; NCI 65828; PROTEIN; PROTEIN KINASE; PYRAZINAMIDE; QUINOLONE DERIVATIVE; RESUSCITATION PROMOTING FACTOR; RIFAMPICIN; THIOLACTOMYCIN; UNCLASSIFIED DRUG;

BACTERIAL IMMUNITY; BACTERICIDAL ACTIVITY; BCG VACCINATION; BINDING AFFINITY; BIOINFORMATICS; BIOSYNTHESIS; BIOTECHNOLOGY; CHEMICAL STRUCTURE; DEPHOSPHORYLATION; DRUG SENSITIVITY; DRUG TARGETING; GENE DELETION; GENE EXPRESSION REGULATION; GENE SEQUENCE; GENE STRUCTURE; GENETIC ANALYSIS; GENETIC CODE; GENETIC IDENTIFICATION; HEALTH CARE PRACTICE; HUMAN; IMMUNOCOMPROMISED PATIENT; LIPID METABOLISM; LIPOGENESIS; LUNG TUBERCULOSIS; MULTIDRUG RESISTANCE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVIEW; TUBERCULOSIS; X RAY CRYSTALLOGRAPHY;

AMINO ACIDS; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; COMPUTATIONAL BIOLOGY; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GENOME, BACTERIAL; HUMANS; LIPID METABOLISM; MYCOBACTERIUM TUBERCULOSIS; PROTEOMICS; TUBERCULOSIS;

MYCOBACTERIUM BOVIS BCG; MYCOBACTERIUM TUBERCULOSIS;

EID: 34548267729     PISSN: 13892037     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920307781369445     Document Type: Review

References (190)

1. Kaufmann, S.H. and Winau, F. (2005) Nat. Immunol., 6, 1063-6.
2. Glynn, J.R., Whiteley, J., Bifani, P.J., Kremer, K. and van Soolingen, D. (2002) Emerg. Infect. Dis., 8, 843-9.
3. WHO (1993) Soz Praventivmed, 38, 251-2.
4. Kaufmann, S.H. and Schaible, U.E. (2005) Curr. Opin. Immunol., 17, 79-87.
5. Salgame, P. (2005) Curr. Opin. Immunol., 17, 374-80.
6. Russell, D.G. (2001) Nat. Rev. Mol. Cell Biol., 2, 569-77.
7. Manabe, Y.C. and Bishai, W.R. (2000) Nat. Med., 6, 1327-9.
8. Young, D., Hussell, T. and Dougan, G. (2002) Nat. Immunol., 3, 1026-32.
9. Nguyen, L. and Pieters, J. (2005) Trends Cell Biol., 15, 269-76.
10. Boshoff, H.I. and Barry, C.E., 3rd (2005) Nat. Rev. Microbiol., 3, 70-80.
11. Sassetti, C.M. and Rubin, E.J. (2003) Proc. Natl. Acad. Sci. USA, 100, 12989-94.
12. Deretic, V., Singh, S., Master, S., Harris, J., Roberts, E., Kyei, G., Davis, A., de Haro, S., Naylor, J., Lee, H.H. and Vergne, I. (2006) Cell Microbiol., 8, 719-27.
13. Mollenkopf, H.J., Grode, L., Mattow, J., Stein, M., Mann, P., Knapp, B., Ulmer, J. and Kaufmann, S.H. (2004) Infect. Immun., 72, 6471-9.
14. Frieden, T.R. and Munsiff, S.S. (2005) Clin. Chest Med., 26, 197-205, v.
15. Sharma, S.K. and Mohan, A. (2006) Chest, 130, 261-72.
16. Cox, J.S., Chen, B., McNeil, M. and Jacobs, W.R., Jr. (1999) Nature, 402, 79-83.
17. Reed, M.B., Domenech, P., Manca, C., Su, H., Barczak, A.K., Kreiswirth, B.N., Kaplan, G. and Barry, C.E., 3rd (2004) Nature, 431, 84-7.
18. Trivedi, O.A., Arora, P., Sridharan, V., Tickoo, R., Mohanty, D. and Gokhale, R.S. (2004) Nature, 428, 441-5.
19. Takayama, K., Wang, C. and Besra, G.S. (2005) Clin. Microbiol. Rev., 18, 81-101.
20. Sutcliffe, I.C. and Harrington, D.J. (2004) FEMS Microbiol. Rev., 28, 645-59.
21. Park, H.D., Guinn, K.M., Harrell, M.I., Liao, R., Voskuil, M.I., Tompa, M., Schoolnik, G.K. and Sherman, D.R. (2003) Mol. Microbiol., 48, 833-43.
22. McKinney, J.D., Honer zu Bentrup, K., Munoz-Elias, E.J., Miczak, A., Chen, B., Chan, W.T., Swenson, D., Sacchettini, J.C., Jacobs, W.R., Jr. and Russell, D.G. (2000) Nature, 406, 735-8.
