Crystal structure of the carboxyltransferase domain of acetyl-coenzyme a carboxylase

Science

Volumn 299, Issue 5615, 2003, Pages 2064-2067

  Zhang, Hailong ^a   Yang, Zhiru ^a   Shen, Yang ^a   Tong, Liang ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CRYSTAL STRUCTURE; FATTY ACIDS; INTERFACES (MATERIALS); MUTAGENESIS;

KINETIC STUDIES;

COENZYMES;

ACETYL COENZYME A CARBOXYLASE; CARBOXYLTRANSFERASE; LONG CHAIN FATTY ACID;

CRYSTAL STRUCTURE; ENZYME;

ARTICLE; CRYSTAL STRUCTURE; DIABETES MELLITUS; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME STRUCTURE; MUTAGENESIS; NONHUMAN; OBESITY; OXIDATION; PRIORITY JOURNAL; PROTEIN DOMAIN;

ACETYL-COA CARBOXYLASE; AMINO ACID SEQUENCE; BINDING SITES; BIOTIN; CATALYSIS; COENZYME A; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ENZYME INHIBITORS; HYDROGEN BONDING; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PYRIDINES; SACCHAROMYCES CEREVISIAE;

EID: 0037470947     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1081366     Document Type: Article

References (24)

1. A. W. Alberts, P. R. Vagelos, in The Enzymes, P. D. Boyer, Ed. (Academic Press, New York, 1972), vol. 6, pp. 37-82.
2. S. J. Wakil, J. K. Stoops, V. C. Joshi, Annu. Rev. Biochem. 52, 537 (1983).
3. J. R. Knowles, Annu. Rev. Biochem. 58, 195 (1989).
4. J. E. Cronan Jr., G. L. Waldrop, Prog. Lipid Res. 41, 407 (2002).
5. J. D. McGarry, N. F. Brown, Eur. J. Biochem. 244, 1 (1997).
6. R. R. Ramsay, R. D. Gandour, F. R. van der Leij, Biochim. Biophys. Acta 1546, 21 (2001).
7. J. W. Campbell, J. E. Cronan Jr., Annu. Rev. Microbiol. 55, 305 (2001).
8. L. Abu-Elheiga, M. M. Matzuk, K. A. H. Abo-Hashema, S. J. Wakil, Science 291, 2613 (2001).
9. J. M. Lenhard, W. K. Gottschalk, Adv. Drug Delivery Rev. 54, 1199 (2002).
10. K. L. Levert, G. L. Waldrop, J. M. Stephens, J. Biol. Chem. 277, 16347 (2002).
11. O. Zagnitko, J. Jelenska, G. Tevzadze, R. Haselkorn, P. Gornicki, Proc. Natl. Acad. Sci. U.S.A. 98, 6617 (2001).
12. W. A. Hendrickson, Science 254, S1 (1991).
13. S. E. Polakis, R. B. Guchhait, E. E. Zwergel, M. D. Lane, J. Biol. Chem. 249, 66S7 (1974).
14. M. M. Benning et al., Biochemistry 35, 8103 (1996).
15. C. K. Engel, M. Mathieu, J. P. Zeeten, J. K. Hiltunen, R. K. Wierenga, EMBO J. 15, 513S (1996).
16. J. Wang, J. A. Hartling, J. M. Flanagan, Cell 91, 447 (1997).
17. M. M. Benning, T. Haller, J. A. Gerlt, H. M. Holden, Biochemistry 39, 4630 (2000).
18. A. M. Mursula, D. M. F. van Aalten, J. K. Hiltunen, R. K. Wierenga, J. Mol. Biol. 309, 845 (2001).
19. H. Zhang, Z. Yang, Y. Shen, L. Tong, data not shown.
20. L. H. Weaver, K. Kwon, D. Beckett, B. W. Matthews, Prot. Sci. 10, 2618 (2001).
21. J. Jelenska, A. Sirikhachornkit, R. Haselkorn, P. Gornicki, J. Biol. Chem. 277, 23208 (2002).
22. M. Carson, J. Mol. Graphics 5, 103 (1987).
23. A. Nicholls, K. A. Sharp, B. Honig, Proteins 11, 281 (1991).
24. We thank R. Abramowitz and C. Ogata for setting up the X4A beamline, R. Khayat and X. Tao for help with data collection at the synchrotron, C. Frank for technical support, P. Gornicki for helpful discussions, and Columbia University (L.T.) for financial support.