The shikimate pathway and its branches in apicomplexan parasites

Journal of Infectious Diseases

Volumn 185, Issue , 2002, Pages S25-S36

  Roberts, Craig W ^a   Roberts, Fiona ^b   Lyons, Russell E ^a   Kirisits, Michael J ^e,g   Mui, Ernest J ^e,g   Finnerty, John ^f   Johnson, Jennifer J ^e,g   Ferguson, David J P ^d   Coggins, John R ^c   Krell, Tino ^c   Coombs, Graham H ^c   Milhous, Wilbur K ⁱ   Kyle, Dennis E ⁱ   Tzipori, Saul ^h   Barnwell, John ^a,k   Dame, John B ^l   Carlton, Jane ^j,m   McLeod, Rima ^e,f,g  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b VICTORIA INFIRMARY   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e Departments of Ophthalmology and Visual Sciences   (United States)

^f UNIVERSITY OF CHICAGO   (United States)

^g MICHAEL REESE HOSPITAL   (United States)

^h TUFTS UNIVERSITY   (United States)

ⁱ WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^j NATIONAL INSTITUTES OF HEALTH   (United States)

^k CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^l UNIVERSITY OF FLORIDA   (United States)

^m J CRAIG VENTER INSTITUTE   (United States)

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Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; AROMATIC AMINO ACID; AROMATIC COMPOUND; CHORISMIC ACID; FOLIC ACID DERIVATIVE; GLYPHOSATE; NAPHTHOQUINONE; PHENYLALANINE; PHOSPHOENOLPYRUVATE; SHIKIMIC ACID; TRYPTOPHAN; TYROSINE; UBIQUINONE;

APICOMPLEXA; CATALYSIS; CELLULAR DISTRIBUTION; CONFERENCE PAPER; CRYPTOSPORIDIUM PARVUM; NONHUMAN; PHYLOGENY; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; REGULATORY MECHANISM; TOXOPLASMA GONDII;

AMINO ACID SEQUENCE; ANIMALS; APICOMPLEXA; GENE EXPRESSION REGULATION; GLYCINE; MOLECULAR SEQUENCE DATA; PHOSPHORUS-OXYGEN LYASES; SHIKIMIC ACID;

EID: 0037083107     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/338004     Document Type: Article

References (105)