23. Hisert, K.B., Kirksey, M.A., Gomez, J.E., Sousa, A.O., Cox, J.S., Jacobs, W.R., Jr., Nathan, C.F. and McKinney, J.D. (2004) Infect. Immun., 72, 5315-21.
24. Pai, R.K., Convery, M., Hamilton, T.A., Boom, W.H. and Harding, C.V. (2003) J. Immunol, 171, 175-84.
25. Vergne, I., Chua, J., Lee, H.H., Lucas, M., Belisle, J. and Deretic, V. (2005) Proc. Natl. Acad. Sci. USA, 102, 4033-8.
26. Walburger, A., Koul, A., Ferrari, G., Nguyen, L., Prescianotto-Baschong, C., Huygen, K., Klebl, B., Thompson, C., Bacher, G. and Pieters, J. (2004) Science, 304, 1800-4.
27. Mukamolova, G.V., Turapov, O.A., Kazarian, K., Telkov, M., Kaprelyants, A.S., Kell, D.B. and Young, M. (2002) Mol. Microbiol., 46, 611-21.
28. Downing, K.J., Mischenko, V.V., Shleeva, M.O., Young, D.I., Young, M., Kaprelyants, A.S., Apt, A.S. and Mizrahi, V. (2005) Infect. Immun., 73, 3038-43.
29. Keep, N.H., Ward, J.M., Cohen-Gonsaud, M. and Henderson, B. (2006) Trends Microbiol., 14, 271-6.
30. Johnson, R., Streicher, E.M., Louw, G.E., Warren, R.M., van Helden, P.D. and Victor, T.C. (2006) Curr. Issues Mol. Biol., 8, 97-111.
31. Lawn, S.D. and Wilkinson, R. (2006) BMJ, 333, 559-60.
32. Cohen, J. (2006) Science, 313, 1554.
33. Zhang, Y. and Amzel, L.M. (2002) Curr. Drug Targets, 3, 131-54.
34. Zhang, Y., Post-Martens, K. and Denkin, S. (2006) Drug Discov. Today, 11, 21-7.
35. Anishetty, S., Pulimi, M. and Pennathur, G. (2005) Comput. Biol. Chem., 29, 368-78.
36. Mdluli, K. and Spigelman, M. (2006) Curr. Opin. Pharmacol., 6, 459-67.
37. Nayyar, A. and Jain, R. (2005) Curr. Med. Chem., 12, 1873-86.
38. Duncan, K. (2004) Curr. Pharm. Des., 10, 3185-94.
39. Andries, K., Verhasselt, P., Guillemont, J., Gohlmann, H.W., Neefs, J.M., Winkler, H., Van Gestel, J., Timmerman, P., Zhu, M., Lee, E., Williams, P., de Chaffoy, D., Huitric, E., Hoffner, S., Cambau, E., Truffot-Pernot, C., Lounis, N. and Jarlier, V. (2005) Science, 307, 223-7.
40. Cole, S.T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S.V., Eiglmeier, K., Gas, S., Barry, C.E., 3rd, Tekaia, F., Badcock, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R., Devlin, K., Feltwell, T., Gentles, S., Hamlin, N., Holroyd, S., Hornsby, T., Jagels, K., Krogh, A., McLean, J., Moule, S., Murphy, L., Oliver, K., Osborne, J., Quail, M.A., Rajandream, M.A., Rogers, J., Rutter, S., Seeger, K., Skelton, J., Squares, R., Squares, S., Sulston, J.E., Taylor, K., Whitehead, S. and Barrell, B.G. (1998) Nature, 393, 537-44.
41. Fleischmann, R.D., Alland, D., Eisen, JA., Carpenter, L., White, O., Peterson, J., DeBoy, R., Dodson, R., Gwinn, M., Haft D., Hickey, E., Kolonay, J.F., Nelson, W.C., Umayam, L.A., Ermolaeva, M., Salzberg, S.L., Delcher, A., Utterback, T., Weidman, J., Khouri, H., Gill, J., Mikula, A., Bishai, W., Jacobs Jr, W.R., Jr., Venter, J.C. and Fraser, C.M. (2002) J. Bacteriol., 184, 5479-90.
