-
1
-
-
0034632717
-
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
-
Artandi S.E., Chang S., Lee S.L., Alson S., Gottlieb G.J., Chin L., DePinho R.A. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature. 406:2000;573-574.
-
(2000)
Nature
, vol.406
, pp. 573-574
-
-
Artandi, S.E.1
Chang, S.2
Lee, S.L.3
Alson, S.4
Gottlieb, G.J.5
Chin, L.6
Depinho, R.A.7
-
2
-
-
0025040233
-
Suppression of human colorectal carcinoma cell growth by wild-type p53
-
Baker S.J., Markowitz S., Fearon E.R., Willson J.K.V., Vogelstein B. Suppression of human colorectal carcinoma cell growth by wild-type p53. Science. 249:1990;912-915.
-
(1990)
Science
, vol.249
, pp. 912-915
-
-
Baker, S.J.1
Markowitz, S.2
Fearon, E.R.3
Willson, J.K.V.4
Vogelstein, B.5
-
3
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist C.J., Kastan M.B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature. 421:2003;499-506.
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
4
-
-
0031955368
-
Cancer resistance genes in mice: Models for the study of tumour modifiers
-
Balmain A., Nagase H. Cancer resistance genes in mice. models for the study of tumour modifiers Trends Genet. 14:1998;139-144.
-
(1998)
Trends Genet.
, vol.14
, pp. 139-144
-
-
Balmain, A.1
Nagase, H.2
-
5
-
-
0037370476
-
The genetics and genomics of cancer
-
Balmain A., Gray J., Ponder B. The genetics and genomics of cancer. Nat. Genet. 33:2003;238-244.
-
(2003)
Nat. Genet.
, vol.33
, pp. 238-244
-
-
Balmain, A.1
Gray, J.2
Ponder, B.3
-
6
-
-
0033601346
-
Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
-
Bell D., Varley J.M., Zydlo T.E., Kang D.H., Wahrer D.C., Shannon K.E., Lubratovitch M., Verselis S.J., Isselbacher K.J., Fraumeni J.F.et al. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science. 286:1999;2528-2531.
-
(1999)
Science
, vol.286
, pp. 2528-2531
-
-
Bell, D.1
Varley, J.M.2
Zydlo, T.E.3
Kang, D.H.4
Wahrer, D.C.5
Shannon, K.E.6
Lubratovitch, M.7
Verselis, S.J.8
Isselbacher, K.J.9
Fraumeni, J.F.10
-
7
-
-
0020679049
-
Patient with 13 chromosome deletion: Evidence that the retinoblastoma gene is a recessive cancer gene
-
Benedict W.F., Murphree A.L., Banerjee A., Spina C.A., Sparkes M.C., Sparkes R.S. Patient with 13 chromosome deletion. evidence that the retinoblastoma gene is a recessive cancer gene Science. 219:1983;973-975.
-
(1983)
Science
, vol.219
, pp. 973-975
-
-
Benedict, W.F.1
Murphree, A.L.2
Banerjee, A.3
Spina, C.A.4
Sparkes, M.C.5
Sparkes, R.S.6
-
8
-
-
0002709148
-
Functions and origins of retroviral transforming genes
-
R. Weiss, N. Teich, H. Varmus, & J. Coffin. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press
-
nd Edition:1985;249-356 Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
-
(1985)
nd Edition
, pp. 249-356
-
-
Bishop, J.M.1
Varmus, H.E.2
-
10
-
-
0032546360
-
Mutations of mitotic checkpoint genes in human cancers
-
Cahill D.P., Lengauer C., Yu J., Riggins G.J., Willson J.K.V., Markowitz S.D., Kinzler K.W., Vogelstein B. Mutations of mitotic checkpoint genes in human cancers. Nature. 392:1998;300-303.
-
(1998)
Nature
, vol.392
, pp. 300-303
-
-
Cahill, D.P.1
Lengauer, C.2
Yu, J.3
Riggins, G.J.4
Willson, J.K.V.5
Markowitz, S.D.6
Kinzler, K.W.7
Vogelstein, B.8
-
11
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley L.C. The phosphoinositide 3-kinase pathway. Science. 296:2002;1655-1657.
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
12
-
-
0020518746
-
Expression of recessive alleles by chromosomal mechanisms in retinoblastoma
-
Cavenee W.K., Dryja T.P., Phillips R.A., Benedict W.F., Godbout R., Gallie B.L., Murphree A.L., Strong L.C., White R.L. Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature. 305:1983;779-784.
-
(1983)
Nature
, vol.305
, pp. 779-784
-
-
Cavenee, W.K.1
Dryja, T.P.2
Phillips, R.A.3
Benedict, W.F.4
Godbout, R.5
Gallie, B.L.6
Murphree, A.L.7
Strong, L.C.8
White, R.L.9
-
13
-
-
0037390446
-
The hereditary nonpolyposis colorectal cancer syndrome: Genetics and clinical implications
-
Chung D.C., Rustgi A.K. The hereditary nonpolyposis colorectal cancer syndrome. genetics and clinical implications Ann. Intern. Med. 138:2003;560-570.
