메뉴 건너뛰기




Volumn 108, Issue 3, 2006, Pages 993-1000

Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia

Author keywords

[No Author keywords available]

Indexed keywords

FLUDARABINE; PROTEIN BAX; PROTEIN P53;

EID: 33746646758     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2005-12-5148     Document Type: Article
Times cited : (210)

References (51)
  • 1
    • 2942584865 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia: Revelations from the B-cell receptor
    • Stevenson FK, Caligaris-Cappio F. Chronic lymphocytic leukemia: revelations from the B-cell receptor. Blood. 2004;103:4389-4395.
    • (2004) Blood , vol.103 , pp. 4389-4395
    • Stevenson, F.K.1    Caligaris-Cappio, F.2
  • 2
    • 15844368449 scopus 로고    scopus 로고
    • Multicentre prospective randomised trial of fludarabine versus cyclophosphamide, doxorubicin, and prednisone (CAP) for treatment of advanced-stage chronic lymphocytic leukaemia: The French Cooperative Group on CLL
    • Johnson S, Smith AG, Loffler H, et al. Multicentre prospective randomised trial of fludarabine versus cyclophosphamide, doxorubicin, and prednisone (CAP) for treatment of advanced-stage chronic lymphocytic leukaemia: The French Cooperative Group on CLL. Lancet. 1996;347:1432-1438.
    • (1996) Lancet , vol.347 , pp. 1432-1438
    • Johnson, S.1    Smith, A.G.2    Loffler, H.3
  • 3
    • 0034649696 scopus 로고    scopus 로고
    • Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia
    • Rai KR, Peterson BL, Appelbaum FR, et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med. 2000;343:1750-1757.
    • (2000) N Engl J Med , vol.343 , pp. 1750-1757
    • Rai, K.R.1    Peterson, B.L.2    Appelbaum, F.R.3
  • 4
    • 0035889147 scopus 로고    scopus 로고
    • Randomized comparison of fludarabine, CAP, and ChOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients
    • Leporrier M, Chevret S, Cazin B, et al. Randomized comparison of fludarabine, CAP, and ChOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients. Blood. 2001;98:2319-2325.
    • (2001) Blood , vol.98 , pp. 2319-2325
    • Leporrier, M.1    Chevret, S.2    Cazin, B.3
  • 5
    • 19944429446 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: An updated retrospective comparative analysis of CALGB 9712 and CALGB 9011
    • Byrd JC, Rai K, Peterson BL, et al. Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: an updated retrospective comparative analysis of CALGB 9712 and CALGB 9011. Blood. 2005;105:49-53.
    • (2005) Blood , vol.105 , pp. 49-53
    • Byrd, J.C.1    Rai, K.2    Peterson, B.L.3
  • 6
    • 23044510136 scopus 로고    scopus 로고
    • Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia
    • Keating MJ, O'Brien S, Albitar M, et al. Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia. J Clin Oncol. 2005;23:4079-4088.
    • (2005) J Clin Oncol , vol.23 , pp. 4079-4088
    • Keating, M.J.1    O'Brien, S.2    Albitar, M.3
  • 7
    • 0027505303 scopus 로고
    • Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2 -deoxyadenosine and 9-beta-D-arabinosyl-2-fluoroadenine
    • Robertson LE, Chubb S, Meyn RE, et al. Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2 -deoxyadenosine and 9-beta-D-arabinosyl-2-fluoroadenine. Blood. 1993;81:143-150.
    • (1993) Blood , vol.81 , pp. 143-150
    • Robertson, L.E.1    Chubb, S.2    Meyn, R.E.3
  • 8
    • 0029859821 scopus 로고    scopus 로고
    • Fludarabine-mediated inhibition of nucleotide excision repair induces apoptosis in quiescent human lymphocytes
    • Sandoval A, Consoli U, Plunkett W. Fludarabine-mediated inhibition of nucleotide excision repair induces apoptosis in quiescent human lymphocytes. Clin Cancer Res. 1996;2:1731-1741.
    • (1996) Clin Cancer Res , vol.2 , pp. 1731-1741
    • Sandoval, A.1    Consoli, U.2    Plunkett, W.3
  • 9
    • 0034669944 scopus 로고    scopus 로고
    • Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria
    • Genini D, Adachi S, Chao Q, et al. Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria. Blood. 2000;96:3537-3543.