42. Camus, J.C., Pryor, M.J., Medigue, C. and Cole, S.T. (2002) Microbiology, 148, 2967-73.
43. Mira, A., Ochman, H. and Moran, N.A. (2001) Trends Genet., 17, 589-96.
44. Blundell, T.L., Jhoti, H. and Abell, C. (2002) Nat. Rev. Drug Discov., 1, 45-54.
45. Williams, S.P., Kuyper, L.F. and Pearce, K.H. (2005) Curr. Opin. Chem. Biol., 9, 371-80.
46. von Itzstein, M., Wu, W.Y., Kok, G.B., Pegg, M.S., Dyason, J.C., Jin, B., Van Phan, T., Smythe, M.L., White, H.F., Oliver, S.W., Colman, P.M., Varghese, J.N., Ryan, D.M., Woods, J.M., Bethall, R.C., Hotham, V.J., Cameron, J.M. and Penn, C.R. (1993) Nature, 363, 418-23.
47. Russell, R.J., Haire, L.F., Stevens, D.J., Collins, P.J., Lin, Y.P., Blackburn, G.M., Hay, A.J., Gamblin, S.J. and Skehel, J.J. (2006) Nature, 443, 45-9.
48. Surleraux, D.L., de Kock, H.A., Verschueren, W.G., Pille, G.M., Maes, L.J., Peeters, A., Vendeville, S., De Meyer, S., Azijn, H., Pauwels, R., de Bethune, M.P., King, N.M., Prabu-Jeyabalan, M., Schiffer, C.A. and Wigerinck, P.B. (2005) J. Med. Chem., 48, 1965-73.
49. Renshaw, P.S., Lightbody, K.L., Veverka, V., Muskett, F.W., Kelly, G., Frenkiel, T.A., Gordon, S.V., Hewinson, R.G., Burke, B., Norman, J., Williamson, R.A. and Carr, M.D. (2005) EMBO J., 24, 2491-8.
50. Cohen-Gonsaud, M., Barthe, P., Bagneris, C., Henderson, B., Ward, J., Roumestand, C. and Keep, N.H. (2005) Nat. Struct. Mol. Biol., 12, 270-3.
51. Terwilliger, T.C., Park, M.S., Waldo, G.S., Berendzen, J., Hung, L.W., Kim, C.Y., Smith, C.V., Sacchettini, J.C., Bellinzoni, M., Bossi, R., De Rossi, E., Mattevi, A., Milano, A., Riccardi, G., Rizzi, M., Roberts, M.M., Coker, A.R., Fossati G., Mascagni, P., Coates, A.R., Wood, S.P., Goulding, C.W., Apostol, M.I., Anderson, D.H., Gill, H.S., Eisenberg, D.S., Taneja, B., Mande, S., Pohl, E., Lamzin, V., Tucker, P., Wilmanns, M., Colovos, C., Meyer-Klaucke, W., Munro, A.W., McLean, K.J., Marshall, K.R., Leys, D., Yang, J.K., Yoon, H.J., Lee, B.I., Lee, M.G., Kwak, J.E., Han, B.W., Lee, J.Y., Baek, S.H., Suh, S.W., Komen, M.M., Arcus, V.L., Baker, E.N., Lott, J.S., Jacobs, W., Jr., Alber, T. and Rupp, B. (2003) Tuberculosis (Edinb), 83, 223-49.
52. Marri, P.R., Bannantine, J.P. and Golding, G.B. (2006) FEMS Microbiol. Rev., 30, 906-25.
53. Diaz, R., Siddiqi, N. and Rubin, E.J. (2006) Tuberculosis (Edinb.), 86, 314-8.
54. Kantardjieff, K. and Rupp, B. (2004) Curr. Pharm. Des., 10, 3195-211.
55. Goulding, C.W., Perry, L.J., Anderson, D., Sawaya, M.R., Cascio, D., Apostol, M.I., Chan, S., Parseghian, A., Wang, S.S., Wu, Y., Cassano, V., Gill, H.S. and Eisenberg, D. (2003) Biophys. Chem., 105, 361-70.
56. Riley, M.L., Schmidt T., Wagner, C., Mewes, H.W. and Frishman, D. (2005) Nucleic Acids Res., 33, D308-10.
57. Frishman, D., Mokrejs, M., Kosykh, D., Kastenmuller, G., Kolesov, G., Zubrzycki, I., Gruber, C., Geier, B., Kaps, A., Albermann, K., Volz, A., Wagner, C., Fellenberg, M., Heumann, K. and Mewes, H.W. (2003) Nucleic Acids Res., 31, 207-11.
58. Mattow, J., Schaible, U.E., Schmidt, F., Hagens, K., Siejak, F., Brestrich, G., Haeselbarth, G., Muller, E.C., Jungblut, P.R. and Kaufmann, S.H. (2003) Electrophoresis, 24, 3405-20.
59. Mollenkopf, H.J., Mattow, J., Schaible, U.E., Grode, L., Kaufmann, S.H. and Jungblut, P.R. (2002) Methods Enzymol., 358, 242-56.
60. Schmidt F., Donahoe, S., Hagens, K., Mattow, J., Schaible, U.E., Kaufmann, S.H., Aebersold, R. and Jungblut, P.R. (2004) Mol. Cell Proteomics, 3, 24-42.