1. Evidence for the shikimate pathway in apicomplexan parasites
2. Targeting the shikimate pathway in the malaria parasite Plasmodium falciparum
3. The shikimate pathway - A metabolic tree with many branches
4. The shikimate pathway
5. Blue-green bacteria synthesise L-tyrosine by the pretyrosine pathway
6. The biosynthesis of shikimate metabolites
7. Biosynthesis of 3-amino-5-hydroxybenzoic acid, the precursor of mC7N units in ansamycin antibiotics
8. Amino acid biosynthesis inhibitors as herbicides
9. (6S)-6-fluoroshikimic acid, an antibacterial agent acting on the aromatic biosynthetic pathway
10. Toxoplasmosis
11. Chemotherapy for falciparum malaria: The armoury, the problems and the prospects
12. Biochemical peculiarities and drug targets in Cryptosporidium parvum: Lessons from other coccidian parasites
13. Laboratory investigations and chemotherapy of Cryptosporidium parvum
14. Antimicrobial resistance - Pharmacological solutions
15. A bacterial model system for understanding multi-drug resistance
16. A continuous, anaerobic spectrophotometric assay for chorismate synthase activity that utilizes photo-reduced flavin mononucleotide
17. The characterisation of the shikimate pathway enzyme dehydroquinase from Pisum sativum
18. Mechanisms of sulfadoxine resistance in Plasmodium falciparum
19. Subcellular localization and characterization of chorismate synthase in the apicomplexan Plasmodium falciparum
20. The evolutionary origin of the 35 kb circular DNA of Plasmodium falciparum: New evidence supports a possible rhodophyte ancestry
21. Plastid origin of an extrachromosomal DNA molecule from Plasmodium
22. Complete gene map of the plastid-like DNA of the malaria parasite Plasmodium falciparum
23. Import of proteins into mitochondria and chloroplasts
24. Antimicrobial agents, diagnostic reagents and vaccines based on unique apicomplexan parasite metabolic pathways, enzymes and nucleic acids
25. Plant-like metabolic pathways provide novel antimicrobial agent targets in pathogenic, apicomplexan parasites
26. Shikimate pathway in apicomplexan parasites
27. Inhibition of Toxoplasma gondii replication by dinitroaniline herbicides
28. A plastid of probable green algal origin in apicomplexan parasites
29. Nuclear-encoded, plastid-targeted genes suggest a single common origin for apicomplexan and dinoflagellate plastids
30. Plastids in human parasites
31. Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan
32. Human indoleamine 2,3-dioxygenase inhibits Toxoplasma gondii growth in fibroblast cells
33. Stable DNA transformation in the obligate intracellular parasite Toxoplasma gondii by complementation of tryptophan auxotrophy
34. Nutritional requirements of Plasmodium falciparum in culture. I. Exogenously supplied dialyzable components necessary for continuous growth
35. Biosynthesis of aromatic compounds: 13C NMR spectroscopy of whole Escherichia coli cells
36. Control of aromatic biosynthesis: The multiplicity of 7-phospho-2-oxo-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) in Escherichia coli W
37. Cloning of an aroF allele encoding a tyrosine-insensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
38. Mutational analysis of the catalytic and feedback sites of the tryptophan-sensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase of Escherichia coli
39. Regulation of tyrosine and phenylalanine biosynthesis in Escherichia coli K-12: Properties of the tyrR gene product
40. Distribution and function of genes concerned with aromatic biosynthesis in Escherichia coli
41. Operator mutations of the Escherichia coli aroF gene
42. The nucleotide sequence of aroG, the gene for 3-deoxy-D-arabinoheptulosonate-7-phosphate synthetase (phe) in Escherichia coli K12
43. Structure and regulation of aroH, the structural gene tor the tryptophan-repressible 3-deoxy-D-arabino-heptulosonic acid-7-phosphate synthetase of Escherichia coli
44. Regulation of aroL expression by TyrR protein and Trp repressor in Escherichia coli K-12
45. Nucleotide sequence of the transcription unit containing the aroL and aroM genes for Escherichia coli K-12
46. Synergism between the Trp repressor and Tyr repressor in repression of the aroL promoter of Escherichia coli K-12
47. Novel mechanisms of translational control in Saccharomyces cerevisiae
48. Repeated DNA sequences upstream from HIS1 also occur at several other co-regulated genes in Saccharomyces cerevisiae and its regulation
49. The Saccharomyces cerevisiae ARO1 gene. An example of the co-ordinate regulation of five enzymes on a single biosynthetic pathway
50. GCN4 protein, a positive transcription factor in yeast, binds general control promoters at all 5′ TGACTC 3′ sequences
51. The general control activator protein GCN4 is essential for a basal level of ARO3 gene expression in Saccharomyces cerevisiae
52. A mutated ARO4 gene for feedback-resistant DAHP synthase which causes both o-fluoroDL-phenylalanine resistance and beta-phenethyl-alcohol overproduction in Saccharomyces cerevisiae
53. Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome
54. Transcriptional enhancement by acidic activators
55. Evidence for regulation of reinitiation in translational control of GCN4 mRNA
56. Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast
57. Evidence for cross-pathway regulation of metabolic gene expression in plants
