-
1
-
-
0032145989
-
The MDM2 gene amplification database
-
Momand J., et al. The MDM2 gene amplification database. Nucleic Acids Res. 26 (1998) 3453-3459
-
(1998)
Nucleic Acids Res.
, vol.26
, pp. 3453-3459
-
-
Momand, J.1
-
2
-
-
0031841384
-
IARC database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools
-
Hainaut P., et al. IARC database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools. Nucleic Acids Res. 26 (1998) 205-213
-
(1998)
Nucleic Acids Res.
, vol.26
, pp. 205-213
-
-
Hainaut, P.1
-
3
-
-
33646807491
-
Transcriptional regulation by p53: one protein, many possibilities
-
Laptenko O., and Prives C. Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ. 13 (2006) 951-961
-
(2006)
Cell Death Differ.
, vol.13
, pp. 951-961
-
-
Laptenko, O.1
Prives, C.2
-
4
-
-
0035841951
-
Genotoxic and non-genotoxic pathways of p53 induction
-
Pluquet O., and Hainaut P. Genotoxic and non-genotoxic pathways of p53 induction. Cancer Lett. 174 (2001) 1-15
-
(2001)
Cancer Lett.
, vol.174
, pp. 1-15
-
-
Pluquet, O.1
Hainaut, P.2
-
5
-
-
4944255743
-
Post-translational modification of p53 in tumorigenesis
-
Bode A.M., and Dong Z. Post-translational modification of p53 in tumorigenesis. Nat. Rev. Cancer 4 (2004) 793-805
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 793-805
-
-
Bode, A.M.1
Dong, Z.2
-
6
-
-
33845270990
-
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
-
Toledo F., and Wahl G.M. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat. Rev. Cancer 6 (2006) 909-923
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 909-923
-
-
Toledo, F.1
Wahl, G.M.2
-
7
-
-
0026649648
-
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
-
Momand J., et al. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69 (1992) 1237-1245
-
(1992)
Cell
, vol.69
, pp. 1237-1245
-
-
Momand, J.1
-
8
-
-
0031583962
-
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
-
Honda R., et al. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 420 (1997) 25-27
-
(1997)
FEBS Lett.
, vol.420
, pp. 25-27
-
-
Honda, R.1
-
9
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
Haupt Y., et al. Mdm2 promotes the rapid degradation of p53. Nature 387 (1997) 296-299
-
(1997)
Nature
, vol.387
, pp. 296-299
-
-
Haupt, Y.1
-
10
-
-
0030965946
-
Regulation of p53 stability by Mdm2
-
Kubbutat M.H.G., et al. Regulation of p53 stability by Mdm2. Nature 387 (1997) 299-303
-
(1997)
Nature
, vol.387
, pp. 299-303
-
-
Kubbutat, M.H.G.1
-
11
-
-
0032518917
-
Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein
-
Roth J., et al. Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. EMBO J. 17 (1998) 554-564
-
(1998)
EMBO J.
, vol.17
, pp. 554-564
-
-
Roth, J.1
-
12
-
-
0027459198
-
Mdm2 expression is induced by wild type p53 activity
-
Barak Y., et al. Mdm2 expression is induced by wild type p53 activity. EMBO J. 12 (1993) 461-468
-
(1993)
EMBO J.
, vol.12
, pp. 461-468
-
-
Barak, Y.1
-
13
-
-
0027244853
-
The p53-mdm-2 autoregulatory feedback loop
-
Wu X., et al. The p53-mdm-2 autoregulatory feedback loop. Genes Dev. 7 (1993) 1126-1132
-
(1993)
Genes Dev.
