메뉴 건너뛰기




Volumn 116, Issue 2, 2004, Pages 235-246

Principles of Tumor Suppression

Author keywords

[No Author keywords available]

Indexed keywords

ARF PROTEIN; CHECKPOINT KINASE 2; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE; PROTEIN P53; RAS PROTEIN; SMAD4 PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN; VON HIPPEL LINDAU PROTEIN; WNT PROTEIN; WT1 PROTEIN;

EID: 0842346437     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(03)01075-4     Document Type: Review
Times cited : (822)

References (105)
  • 1
    • 0034632717 scopus 로고    scopus 로고
    • Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    • Artandi S.E., Chang S., Lee S.L., Alson S., Gottlieb G.J., Chin L., DePinho R.A. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature. 406:2000;573-574.
    • (2000) Nature , vol.406 , pp. 573-574
    • Artandi, S.E.1    Chang, S.2    Lee, S.L.3    Alson, S.4    Gottlieb, G.J.5    Chin, L.6    Depinho, R.A.7
  • 3
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist C.J., Kastan M.B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature. 421:2003;499-506.
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 4
    • 0031955368 scopus 로고    scopus 로고
    • Cancer resistance genes in mice: Models for the study of tumour modifiers
    • Balmain A., Nagase H. Cancer resistance genes in mice. models for the study of tumour modifiers Trends Genet. 14:1998;139-144.
    • (1998) Trends Genet. , vol.14 , pp. 139-144
    • Balmain, A.1    Nagase, H.2
  • 5
    • 0037370476 scopus 로고    scopus 로고
    • The genetics and genomics of cancer
    • Balmain A., Gray J., Ponder B. The genetics and genomics of cancer. Nat. Genet. 33:2003;238-244.
    • (2003) Nat. Genet. , vol.33 , pp. 238-244
    • Balmain, A.1    Gray, J.2    Ponder, B.3
  • 7
    • 0020679049 scopus 로고
    • Patient with 13 chromosome deletion: Evidence that the retinoblastoma gene is a recessive cancer gene
    • Benedict W.F., Murphree A.L., Banerjee A., Spina C.A., Sparkes M.C., Sparkes R.S. Patient with 13 chromosome deletion. evidence that the retinoblastoma gene is a recessive cancer gene Science. 219:1983;973-975.
    • (1983) Science , vol.219 , pp. 973-975
    • Benedict, W.F.1    Murphree, A.L.2    Banerjee, A.3    Spina, C.A.4    Sparkes, M.C.5    Sparkes, R.S.6
  • 8
    • 0002709148 scopus 로고
    • Functions and origins of retroviral transforming genes
    • R. Weiss, N. Teich, H. Varmus, & J. Coffin. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press
    • nd Edition:1985;249-356 Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
    • (1985) nd Edition , pp. 249-356
    • Bishop, J.M.1    Varmus, H.E.2
  • 11
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley L.C. The phosphoinositide 3-kinase pathway. Science. 296:2002;1655-1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 13
    • 0037390446 scopus 로고    scopus 로고
    • The hereditary nonpolyposis colorectal cancer syndrome: Genetics and clinical implications
    • Chung D.C., Rustgi A.K. The hereditary nonpolyposis colorectal cancer syndrome. genetics and clinical implications Ann. Intern. Med. 138:2003;560-570.
    • (2003) Ann. Intern. Med. , vol.138 , pp. 560-570
    • Chung, D.C.1    Rustgi, A.K.2
  • 14
    • 0015749593 scopus 로고
    • A general theory of carcinogenesis
    • Comings D.E. A general theory of carcinogenesis. Proc. Natl. Acad. Sci. USA. 70:1973;3324-3328.
    • (1973) Proc. Natl. Acad. Sci. USA , vol.70 , pp. 3324-3328
    • Comings, D.E.1
  • 15
    • 0034643955 scopus 로고    scopus 로고
    • Accommodating haploinsufficient tumour suppressor genes in Knudson's model
    • Cook W.D., McCaw B.J. Accommodating haploinsufficient tumour suppressor genes in Knudson's model. Oncogene. 19:2000;3434-3438.