    • (2000) Blood , vol.96 , pp. 3537-3543
    • Genini, D.1    Adachi, S.2    Chao, Q.3
  • 10
    • 0030687662 scopus 로고    scopus 로고
    • P53, MDM-2, BAX and BCL-2 and drug resistance in chronic lymphocytic leukemia
    • Johnston JB, Daeninck P, Verburg L, et al. P53, MDM-2, BAX and BCL-2 and drug resistance in chronic lymphocytic leukemia. Leuk Lymphoma. 1997;26:435-449.
    • (1997) Leuk Lymphoma , vol.26 , pp. 435-449
    • Johnston, J.B.1    Daeninck, P.2    Verburg, L.3
  • 11
    • 4444228658 scopus 로고    scopus 로고
    • Fludarabine treatment of patients with chronic lymphocytic leukemia induces a p53-dependent gene expression response
    • Rosenwald A, Chuang EY, Davis RE, et al. Fludarabine treatment of patients with chronic lymphocytic leukemia induces a p53-dependent gene expression response. Blood. 2004;104:1428-1434.
    • (2004) Blood , vol.104 , pp. 1428-1434
    • Rosenwald, A.1    Chuang, E.Y.2    Davis, R.E.3
  • 12
    • 0038509118 scopus 로고    scopus 로고
    • Mechanism of action of purine analogues in chronic lymphocytic leukaemia
    • Pettitt AR. Mechanism of action of purine analogues in chronic lymphocytic leukaemia. Br J Haematol. 2003;121:692-702.
    • (2003) Br J Haematol , vol.121 , pp. 692-702
    • Pettitt, A.R.1
  • 13
    • 0029978058 scopus 로고    scopus 로고
    • Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: Relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance
    • Thomas A, El Rouby S, Reed JC, et al. Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance. Oncogene. 1996;12:1055-1062.
    • (1996) Oncogene , vol.12 , pp. 1055-1062
    • Thomas, A.1    El Rouby, S.2    Reed, J.C.3
  • 14
    • 0033028601 scopus 로고    scopus 로고
    • Purine analogues kill resting lymphocytes by p53-dependent and -independent mechanisms
    • Pettitt AR, Clarke AR, Cawley JC, Griffiths SD. Purine analogues kill resting lymphocytes by p53-dependent and -independent mechanisms. Br J Haematol. 1999;105:986-988.
    • (1999) Br J Haematol , vol.105 , pp. 986-988
    • Pettitt, A.R.1    Clarke, A.R.2    Cawley, J.C.3    Griffiths, S.D.4
  • 15
    • 0028987180 scopus 로고
    • p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias
    • Dohner H, Fischer K, Bentz M, et al. p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias. Blood. 1995;85:1580-1589.
    • (1995) Blood , vol.85 , pp. 1580-1589
    • Dohner, H.1    Fischer, K.2    Bentz, M.3
  • 16
    • 0027436745 scopus 로고
    • p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression
    • El Rouby S, Thomas A, Costin D, et al. p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression. Blood. 1993;82:3452-3459.
    • (1993) Blood , vol.82 , pp. 3452-3459
    • El Rouby, S.1    Thomas, A.2    Costin, D.3
  • 17
    • 0031442979 scopus 로고    scopus 로고
    • p53 abnormalities in CLL are associated with excess of prolymphocytes and poor prognosis
    • Lens D, Dyer MJ, Garcia-Marco JM, et al. p53 abnormalities in CLL are associated with excess of prolymphocytes and poor prognosis. Br J Haematol. 1997;99:848-857.
    • (1997) Br J Haematol , vol.99 , pp. 848-857
    • Lens, D.1    Dyer, M.J.2    Garcia-Marco, J.M.3
  • 18
    • 17744410949 scopus 로고    scopus 로고
    • p53 expression in B-cell chronic lymphocytic leukemia: A marker of disease progression and poor prognosis
    • Cordone I, Masi S, Mauro FR, et al. p53 expression in B-cell chronic lymphocytic leukemia: a marker of disease progression and poor prognosis. Blood. 1998;91:4342-4349.
    • (1998) Blood , vol.91 , pp. 4342-4349
    • Cordone, I.1    Masi, S.2    Mauro, F.R.3
  • 19
    • 0035437138 scopus 로고    scopus 로고
    • p53 dysfunction in B-cell chronic lymphocytic leukemia: Inactivation of ATM as an alternative to TP53 mutation
    • Pettitt AR, Sherrington PD, Stewart G, Cawley JC, Taylor AM, Stankovic T. p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation. Blood. 2001;98:814-822.