, vol.7
, pp. 1126-1132
-
-
Wu, X.1
-
14
-
-
0028823020
-
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
-
Montes de Oca Luna R., et al. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378 (1995) 203-206
-
(1995)
Nature
, vol.378
, pp. 203-206
-
-
Montes de Oca Luna, R.1
-
15
-
-
0028834902
-
Rescue of embryonic lethality in mdm2-deficient mice by absence of p53
-
Jones S.N., et al. Rescue of embryonic lethality in mdm2-deficient mice by absence of p53. Nature 378 (1995) 206-208
-
(1995)
Nature
, vol.378
, pp. 206-208
-
-
Jones, S.N.1
-
16
-
-
33748674375
-
Tumour biology: policing of oncogene activity by p53
-
Efeyan A., et al. Tumour biology: policing of oncogene activity by p53. Nature 443 (2006) 159
-
(2006)
Nature
, vol.443
, pp. 159
-
-
Efeyan, A.1
-
17
-
-
0032549704
-
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
-
Pomerantz J., et al. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 92 (1998) 713-723
-
(1998)
Cell
, vol.92
, pp. 713-723
-
-
Pomerantz, J.1
-
18
-
-
0032549711
-
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
-
Zhang Y., et al. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92 (1998) 725-734
-
(1998)
Cell
, vol.92
, pp. 725-734
-
-
Zhang, Y.1
-
19
-
-
0030728468
-
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
-
Kamijo T., et al. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91 (1997) 649-659
-
(1997)
Cell
, vol.91
, pp. 649-659
-
-
Kamijo, T.1
-
20
-
-
21244451434
-
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor
-
Chen D., et al. ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell 121 (2005) 1071-1083
-
(2005)
Cell
, vol.121
, pp. 1071-1083
-
-
Chen, D.1
-
21
-
-
2342447397
-
The ubiquitin ligase COP1 is a critical negative regulator of p53
-
Dornan D., et al. The ubiquitin ligase COP1 is a critical negative regulator of p53. Nature 429 (2004) 86-92
-
(2004)
Nature
, vol.429
, pp. 86-92
-
-
Dornan, D.1
-
22
-
-
0037459377
-
Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation
-
Leng R.P., et al. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. Cell 112 (2003) 779-791
-
(2003)
Cell
, vol.112
, pp. 779-791
-
-
Leng, R.P.1
-
23
-
-
0018760324
-
Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
-
Linzer D.I., and Levine A.J. Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell 17 (1979) 43-52
-
(1979)
Cell
, vol.17
, pp. 43-52
-
-
Linzer, D.I.1
Levine, A.J.2
-
24
-
-
0018348655
-
T antigen is bound to a host protein in SV40-transformed cells
-
Lane D.P., and Crawford L.V. T antigen is bound to a host protein in SV40-transformed cells. Nature 278 (1979) 261-263
-
(1979)
Nature
, vol.278
, pp. 261-263
-
-
Lane, D.P.1
Crawford, L.V.2
-
25
-
-
0842346437
-
Principles of tumor suppression
-
Sherr C.J. Principles of tumor suppression. Cell 116 (2004) 235-246
-
(2004)
Cell
, vol.116
, pp. 235-246
-
-
Sherr, C.J.1
-
26
-
-
0026561121
-
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
-
Donehower L.A., et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356 (1992) 215-221
-
(1992)
Nature
, vol.356
, pp. 215-221
-
-
Donehower, L.A.1
-
27
-
-
0028118111
-
Tumor spectrum analysis in p53-mutant mice
-
Jacks T., et al. Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4 (1994) 1-7
-
(1994)
Curr. Biol.
, vol.4
, pp. 1-7
-
-
Jacks, T.1
-
28
-
-
0028176453
-
Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene
-
Purdie C.A., et al. Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene. Oncogene 9 (1994) 603-609
-
(1994)
Oncogene
, vol.9
, pp. 603-609
-
-
Purdie, C.A.1
-
29
-
-
0027226306
-
Genetic background alters the spectrum of tumors that develop in p53-deficient mice
-
Harvey M., et al. Genetic background alters the spectrum of tumors that develop in p53-deficient mice. FASEB J. 7 (1993) 938-943
-
(1993)
FASEB J.
, vol.7
, pp. 938-943
-
-
Harvey, M.1
-
30
-
-
0032541321
-
Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation
-
Venkatachalam S., et al. Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation. EMBO J. 17 (1998) 4657-4667
-
(1998)
EMBO J.
, vol.17
, pp. 4657-4667
-
-
Venkatachalam, S.1
-
31
-
-
0034750997
-
+/- mouse model in carcinogenicity testing
-
+/- mouse model in carcinogenicity testing. Toxicol. Pathol. 29 Suppl (2001) 147-154
-
(2001)
Toxicol. Pathol.
, vol.29
, Issue.SUPPL
, pp. 147-154
-
-
Venkatachalam, S.1
-
32
-
-
0027315653
-
p53 and the Li-Fraumeni syndrome
-
Malkin D. p53 and the Li-Fraumeni syndrome. Cancer Genet. Cytogenet. 66 (1993) 83-92
-
(1993)
Cancer Genet. Cytogenet.
, vol.66
, pp. 83-92
-
-
Malkin, D.1
-
33
-
-
0038049143
-
Cancer and ageing: rival demons?