58. Subcellular localization of the common shikimate-pathway enzymes in Pisum sativum
59. Evidence from Solanum tuberosum in support of the dual-pathway hypothesis of aromatic biosynthesis
60. 3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase from carrot roots (Daucus carota) is a hysteric enzyme
61. Differential induction of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase genes in Arabidopsis thaliana by wounding and pathogenic attack
62. The two-isozyme system of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase m Nicotiana silvestris and other higher plants
63. Light and fungal elicitor induce 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase mRNA in suspension cultured cells of parsley (Petroselinum crispum L.)
64. Induction of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase activity by fungal elicitor in cultures of Petroselinum crispum
65. Differential expression of tomato (Lycopersicon esculentum) genes encoding shikimate pathway isoenzymes. I. 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
66. Structure, expression, and evolution of the 5-enolpyruvylshikimate-3-phosphate synthase genes of petunia and tomato
67. Organ-specific differences in the ratio of alternatively spliced chorismate synthase (LeCS2) transcripts in tomato
68. Changing gene expression during dark-induced chloroplast dedifferentiation in Euglena gracilis
69. Overproduction by gene amplification of the multifunctional arom protein confers glyphosate tolerance to a plastid-free mutant of Euglena gracilis
70. Cytosolic and plastid forms of 5-enolpyruvylshikimate-3-phosphate synthase in Euglena grocilis are differentially expressed during light-induced chloroplast development
71. Biochemical basis for glyphosate tolerance in a bacterium and plant tissue culture
72. 5-Enolpyruvylshikimate-3-phosphate synthase of Klebsiella pneumoniae 2. Inhibition by glyphosate [N-(phosphonomethyl)glycine]
73. Comparative action of glyphosate as a trigger of energy drain in eubacteria
74. Glyphosate sensitivity of 5-enol-pyruvylshikimate-3-phosphate synthase from Bacillus subtilis depends upon state of activation induced by monovalent cations
75. Amino acid synthesis
76. RNAi in the malaria parasite Plasmodium falciparum
77. Functionalized 3,5-dihydroxybenzoates as potent novel inhibitors of EPSP synthase
78. New EPSP synthase inhibitors: Synthesis and evaluation of an aromatic tetrahedral intermediate mimic containing a 3-malonate ether as a 3-phosphate surrogate
79. An EPSP synthase inhibitor joining shikimate 3-phosphate with glyphosate: Synthesis and ligand binding studies
80. New aromatic inhibitors of EPSP synthase incorporating hydroxymalonates as novel 3-phosphate replacements
81. Fluorine-containing analogues of intermediates in the shikimate pathway
82. Dehydroquinate synthase: The use of substrate analogues to probe the early steps of the catalyzed reaction
83. Dehydroquinate synthase: The use of substrate analogues to probe the early steps of the catalyzed reaction
84. Reaction of (6R)-6-F-EPSP with recombinant Escherichia coli chorismate synthase generates a stable flavin mononucleotide semiquinone radical
85. Escherichia coli chorismate synthase catalyzes the conversion of (6S)-6-fluoro-5-enolpyruvylshikimate-3-phosphate to 6-fluorochorismate. Implications for the enzyme mechanism and the antimicrobial action of (6S)-6-fluoroshikimate
86. Inhibition of chorismate synthase by (6R)- and (6S)-fluoro-5-enolpyruvyl shikimate 3-P04
87. Selection and characterization of a carrot cell line tolerant to glyphosate
88. An altered aroA gene product confers resistance to the herbicide glyphosate
89. A single amino acid substitution in the enzyme 5-enolpyruvylshikimate-3-phosphate synthase confers resistance to the herbicide glyphosate
90. Substitution of Gly-96 to Ala in the 5-enolpyruvylshikimate-3-phosphate synthase of Klebsiella pneumoniae results in a greatly reduced affinity for the herbicide glyphosate
91. Selective overproduction of 5-enol-pyruvylshikimic acid 3-phosphate synthase in a plant cell culture which tolerates high doses of the herbicide glyphosate
92. Over-production of 5-enolpyruvylshikimate-3-phosphate synthase in a glyphosate-tolerant Petunia hybrida cell line
93. Molecular basis for the overproduction of 5-enolpyruvylshikimate-3-phosphate synthase in a glyphosate tolerant cell suspension culture of Corydalis sempervirens
94. Engineering herbicide tolerance in transgenic plants
95. Expression of glyphosate resistance in carrot somatic hybrid cells through the transfer of an amplified 5-enopyruvylshikimate-3-phosphate synthase gene
96. Gene amplification in glyphosate tolerant tobacco cells
97. N-(phosphonomethyl)glycine (glyphosate) tolerance in Euglena gracilis acquired by either overproduced or resistant 5-enolpyruvylshikimate-3-phosphate synthase
98. Transport of the antibacterial agent (6S)-6-fluoroshikimate and other shikimate analogues by the shikimate transport system of Escherichia coli
99. Analysis of genetic diversity at the arom locus in isolates of Pneumocystis carinii
100. The Mycobacterium tuberculosis shikimate pathway genes: Evolutionary relationship between biosynthetic and catabolic 3-dehydroquinases
101. The impact of genomics on novel antibacterial targets