Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase A (MptpA) inhibitors based on natural products and a fragment-based approach

ChemBioChem

Volumn 6, Issue 10, 2005, Pages 1749-1753

  Manger, Michael ^a,b   Scheck, Michael ^a,b   Prinz, Heino ^a,b   Von Kries, Jens Peter ^e,f   Langer, Thomas ^d   Saxena, Krishna ^d   Schwalbe, Harald ^d   Fürstner, Alois ^c   Rademann, Jörg ^e,f   Waldmann, Herbert ^a,b  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b TU DORTMUND UNIVERSITY   (Germany)

^c MAX PLANCK INSTITUT FÜR KOHLENFORSCHUNG   (Germany)

^d GOETHE UNIVERSITY   (Germany)

^e LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^f FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Enzymes; Inhibitors; Natural products; Phosphatases; Stevastelins

Indexed keywords

2,5 DIMETHYLPYRROL 1 YL BENZOIC ACID; 5 HYDROXY 2 (PYRROL 1 YL) DERIVATIVE; BACTERIAL ENZYME; HYDROXYPYRROL 1 YL BENZOIC ACID; NATURAL PRODUCT; PRODIGIOSIN; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; PYRROL 1 YL BENZOIC ACID; ROSEOPHILIN; STEVASTELIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG INHIBITION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION;

BACTERIAL PROTEINS; DEPSIPEPTIDES; ENZYME INHIBITORS; HETEROCYCLIC COMPOUNDS, 3-RING; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PEPTIDE LIBRARY; PROTEIN-TYROSINE-PHOSPHATASE; PYRROLES; RECOMBINANT FUSION PROTEINS;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM TUBERCULOSIS;

EID: 26944488334     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbic.200500171     Document Type: Article

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