Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid

Nature Medicine

Volumn 12, Issue 9, 2006, Pages 1027-1029

  Vilchèze, Catherine ^a   Wang, Feng ^b   Arai, Masayoshi ^a   Hazbón, Manzour Hernando ^c   Colangeli, Roberto ^c   Kremer, Laurent ^d   Weisbrod, Torin R ^a   Alland, David ^c   Sacchettini, James C ^b   Jacobs Jr , William R ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^d UNIVERSITÉ DE MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; ISONIAZID; MYCOLIC ACID; PROTEIN INHA; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; BIOSYNTHESIS; DRUG TARGETING; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, BACTERIAL; ISONIAZID; MYCOBACTERIUM TUBERCULOSIS; MYCOLIC ACIDS; NAD; OXIDOREDUCTASES; POINT MUTATION;

MYCOBACTERIUM TUBERCULOSIS;

EID: 33748469322     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1466     Document Type: Article

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