-
(2003)
Ann. Intern. Med.
, vol.138
, pp. 560-570
-
-
Chung, D.C.1
Rustgi, A.K.2
-
14
-
-
0015749593
-
A general theory of carcinogenesis
-
Comings D.E. A general theory of carcinogenesis. Proc. Natl. Acad. Sci. USA. 70:1973;3324-3328.
-
(1973)
Proc. Natl. Acad. Sci. USA
, vol.70
, pp. 3324-3328
-
-
Comings, D.E.1
-
15
-
-
0034643955
-
Accommodating haploinsufficient tumour suppressor genes in Knudson's model
-
Cook W.D., McCaw B.J. Accommodating haploinsufficient tumour suppressor genes in Knudson's model. Oncogene. 19:2000;3434-3438.
-
(2000)
Oncogene
, vol.19
, pp. 3434-3438
-
-
Cook, W.D.1
Mccaw, B.J.2
-
17
-
-
0021675797
-
Participation of p53 cellular tumour antigen in transformation of normal embryonic cells
-
Eliyahu D., Raz A., Gruss P., Givol D., Oren M. Participation of p53 cellular tumour antigen in transformation of normal embryonic cells. Nature. 312:1984;646-649.
-
(1984)
Nature
, vol.312
, pp. 646-649
-
-
Eliyahu, D.1
Raz, A.2
Gruss, P.3
Givol, D.4
Oren, M.5
-
18
-
-
0023764396
-
Meth A fibrosarcoma cells express two transforming mutant p53 species
-
Eliyahu D., Goldfinger N., Pinhasi-Kimhi O., Shaulsky G., Skurnick Y., Ara N., Rotter V., Oren M. Meth A fibrosarcoma cells express two transforming mutant p53 species. Oncogene. 3:1988;313-321.
-
(1988)
Oncogene
, vol.3
, pp. 313-321
-
-
Eliyahu, D.1
Goldfinger, N.2
Pinhasi-Kimhi, O.3
Shaulsky, G.4
Skurnick, Y.5
Ara, N.6
Rotter, V.7
Oren, M.8
-
19
-
-
0036491931
-
The BRCA1 suppressor hypothesis: An explanation for the tissue-specific tumor development in BRCA1 patients
-
Elledge S.J., Amon A. The BRCA1 suppressor hypothesis. an explanation for the tissue-specific tumor development in BRCA1 patients Cancer Cell. 1:2002;129-132.
-
(2002)
Cancer Cell
, vol.1
, pp. 129-132
-
-
Elledge, S.J.1
Amon, A.2
-
22
-
-
0023959795
-
Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life
-
Finlay C.A., Hinds P.W., Tan T.H., Eliyahu D., Oren M., Levine A.J. Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol. Cell. Biol. 8:1988;531-539.
-
(1988)
Mol. Cell. Biol.
, vol.8
, pp. 531-539
-
-
Finlay, C.A.1
Hinds, P.W.2
Tan, T.H.3
Eliyahu, D.4
Oren, M.5
Levine, A.J.6
-
23
-
-
0024382760
-
The p53 proto-oncogene can act as a suppressor of transformation
-
Finlay C.A., Hinds P.W., Levine A.J. The p53 proto-oncogene can act as a suppressor of transformation. Cell. 57:1989;1083-1093.
-
(1989)
Cell
, vol.57
, pp. 1083-1093
-
-
Finlay, C.A.1
Hinds, P.W.2
Levine, A.J.3
-
24
-
-
0027742295
-
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
-
Fishel R., Lescoe M.K., Rao M.R.S., Copeland N.G., Jenkins N.A., Garber J., Kane M., Kolodner R. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell. 75:1993;1027-1038.
-
(1993)
Cell
, vol.75
, pp. 1027-1038
-
-
Fishel, R.1
Lescoe, M.K.2
Rao, M.R.S.3
Copeland, N.G.4
Jenkins, N.A.5
Garber, J.6
Kane, M.7
Kolodner, R.8
-
25
-
-
0017060019
-
Sporadic bilateral retinoblastoma and 13q-deletion
-
Francke U., Kung F. Sporadic bilateral retinoblastoma and 13q-deletion. Med. Pediatr. Oncol. 2:1976;379-385.
-
(1976)
Med. Pediatr. Oncol.
, vol.2
, pp. 379-385
-
-
Francke, U.1
Kung, F.2
-
26
-
-
0022506980
-
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
-
Friend S.H., Bernards R., Rogelj S., Weinberg R.A., Rapaport J.M., Albert D.M., Dryja T.P. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature. 323:1986;643-646.
-
(1986)
Nature
, vol.323
, pp. 643-646
-
-
Friend, S.H.1
Bernards, R.2
Rogelj, S.3
Weinberg, R.A.4
Rapaport, J.M.5
Albert, D.M.6
Dryja, T.P.7
-
27
-
-
0023222358
-
Nevoid basal-cell carcinoma syndrome
-
Gorlin R.J. Nevoid basal-cell carcinoma syndrome. Medicine. 66:1987;98-113.