    • (2001) Blood , vol.98 , pp. 814-822
    • Pettitt, A.R.1    Sherrington, P.D.2    Stewart, G.3    Cawley, J.C.4    Taylor, A.M.5    Stankovic, T.6
  • 20
    • 0000303499 scopus 로고    scopus 로고
    • ATM associates with and phosphorylates p53: Mapping the region of interaction
    • Khanna KK, Keating KE, Kozlov S, et al. ATM associates with and phosphorylates p53: mapping the region of interaction. Nat Genet. 1998;20:398-400.
    • (1998) Nat Genet , vol.20 , pp. 398-400
    • Khanna, K.K.1    Keating, K.E.2    Kozlov, S.3
  • 21
    • 0031840253 scopus 로고    scopus 로고
    • ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins
    • Waterman MJ, Stavridi ES, Waterman JL, Halazonetis TD. ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins. Nat Genet. 1998;19:175-178.
    • (1998) Nat Genet , vol.19 , pp. 175-178
    • Waterman, M.J.1    Stavridi, E.S.2    Waterman, J.L.3    Halazonetis, T.D.4
  • 22
    • 0033513587 scopus 로고    scopus 로고
    • Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia
    • Stankovic T, Weber P, Stewart G, et al. Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia. Lancet. 1999;353:26-29.
    • (1999) Lancet , vol.353 , pp. 26-29
    • Stankovic, T.1    Weber, P.2    Stewart, G.3
  • 23
    • 0032532095 scopus 로고    scopus 로고
    • Deficiency of the ATM protein expression defines an aggressive subgroup of B-cell chronic lymphocytic leukemia
    • Starostik P, Manshouri T, O'Brien S, et al. Deficiency of the ATM protein expression defines an aggressive subgroup of B-cell chronic lymphocytic leukemia. Cancer Res. 1998;58:4552-4557.
    • (1998) Cancer Res , vol.58 , pp. 4552-4557
    • Starostik, P.1    Manshouri, T.2    O'Brien, S.3
  • 24
    • 0030992389 scopus 로고    scopus 로고
    • Expression profile of MDM-2 proteins in chronic lymphocytic leukemia and their clinical relevance
    • Haidar MA, El-Hajj H, Bueso-Ramos CE, et al. Expression profile of MDM-2 proteins in chronic lymphocytic leukemia and their clinical relevance. Am J Hematol. 1997;54:189-195.
    • (1997) Am J Hematol , vol.54 , pp. 189-195
    • Haidar, M.A.1    El-Hajj, H.2    Bueso-Ramos, C.E.3
  • 25
    • 0037263346 scopus 로고    scopus 로고
    • Altered expression of p53 and MDM2 proteins in hematological malignancies
    • Konikova E, Kusenda J. Altered expression of p53 and MDM2 proteins in hematological malignancies. Neoplasma. 2003;50:31-40.
    • (2003) Neoplasma , vol.50 , pp. 31-40
    • Konikova, E.1    Kusenda, J.2
  • 26
    • 0346455771 scopus 로고    scopus 로고
    • The MDM2-p53 interaction
    • Moll UM, Petrenko O. The MDM2-p53 interaction. Mol Cancer Res. 2003;1:1001-1008.
    • (2003) Mol Cancer Res , vol.1 , pp. 1001-1008
    • Moll, U.M.1    Petrenko, O.2
  • 27
    • 10744221485 scopus 로고    scopus 로고
    • In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    • Vassilev LT, Vu BT, Graves B, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science. 2004;303:844-848.
    • (2004) Science , vol.303 , pp. 844-848
    • Vassilev, L.T.1    Vu, B.T.2    Graves, B.3
  • 28
    • 27644568226 scopus 로고    scopus 로고
    • MDM2 antagonists induce p53-dependent apoptosis in AML: Implications for leukemia therapy
    • Kojima K, Konopleva M, Samudio IJ, et al. MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy. Blood. 2005;106:3150-3159.
    • (2005) Blood , vol.106 , pp. 3150-3159
    • Kojima, K.1    Konopleva, M.2    Samudio, I.J.3
  • 29
    • 11144224782 scopus 로고    scopus 로고
    • Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis
    • Thompson T, Tovar C, Yang H, et al. Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis. J Biol Chem. 2004;279:53015-53022.