    • (2000) Oncogene , vol.19 , pp. 3434-3438
    • Cook, W.D.1    Mccaw, B.J.2
  • 16
  • 17
    • 0021675797 scopus 로고
    • Participation of p53 cellular tumour antigen in transformation of normal embryonic cells
    • Eliyahu D., Raz A., Gruss P., Givol D., Oren M. Participation of p53 cellular tumour antigen in transformation of normal embryonic cells. Nature. 312:1984;646-649.
    • (1984) Nature , vol.312 , pp. 646-649
    • Eliyahu, D.1    Raz, A.2    Gruss, P.3    Givol, D.4    Oren, M.5
  • 19
    • 0036491931 scopus 로고    scopus 로고
    • The BRCA1 suppressor hypothesis: An explanation for the tissue-specific tumor development in BRCA1 patients
    • Elledge S.J., Amon A. The BRCA1 suppressor hypothesis. an explanation for the tissue-specific tumor development in BRCA1 patients Cancer Cell. 1:2002;129-132.
    • (2002) Cancer Cell , vol.1 , pp. 129-132
    • Elledge, S.J.1    Amon, A.2
  • 22
    • 0023959795 scopus 로고
    • Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life
    • Finlay C.A., Hinds P.W., Tan T.H., Eliyahu D., Oren M., Levine A.J. Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol. Cell. Biol. 8:1988;531-539.
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 531-539
    • Finlay, C.A.1    Hinds, P.W.2    Tan, T.H.3    Eliyahu, D.4    Oren, M.5    Levine, A.J.6
  • 23
    • 0024382760 scopus 로고
    • The p53 proto-oncogene can act as a suppressor of transformation
    • Finlay C.A., Hinds P.W., Levine A.J. The p53 proto-oncogene can act as a suppressor of transformation. Cell. 57:1989;1083-1093.
    • (1989) Cell , vol.57 , pp. 1083-1093
    • Finlay, C.A.1    Hinds, P.W.2    Levine, A.J.3
  • 25
    • 0017060019 scopus 로고
    • Sporadic bilateral retinoblastoma and 13q-deletion
    • Francke U., Kung F. Sporadic bilateral retinoblastoma and 13q-deletion. Med. Pediatr. Oncol. 2:1976;379-385.
    • (1976) Med. Pediatr. Oncol. , vol.2 , pp. 379-385
    • Francke, U.1    Kung, F.2
  • 26
    • 0022506980 scopus 로고
    • A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
    • Friend S.H., Bernards R., Rogelj S., Weinberg R.A., Rapaport J.M., Albert D.M., Dryja T.P. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature. 323:1986;643-646.
    • (1986) Nature , vol.323 , pp. 643-646
    • Friend, S.H.1    Bernards, R.2    Rogelj, S.3    Weinberg, R.A.4    Rapaport, J.M.5    Albert, D.M.6    Dryja, T.P.7
  • 27
    • 0023222358 scopus 로고
    • Nevoid basal-cell carcinoma syndrome
    • Gorlin R.J. Nevoid basal-cell carcinoma syndrome. Medicine. 66:1987;98-113.
    • (1987) Medicine , vol.66 , pp. 98-113
    • Gorlin, R.J.1
  • 28
    • 0035947772 scopus 로고    scopus 로고
    • E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner
    • Gottardi C.J., Wong E., Gumbiner B.M. E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner. J. Cell Biol. 153:2001;1049-1060.
    • (2001) J. Cell Biol. , vol.153 , pp. 1049-1060
    • Gottardi, C.J.1    Wong, E.2    Gumbiner, B.M.3
  • 33
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging machanisms of the angiogenic switch during tumorigenesis
    • Hanahan D., Folkman J. Patterns and emerging machanisms of the angiogenic switch during tumorigenesis. Cell. 86:1996;353-364.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 34
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell. 100:2000;57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 35
    • 0034306996 scopus 로고    scopus 로고
    • The Rb/E2F pathway: Expanding roles and emerging paradigms
    • Harbour J.W., Dean D.C. The Rb/E2F pathway. expanding roles and emerging paradigms Genes Dev. 14:2000;2393-2409.