61. Rachman, H., Strong, M., Schaible, U., Schuchhardt, J., Hagens, K., Mollenkopf, H., Eisenberg, D. and Kaufmann, S.H. (2006) Microbes Infect., 8, 747-57.
62. Daugelat, S., Kowall, J., Mattow, J., Bumann, D., Winter, R., Hurwitz, R. and Kaufmann, S.H. (2003) Microbes Infect., 5, 1082-95.
63. Geerlof, A., Brown, J., Coutard, B., Egloff, M.P., Enguita, F.J., Fogg, M.J., Gilbert, R.J., Groves, M.R., Haouz, A., Nettleship, J.E., Nordlund, P., Owens, R.J., Ruff, M., Sainsbury, S., Svergun, D.I. and Wilmanns, M. (2006) Acta Crystallogr. D. Biol., Crystallogr, 62, 1125-36.
64. Mueller-Dieckmann, J. (2006) Acta Crystallogr. D Biol., Crystallogr., 62, 1446-52.
65. Eswaran, J., von Kries, J.P., Marsden, B., Longman, E., Debreczeni, J.E;, Ugochukwu, E., Turnbull, A., Lee, W.H., Knapp, S. and Barr, A.J. (2006) Biochem. J., 395, 483-91.
66. Singh, R.K., Kefala, G., Janowski, R., Mueller-Dieckmann, C., von Kries, J.P. and Weiss, M.S. (2005) J. Mol. Biol., 346, 1-11.
67. Schade, M. and Oschkinat, H. (2005) Curr. Opin. Drug Discov. Devel., 8, 365-73.
68. Franzblau, S.G., Witzig, R.S., McLaughlin, J.C., Torres, P., Madico, G., Hernandez, A., Degnan, M.T., Cook, M.B., Quenzer, V.K., Ferguson, R.M. and Gilman, R.H. (1998) J. Clin. Microbiol., 36, 362-6.
69. Patzel, V., Rutz, S., Dietrich, I., Koberle, C., Scheffold, A. and Kaufmann, S.H. (2005) Nat. Biotechnol., 23, 1440-4.
70. Strong, M. and Goulding, C.W. (2006) Methods Biochem. Anal., 49, 245-69.
71. Arcus, V.L., Lott, J.S., Johnston, J.M. and Baker, E.N. (2006) Drug Discov. Today, 11, 28-34.
72. Smith, C.V. and Sacchettini, J.C. (2003) Curr. Opin. Struct. Biol., 13, 658-64.
73. Schroeder, E.K., de Souza, N., Santos, D.S., Blanchard, J.S. and Basso, L.A. (2002) Curr. Pharm. Biotechnol., 3, 197-225.
74. Leonardi, R., Zhang, Y.M., Rock, C.O. and Jackowski, S. (2005) Prog. Lipid Res., 44, 125-53.
75. Sambandamurthy, V.K. and Jacobs, W.R., Jr. (2005) Microbes. Infect, 7, 955-61.
76. Sambandamurthy, V.K., Wang, X., Chen, B., Russell, R.G., Derrick, S., Collins, F.M., Morris, S.L. and Jacobs, W.R., Jr. (2002) Nat. Med, 8, 1171-4.
77. Wang, S. and Eisenberg, D. (2003) Protein Sci., 12, 1097-108.
78. Wang, F., Cassidy, C. and Sacchettini, J.C. (2006) Antimicrob. Agents Chemother., 50, 2762-71.
79. Gopalan, G., Chopra, S., Ranganathan, A. and Swaminathan, K. (2006) Proteins, 65, 796-802.
80. Zheng, R., Dam, T.K., Brewer, C.F. and Blanchard, J.S. (2004) Biochemistry, 43, 7171-8.
81. Chaudhuri, B.N., Sawaya, M.R., Kim, C.Y., Waldo, G.S., Park, M.S., Terwilliger, T.C. and Yeates, T.O. (2003) Structure, 11, 753-64,
82. Jordan, S.W. and Cronan, J.E., Jr. (1997) J. Biol. Chem., 272, 17903-6.
83. Jones, D.D., Stott, K.M., Howard, M.J. and Perham, R.N. (2000) Biochemistry, 39, 8448-59.
84. Ma, Q., Zhao, X., Eddine, A.N., Geerlof, A., Li, X., Cronan, J.E., Kaufmann, S.H. and Wilmanns, M. (2006) Proc. Natl. Acad. Sci. USA, 103, 8662-7.