    • (2004) J Biol Chem , vol.279 , pp. 53015-53022
    • Thompson, T.1    Tovar, C.2    Yang, H.3
  • 30
    • 13944257800 scopus 로고    scopus 로고
    • Transcription, apoptosis and p53: Catch-22
    • Schuler M, Green DR. Transcription, apoptosis and p53: catch-22. Trends Genet. 2005;21:182-187.
    • (2005) Trends Genet , vol.21 , pp. 182-187
    • Schuler, M.1    Green, D.R.2
  • 31
    • 0036721455 scopus 로고    scopus 로고
    • Spontaneous and drug-induced apoptosis is mediated by conformational changes of Bax and Bak in B-cell chronic lymphocytic leukemia
    • Bellosillo B, Villamor N, Lopez-Guillermo A, et al. Spontaneous and drug-induced apoptosis is mediated by conformational changes of Bax and Bak in B-cell chronic lymphocytic leukemia. Blood. 2002;100:1810-1816.
    • (2002) Blood , vol.100 , pp. 1810-1816
    • Bellosillo, B.1    Villamor, N.2    Lopez-Guillermo, A.3
  • 32
    • 27744487598 scopus 로고    scopus 로고
    • Nongenotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma
    • Stuhmer T, Chatterjee M, Hildebrandt M, et al. Nongenotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma. Blood. 2005;106:3609-3617.
    • (2005) Blood , vol.106 , pp. 3609-3617
    • Stuhmer, T.1    Chatterjee, M.2    Hildebrandt, M.3
  • 33
    • 20144373877 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia cells display p53-dependent drug-induced Puma upregulation
    • Mackus WJ, Kater AP, Grummels A, et al. Chronic lymphocytic leukemia cells display p53-dependent drug-induced Puma upregulation. Leukemia. 2005;19:427-434.
    • (2005) Leukemia , vol.19 , pp. 427-434
    • Mackus, W.J.1    Kater, A.P.2    Grummels, A.3
  • 34
    • 1642345125 scopus 로고    scopus 로고
    • Induction of caspase-dependent programmed cell death in B-cell chronic lymphocytic leukemia by anti-CD22 immunotoxins
    • Decker T, Oelsner M, Kreitman RJ, et al. Induction of caspase-dependent programmed cell death in B-cell chronic lymphocytic leukemia by anti-CD22 immunotoxins. Blood. 2004;103:2718-2726.
    • (2004) Blood , vol.103 , pp. 2718-2726
    • Decker, T.1    Oelsner, M.2    Kreitman, R.J.3
  • 35
    • 0033535350 scopus 로고    scopus 로고
    • Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis
    • Desagher S, Osen-Sand A, Nichols A, et al. Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis. J Cell Biol. 1999;144:891-901.
    • (1999) J Cell Biol , vol.144 , pp. 891-901
    • Desagher, S.1    Osen-Sand, A.2    Nichols, A.3
  • 37
    • 4944255743 scopus 로고    scopus 로고
    • Post-translational modification of p53 in tumorigenesis
    • Bode AM, Dong Z. Post-translational modification of p53 in tumorigenesis. Nat Rev Cancer. 2004;4:793-805.
    • (2004) Nat Rev Cancer , vol.4 , pp. 793-805
    • Bode, A.M.1    Dong, Z.2
  • 38
    • 0842278331 scopus 로고    scopus 로고
    • Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
    • Chipuk JE, Kuwana T, Bouchier-Hayes L, et al. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science. 2004;303:1010-1014.
    • (2004) Science , vol.303 , pp. 1010-1014
    • Chipuk, J.E.1    Kuwana, T.2    Bouchier-Hayes, L.3
  • 39
    • 2342553892 scopus 로고    scopus 로고
    • Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
    • Leu JI, Dumont P, Hafey M, Murphy ME, George DL. Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol. 2004;6:443-450.
    • (2004) Nat Cell Biol , vol.6 , pp. 443-450
    • Leu, J.I.1    Dumont, P.2    Hafey, M.3    Murphy, M.E.4    George, D.L.5
  • 40
    • 0037349289 scopus 로고    scopus 로고
    • p53 has a direct apoptogenic role at the mitochondria
    • Mihara M, Erster S, Zaika A, et al. p53 has a direct apoptogenic role at the mitochondria. Mol Cell. 2003;11:577-590.