-
Campisi J. Cancer and ageing: rival demons?. Nat. Rev. Cancer 3 (2003) 339-349
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 339-349
-
-
Campisi, J.1
-
34
-
-
0037011958
-
p53 mutant mice that display early ageing-associated phenotypes
-
Tyner S.D., et al. p53 mutant mice that display early ageing-associated phenotypes. Nature 415 (2002) 45-53
-
(2002)
Nature
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
-
35
-
-
23844535164
-
Complicating the role of p53 in aging
-
Gentry A., and Venkatachalam S. Complicating the role of p53 in aging. Aging Cell 4 (2005) 157-160
-
(2005)
Aging Cell
, vol.4
, pp. 157-160
-
-
Gentry, A.1
Venkatachalam, S.2
-
36
-
-
1042266548
-
Modulation of mammalian life span by the short isoform of p53
-
Maier B., et al. Modulation of mammalian life span by the short isoform of p53. Genes Dev. 18 (2004) 306-319
-
(2004)
Genes Dev.
, vol.18
, pp. 306-319
-
-
Maier, B.1
-
37
-
-
0035370372
-
Insulin/IGF signalling and ageing: seeing the bigger picture
-
Gems D., and Partridge L. Insulin/IGF signalling and ageing: seeing the bigger picture. Curr. Opin. Genet. Dev. 11 (2001) 287-292
-
(2001)
Curr. Opin. Genet. Dev.
, vol.11
, pp. 287-292
-
-
Gems, D.1
Partridge, L.2
-
38
-
-
24344447780
-
p63 deficiency activates a program of cellular senescence and leads to accelerated aging
-
Keyes W.M., et al. p63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev. 19 (2005) 1986-1999
-
(2005)
Genes Dev.
, vol.19
, pp. 1986-1999
-
-
Keyes, W.M.1
-
39
-
-
0037112844
-
Super p53″ mice exhibit enhanced DNA damage response, are tumor resistant and age normally
-
Garcia-Cao I., et al. Super p53″ mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J. 21 (2002) 6225-6235
-
(2002)
EMBO J.
, vol.21
, pp. 6225-6235
-
-
Garcia-Cao, I.1
-
40
-
-
33745223517
-
Increased p53 activity does not accelerate telomere-driven ageing
-
Garcia-Cao I., et al. Increased p53 activity does not accelerate telomere-driven ageing. EMBO Rep. 7 (2006) 546-552
-
(2006)
EMBO Rep.
, vol.7
, pp. 546-552
-
-
Garcia-Cao, I.1
-
41
-
-
29944447632
-
Tumor suppression and normal aging in mice with constitutively high p53 activity
-
Mendrysa S.M., et al. Tumor suppression and normal aging in mice with constitutively high p53 activity. Genes Dev. 20 (2006) 16-21
-
(2006)
Genes Dev.
, vol.20
, pp. 16-21
-
-
Mendrysa, S.M.1
-
42
-
-
33645711615
-
Tumor suppression by p53 without accelerated aging: just enough of a good thing?
-
Mendrysa S.M., and Perry M.E. Tumor suppression by p53 without accelerated aging: just enough of a good thing?. Cell Cycle 5 (2006) 714-717
-
(2006)
Cell Cycle
, vol.5
, pp. 714-717
-
-
Mendrysa, S.M.1
Perry, M.E.2
-
43
-
-
24344448786
-
p53 isoforms can regulate p53 transcriptional activity
-
Bourdon J.C., et al. p53 isoforms can regulate p53 transcriptional activity. Genes Dev. 19 (2005) 2122-2137
-
(2005)
Genes Dev.
, vol.19
, pp. 2122-2137
-
-
Bourdon, J.C.1
-
44
-
-
0036128899
-
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound
-
Bykov V.J.N., et al. Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nat. Med. 8 (2002) 282-288
-
(2002)
Nat. Med.
, vol.8
, pp. 282-288
-
-
Bykov, V.J.N.1
-
45
-
-
0033601370
-
Pharmacological rescue of mutant p53 conformation and function
-
Foster B.A., et al. Pharmacological rescue of mutant p53 conformation and function. Science 286 (1999) 2507-2510
-
(1999)
Science
, vol.286
, pp. 2507-2510
-
-
Foster, B.A.1
-
46
-
-
85047687410
-
The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein
-
Takimoto R., et al. The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein. Cancer Biol. Ther. 1 (2002) 47-55
-
(2002)
Cancer Biol. Ther.
, vol.1
, pp. 47-55
-
-
Takimoto, R.1
-
47
-
-
33845901313
-
MDM2 inhibitors for cancer therapy
-
Vassilev L.T. MDM2 inhibitors for cancer therapy. Trends Mol. Med. 13 (2007) 23-31
-
(2007)
Trends Mol. Med.