    • (2000) Genes Dev. , vol.14 , pp. 2393-2409
    • Harbour, J.W.1    Dean, D.C.2
  • 37
    • 0023394825 scopus 로고
    • Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines
    • Hinds P.W., Finlay C.A., Frey A.B., Levine A.J. Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines. Mol. Cell. Biol. 7:1987;2863-2869.
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 2863-2869
    • Hinds, P.W.1    Finlay, C.A.2    Frey, A.B.3    Levine, A.J.4
  • 38
    • 0024535277 scopus 로고
    • Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation
    • Hinds P., Finlay C., Levine A.J. Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation. J. Virol. 63:1989;739-746.
    • (1989) J. Virol. , vol.63 , pp. 739-746
    • Hinds, P.1    Finlay, C.2    Levine, A.J.3
  • 40
    • 0027285475 scopus 로고
    • Ubiquitous somatic mutations in simple repeated sequences reveals a new mechanism for colonic carcinogenesis
    • Ionov Y., Peinado M.A., Malkhosyan S., Shibata D., Perucho M. Ubiquitous somatic mutations in simple repeated sequences reveals a new mechanism for colonic carcinogenesis. Nature. 363:1993;558-561.
    • (1993) Nature , vol.363 , pp. 558-561
    • Ionov, Y.1    Peinado, M.A.2    Malkhosyan, S.3    Shibata, D.4    Perucho, M.5
  • 41
    • 0037115914 scopus 로고    scopus 로고
    • Homologous repair of DNA damage and tumorigenesis: The BRCA connection
    • Jasin M. Homologous repair of DNA damage and tumorigenesis. the BRCA connection Oncogene. 21:2002;8981-8993.
    • (2002) Oncogene , vol.21 , pp. 8981-8993
    • Jasin, M.1
  • 43
    • 0036718539 scopus 로고    scopus 로고
    • Molecular basis of the VHL hereditary cancer syndrome
    • Kaelin W.G. Jr. Molecular basis of the VHL hereditary cancer syndrome. Nat. Rev. Cancer. 2:2002;673-682.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 673-682
    • Kaelin, W.G.Jr.1
  • 46
  • 50
    • 0015043748 scopus 로고
    • Mutation and cancer: Statistical study of retinoblastoma
    • Knudson A.G. Mutation and cancer. statistical study of retinoblastoma Proc. Natl. Acad. Sci. USA. 68:1971;820-823.
    • (1971) Proc. Natl. Acad. Sci. USA , vol.68 , pp. 820-823
    • Knudson, A.G.1
  • 51
    • 0001201784 scopus 로고
    • Mutation and human cancer
    • Knudson A.G. Mutation and human cancer. Adv. Cancer Res. 17:1973;317-352.
    • (1973) Adv. Cancer Res. , vol.17 , pp. 317-352
    • Knudson, A.G.1
  • 56
    • 0018348655 scopus 로고
    • T antigen is bound to a host protein in SV40-transformed cells
    • Lane D.P., Crawford L.V. T antigen is bound to a host protein in SV40-transformed cells. Nature. 278:1979;261-263.
    • (1979) Nature , vol.278 , pp. 261-263
    • Lane, D.P.1    Crawford, L.V.2
  • 57
    • 0031931414 scopus 로고    scopus 로고
    • Characterization of the p53-dependent postmitotic checkpoint following spindle disruption
    • Lanni J.S., Jacks T. Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol. Cell. Biol. 18:1998;1055-1064.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1055-1064
    • Lanni, J.S.1    Jacks, T.2
  • 58
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • Lengauer C., Kinzler K.W., Vogelstein B. Genetic instabilities in human cancers. Nature. 396:1998;643-649.
    • (1998) Nature , vol.396 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 59
    • 0018760324 scopus 로고
    • Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
    • Linzer D.I., Levine A.J. Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell. 17:1979;43-52.
    • (1979) Cell , vol.17 , pp. 43-52
    • Linzer, D.I.1    Levine, A.J.2
  • 61
    • 0032904432 scopus 로고    scopus 로고
    • Pten: A tumour suppressor that functions as a phospholipid phosphatase
    • Maehama T., Dixon J.E. Pten. a tumour suppressor that functions as a phospholipid phosphatase Trends Cell Biol. 9:1999;125-128.
