Acetyl-coenzyme A carboxylase: Crucial metabolic enzyme and attractive target for drug discovery

Cellular and Molecular Life Sciences

Volumn 62, Issue 16, 2005, Pages 1784-1803

  Tong, L ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Biotin dependent carboxylases; Diabetes; Enzyme catalysis and mechanism; Fatty acid metabolism; Metabolic syndrome; Obesity; Protein structure and function; Structure based drug design

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CARBOXYLASE; CARBOXYLTRANSFERASE; CP 640186; ENZYME INHIBITOR; HALOXYFOP; MOIRAMIDE B; SETHOXYDIM; SORAPHEN A; UNCLASSIFIED DRUG;

BIOCHEMISTRY; BODY FAT; BODY WEIGHT; CARBOXYLATION; CATALYSIS; CRYSTAL STRUCTURE; DIABETES MELLITUS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME DEFICIENCY; EUKARYOTE; FATTY ACID METABOLISM; FATTY ACID OXIDATION; GENE EXPRESSION; HUMAN; KINETICS; METABOLIC SYNDROME X; MOLECULAR BIOLOGY; NONHUMAN; OBESITY; PROKARYOTE; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; VALIDATION PROCESS;

ACETYL-COA CARBOXYLASE; AMINO ACID SEQUENCE; ANIMALS; CATALYSIS; DIABETES MELLITUS; DRUG DESIGN; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; OBESITY; PROTEIN BINDING; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

CELLULAR ORGANISMS; EUKARYOTA; PROKARYOTA;

EID: 23944509003     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-005-5121-4     Document Type: Review

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