-
(1987)
Medicine
, vol.66
, pp. 98-113
-
-
Gorlin, R.J.1
-
28
-
-
0035947772
-
E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner
-
Gottardi C.J., Wong E., Gumbiner B.M. E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner. J. Cell Biol. 153:2001;1049-1060.
-
(2001)
J. Cell Biol.
, vol.153
, pp. 1049-1060
-
-
Gottardi, C.J.1
Wong, E.2
Gumbiner, B.M.3
-
29
-
-
0033555627
-
Mutational inactivation of transforming growth factor β receptor type II in microsatellite stable colon cancers
-
Grady W.M., Myeroff L.L., Swinler S.E., Rajput A., Thiagalingam S., Lutterbaugh J.D., Neumann A., Brattain M.G., Chang J., Kim S.J.et al. Mutational inactivation of transforming growth factor β receptor type II in microsatellite stable colon cancers. Cancer Res. 59:1999;320-324.
-
(1999)
Cancer Res.
, vol.59
, pp. 320-324
-
-
Grady, W.M.1
Myeroff, L.L.2
Swinler, S.E.3
Rajput, A.4
Thiagalingam, S.5
Lutterbaugh, J.D.6
Neumann, A.7
Brattain, M.G.8
Chang, J.9
Kim, S.J.10
-
30
-
-
0025938038
-
Identification and characterization of the familial adenomatous polyposis coli gene
-
Groden J., Thliveris A., Samowitz W., Carlson M., Gelbert L., Albertsen H., Joslyn G., Stevens J., Spirio L., Robertson M.et al. Identification and characterization of the familial adenomatous polyposis coli gene. Cell. 66:1991;589-600.
-
(1991)
Cell
, vol.66
, pp. 589-600
-
-
Groden, J.1
Thliveris, A.2
Samowitz, W.3
Carlson, M.4
Gelbert, L.5
Albertsen, H.6
Joslyn, G.7
Stevens, J.8
Spirio, L.9
Robertson, M.10
-
31
-
-
15844386165
-
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
-
a
-
Hahn H., Wicking C., Zaphiropoulous P.G., Gailani M.R., Shanley S., Chidambaram A., Vorechovsky I., Holmberg E., Unden A.B., Gillies S.et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell. 85:1996;841-851. a.
-
(1996)
Cell
, vol.85
, pp. 841-851
-
-
Hahn, H.1
Wicking, C.2
Zaphiropoulous, P.G.3
Gailani, M.R.4
Shanley, S.5
Chidambaram, A.6
Vorechovsky, I.7
Holmberg, E.8
Unden, A.B.9
Gillies, S.10
-
32
-
-
0030593038
-
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
-
b
-
Hahn S.A., Schutte M., Hoque A.T., Moskaluk C.A., da Costa L.T., Rozenblum E., Weinstein C.L., Fischer A., Yeo C.J., Hruban R.H., Kern S.E. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science. 271:1996;350-353. b.
-
(1996)
Science
, vol.271
, pp. 350-353
-
-
Hahn, S.A.1
Schutte, M.2
Hoque, A.T.3
Moskaluk, C.A.4
Da Costa, L.T.5
Rozenblum, E.6
Weinstein, C.L.7
Fischer, A.8
Yeo, C.J.9
Hruban, R.H.10
Kern, S.E.11
-
33
-
-
0030576517
-
Patterns and emerging machanisms of the angiogenic switch during tumorigenesis
-
Hanahan D., Folkman J. Patterns and emerging machanisms of the angiogenic switch during tumorigenesis. Cell. 86:1996;353-364.
-
(1996)
Cell
, vol.86
, pp. 353-364
-
-
Hanahan, D.1
Folkman, J.2
-
34
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell. 100:2000;57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
35
-
-
0034306996
-
The Rb/E2F pathway: Expanding roles and emerging paradigms
-
Harbour J.W., Dean D.C. The Rb/E2F pathway. expanding roles and emerging paradigms Genes Dev. 14:2000;2393-2409.
-
(2000)
Genes Dev.
, vol.14
, pp. 2393-2409
-
-
Harbour, J.W.1
Dean, D.C.2
-
36
-
-
0014692015
-
Suppression of malignancy by cell fusion
-
Harris H., Miller O.J., Klein G., Worst P., Tachibana T. Suppression of malignancy by cell fusion. Nature. 223:1969;363-368.
-
(1969)
Nature
, vol.223
, pp. 363-368
-
-
Harris, H.1
Miller, O.J.2
Klein, G.3
Worst, P.4
Tachibana, T.5
-
37
-
-
0023394825
-
Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines
-
Hinds P.W., Finlay C.A., Frey A.B., Levine A.J. Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines. Mol. Cell. Biol. 7:1987;2863-2869.
-
(1987)
Mol. Cell. Biol.
, vol.7
, pp. 2863-2869
-
-
Hinds, P.W.1
Finlay, C.A.2
Frey, A.B.3
Levine, A.J.4
-
38
-
-
0024535277
-
Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation
-
Hinds P., Finlay C., Levine A.J. Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation. J. Virol. 63:1989;739-746.
