Crystal structure of Mycobacterium tuberculosis diaminopimelate decarboxylase, an essential enzyme in bacterial lysine biosynthesis

Journal of Biological Chemistry

Volumn 278, Issue 20, 2003, Pages 18588-18596

  Gokulan, Kuppan ^a   Rupp, Bernhard ^a,b   Pavelka Jr , Martin S ^c,d   Jacobs Jr , William R ^c   Sacchettini, James C ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIOSYNTHESIS; CATALYST ACTIVITY; CRYSTAL STRUCTURE; DRUG PRODUCTS; ENZYME KINETICS; GENETIC ENGINEERING;

GENE ENCODING;

BIOCHEMICAL ENGINEERING;

DIAMINOPIMELATE DECARBOXYLASE; DIAMINOPIMELIC ACID; LYSINE; ORNITHINE DECARBOXYLASE; PYRIDOXAL 5 PHOSPHATE; TRIOSEPHOSPHATE ISOMERASE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CARBOXYLYASE; LIGAND; LYSA PROTEIN, BACTERIA; PYRIDOXINE;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL GENE; BACTERIAL SURVIVAL; BETA SHEET; BIOSYNTHESIS; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; IMMUNE DEFICIENCY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI; ANIMAL; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; ESCHERICHIA COLI; FEMALE; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; MOUSE; MOUSE MUTANT; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; SEQUENCE HOMOLOGY; TIME; X RAY CRYSTALLOGRAPHY;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); EUKARYOTA; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; TRYPANOSOMA; TRYPANOSOMA BRUCEI; UNCULTURED ACTINOMYCETE;

AMINO ACID SEQUENCE; ANIMALS; BACTERIAL PROTEINS; BINDING SITES; CARBOXY-LYASES; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; FEMALE; LIGANDS; LYSINE; MICE; MICE, SCID; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SEQUENCE HOMOLOGY, AMINO ACID; TIME FACTORS; VITAMIN B 6;

EID: 0038043194     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M301549200     Document Type: Article

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