Protein kinase G from pathogenic mycobacteria promotes survival within macrophages

Science

Volumn 304, Issue 5678, 2004, Pages 1800-1804

  Walburger, Anne ^a   Koul, Anil ^b   Ferrari, Giorgio ^a   Nguyen, Liem ^a   Prescianotto Baschong, Cristina ^a   Huygen, Kris ^c   Klebl, Bert ^b   Thompson, Charles ^a   Bacher, Gerald ^b   Pieters, Jean ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b Axxima Pharmaceuticals AG   (Germany)

^c PASTEUR INSTITUTE OF BRUSSELS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BACTERIA; CELLS;

CHEMICAL INHIBITION; INACTIVATION; MACROPHAGES;

PROTEINS;

CYCLIC GMP DEPENDENT PROTEIN KINASE;

BIOLOGY;

ARTICLE; BACTERIAL CELL; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; CELL DEATH; CELL FUSION; ENZYME INACTIVATION; ENZYME ISOLATION; ENZYME RELEASE; GENE DISRUPTION; GENE LOCATION; HOST PATHOGEN INTERACTION; INTRACELLULAR TRANSPORT; LYSOSOME; MACROPHAGE; MYCOBACTERIOSIS; MYCOBACTERIUM; NONHUMAN; PHAGOSOME; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AMIDES; ANIMALS; CELL LINE; CYCLIC GMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; GENE DELETION; LYSOSOMES; MACROPHAGES; MICE; MYCOBACTERIUM BOVIS; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; PHAGOSOMES; SIGNAL TRANSDUCTION; THIOPHENES; VACUOLES;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); CORYNEBACTERINEAE; EUKARYOTA; MYCOBACTERIUM; UNCULTURED ACTINOMYCETE;

EID: 2942718724     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1099384     Document Type: Article

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36. We thank N. Silbereisen, M. Gerhofer, S. Steyrer, and M. Roth-Richter for excellent technical assistance; G. Vogel for help with sequencing L. Landmann, U. M. Spomitz, and R. Zeller for use of electron microscope facilities; A. Choidas for help with kinase assays; W. R. Jacobs and A. Tyagi for mycobacterial expression plasmids; D. Young for luminescent M. tuberculosis; and G. Cornelis and M. Spiess for critical reading of the manuscript. Axxima is a pharmaceutical company involved in drug discovery and development in the field of pathogen-host signal transduction research. Supported by a FEBS fellowship (A.W.) and grants from the World Health Organizartion, Olga Mayenfisch Stiftung, and Swiss National Science Foundation (J.P.).