85. Heath, R.J., White, S.W. and Rock, C.O. (2001) Prog. Lipid Res., 40, 467-97.
86. Rozwarski, D.A., Vilcheze, C., Sugantino, M., Bittman, R. and Sacchettini, J.C. (1999) J. Biol. Chem., 274, 15582-9.
87. Cohen-Gonsaud, M., Ducasse, S., Hoh, F., Zerbib, D., Labesse, G. and Quemard, A. (2002) J. Mol. Biol., 320, 249-61.
88. Slayden, R.A., Lee, R.E. and Barry, C.E., 3rd (2000) Mol. Microbiol., 38, 514-25.
89. Wilson, M., DeRisi, J., Kristensen, H.H., Imboden, P., Rane, S., Brown, P.O. and Schoolnik, G.K. (1999) Proc. Natl. Acad. Sci. USA, 96, 12833-8.
90. Veyron-Churlet, R., Guerrini, O., Mourey, L., Daffe, M. and Zerbib, D. (2004) Mol. Mcrobiol., 54, 1161-72.
91. Vilcheze, C., Wang, F., Arai, M., Hazbon, M.H., Colangeli, R., Kromer, L., Weisbrod, T.R., Alland, D., Sacchettini, J.C. and Jacobs, W.R., Jr, (2006) Nat. Med., 12, 1027-9.
92. Kremer, L., Douglas, J.D., Baulard, A.R., Morehouse, C., Guy, M.R., Alland, D., Dover, L.G., Lakey, J.H., Jacobs, W.R., Jr., Brennan, P.J., Minnikin, D.E. and Besra, G.S. (2000) J. Biol. Chem., 275, 16857-64.
93. Douglas, J.D., Senior, S.J., Morehouse, C., Phetsukiri, B., Campbell, I.B., Besra, G.S. and Minnikin, D.E. (2002) Microbiology, 148, 3101-9.
94. Kim, P., Zhang, Y.M., Shenoy, G., Nguyen, Q.A., Boshoff, H.I., Manjunatha, U.H., Goodwin, M.B., Lonsdale, J., Price, A.C., Miller, D.J., Duncan, K., White, S.W., Rock, C.O., Barry, C.E., 3rd and Dowd, C.S. (2006) J. Med. Chem., 49, 159-71.
95. Cronan, J.E., Jr. and Waldrop, G.L. (2002) Prog. Lipid Res., 41, 407-35
96. Tong, L. (2005) Cell Mol. Life Sci., 62, 1784-803.
97. Gande, R., Gibson, K.J., Brown, A.K., Krumbach, K., Dover, L.G., Sahm, H., Shioyama, S., Oikawa, T., Besra, G.S. and Eggeling, L. (2004) J. Biol. Chem., 279, 44847-57.
98. Portevin, D., de Sousa-D'Auria, C., Montrozier, H., Houssin, C., Stella, A., Laneelle, M.A., Bardou, F., Guilhot, C. and Daffe, M. (2005) J. Biol. Chem., 280, 8862-74.
99. Lin, T.W., Melgar, M.M., Kurth, D., Swamidass, S.J., Purdon, J., Tseng, T., Gago, G., Baldi, P., Gramajo, H. and Tsai, S.C. (2006) Proc. Natl. Acad. Sci. USA, 103, 3072-7.
100. Diacovich, L., Mitchell, D.L., Pham, H., Gago, G., Melgar, M.M., Khosla, C., Gramajo, H. and Tsai, S.C. (2004) Biochemistry, 43, 14027-36.
101. Zhang, H., Yang, Z., Shen, Y. and Tong, L. (2003) Science, 299, 2064-7.
102. Hall, P.R., Wang, Y.F., Rivera-Hainaj, R.E., Zheng, X., Pustai-Carey, M., Carey, P.R. and Yee, V.C. (2003) EMBO J., 22, 2334-47.
103. Holton, S.J., King-Scott, S., Eddine, A.N., Kaufmann, S.H. and Wilmanns, M. (2006) FEBS Lett., 580, 6898-902.
104. Diacovich, L., Peiru, S., Kurth, D., Rodriguez, E., Podesta, F., Khosla, C. and Gramajo, H. (2002) J. Biol. Chem., 277, 31228-36.
105. Musayev, F., Sachdeva, S., Scarsdale, J.N., Reynolds, K.A. and Wright, H.T. (2005) J. Mol. Biol., 346, 1313-21.
106. Scarsdale, J.N., Kazanina, G., He, X., Reynolds, K.A. and Wright, H.T. (2001) J. Biol. Chem., 276, 20516-22.
107. Dyer, D.H., Lyle, K.S., Rayment, I. and Fox, B.G. (2005) Protein Sci, 14, 1508-17.
108. Sankaranarayanan, R., Saxena, P., Marathe, U.B., Gokhale, R.S., Shanmugam, V.M. and Rukmini, R. (2004) Nat. Struct. Mol. Biol., 11, 894-900.