    • (1999) Trends Cell Biol. , vol.9 , pp. 125-128
    • Maehama, T.1    Dixon, J.E.2
  • 64
    • 0021835959 scopus 로고
    • Rearrangements of the cellular p53 gene in erythroleukemic cells transformed by Friend virus
    • Mowat M., Cheng A., Kimura N., Bernstein A., Benchimol S. Rearrangements of the cellular p53 gene in erythroleukemic cells transformed by Friend virus. Nature. 314:1985;633-636.
    • (1985) Nature , vol.314 , pp. 633-636
    • Mowat, M.1    Cheng, A.2    Kimura, N.3    Bernstein, A.4    Benchimol, S.5
  • 65
    • 0033604515 scopus 로고    scopus 로고
    • Hedgehog signal transduction: From flies to vertebrates
    • Murone M., Rosenthal A., de Sauvage F.J. Hedgehog signal transduction. from flies to vertebrates Exp. Cell Res. 253:1999;25-33.
    • (1999) Exp. Cell Res. , vol.253 , pp. 25-33
    • Murone, M.1    Rosenthal, A.2    De Sauvage, F.J.3
  • 66
    • 0035063183 scopus 로고    scopus 로고
    • The Rb/E2F pathway and cancer
    • Nevins J.R. The Rb/E2F pathway and cancer. Hum. Mol. Genet. 10:2001;699-703.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 699-703
    • Nevins, J.R.1
  • 67
    • 0036831681 scopus 로고    scopus 로고
    • Centrosome aberrations: Cause or consequence of cancer progression
    • Nigg E.A. Centrosome aberrations. cause or consequence of cancer progression Nat. Rev. Cancer. 2:2002;815-825.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 815-825
    • Nigg, E.A.1
  • 68
    • 0017157366 scopus 로고
    • Partial deletions and trisomies of chromosome 13: Mapping of bands associated with particular malformations
    • Noel B., Quack B., Rethore M.O. Partial deletions and trisomies of chromosome 13. mapping of bands associated with particular malformations Clin. Genet. 9:1976;593-602.
    • (1976) Clin. Genet. , vol.9 , pp. 593-602
    • Noel, B.1    Quack, B.2    Rethore, M.O.3
  • 69
    • 0036258111 scopus 로고    scopus 로고
    • The IARC TP53 database: New online mutation analysis and recommendations to users
    • Olivier M., Eeles R., Hollstein M., Khan M.A., Harris C.C., Hainaut P. The IARC TP53 database. new online mutation analysis and recommendations to users Hum. Mutat. 19:2002;607-614.
    • (2002) Hum. Mutat. , vol.19 , pp. 607-614
    • Olivier, M.1    Eeles, R.2    Hollstein, M.3    Khan, M.A.4    Harris, C.C.5    Hainaut, P.6
  • 70
    • 0020682479 scopus 로고
    • Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen
    • Oren M., Levine A.J. Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen. Proc. Natl. Acad. Sci. USA. 80:1983;56-59.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 56-59
    • Oren, M.1    Levine, A.J.2
  • 71
    • 0021673319 scopus 로고
    • Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation
    • Parada L.F., Land H., Weinberg R.A., Wolf D., Rotter V. Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation. Nature. 312:1984;649-651.
    • (1984) Nature , vol.312 , pp. 649-651
    • Parada, L.F.1    Land, H.2    Weinberg, R.A.3    Wolf, D.4    Rotter, V.5
  • 72
    • 0031557898 scopus 로고    scopus 로고
    • The adenomatous polyposis coli (APC) tumor suppressor
    • Polakis P. The adenomatous polyposis coli (APC) tumor suppressor. Biochim. Biophys. Acta. 1332:1997;F127-F147.
    • (1997) Biochim. Biophys. Acta , vol.1332
    • Polakis, P.1
  • 74
    • 0032475878 scopus 로고    scopus 로고
    • Signaling to p53: Breaking the MDM2-p53 circuit
    • Prives C. Signaling to p53. breaking the MDM2-p53 circuit Cell. 95:1998;5-8.