-
(1989)
J. Virol.
, vol.63
, pp. 739-746
-
-
Hinds, P.1
Finlay, C.2
Levine, A.J.3
-
39
-
-
0032524069
-
Mutations in the SMAD4/DPC4 gene in juvenile polyposis
-
Howe J.R., Roth S., Ringold J.C., Summers R.W., Jarvinen H.J., Sistonen P., Tomlinson I.P., Houlston R.S., Bevan S., Mitros F.A.et al. Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science. 280:1998;1086-1088.
-
(1998)
Science
, vol.280
, pp. 1086-1088
-
-
Howe, J.R.1
Roth, S.2
Ringold, J.C.3
Summers, R.W.4
Jarvinen, H.J.5
Sistonen, P.6
Tomlinson, I.P.7
Houlston, R.S.8
Bevan, S.9
Mitros, F.A.10
-
40
-
-
0027285475
-
Ubiquitous somatic mutations in simple repeated sequences reveals a new mechanism for colonic carcinogenesis
-
Ionov Y., Peinado M.A., Malkhosyan S., Shibata D., Perucho M. Ubiquitous somatic mutations in simple repeated sequences reveals a new mechanism for colonic carcinogenesis. Nature. 363:1993;558-561.
-
(1993)
Nature
, vol.363
, pp. 558-561
-
-
Ionov, Y.1
Peinado, M.A.2
Malkhosyan, S.3
Shibata, D.4
Perucho, M.5
-
41
-
-
0037115914
-
Homologous repair of DNA damage and tumorigenesis: The BRCA connection
-
Jasin M. Homologous repair of DNA damage and tumorigenesis. the BRCA connection Oncogene. 21:2002;8981-8993.
-
(2002)
Oncogene
, vol.21
, pp. 8981-8993
-
-
Jasin, M.1
-
42
-
-
15844381336
-
Human homolog of patched, a candidate gene for basal cell nevus syndrome
-
Johnson R.L., Rothman A.L., Xie J., Goodrich L.V., Bare J.W., Bonifas J.M., Quinn A.G., Myers R.M., Cox D.R., Epstein E.H., Scott M.P. Human homolog of patched, a candidate gene for basal cell nevus syndrome. Science. 272:1996;1668-1671.
-
(1996)
Science
, vol.272
, pp. 1668-1671
-
-
Johnson, R.L.1
Rothman, A.L.2
Xie, J.3
Goodrich, L.V.4
Bare, J.W.5
Bonifas, J.M.6
Quinn, A.G.7
Myers, R.M.8
Cox, D.R.9
Epstein, E.H.10
Scott, M.P.11
-
43
-
-
0036718539
-
Molecular basis of the VHL hereditary cancer syndrome
-
Kaelin W.G. Jr. Molecular basis of the VHL hereditary cancer syndrome. Nat. Rev. Cancer. 2:2002;673-682.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 673-682
-
-
Kaelin, W.G.Jr.1
-
44
-
-
0028121279
-
A cell cycle regulator involved in genesis of many tumor types
-
Kamb A., Gruis N.A., Weaver-Feldhaus J., Liu Q., Harshman K., Tavtigian S.V., Stockert E., Day R.S. III, Johnson B.E., Skolnick M.H. A cell cycle regulator involved in genesis of many tumor types. Science. 264:1994;436-440.
-
(1994)
Science
, vol.264
, pp. 436-440
-
-
Kamb, A.1
Gruis, N.A.2
Weaver-Feldhaus, J.3
Liu, Q.4
Harshman, K.5
Tavtigian, S.V.6
Stockert, E.7
Day III, R.S.8
Johnson, B.E.9
Skolnick, M.H.10
-
45
-
-
0030728468
-
ARF
-
ARF. Cell. 91:1997;649-659.
-
(1997)
Cell
, vol.91
, pp. 649-659
-
-
Kamijo, T.1
Zindy, F.2
Roussel, M.F.3
Quelle, D.E.4
Downing, J.R.5
Ashmun, R.A.6
Grosveld, G.7
Sherr, C.J.8
-
47
-
-
0026318356
-
Participation of p53 protein in the cellular response to DNA damage
-
Kastan M.B., Onyekwere O., Sidransky D., Vogelstein B., Craig R.W. Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51:1991;6304-6311.
-
(1991)
Cancer Res.
, vol.51
, pp. 6304-6311
-
-
Kastan, M.B.1
Onyekwere, O.2
Sidransky, D.3
Vogelstein, B.4
Craig, R.W.5
-
48
-
-
0025815451
-
Identification of p53 as a sequence-specific DNA binding protein
-
Kern S.E., Kinzler K.W., Bruskin A., Jarosz D., Friedman P., Prives C., Vogelstein B. Identification of p53 as a sequence-specific DNA binding protein. Science. 252:1991;1708-1711.
-
(1991)
Science
, vol.252
, pp. 1708-1711
-
-
Kern, S.E.1
Kinzler, K.W.2
Bruskin, A.3
Jarosz, D.4
Friedman, P.5
Prives, C.6
Vogelstein, B.7
-
49
-
-
0025817880
-
Identification of FAP locus genes from chromosome 5q21
-
Kinzler K.W., Nilbert M.C., Su L.K., Vogelstein B., Bryan T.M., Levy D.B., Smith K.J., Preisinger A.C., Hedge P., McKechnie D.et al. Identification of FAP locus genes from chromosome 5q21. Science. 253:1991;661-665.