    • (2003) Mol Cell , vol.11 , pp. 577-590
    • Mihara, M.1    Erster, S.2    Zaika, A.3
  • 42
    • 3242690522 scopus 로고    scopus 로고
    • In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation
    • Erster S, Mihara M, Kim RH, Petrenko O, Moll UM. In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation. Mol Cell Biol. 2004;24:6728-6741.
    • (2004) Mol Cell Biol , vol.24 , pp. 6728-6741
    • Erster, S.1    Mihara, M.2    Kim, R.H.3    Petrenko, O.4    Moll, U.M.5
  • 44
    • 16844362817 scopus 로고    scopus 로고
    • Lack of correlation between p53-dependent transcriptional activity and the ability to induce apoptosis among 179 mutant p53s
    • Kakudo Y, Shibata H, Otsuka K, Kato S, Ishioka C. Lack of correlation between p53-dependent transcriptional activity and the ability to induce apoptosis among 179 mutant p53s. Cancer Res. 2005;65:2108-2114.
    • (2005) Cancer Res , vol.65 , pp. 2108-2114
    • Kakudo, Y.1    Shibata, H.2    Otsuka, K.3    Kato, S.4    Ishioka, C.5
  • 45
    • 21444432928 scopus 로고    scopus 로고
    • Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria
    • Arima Y, Nitta M, Kuninaka S, et al. Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria. J Biol Chem. 2005;280:19166-19176.
    • (2005) J Biol Chem , vol.280 , pp. 19166-19176
    • Arima, Y.1    Nitta, M.2    Kuninaka, S.3
  • 46
    • 32544442894 scopus 로고    scopus 로고
    • Dissection of transcriptional and non-transcriptional p53 activities in the response to genotoxic stress
    • Speidel D, Helmbold H, Deppert W. Dissection of transcriptional and non-transcriptional p53 activities in the response to genotoxic stress. Oncogene. 2006;25:940-953.
    • (2006) Oncogene , vol.25 , pp. 940-953
    • Speidel, D.1    Helmbold, H.2    Deppert, W.3
  • 47
    • 0033839403 scopus 로고    scopus 로고
    • Bcl-2 and bax expression and chlorambucil-induced apoptosis in the T-cells and leukaemic B-cells of untreated B-cell chronic lymphocytic leukaemia patients
    • Thomas A, Pepper C, Hoy T, Bentley P. Bcl-2 and bax expression and chlorambucil-induced apoptosis in the T-cells and leukaemic B-cells of untreated B-cell chronic lymphocytic leukaemia patients. Leuk Res. 2000;24:813-821.
    • (2000) Leuk Res , vol.24 , pp. 813-821
    • Thomas, A.1    Pepper, C.2    Hoy, T.3    Bentley, P.4
  • 48
    • 27644450586 scopus 로고    scopus 로고
    • Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL
    • Austen B, Powell JE, Alvi A, et al. Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL. Blood. 2005;106:3175-3182.
    • (2005) Blood , vol.106 , pp. 3175-3182
    • Austen, B.1    Powell, J.E.2    Alvi, A.3
  • 49
    • 0037103272 scopus 로고    scopus 로고
    • Relationship between p53 dysfunction, CD38 expression, and IgVH mutation in chronic lymphocytic leukemia
    • Lin K, Sherrington PD, Dennis M, Matrai Z, Cawley JC, Pettitt AR. Relationship between p53 dysfunction, CD38 expression, and IgVH mutation in chronic lymphocytic leukemia. Blood. 2002;100:1404-1409.
    • (2002) Blood , vol.100 , pp. 1404-1409
    • Lin, K.1    Sherrington, P.D.2    Dennis, M.3    Matrai, Z.4    Cawley, J.C.5    Pettitt, A.R.6
  • 50
    • 16444380911 scopus 로고    scopus 로고
    • Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors
    • Carvajal D, Tovar C, Yang H, Vu BT, Heimbrook DC, Vassilev LT. Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors. Cancer Res. 2005;65:1918-1924.
    • (2005) Cancer Res , vol.65 , pp. 1918-1924
    • Carvajal, D.1    Tovar, C.2    Yang, H.3    Vu, B.T.4    Heimbrook, D.C.5    Vassilev, L.T.6
  • 51
    • 11144357657 scopus 로고    scopus 로고
    • Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions
    • Lozanski G, Heerema NA, Flinn IW, et al. Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions. Blood. 2004;103:3278-3281.
    • (2004) Blood , vol.103 , pp. 3278-3281
    • Lozanski, G.1    Heerema, N.A.2    Flinn, I.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.