    • (1998) Cell , vol.95 , pp. 5-8
    • Prives, C.1
  • 75
    • 0029587551 scopus 로고
    • Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
    • Quelle D.E., Zindy F., Ashmun R.A., Sherr C.J. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell. 83:1995;993-1000.
    • (1995) Cell , vol.83 , pp. 993-1000
    • Quelle, D.E.1    Zindy, F.2    Ashmun, R.A.3    Sherr, C.J.4
  • 76
    • 0035890321 scopus 로고    scopus 로고
    • Haplo-insufficiency? Let me count the ways
    • Quon K.C., Berns A. Haplo-insufficiency? Let me count the ways. Genes Dev. 15:2001;2917-2921.
    • (2001) Genes Dev. , vol.15 , pp. 2917-2921
    • Quon, K.C.1    Berns, A.2
  • 79
    • 0032517341 scopus 로고    scopus 로고
    • INK4a/CDKN2A tumor suppressor and its relatives
    • INK4a/CDKN2A tumor suppressor and its relatives. Biochim. Biophys. Acta. 1378:1998;F115-F177.
    • (1998) Biochim. Biophys. Acta. , vol.1378
    • Ruas, M.1    Peters, G.2
  • 82
    • 0034707053 scopus 로고    scopus 로고
    • In search of the tumour-suppressor functions of BRCA1 and BRCA2
    • Scully R., Livingston D.M. In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature. 408:2000;429-432.
    • (2000) Nature , vol.408 , pp. 429-432
    • Scully, R.1    Livingston, D.M.2
  • 83
    • 0033233243 scopus 로고    scopus 로고
    • 2 homeostasis by hypoxia-inducible factor 1
    • 2 homeostasis by hypoxia-inducible factor 1. Annu. Rev. Cell Dev. Biol. 15:1999;551-578.
    • (1999) Annu. Rev. Cell Dev. Biol. , vol.15 , pp. 551-578
    • Semenza, G.1
  • 84
    • 0027769876 scopus 로고
    • A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano M., Hannon G.J., Beach D. A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4. Nature. 366:1993;704-707.
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 88
    • 0035487104 scopus 로고    scopus 로고
    • The INK4a/ARF network in tumour suppression
    • Sherr C.J. The INK4a/ARF network in tumour suppression. Nat. Rev. Mol. Cell Biol. 2:2001;731-737.
    • (2001) Nat. Rev. Mol. Cell Biol. , vol.2 , pp. 731-737
    • Sherr, C.J.1
  • 89
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-β signaling from cell membrane to the nucleus
    • Shi Y., Massagué J. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell. 113:2003;685-700.
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massagué, J.2
  • 90
    • 0034653689 scopus 로고    scopus 로고
    • The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression
    • Shih I.M., Yu J., He T.C., Vogelstein B., Kinzler K.W. The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression. Cancer Res. 60:2000;1671-1676.
    • (2000) Cancer Res. , vol.60 , pp. 1671-1676
    • Shih, I.M.1    Yu, J.2    He, T.C.3    Vogelstein, B.4    Kinzler, K.W.5
  • 91
    • 0034798285 scopus 로고    scopus 로고
    • Atm: Genome stability, neuronal development, and cancer cross paths
    • Shiloh Y., Kastan M.B. Atm. genome stability, neuronal development, and cancer cross paths Adv. Cancer Res. 83:2001;209-254.
    • (2001) Adv. Cancer Res. , vol.83 , pp. 209-254
    • Shiloh, Y.1    Kastan, M.B.2
  • 92
    • 0242499448 scopus 로고    scopus 로고
    • TGF-β cytostatic and apoptotic programs in homeostasis and cancer
    • Siegel P.M., Massagué J. TGF-β cytostatic and apoptotic programs in homeostasis and cancer. Nat. Rev. Cancer. 11:2003;807-821.
    • (2003) Nat. Rev. Cancer , vol.11 , pp. 807-821
    • Siegel, P.M.1    Massagué, J.2
  • 93
    • 0017225738 scopus 로고
    • Suppression of malignancy in human cells
    • Stanbridge E.J. Suppression of malignancy in human cells. Nature. 260:1976;17-20.