-
(1991)
Science
, vol.253
, pp. 661-665
-
-
Kinzler, K.W.1
Nilbert, M.C.2
Su, L.K.3
Vogelstein, B.4
Bryan, T.M.5
Levy, D.B.6
Smith, K.J.7
Preisinger, A.C.8
Hedge, P.9
Mckechnie, D.10
-
50
-
-
0015043748
-
Mutation and cancer: Statistical study of retinoblastoma
-
Knudson A.G. Mutation and cancer. statistical study of retinoblastoma Proc. Natl. Acad. Sci. USA. 68:1971;820-823.
-
(1971)
Proc. Natl. Acad. Sci. USA
, vol.68
, pp. 820-823
-
-
Knudson, A.G.1
-
51
-
-
0001201784
-
Mutation and human cancer
-
Knudson A.G. Mutation and human cancer. Adv. Cancer Res. 17:1973;317-352.
-
(1973)
Adv. Cancer Res.
, vol.17
, pp. 317-352
-
-
Knudson, A.G.1
-
53
-
-
0030975671
-
-/- colon carcinoma
-
-/- colon carcinoma. Science. 275:1997;1784-1787.
-
(1997)
Science
, vol.275
, pp. 1784-1787
-
-
Korinek, V.1
Barker, N.2
Morin, P.J.3
Van Wichen, D.4
De Weger, R.5
Kinzler, K.W.6
Vogelstein, B.7
Clevers, H.8
-
54
-
-
0031848068
-
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
-
Korinek V., Barker N., Moerer P., van Donselaar E., Huls G., Peters P.J., Clevers H. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat. Genet. 19:1998;379-383.
-
(1998)
Nat. Genet.
, vol.19
, pp. 379-383
-
-
Korinek, V.1
Barker, N.2
Moerer, P.3
Van Donselaar, E.4
Huls, G.5
Peters, P.J.6
Clevers, H.7
-
56
-
-
0018348655
-
T antigen is bound to a host protein in SV40-transformed cells
-
Lane D.P., Crawford L.V. T antigen is bound to a host protein in SV40-transformed cells. Nature. 278:1979;261-263.
-
(1979)
Nature
, vol.278
, pp. 261-263
-
-
Lane, D.P.1
Crawford, L.V.2
-
57
-
-
0031931414
-
Characterization of the p53-dependent postmitotic checkpoint following spindle disruption
-
Lanni J.S., Jacks T. Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol. Cell. Biol. 18:1998;1055-1064.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 1055-1064
-
-
Lanni, J.S.1
Jacks, T.2
-
59
-
-
0018760324
-
Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
-
Linzer D.I., Levine A.J. Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell. 17:1979;43-52.
-
(1979)
Cell
, vol.17
, pp. 43-52
-
-
Linzer, D.I.1
Levine, A.J.2
-
61
-
-
0032904432
-
Pten: A tumour suppressor that functions as a phospholipid phosphatase
-
Maehama T., Dixon J.E. Pten. a tumour suppressor that functions as a phospholipid phosphatase Trends Cell Biol. 9:1999;125-128.
-
(1999)
Trends Cell Biol.
, vol.9
, pp. 125-128
-
-
Maehama, T.1
Dixon, J.E.2
-
62
-
-
0025633582
-
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
-
Malkin D., Li F.P., Strong L.C., Fraumeni J.F. Jr., Nelson C.E., Kim D.H., Kass J., Gryka M.A., Bischoff F.Z., Tainsky M.A.et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science. 250:1990;1233-1238.
-
(1990)
Science
, vol.250
, pp. 1233-1238
-
-
Malkin, D.1
Li, F.P.2
Strong, L.C.3
Fraumeni, J.F.Jr.4
Nelson, C.E.5
Kim, D.H.6
Kass, J.7
Gryka, M.A.8
Bischoff, F.Z.9
Tainsky, M.A.10
-
63
-
-
0030949463
-
Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
-
Morin P.J., Sparks A.B., Korinek V., Barker N., Clevers H., Vogelstein B., Kinzler K.W. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science. 275:1997;1787-1790.
-
(1997)
Science
, vol.275
, pp. 1787-1790
-
-
Morin, P.J.1
Sparks, A.B.2
Korinek, V.3
Barker, N.4
Clevers, H.5
Vogelstein, B.6
Kinzler, K.W.7
-
64
-
-
0021835959
-
Rearrangements of the cellular p53 gene in erythroleukemic cells transformed by Friend virus
-
Mowat M., Cheng A., Kimura N., Bernstein A., Benchimol S. Rearrangements of the cellular p53 gene in erythroleukemic cells transformed by Friend virus. Nature. 314:1985;633-636.
-
(1985)
Nature
, vol.314
, pp. 633-636
-
-
Mowat, M.1
Cheng, A.2
Kimura, N.3
Bernstein, A.4
Benchimol, S.5
-
65
-
-
0033604515
-
Hedgehog signal transduction: From flies to vertebrates
-
Murone M., Rosenthal A., de Sauvage F.J. Hedgehog signal transduction. from flies to vertebrates Exp. Cell Res. 253:1999;25-33.