109. Huang, C.C., Smith, C.V., Glickman, M.S., Jacobs, W.R., Jr. and Sacchettini, J.C. (2002) J. Biol. Chem., 277, 11559-69.
110. Ronning, D.R., Vissa, V., Besra, G.S., Belisle, J.T. and Sacchettini, J.C. (2004) J. Biol. Chem., 279, 36771-7.
111. Anderson, D.H., Harth, G., Horwitz, M.A. and Eisenberg, D. (2001) J. Mol. Biol., 307, 671-81.
112. Sulzenbacher, G., Canaan, S., Bordat, Y., Neyrolles, O., Stadthagen, G., Roig-Zamboni, V., Rauzier, J., Maurin, D., Laval, F., Daffe, M., Cambillau, C., Gicquel, B., Bourne, Y. and Jackson, M. (2006) EMBO J., 25, 1436-44.
113. Wong, H.C., Liu, G., Zhang, Y.M., Rock, C.O. and Zheng, J. (2002) J. Biol. Chem., 277, 15874-80.
114. Perez, E., Constant, P., Laval, F., Lemassu, A., Laneelle, M.A., Daffe, M. and Guilhot, C. (2004) J. Biol. Chem., 279, 42584-92.
115. Brennan, P.J. (2003) Tuberculosis (Edinb.), 83, 91-7.
116. Chua, J., Vergne, I., Master, S. and Deretic, V. (2004) Curr. Opin. Mcrobiol., 7, 71-7.
117. Norman, R.A., McAlister, M.S., Murray-Rust, J., Movahedzadeh, F., Stoker, N.G. and McDonald, N.Q. (2002) Structure, 10, 393-402.
118. Smith, C.V., Sharma, V. and Sacchettini, J.C. (2004) Tuberculosis (Edinb), 84, 45-55.
119. Anstrom, D.M. and Remington, S.J. (2006) Protein Sci., 15, 2002-7.
120. Munoz-Élias, E.J. and McKinney, J.D. (2005) Nat. Med., 11, 638-44.
121. Gould, T.A., van de Langemheen, H., Munoz-Elias, E.J., McKinney, J.D. and Sacchettini, J.C. (2006) Mol. Microbiol., 61, 940-7.
122. Noble, M.E., Endicott, J.A. and Johnson, L.N. (2004) Science, 303, 1800-5.
123. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) Science, 298, 1912-34.
124. Cozzone, A.J. (2005) J. Mol. Mcrobiol. Biotechnol., 9, 198-213.
125. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Cell, 117, 699-711.
126. Av-Gay, Y. and Everett, M. (2000) Trends Microbial., 8, 238-44.
127. Koul, A., Choidas, A., Treder, M., Tyagi, A.K., Drlica, K., Singh, Y. and Ullrich, A. (2000) J. Bacteriol., 182, 5425-32.
128. Watkins, H.A. and Baker, E.N. (2006) J. Bacteriol., 188, 3589-99.
129. Greenstein, A.E., Grundner, C, Echols, N., Gay, L.M., Lombana, T.A., Miecskowski, C.A., Pullen, K.E., Sung, P.Y. and Alber, T. (2005) J. Mol. Microbiol. Biotechnol., 9, 167-81.
130. Koul, A., Herget, T., Klebl, B. and Ullrich, A. (2004) Nat. Rev. Microbiol., 2, 189-202.
131. Tyag, J.S. and Saini, D.K. (2004) Microbiology, 150, 4-7.
132. Haydel, S.E. and Clark-Curtiss, J.E. (2004) FEMS Microbiol. Lett., 236, 341-7.
133. Zahrt, T.C. and Deretic, V. (2001) Proc. Natl. Acad. Sci. USA, 98, 12706-11.
134. Malhotra, V., Sharma, D., Ramanathan, V.D., Shakila, H., Saini, D.K., Chakravorty, S., Das, T.K., Li, Q., Silver, R.F., Narayanan, P.R. and Tyagi, J.S. (2004) FEMS Mcrobiol. Lett., 231, 237-45.
135. Parish, T., Smith, D.A., Roberts, G., Betts, J. and Stoker, N.G. (2003) Microbiology, 149, 1423-35.
136. Perez, E., Samper, S., Bordas, Y., Guilhot, C., Gicquel, B. and Martin, C. (2001) Mol. Microbiol., 41, 179-87.
137. Rickman, L., Saldanha, J.W., Hunt, D.M., Hoar, D.N., Colston, M.J., Millar, J.B. and Buton, R.S. (2004) Biochem. Biophys. Res. Commun., 314, 259-67.
138. Leyten, E.M., Lin, M.X, Franken, K.L., Eriggen, A.H., Prins, C., van Meijgaarden, K.E., Voskuil, M.I.; Weldingh, K., Andersen, P., Schoolnik, G.K., Arend, S.M., Ottenhoff, T.H. and Klein, M.R. (2006) Microbes Infect., 8, 2052-60.
