The common aromatic amino acid biosynthesis pathway is essential in Mycobacterium tuberculosis

Microbiology

Volumn 148, Issue 10, 2002, Pages 3069-3077

  Parish, Tanya ^a   Stoker, Neil G ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Auxotrophs; Bacteriophage L5; Chorismate biosynthesis; Excisionase; Gene replacement

Indexed keywords

AROMATIC AMINO ACID; CHORISMIC ACID; GENTAMICIN; KANAMYCIN; PHOSPHOTRANSFERASE; SHIKIMIC ACID;

ALLELE; AMINO ACID SYNTHESIS; ARTICLE; BACTERIAL CHROMOSOME; CATALYSIS; CONTROLLED STUDY; CULTURE MEDIUM; GENE DISRUPTION; GENE ISOLATION; GENE TARGETING; GENETIC ORGANIZATION; HOMOLOGOUS RECOMBINATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OPERON; PRIORITY JOURNAL; WILD TYPE;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; UNCULTURED ACTINOMYCETE;

EID: 0036773752     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-148-10-3069     Document Type: Article

References (25)

1. Cole, S. T., Brosch, R., Parkhill, J. & 39 other authors (1998). Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393, 537-544.
2. Cole, S. T., Eiglmeier, K., Parkhill, J. & 41 other authors (2001). Massive gene decay in the leprosy bacillus. Nature 409, 1007-1011.
3. Dilts, D. A., Riesenfeld-Orn, I., Fulginiti, J. P. & 11 other authors (2000). Phase I clinical trials of aroA aroD and aroA aroD htrA attenuated S. typhi vaccines; effect of formulation on safety and immunogenicity. Vaccine 18, 1473-1484.
4. Dye, C., Scheele, S., Dolin, P., Pathania, V. & Raviglione, M. C. (1999). Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. J A M A (J Am Med Assoc) 282, 677-686.
5. Fine, P. E. M. (2001). BCG: the challenge continues. Scand J Infect Dis 33, 243-245.
6. Garbe, T., Jones, C., Charles, I., Dougan, G. & Young, D. (1990). Cloning and characterization of the aroA gene from Mycobacterium tuberculosis. J Bacteriol 172, 6774-6782.
7. Garbe, T., Servos, S., Hawkins, A., Dimitriadis, G., Young, D., Dougan, G. & Charles, I. (1991). The Mycobacterium tuberculosis shikimate pathway genes - evolutionary relationship between biosynthetic and catabolic 3-dehydroquinases. Mol Gen Genet 228, 385-392.
8. Gourley, D. G., Shrive, A. K., Polikarpov, I., Krell, T., Coggins, J. R., Hawkins, A. R., Isaacs, N. W. & Sawyer, L. (1999). The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction. Nat Struct Biol 6, 521-525.
9. Gu, Y., Reshetnikova, L., Li, Y., Yan, H., Singh, S. V. & Ji, X. (2001). Crystallization and preliminary X-ray diffraction analysis of shikimate kinase from Mycobacterium tuberculosis in complex with MgADP. Acta Crystallogr D Biol Crystallogr 57, 1870-1871.
10. Gunel-Ozcan, A., Brown, K. A., Allen, A. G. & Maskell, D. J. (1997). Salmonella typhimurium aroB mutants are attentuated in BALB/c mice. Microb Pathog 23, 311-316.
11. Hinds, J., Mahenthiralingam, E., Kempsell, K. E., Duncan, K., Stokes, R. W., Parish, T. & Stoker, N. G. (1999). Enhanced gene replacement in mycobacteria. Microbiology 145, 519-527.
12. Hoiseth, H. K. & Stocker, B. A. (1981). Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines. Nature 291, 238-239.
13. Hondalus, M. K., Bardarov, S., Russell, R., Chan, J., Jacobs, W. R. & Bloom, B. R. (2000). Attenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosis. Infect Immun 68, 2888-2898.
14. Ingham, A., Zhang, Y. & Prideaux, C. (2002). Attenuation of Actinobacillus pleuropneumoniae by inactivation of aroQ. Vet Microbiol 84, 263-273.
15. Mahenthiralingam, E., Marklund, B. I., Brooks, L. A., Smith, D. A., Bancroft, G. J. & Stokes, R. W. (1998). Site-directed mutagenesis of the 19-kilodalton lipoprotein antigen reveals no essential role for the protein in the growth and virulence of Mycobacterium intracellulare. Infect Immun 66, 3626-3634.
16. Parish, T. & Stoker, N. G. (2000a). Use of a flexible cassette method to generate a double unmarked Mycobacterium tuberculosis tlyA plcABC mutant by gene replacement. Microbiology 146, 1969-1975.
17. Parish, T. & Stoker, N. G. (2000b). glnE is an essential gene in Mycobacterium tuberclosis. J Bacteriol 182, 5715-5720.
18. Parish, T., Gordhan, B. G., McAdam, R. A., Duncan, K., Mizrahi, V. & Stoker, N. G. (1999). Production of mutants in amino acid biosynthesis genes of Mycobacterium tuberculosis by homologous recombination. Microbiology 145, 3497-3503.
19. Parish, T., Lewis, J. & Stoker, N. G. (2001). Use of the mycobacteriophage L5 excisionase in Mycobacterium tuberculosis to demonstrate gene essentiality. Tuberculosis 81, 359-364.
20. Pittard, A. J. (1987). Biosynthesis of the aromatic amino acids. In Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology, pp. 368-394. Edited by J. L. Ingraham, K. B. Low, B. Magasanik, M. Schaechter & H. E. Umbarger. Washington, DC: American Society for Microbiology.
21. Simmons, C. P., Hodgson, A. L. M. & Strugnell, R. A. (1997). Attenuation and vaccine potential of aroQ mutants of Corynebacterium pseudotuberculosis. Infect Immun 65, 3048-3056.
22. Smith, D. A., Parish, T., Stoker, N. G. & Bancroft, G. J. (2001). Characterization of auxotrophic: mutants of Mycobacterium tuberculosis and their potential as vaccine candidates. Infect Immun 69, 1142-1150.
23. Stover, C. K., Delacruz, V. F., Fuerst, T. R. & 11 other authors (1991). New use of BCG for recombinant vaccines. Nature 351, 456-460.
24. Vaughan, L. M., Smith, P. R. & Foster, T. J. (1993). An aromatic-dependent mutant of the fish pathogen Aeromonas salmonicida is attenuated in fish and is effective as a live vaccine against the salmonid disease furunculosis. Infect Immun 61, 2172-2181.
25. Vinella, D., Gagny, B., JoseleauPetit, D., Dari, R. & Cashel, M. (1996). Mecillinam resistance in Escherichia coli is conferred by loss of a second activity of the AroK protein. J Bacteriol 178, 3818-3828.