Retention of wild-type p53 in tumors from p53 heterozygous mice: Reduction of p53 dosage can promote cancer formation

EMBO Journal

Volumn 17, Issue 16, 1998, Pages 4657-4667

  Venkatachalam, Sundaresan ^a   Shi, Yu Ping ^b   Jones, Stephen N ^a,c   Vogel, Hannes ^d   Bradley, Allan ^c   Pinkel, Dan ^b   Donehower, Lawrence A ^a  

^a Division of Molecular Virology   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Genomic instability; Loss of heterozygosity; Mouse; p53; Tumor suppressor

Indexed keywords

OLIGONUCLEOTIDE; PROTEIN P53;

ANIMAL CELL; ARTICLE; CANCER SUSCEPTIBILITY; CARCINOGENESIS; GAMMA IRRADIATION; GENE DOSAGE; GENE MUTATION; HETEROZYGOSITY LOSS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECESSIVE GENE; TUMOR SUPPRESSOR GENE;

ANIMALS; BASE SEQUENCE; CHROMOSOME MAPPING; DNA PRIMERS; GENE DOSAGE; GENES, P53; HETEROZYGOTE; LOSS OF HETEROZYGOSITY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASMS, EXPERIMENTAL; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0032541321     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.16.4657     Document Type: Article

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