139. Bagchi, G., Chauhan, S., Sharma, D. and Tyagi, J.S. (2005) Microbiology, 151, 4045-53.
140. Roberts, D.M., Liao, R.P., Wisedchaisri, G., Hol, W.G. and Sherman, D.R. (2004) J. Biol. Chem., 279, 23082-7.
141. Hu, Y., Movahedzadeh, F., Stoker, N.G. and Coates, A.R. (2006) Infect. Immun., 74, 861-8.
142. Gay, L.M., Ng, H.L. and Alber, T. (2006) J. Mol. Biol., 360, 409-20.
143. Young, T.A., Delagoutte, B., Endrizzi, J.A., Falick, A.M. and Alber, T. (2003) Nat. Struct. Biol., 10, 168-74.
144. Ortiz-Lombardia, M., Pompeo, F., Boitel, B. and Alzari, P.M. (2003) J. Biol. Chem., 278, 13094-100.
145. Boitel, B., Ortiz-Lombardia, M., Duran, R., Pompeo, F., Cole, S.T., Cervenansky, C. and Alzari, P.M. (2003) Mol. Microbiol., 49, 1493-508.
146. Grundner, C., Ng, H.L. and Alber, T. (2005) Structure (Camb), 13, 1625-34.
147. Muller, D., Krick, A., Kehraus, S., Mehner, C., Hart, M., Kupper, F.C., Saxena, K., Prinz, H., Schwalbe, H., Janning, P., Waldmann, H. and Konig, G.M. (2006) J. Med. Chem., 49, 4871-8.
148. Manger, M., Scheck, M., Prinz, H., von Kries, J.P., Langer, T., Saxena, K., Schwalbe, H., Furstner, A., Rademann, J. and Waldmann, H. (2005) Chembiochem, 6, 1749-53.
149. Nowak, E., Panjikar, S., Konarev, P., Svergun, D.I. and Tucker, P.A. (2006) J. Biol. Chem., 281, 9659-66.
150. Nowak, E., Panjikar, S., Morth, J.P., Jordanova, R., Svergun, D.I. and Tucker, P.A. (2006) Structure, 14, 275-85.
151. Morth, J.P., Gosmann, S., Nowak, E. and Tucker, P.A. (2005) FEBS Lett., 579, 4145-8.
152. Morth, J.P., Feng, V., Perry, L.J., Svergun, D.I. and Tucker, P.A. (2004) Structure (Camb), 12, 1595-605.
153. Wisedchaisri, G., Wu, M., Rice, A.E., Roberts, D.M., Sherman, D.R. and Hol, W.G. (2005) J. Mol. Biol., 354, 630-41.
154. Parish, T., Gordhan, B.G., McAdam, R.A., Duncan, K., Mizrahi, V. and Stoker, N.G. (1999) Microbiology, 145 (Pt 12), 3497-503.
155. Parish, T. and Stoker, N.G. (2002), Microbiology, 148, 3069-77.
156. Hondalus, M.K., Bardarov, S., Russell, R., Chan, J., Jacobs, W.R., Jr. and Bloom, B.R. (2000) Infect. Immun., 68, 2888-98.
157. Gordhan, B.G., Smith, D.A., Alderton, H., McAdam, R.A., Bancroft, G.J. and Mizrahi, V. (2002) Infect. Immun., 70, 3080-4.
158. Roy, E., De Silva, A.D., Sambandamurthy, V.K., Clark, S.O., Stavropoulos, E., Jacobs, W.R., Jr., Brennan, J., Chan, J., Williams, A., Colston, M.J. and Tascon, R.E. (2006) Immunol. Lett., 103, 196-9.
159. Smith, D.A., Parish, T., Stoker, N.G. and Bancroft, G.J. (2001) Infect. Immun., 69, 1142-50.
160. Sambandamurthy, V.K., Derrick, S.C., Jalapathy, K.V., Chen, B., Russell, R.G., Morris, S.L. and Jacobs, W.R., Jr. (2005) Infect Immun., 73, 1196-203.
161. Pavelka, M.S., Jr., Chen, B., Kelley, C.L., Collins, F.M. and Jacobs Jr, W.R., Jr. (2003) Infect. Immun., 71, 4190-2.
162. Hutton, C.A., Southwood, T.J. and Turner, J.J. (2003) Mini Rev. Med. Chem., 3, 115-27.
163. Fuchs, T.M., Schneider, B., Krumbach, K., Eggeling, L. and Gross, R. (2000) J. Bacteriol., 182, 3626-31.
164. Kanehisa, M., Goto, S., Kawashima, S., Okuno, Y. and Hattori, M. (2004) Nucleic Acids Res., 32, D277-80.
165. Cirilli, M., Zheng, R., Scapin, G. and Blanchard, J.S. (2003) Biochemistry 42, 10644-50.
166. Gokulan, K., Rupp, B., Pavelka, M.S., Jr, Jacobs, W.R, Jr. and Sacchettini, J.G. (2003) J. Biol. Chem., 278 18588-96.