-
(1999)
Exp. Cell Res.
, vol.253
, pp. 25-33
-
-
Murone, M.1
Rosenthal, A.2
De Sauvage, F.J.3
-
66
-
-
0035063183
-
The Rb/E2F pathway and cancer
-
Nevins J.R. The Rb/E2F pathway and cancer. Hum. Mol. Genet. 10:2001;699-703.
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 699-703
-
-
Nevins, J.R.1
-
67
-
-
0036831681
-
Centrosome aberrations: Cause or consequence of cancer progression
-
Nigg E.A. Centrosome aberrations. cause or consequence of cancer progression Nat. Rev. Cancer. 2:2002;815-825.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 815-825
-
-
Nigg, E.A.1
-
68
-
-
0017157366
-
Partial deletions and trisomies of chromosome 13: Mapping of bands associated with particular malformations
-
Noel B., Quack B., Rethore M.O. Partial deletions and trisomies of chromosome 13. mapping of bands associated with particular malformations Clin. Genet. 9:1976;593-602.
-
(1976)
Clin. Genet.
, vol.9
, pp. 593-602
-
-
Noel, B.1
Quack, B.2
Rethore, M.O.3
-
69
-
-
0036258111
-
The IARC TP53 database: New online mutation analysis and recommendations to users
-
Olivier M., Eeles R., Hollstein M., Khan M.A., Harris C.C., Hainaut P. The IARC TP53 database. new online mutation analysis and recommendations to users Hum. Mutat. 19:2002;607-614.
-
(2002)
Hum. Mutat.
, vol.19
, pp. 607-614
-
-
Olivier, M.1
Eeles, R.2
Hollstein, M.3
Khan, M.A.4
Harris, C.C.5
Hainaut, P.6
-
70
-
-
0020682479
-
Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen
-
Oren M., Levine A.J. Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen. Proc. Natl. Acad. Sci. USA. 80:1983;56-59.
-
(1983)
Proc. Natl. Acad. Sci. USA
, vol.80
, pp. 56-59
-
-
Oren, M.1
Levine, A.J.2
-
71
-
-
0021673319
-
Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation
-
Parada L.F., Land H., Weinberg R.A., Wolf D., Rotter V. Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation. Nature. 312:1984;649-651.
-
(1984)
Nature
, vol.312
, pp. 649-651
-
-
Parada, L.F.1
Land, H.2
Weinberg, R.A.3
Wolf, D.4
Rotter, V.5
-
72
-
-
0031557898
-
The adenomatous polyposis coli (APC) tumor suppressor
-
Polakis P. The adenomatous polyposis coli (APC) tumor suppressor. Biochim. Biophys. Acta. 1332:1997;F127-F147.
-
(1997)
Biochim. Biophys. Acta
, vol.1332
-
-
Polakis, P.1
-
73
-
-
0026630266
-
APC mutations occur early during colorectal tumorigenesis
-
Powell S.M., Zilz N., Beazer-Barclay Y., Bryan T.M., Hamilton S.R., Thibodeau S.N., Vogelstein B., Kinzler K.W. APC mutations occur early during colorectal tumorigenesis. Nature. 359:1992;235-237.
-
(1992)
Nature
, vol.359
, pp. 235-237
-
-
Powell, S.M.1
Zilz, N.2
Beazer-Barclay, Y.3
Bryan, T.M.4
Hamilton, S.R.5
Thibodeau, S.N.6
Vogelstein, B.7
Kinzler, K.W.8
-
74
-
-
0032475878
-
Signaling to p53: Breaking the MDM2-p53 circuit
-
Prives C. Signaling to p53. breaking the MDM2-p53 circuit Cell. 95:1998;5-8.
-
(1998)
Cell
, vol.95
, pp. 5-8
-
-
Prives, C.1
-
75
-
-
0029587551
-
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
-
Quelle D.E., Zindy F., Ashmun R.A., Sherr C.J. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell. 83:1995;993-1000.
-
(1995)
Cell
, vol.83
, pp. 993-1000
-
-
Quelle, D.E.1
Zindy, F.2
Ashmun, R.A.3
Sherr, C.J.4
-
76
-
-
0035890321
-
Haplo-insufficiency? Let me count the ways
-
Quon K.C., Berns A. Haplo-insufficiency? Let me count the ways. Genes Dev. 15:2001;2917-2921.
-
(2001)
Genes Dev.
, vol.15
, pp. 2917-2921
-
-
Quon, K.C.1
Berns, A.2
-
77
-
-
0035499267
-
Stem cells, cancer, and cancer stem cells
-
Reya T., Morrison S.J., Clarke M.F., Weissman I.L. Stem cells, cancer, and cancer stem cells. Nature. 414:2001;105-111.
-
(2001)
Nature
, vol.414
, pp. 105-111
-
-
Reya, T.1
Morrison, S.J.2
Clarke, M.F.3
Weissman, I.L.4
-
79
-
-
0032517341
-
INK4a/CDKN2A tumor suppressor and its relatives
-
INK4a/CDKN2A tumor suppressor and its relatives. Biochim. Biophys. Acta. 1378:1998;F115-F177.