    • (1976) Nature , vol.260 , pp. 17-20
    • Stanbridge, E.J.1
  • 94
    • 0017250977 scopus 로고
    • DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA
    • Stehelin D., Varmus H.E., Bishop J.M., Vogt P.K. DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature. 260:1976;170-173.
    • (1976) Nature , vol.260 , pp. 170-173
    • Stehelin, D.1    Varmus, H.E.2    Bishop, J.M.3    Vogt, P.K.4
  • 95
    • 0037086001 scopus 로고    scopus 로고
    • Living with lethal PIP3 levels: Viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB
    • Stocker H., Andjelkovic M., Oldham S., Laffargue M., Wymann M.P., Hemmings B.A., Hafen E. Living with lethal PIP3 levels. viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB Science. 295:2002;2088-2091.
    • (2002) Science , vol.295 , pp. 2088-2091
    • Stocker, H.1    Andjelkovic, M.2    Oldham, S.3    Laffargue, M.4    Wymann, M.P.5    Hemmings, B.A.6    Hafen, E.7
  • 96
    • 0027756014 scopus 로고
    • Association of the APC tumor suppressor protein with catenins
    • Su L.K., Vogelstein B., Kinzler K.W. Association of the APC tumor suppressor protein with catenins. Science. 262:1993;1734-1737.
    • (1993) Science , vol.262 , pp. 1734-1737
    • Su, L.K.1    Vogelstein, B.2    Kinzler, K.W.3
  • 97
    • 0142011466 scopus 로고    scopus 로고
    • Pten: From pathology to biology
    • Sulis M.L., Parsons R. Pten. from pathology to biology Trends Cell Biol. 13:2003;478-483.
    • (2003) Trends Cell Biol. , vol.13 , pp. 478-483
    • Sulis, M.L.1    Parsons, R.2
  • 98
    • 0035902140 scopus 로고    scopus 로고
    • The hedgehog and Wnt signalling pathways in cancer
    • Taipale J., Beachy P.A. The hedgehog and Wnt signalling pathways in cancer. Nature. 411:2001;349-354.
    • (2001) Nature , vol.411 , pp. 349-354
    • Taipale, J.1    Beachy, P.A.2
  • 99
    • 0042701991 scopus 로고    scopus 로고
    • Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
    • Tee A.R., Manning B.D., Roux P.P., Cantley L.C., Blenis J. Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr. Biol. 13:2003;1259-1268.
    • (2003) Curr. Biol. , vol.13 , pp. 1259-1268
    • Tee, A.R.1    Manning, B.D.2    Roux, P.P.3    Cantley, L.C.4    Blenis, J.5
  • 102
    • 0032541321 scopus 로고    scopus 로고
    • Retention of wild-type p53 in tumors from p53 heterozygous mice: Reduction of p53 dosage can promote cancer formation
    • Venkatachalam S., Shi Y.P., Jones S.N., Vogel H., Bradley A., Pinkel D., Donehower L.A. Retention of wild-type p53 in tumors from p53 heterozygous mice. reduction of p53 dosage can promote cancer formation EMBO J. 17:1998;4657-4667.
    • (1998) EMBO J. , vol.17 , pp. 4657-4667
    • Venkatachalam, S.1    Shi, Y.P.2    Jones, S.N.3    Vogel, H.4    Bradley, A.5    Pinkel, D.6    Donehower, L.A.7
  • 103
    • 0032959871 scopus 로고    scopus 로고
    • Control of neuronal precursor proliferation in the cerebellum by Sonic hedgehog
    • Wechsler-Reya R.J., Scott M.P. Control of neuronal precursor proliferation in the cerebellum by Sonic hedgehog. Neuron. 22:2003;103-114.
    • (2003) Neuron , vol.22 , pp. 103-114
    • Wechsler-Reya, R.J.1    Scott, M.P.2
  • 104
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg R.A. The retinoblastoma protein and cell cycle control. Cell. 81:1995;323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 105
    • 0034614576 scopus 로고    scopus 로고
    • Stem cells: Units of development, units of regeneration, and units in evolution
    • Weissman I.L. Stem cells. units of development, units of regeneration, and units in evolution Cell. 100:2000;157-168.
    • (2000) Cell , vol.100 , pp. 157-168
    • Weissman, I.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.