167. Kefala, G. and Weiss, M.S. (2006) Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun., 62 1116-9
168. Kefala G., Janowski, R., Panjikar, S., Mueller-Dieckmann, C., and Weiss, M.S. (2005) Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun., 61, 718-21
169. Weyand, S., Kefala, G. and Weiss, M.S. (2006) Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun., 62 794-7.
170. Kefala, G., Petry, L.J. and Weiss, M.S. (2005) Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun., 61, 782-4.
171. Weyand, S., Kefala, G. and Weiss, M.S. (2007) J. Mol. Biol., 367, 825-38.
172. Koon, N., Squire, C.J. and Baker, E.N. (2004) Proc. Natl. Acad. Sci, USA, 101, 8295-300.
173. Alifano, P., Fani, R., Lie, P., Lazcano, A., Bazzicallipo, M., Carlomagno, M.S. and Bruni, C.B. (1996) Microbiol. Rev., 60, 44-69.
174. Cho, Y., Sharma, V. and Sacchettini, J.C. (2003) J. Biol. Chem., 278, 8333-9.
175. Vega, M.C., Zou, P., Fernandez, F.J., Murphy, G.E., Sterner, R., Popov, A. and Wilmanns, M. (2005) Mol. Microbiol., 55, 675-86.
176. Barona-Gomez, F. and Hodgson, D.A. (2003) EMBO Rep., 4, 296-300.
177. Kuper, J., Doenges, C. and Wilmanns, M. (2005) EMBO Rep., 6, 134-9.
178. Roberts, C.W., Roberts, F., Lyons, R.E., Kirisits, M.J., Mui, E.J., Finnerty, J., Johnson, J.J., Ferguson, D.J., Coggins, J.R., Krell, T., Coombs, G.H., Milhous, W.K., Kyle, D.E., Tzipori, S., Barnwell, J., Dame, J.B., Carlton, J. and McLeod, R. (2002) J. Infect. Dis., 185 (Suppl 1), S25-36.
179. Coggins, J.R., Abell, C., Evans, L.B., Frederickson, M., Robinson, D.A., Roszak, A.W. and Lapthorn, A.P. (2003) Biochem. Soc. Trans., 31, 548-52.
180. Gu, Y., Reshetnikova, L., Li, Y., Wu, Y., Yan, H., Singh, S. and Ji, X. (2002) J. Mol. Biol., 319, 779-89.
181. Gan, J., Gu, Y., Li, Y., Yan, H. and Ji, X. (2006) Biochemistry, 45, 8539-45.
182. Hartmann, M.D., Bourenkov, G.P., Oberschall, A., Strizhov, N. and Bartunik, H.D. (2006) J. Mol. Biol., 364, 411-423.
183. Dias, M.V., Borges, J.C., Ely, F., Pereira, J.H., Canduri, F., Ramos, C.H., Frazzon, J., Palma, M.S., Basso, L.A., Santos, D.S. and de Azevedo, W.F., Jr. (2006) J. Struct. Biol., 154, 130-43.
184. Webby, C.J., Baker, H.M., Lott, J.S., Baker, E.N. and Parker, E.J (2005) J. Mol. Biol., 354, 927-39.
185. Alangaden, G.J. and Lerner, S.A. (1997) Clin. Infect. Dis., 25, 1213-21.
186. Nuermberger, E.L., Yoshimatsu, T., Tyagi, S., Williams, K. Rosenthal, I., O'Brien, R.J., Vernon, A.A., Chaisson, R.E., Bishai, W.R. and Grosset, J.H. (2004) Am. J. Respir. Crit. Care Med, 170, 1131-4.
187. Montero, C., Mateu, G., Rodriguez, R. and Takiff, H. (2001) Antimicrob. Agents Chemother., 45, 3387-92.
188. Hegde, S.S., Vetting, M.W., Roderick, S.L., Mitchenall, L.A., Maxwell, A., Takiff, H.E. and Blanchard, J.S. (2005) Science, 308, 1480-3.
189. Wehenkel, A., Fernandez, P., Bellinzoni, M., Catherinot, V., Barilone, N., Labesse, G., Jackson, M. and Alzari, P.M. (2006) FEBS Lett., 580, 3048-22.
190. Sharma, V., Sharma, S., Hoener zu Bentrup, K., McKinney, J.D. Russell, D.G., Jacobs, W.R., Jr. and Sacchettini, J.C. (2000) Nat Struct. Biol., 7, 663-8.