-
(1998)
Biochim. Biophys. Acta.
, vol.1378
-
-
Ruas, M.1
Peters, G.2
-
80
-
-
0027738023
-
Association of the APC gene product with beta-catenin
-
Rubinfeld B., Souza B., Albert I., Muller O., Chamberlain S.H., Masiarz F.R., Munemitsu S., Polakis P. Association of the APC gene product with beta-catenin. Science. 262:1993;1731-1734.
-
(1993)
Science
, vol.262
, pp. 1731-1734
-
-
Rubinfeld, B.1
Souza, B.2
Albert, I.3
Muller, O.4
Chamberlain, S.H.5
Masiarz, F.R.6
Munemitsu, S.7
Polakis, P.8
-
81
-
-
9344223357
-
DPC4 gene in various tumor types
-
Schutte M., Hruban R.H., Hedrick L., Cho K.R., Nadasdy G.M., Weinstein C.L., Bova G.S., Isaacs W.B., Cairns P., Nawroz H.et al. DPC4 gene in various tumor types. Cancer Res. 56:1996;2527-2530.
-
(1996)
Cancer Res.
, vol.56
, pp. 2527-2530
-
-
Schutte, M.1
Hruban, R.H.2
Hedrick, L.3
Cho, K.R.4
Nadasdy, G.M.5
Weinstein, C.L.6
Bova, G.S.7
Isaacs, W.B.8
Cairns, P.9
Nawroz, H.10
-
82
-
-
0034707053
-
In search of the tumour-suppressor functions of BRCA1 and BRCA2
-
Scully R., Livingston D.M. In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature. 408:2000;429-432.
-
(2000)
Nature
, vol.408
, pp. 429-432
-
-
Scully, R.1
Livingston, D.M.2
-
83
-
-
0033233243
-
2 homeostasis by hypoxia-inducible factor 1
-
2 homeostasis by hypoxia-inducible factor 1. Annu. Rev. Cell Dev. Biol. 15:1999;551-578.
-
(1999)
Annu. Rev. Cell Dev. Biol.
, vol.15
, pp. 551-578
-
-
Semenza, G.1
-
84
-
-
0027769876
-
A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4
-
Serrano M., Hannon G.J., Beach D. A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4. Nature. 366:1993;704-707.
-
(1993)
Nature
, vol.366
, pp. 704-707
-
-
Serrano, M.1
Hannon, G.J.2
Beach, D.3
-
85
-
-
0029993450
-
Role of the INK4a locus in tumor suppression and cell mortality
-
Serrano M., Lee H.-W., Chin L., Cordon-Cardo C., Beach D., DePinho R.A. Role of the INK4a locus in tumor suppression and cell mortality. Cell. 85:1996;27-37.
-
(1996)
Cell
, vol.85
, pp. 27-37
-
-
Serrano, M.1
Lee, H.-W.2
Chin, L.3
Cordon-Cardo, C.4
Beach, D.5
Depinho, R.A.6
-
88
-
-
0035487104
-
The INK4a/ARF network in tumour suppression
-
Sherr C.J. The INK4a/ARF network in tumour suppression. Nat. Rev. Mol. Cell Biol. 2:2001;731-737.
-
(2001)
Nat. Rev. Mol. Cell Biol.
, vol.2
, pp. 731-737
-
-
Sherr, C.J.1
-
89
-
-
0038682002
-
Mechanisms of TGF-β signaling from cell membrane to the nucleus
-
Shi Y., Massagué J. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell. 113:2003;685-700.
-
(2003)
Cell
, vol.113
, pp. 685-700
-
-
Shi, Y.1
Massagué, J.2
-
90
-
-
0034653689
-
The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression
-
Shih I.M., Yu J., He T.C., Vogelstein B., Kinzler K.W. The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression. Cancer Res. 60:2000;1671-1676.
-
(2000)
Cancer Res.
, vol.60
, pp. 1671-1676
-
-
Shih, I.M.1
Yu, J.2
He, T.C.3
Vogelstein, B.4
Kinzler, K.W.5
-
91
-
-
0034798285
-
Atm: Genome stability, neuronal development, and cancer cross paths
-
Shiloh Y., Kastan M.B. Atm. genome stability, neuronal development, and cancer cross paths Adv. Cancer Res. 83:2001;209-254.
-
(2001)
Adv. Cancer Res.
, vol.83
, pp. 209-254
-
-
Shiloh, Y.1
Kastan, M.B.2
-
92
-
-
0242499448
-
TGF-β cytostatic and apoptotic programs in homeostasis and cancer
-
Siegel P.M., Massagué J. TGF-β cytostatic and apoptotic programs in homeostasis and cancer. Nat. Rev. Cancer. 11:2003;807-821.
-
(2003)
Nat. Rev. Cancer
, vol.11
, pp. 807-821
-
-
Siegel, P.M.1
Massagué, J.2
-
93
-
-
0017225738
-
Suppression of malignancy in human cells
-
Stanbridge E.J. Suppression of malignancy in human cells. Nature. 260:1976;17-20.