, vol.13
, pp. 23-31
-
-
Vassilev, L.T.1
-
48
-
-
0035895350
-
Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53
-
Stoll R., et al. Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53. Biochemistry 40 (2001) 336-344
-
(2001)
Biochemistry
, vol.40
, pp. 336-344
-
-
Stoll, R.1
-
49
-
-
0035977612
-
Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp
-
Duncan S.J., et al. Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp. J. Am. Chem. Soc. 123 (2001) 554-560
-
(2001)
J. Am. Chem. Soc.
, vol.123
, pp. 554-560
-
-
Duncan, S.J.1
-
50
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev L.T., et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 (2004) 844-848
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
-
51
-
-
11144315535
-
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
-
Issaeva N., et al. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat. Med. 10 (2004) 1321-1328
-
(2004)
Nat. Med.
, vol.10
, pp. 1321-1328
-
-
Issaeva, N.1
-
52
-
-
30744449974
-
NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro
-
Krajewski M., et al. NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro. Nat. Med. 11 (2005) 1135-1136
-
(2005)
Nat. Med.
, vol.11
, pp. 1135-1136
-
-
Krajewski, M.1
-
53
-
-
18744406282
-
Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors
-
Lai Z., et al. Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 14734-14739
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 14734-14739
-
-
Lai, Z.1
-
54
-
-
20444369867
-
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
-
Yang Y., et al. Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell 7 (2005) 547-559
-
(2005)
Cancer Cell
, vol.7
, pp. 547-559
-
-
Yang, Y.1
-
55
-
-
33845611951
-
Modeling the therapeutic efficacy of p53 restoration in tumors
-
Martins C.P., et al. Modeling the therapeutic efficacy of p53 restoration in tumors. Cell 127 (2006) 1323-1334
-
(2006)
Cell
, vol.127
, pp. 1323-1334
-
-
Martins, C.P.1
-
56
-
-
33846899456
-
Restoration of p53 function leads to tumour regression in vivo
-
Ventura A., et al. Restoration of p53 function leads to tumour regression in vivo. Nature 445 (2007) 661-665
-
(2007)
Nature
, vol.445
, pp. 661-665
-
-
Ventura, A.1
-
57
-
-
33846937033
-
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
-
Xue W., et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 445 (2007) 656-660
-
(2007)
Nature
, vol.445
, pp. 656-660
-
-
Xue, W.1
-
58
-
-
0028070989
-
p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
-
Caelles C., et al. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 370 (1994) 220-223
-
(1994)
Nature
, vol.370
, pp. 220-223
-
-
Caelles, C.1
-
59
-
-
0029092356
-
Induction of apoptosis in HeLa cells by trans-activation-deficient p53
-
Haupt Y., et al. Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev. 9 (1995) 2170-2183
-
(1995)
Genes Dev.
, vol.9
, pp. 2170-2183
-
-
Haupt, Y.1
-
60
-
-
0034717014
-
Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling
-
Marchenko N.D., et al. Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling. J. Biol. Chem. 275 (2000) 16202-16212
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 16202-16212
-
-
Marchenko, N.D.1
-
61
-
-
0035910385
-
Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells
-
Sansome C., et al. Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells. FEBS Lett. 488 (2001) 110-115
-
(2001)
FEBS Lett.
, vol.488
, pp. 110-115
-
-
Sansome, C.1
-
62
-
-
33746883125
-
p53 and Nur77/TR3 - transcription factors that directly target mitochondria for cell death induction
-
Moll U.M., et al. p53 and Nur77/TR3 - transcription factors that directly target mitochondria for cell death induction. Oncogene 25 (2006) 4725-4743
-
(2006)
Oncogene
, vol.25
, pp. 4725-4743
-
-
Moll, U.M.1
-
63
-
-
21444432928
-
Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria
-
Arima Y., et al. Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria. J. Biol. Chem. 280 (2005) 19166-19176
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 19166-19176
-
-
Arima, Y.1
-
64
-
-
0037372005
-
The codon 72 polymorphic variants of p53 have markedly different apoptotic potential
-
Dumont P., et al. The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat. Genet. 33 (2003) 357-365
-
(2003)
Nat. Genet.
, vol.33
, pp. 357-365
-
-
Dumont, P.1
-
65
-
-
2342553892
-
Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
-
Leu J.I., et al. Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat. Cell Biol. 6 (2004) 443-450
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 443-450
-
-
Leu, J.I.1
-
66
-
-
4544381708
-
Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and -independent pathways
-
Yamaguchi H., et al. Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and -independent pathways. J. Biol. Chem. 279 (2004) 39431-39437
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 39431-39437
-
-
Yamaguchi, H.1
-
67
-
-
18144382261
-
p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase
-
Zhao Y., et al. p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase. Cancer Res. 65 (2005) 3745-3750
-
(2005)
Cancer Res.