-
(1976)
Nature
, vol.260
, pp. 17-20
-
-
Stanbridge, E.J.1
-
94
-
-
0017250977
-
DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA
-
Stehelin D., Varmus H.E., Bishop J.M., Vogt P.K. DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature. 260:1976;170-173.
-
(1976)
Nature
, vol.260
, pp. 170-173
-
-
Stehelin, D.1
Varmus, H.E.2
Bishop, J.M.3
Vogt, P.K.4
-
95
-
-
0037086001
-
Living with lethal PIP3 levels: Viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB
-
Stocker H., Andjelkovic M., Oldham S., Laffargue M., Wymann M.P., Hemmings B.A., Hafen E. Living with lethal PIP3 levels. viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB Science. 295:2002;2088-2091.
-
(2002)
Science
, vol.295
, pp. 2088-2091
-
-
Stocker, H.1
Andjelkovic, M.2
Oldham, S.3
Laffargue, M.4
Wymann, M.P.5
Hemmings, B.A.6
Hafen, E.7
-
96
-
-
0027756014
-
Association of the APC tumor suppressor protein with catenins
-
Su L.K., Vogelstein B., Kinzler K.W. Association of the APC tumor suppressor protein with catenins. Science. 262:1993;1734-1737.
-
(1993)
Science
, vol.262
, pp. 1734-1737
-
-
Su, L.K.1
Vogelstein, B.2
Kinzler, K.W.3
-
97
-
-
0142011466
-
Pten: From pathology to biology
-
Sulis M.L., Parsons R. Pten. from pathology to biology Trends Cell Biol. 13:2003;478-483.
-
(2003)
Trends Cell Biol.
, vol.13
, pp. 478-483
-
-
Sulis, M.L.1
Parsons, R.2
-
98
-
-
0035902140
-
The hedgehog and Wnt signalling pathways in cancer
-
Taipale J., Beachy P.A. The hedgehog and Wnt signalling pathways in cancer. Nature. 411:2001;349-354.
-
(2001)
Nature
, vol.411
, pp. 349-354
-
-
Taipale, J.1
Beachy, P.A.2
-
99
-
-
0042701991
-
Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
-
Tee A.R., Manning B.D., Roux P.P., Cantley L.C., Blenis J. Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr. Biol. 13:2003;1259-1268.
-
(2003)
Curr. Biol.
, vol.13
, pp. 1259-1268
-
-
Tee, A.R.1
Manning, B.D.2
Roux, P.P.3
Cantley, L.C.4
Blenis, J.5
-
101
-
-
4243110417
-
Pten dose dictates cancer progression in the prostate
-
Trotman L.C., Niki M., Dotan Z.A., Koutcher J.A., Di Cristofano A., Xiao A., Khoo A.S., Roy-Burman P., Greenberg N.M., Van Dyke T.et al. Pten dose dictates cancer progression in the prostate. PLoS Biology. 1:2003;385-396.
-
(2003)
PLoS Biology
, vol.1
, pp. 385-396
-
-
Trotman, L.C.1
Niki, M.2
Dotan, Z.A.3
Koutcher, J.A.4
Di Cristofano, A.5
Xiao, A.6
Khoo, A.S.7
Roy-Burman, P.8
Greenberg, N.M.9
Van Dyke, T.10
-
102
-
-
0032541321
-
Retention of wild-type p53 in tumors from p53 heterozygous mice: Reduction of p53 dosage can promote cancer formation
-
Venkatachalam S., Shi Y.P., Jones S.N., Vogel H., Bradley A., Pinkel D., Donehower L.A. Retention of wild-type p53 in tumors from p53 heterozygous mice. reduction of p53 dosage can promote cancer formation EMBO J. 17:1998;4657-4667.
-
(1998)
EMBO J.
, vol.17
, pp. 4657-4667
-
-
Venkatachalam, S.1
Shi, Y.P.2
Jones, S.N.3
Vogel, H.4
Bradley, A.5
Pinkel, D.6
Donehower, L.A.7
-
103
-
-
0032959871
-
Control of neuronal precursor proliferation in the cerebellum by Sonic hedgehog
-
Wechsler-Reya R.J., Scott M.P. Control of neuronal precursor proliferation in the cerebellum by Sonic hedgehog. Neuron. 22:2003;103-114.
-
(2003)
Neuron
, vol.22
, pp. 103-114
-
-
Wechsler-Reya, R.J.1
Scott, M.P.2
-
104
-
-
0029033861
-
The retinoblastoma protein and cell cycle control
-
Weinberg R.A. The retinoblastoma protein and cell cycle control. Cell. 81:1995;323-330.
-
(1995)
Cell
, vol.81
, pp. 323-330
-
-
Weinberg, R.A.1
-
105
-
-
0034614576
-
Stem cells: Units of development, units of regeneration, and units in evolution
-
Weissman I.L. Stem cells. units of development, units of regeneration, and units in evolution Cell. 100:2000;157-168.
-
(2000)
Cell
, vol.100
, pp. 157-168
-
-
Weissman, I.L.1
|