, vol.65
, pp. 3745-3750
-
-
Zhao, Y.1
-
68
-
-
33847276654
-
Monoubiquitylation promotes mitochondrial p53 translocation
-
Marchenko N.D., et al. Monoubiquitylation promotes mitochondrial p53 translocation. EMBO J. 26 (2007) 923-934
-
(2007)
EMBO J.
, vol.26
, pp. 923-934
-
-
Marchenko, N.D.1
-
69
-
-
0037349289
-
p53 has a direct apoptogenic role at the mitochondria
-
Mihara M., et al. p53 has a direct apoptogenic role at the mitochondria. Mol. Cell 11 (2003) 577-590
-
(2003)
Mol. Cell
, vol.11
, pp. 577-590
-
-
Mihara, M.1
-
70
-
-
0442323478
-
Defining the p53 DNA-binding domain/Bcl-xL-binding interface using NMR
-
Petros A.M., et al. Defining the p53 DNA-binding domain/Bcl-xL-binding interface using NMR. FEBS Lett. 559 (2004) 171-174
-
(2004)
FEBS Lett.
, vol.559
, pp. 171-174
-
-
Petros, A.M.1
-
71
-
-
33646826684
-
WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization
-
Tomita Y., et al. WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization. J. Biol. Chem. 281 (2006) 8600-8606
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 8600-8606
-
-
Tomita, Y.1
-
72
-
-
33747620737
-
Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation
-
Strom E., et al. Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat. Chem. Biol. 2 (2006) 474-479
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 474-479
-
-
Strom, E.1
-
73
-
-
33748670457
-
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
-
Christophorou M.A., et al. The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature 443 (2006) 214-217
-
(2006)
Nature
, vol.443
, pp. 214-217
-
-
Christophorou, M.A.1
-
74
-
-
0842278331
-
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
-
Chipuk J.E., et al. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303 (2004) 1010-1014
-
(2004)
Science
, vol.303
, pp. 1010-1014
-
-
Chipuk, J.E.1
-
75
-
-
0344925540
-
Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription
-
Chipuk J.E., et al. Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription. Cancer Cell 4 (2003) 371-381
-
(2003)
Cancer Cell
, vol.4
, pp. 371-381
-
-
Chipuk, J.E.1
-
76
-
-
24644436766
-
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
-
Chipuk J.E., et al. PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science 309 (2005) 1732-1735
-
(2005)
Science
, vol.309
, pp. 1732-1735
-
-
Chipuk, J.E.1
-
77
-
-
33845193134
-
The Bad guy cooperates with a good Cop p53: Bad is transcriptionally up-regulated by p53 and forms Bad/p53 complex at the mitochondria to induce apoptosis
-
Jiang P., et al. The Bad guy cooperates with a good Cop p53: Bad is transcriptionally up-regulated by p53 and forms Bad/p53 complex at the mitochondria to induce apoptosis. Mol. Cell. Biol. 26 (2006) 9071-9082
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 9071-9082
-
-
Jiang, P.1
-
78
-
-
33749845328
-
Mitochondrially targeted wild-type p53 suppresses growth of mutant p53 lymphomas in vivo
-
Palacios G., and Moll U.M. Mitochondrially targeted wild-type p53 suppresses growth of mutant p53 lymphomas in vivo. Oncogene 25 (2006) 6133-6139
-
(2006)
Oncogene
, vol.25
, pp. 6133-6139
-
-
Palacios, G.1
Moll, U.M.2
-
79
-
-
27544490654
-
Mitochondrially targeted p53 has tumor suppressor activities in vivo
-
Talos F., et al. Mitochondrially targeted p53 has tumor suppressor activities in vivo. Cancer Res. 65 (2005) 9971-9981
-
(2005)
Cancer Res.
, vol.65
, pp. 9971-9981
-
-
Talos, F.1
-
80
-
-
33746646758
-
Mdm2 inhibitor nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia
-
Kojima K., et al. Mdm2 inhibitor nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia. Blood 108 (2006) 993-1000
-
(2006)
Blood
, vol.108
, pp. 993-1000
-
-
Kojima, K.1
-
81
-
-
33845185824
-
Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo
-
Ringshausen I., et al. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. Cancer Cell 10 (2006) 501-514
-
(2006)
Cancer Cell
, vol.10
, pp. 501-514
-
-
Ringshausen, I.1
|